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Aliases & Descriptions for MAG
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases GMA 2 , 3 , 5 S-MAG 1 , 2 SIGLEC-4A 1 , 2 SIGLEC4A 1 , 2 Siglec-4a 3
Descriptions myelin associated glycoprotein 2 myelin-associated glycoprotein 2 sialic acid-binding immunoglobulin-like lectin 4A 2
Search outside databases for aliases for MAG genePrevious GC identifers: GC19P036400 GC19P036231 GC19P040459
Summaries for MAG (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for MAG : The protein encoded by this gene is a type I membrane protein and member of the immunoglobulinsuperfamily. It is thought to be involved in the process of myelination. It is a lectin that bindsto sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Twoalternatively spliced transcripts encoding different isoforms have been described for this gene.[provided by RefSeq] UniProtKB/Swiss-Prot: MAG_HUMAN, P20916 Function : Adhesion molecule in postnatal neural development that mediates sialic-acid dependentcell-cell interactions between neuronal and myelinating cells. Preferentially binds toalpha-2,3-linked sialic acid (By similarity)
Genomic Location for MAG
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MAG gene Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1 MAG Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P040474:
(about GC identifiers )
Start:
40,474,868 bp from pter
End:
40,496,547 bp from pter
Size:
21,680 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000019.8 NT_011109.15 Proteins for MAG
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MAG_HUMAN, P20916 (See
protein sequence )Recommended Name: Myelin-associated glycoprotein precursor Size : 626 amino acids; 69069 Da
Subunit : Binds to RTN4R (By similarity)
Subcellular location : Membrane; Single-pass type I membrane protein
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_002352.1 NP_542167.1 ENSEMBL proteins: ENSP00000262624 ENSP00000355234 ENSP00000376048 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table Antibodies for MAG: Assays for MAG:
Protein
Domains/ Families for MAG(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P20916 ProtoNet protein and cluster: P20916
2 Blocks protein families : IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set UniProtKB/Swiss-Prot: MAG_HUMAN, P20916 Similarity : Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin)family Similarity : Contains 4 Ig-like C2-type (immunoglobulin-like) domainsSimilarity : Contains 1 Ig-like V-type (immunoglobulin-like) domain
Gene Function for MAG
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_002361 Applied Biosystems Silencer ® siRNAs for MAG Sigma-Aldrich siRNA and siRNA Panels for MAG Sigma-Aldrich shRNA for MAG Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_002361                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_002361                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_002361  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002361 UniProtKB/Swiss-Prot: MAG_HUMAN, P20916 Function : Adhesion molecule in postnatal neural development that mediates sialic-acid dependentcell-cell interactions between neuronal and myelinating cells. Preferentially binds toalpha-2,3-linked sialic acid (By similarity)
Genatlas biochemistry entry for MAG :myelin associated glycoprotein,expressed on oligodendrocytes in the CNS and Schwann cells in theperipheral nervous system,interacting with neuronal processes,sialoadhesin family,Ig superfamily
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Mag) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IEA -- GO:0005529 sugar binding
IEA --
About this table
Pathways & Interactions for MAG
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for MAG (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for MAG 5/31 Interacting proteins for MAG (ENSP00000262624 3 ) via UniProtKB, MINT, and/or STRING (see all 31
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007155 cell adhesion
IEA --
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Drugs & Compounds for MAG (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MAG 10/29 Novoseek chemical compound relationships for MAG gene (see all 29
)
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
sglpg
92.89
12
16829480 (3), 11602387 (3), 9920969 (2), 1695241 (1) (see all 5 )
gq1balpha
87.30
3
17870542 (1), 17507233 (1), 9668345 (1)
gt1aalpha
79.54
2
10608819 (1)
2',3'-cyclic nucleotide
77.46
10
7509848 (1), 10417810 (1), 18496213 (1), 1383426 (1) (see all 9 )
sulfatide
75.60
16
1282933 (3), 17915254 (2), 11160960 (2), 1706491 (1) (see all 11 )
gangliotetraose
70.11
1
8570640 (1)
sialic acid
63.32
32
9298990 (5), 9874234 (4), 10570219 (3), 9084450 (2) (see all 13 )
ammonium metavanadate
55.52
2
1697896 (1), 8562321 (1)
ganglioside
49.69
6
1966017 (1), 12161033 (1), 10420586 (1)
neurocan
48.65
1
10483914 (1)
About this table
Transcripts for MAG(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_002361 Sigma-Aldrich siRNA and siRNA Panels for MAG Sigma-Aldrich shRNA for MAG Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_002361 NM_080600
REFSEQ mRNAs for MAG gene (2 alternative transcripts): NM_002361.2 NM_080600.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002361 NM_080600
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_002361                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_002361                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_002361  
Additional cDNA sequence: AK094545.1 AK222649.1 AK222680.1 AK223562.1 AK294644.1 AK308976.1 BC034042.1 BC053347.1 BC093045.1 CR614873.1 M29273.1 X98405.1
13 DOTS entries : DT.100777832 DT.95116020 DT.121497014 DT.100777830 DT.121497027 DT.100020126 DT.95116022 DT.100775956 DT.121497045 DT.121497048 DT.91763583 DT.100775960 DT.95128281
24/286 AceView cDNA sequences (see all 286
):X52785 BM664837 AW337790 BQ059060 BM478063 BX280770 BF111811 NM_002361 CR614873 F09020 BE874674 BU727996 NM_080600 BQ632310 BU192138 BM702139 T27881 BM475659 AW408631 BQ055266 BX350637 BG685870 BG176660 AI859588
highest scoring ESTs for MAG :M29273 AI083801 AI289321 AI497958 AI859707 AI948541 AL582015 AW118545 BC034042 BC053347
Unigene Cluster for MAG: Myelin associated glycoprotein Hs.643440 [show with all ESTs ] Unigene Representative Sequence: BC093045 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MAG (see all 8
) ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b SP1 :             -                                   -       SP2 :             -                                 -   -       SP3 :             -       -   -                                 SP4 :             -           -   -   -   -   -   -   -           -   -       SP5 :             -         -   -                              
About this scheme ECgene alternative splicing isoforms for MAG 3 Ensembl transcripts including schematic representations : ENST00000262624
ENST00000361922
ENST00000392213
Expression for MAG
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MAG expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MAG 1 / 2 / 3
3 probe-sets matching MAG gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAATAAATGCSOURCE GeneReport for Unigene cluster: Hs.643440 Expression variation in blood from EXPOLDB for MAG
Orthologs for MAG
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MAG gene from 5 species
About this table Species with no ortholog for MAG ENSEMBL Gene Tree for MAG Paralogs for MAG (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MAG gene SIGLEC1 2 CD22 2
SNPs/Variants for MAG (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MAG (up to first 250kb)
Disorders & Mutations for MAG
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 159460 10/31 Novoseek disease relationships for MAG gene (see all 31
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
monoclonal gammopathy
83.13
30
8383189 (2), 10229128 (1), 7681445 (1), 12407306 (1) (see all 22 )
polyneuropathy
82.59
38
7516055 (3), 7691993 (2), 7543988 (2), 11985632 (2) (see all 24 )
gammopathy
77.96
9
16829480 (1), 1371150 (1), 9600601 (1), 8676156 (1) (see all 7 )
demyelination
69.40
12
16421127 (2), 1706491 (1), 16969155 (1), 1694384 (1) (see all 9 )
polyneuropathy motor
67.18
1
1706491 (1)
myelin degeneration
63.39
1
12528815 (1)
sensory neuropathy
52.52
1
1706491 (1)
multiple sclerosis
52.09
17
7515411 (3), 1705050 (1), 12020971 (1), 9001700 (1) (see all 13 )
charcot-marie-tooth disease
51.00
1
10848494 (1)
waldenstrom macroglobulinemia
50.81
3
8383189 (1), 7504399 (1)
About this table Human Gene Mutation Database : MAG Genetic Association Database: MAG Human Genome Epidemiology Navigator: MAG (12 documents)
Medical News for MAG (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MAG (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/303 PubMed articles for MAG gene (see all 303
): cDNA cloning and amino acid sequence for human myelin-associated glycoprotein. (PubMed id 2476987) 2, 3, 4 Sato S....Miyatake T. (1989) Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the Chinese Han population. (PubMed id 16039057) 1, 3, 6 Wan C....Wang L. (2005) Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene and study of their association with multiple sclerosis. (PubMed id 12020971) 1, 3, 6 D'Alfonso S....Momigliano-Richiardi P. (2002) The DNA sequence and biology of human chromosome 19. (PubMed id 15057824) 3, 4 Grimwood J.... Lucas S.M. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Identification of the glycosylated sequons of human myelin-associated glycoprotein. (PubMed id 7505568) 3, 4 Burger D.... Steck A.J. (1993) Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. (PubMed id 8432525) 2, 3 Trask B....Carrano A. (1993) Molecular cloning of human myelin-associated glycoprotein. (PubMed id 2479762) 3, 4 Spagnol G.... Latov N. (1989) MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. (PubMed id 17974963) 1, 3 Swanson B.J....Hollingsworth M.A. (2007) Possible association of the MAG locus with schizophrenia in a Chinese Han cohort of family trios. (PubMed id 15820319) 1, 3 Yang Y.F....He L. (2005)
Search for MAG
(in PubMed ,
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Genome Databases showing MAG
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MAG
(According to HUGE )
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Specialized Databases showing MAG (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
ATLAS Chromosomes in Cancer entry for MAG Genetics and Cytogenetics in Oncology and Haematology Functional Glycomics Gateway - Glycan Binding http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_271
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-- Services for MAG (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for MAG:
Recombinant Proteins (MAG ) Antibodies (MAG )
Search Tocris compounds for MAG
Antibodies for MAG
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009