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Aliases for MAG Gene

Aliases for MAG Gene

  • Myelin Associated Glycoprotein 2 3
  • GMA 3 4 6
  • Sialic Acid Binding Ig-Like Lectin 4A 2 3
  • SIGLEC-4A 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 4A 3
  • Myelin-Associated Glycoprotein 3
  • SIGLEC4A 3
  • S-MAG 3

External Ids for MAG Gene

Previous Symbols for MAG Gene

  • GMA

Summaries for MAG Gene

Entrez Gene Summary for MAG Gene

  • The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for MAG Gene

MAG (Myelin Associated Glycoprotein) is a Protein Coding gene. Diseases associated with MAG include central pontine myelinolysis and wallerian degeneration. Among its related pathways are Signaling by FGFR and Signaling by GPCR. An important paralog of this gene is SIGLEC5.

UniProtKB/Swiss-Prot for MAG Gene

  • Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAG Gene

Genomics for MAG Gene

Genomic Location for MAG Gene

Start:
35,292,086 bp from pter
End:
35,313,807 bp from pter
Size:
21,722 bases
Orientation:
Plus strand

Genomic View for MAG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAG Gene

Regulatory Elements for MAG Gene

Proteins for MAG Gene

  • Protein details for MAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20916-MAG_HUMAN
    Recommended name:
    Myelin-associated glycoprotein
    Protein Accession:
    P20916
    Secondary Accessions:
    • B7Z2E5
    • F5GYC0
    • Q567S4

    Protein attributes for MAG Gene

    Size:
    626 amino acids
    Molecular mass:
    69069 Da
    Quaternary structure:
    • Binds to RTN4R.

    Alternative splice isoforms for MAG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAG Gene

Proteomics data for MAG Gene at MOPED

Post-translational modifications for MAG Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn99, Asn223, Asn246, Asn315, Asn406, Asn450, and Asn454

Other Protein References for MAG Gene

No data available for DME Specific Peptides for MAG Gene

Domains for MAG Gene

Gene Families for MAG Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins

UniProtKB/Swiss-Prot:

MAG_HUMAN
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.:
    • P20916
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • P20916
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.:
    • P20916
genes like me logo Genes that share domains with MAG: view

Function for MAG Gene

Molecular function for MAG Gene

GENATLAS Biochemistry: myelin associated glycoprotein,expressed on oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system,interacting with neuronal processes,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).

Gene Ontology (GO) - Molecular Function for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with MAG: view
genes like me logo Genes that share phenotypes with MAG: view

Animal Models for MAG Gene

MGI Knock Outs for MAG:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MAG Gene

Localization for MAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAG Gene COMPARTMENTS Subcellular localization image for MAG gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0033270 paranode region of axon IEA --
GO:0043209 myelin sheath --
GO:0043220 Schmidt-Lanterman incisure IEA --
genes like me logo Genes that share ontologies with MAG: view

Pathways for MAG Gene

genes like me logo Genes that share pathways with MAG: view

Pathways by source for MAG Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for MAG Gene
1 Cell Signaling Technology pathway for MAG Gene

Gene Ontology (GO) - Biological Process for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007596 blood coagulation TAS --
GO:0021762 substantia nigra development IEP 22926577
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
GO:0050770 regulation of axonogenesis TAS --
genes like me logo Genes that share ontologies with MAG: view

Compounds for MAG Gene

(40) Novoseek inferred chemical compound relationships for MAG Gene

Compound -log(P) Hits PubMed IDs
sglpg 92.7 10
gq1balpha 90 5
gt1aalpha 79.1 1
2,3-cyclic nucleotide 76.7 9
sulfatide 76.1 15
genes like me logo Genes that share compounds with MAG: view

Transcripts for MAG Gene

Unigene Clusters for MAG Gene

Myelin associated glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for MAG Gene

GeneLoc Exon Structure for
MAG
ECgene alternative splicing isoforms for
MAG

Expression for MAG Gene

mRNA expression in normal human tissues for MAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAG Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (17.1), Brain - Substantia nigra (8.5), Brain - Hippocampus (4.5), and Brain - Hypothalamus (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAG Gene

SOURCE GeneReport for Unigene cluster for MAG Gene Hs.643440

genes like me logo Genes that share expressions with MAG: view

Orthologs for MAG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAG 37
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAG 36
  • 89.7 (n)
  • 94.31 (a)
MAG 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAG 36
  • 92.39 (n)
  • 96.65 (a)
MAG 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mag 36
  • 87.26 (n)
  • 94.24 (a)
Mag 16
Mag 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAG 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 22 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mag 36
  • 88.66 (n)
  • 95.37 (a)
lizard
(Anolis carolinensis)
Reptilia MAG 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mag 36
  • 60.04 (n)
  • 52.02 (a)
zebrafish
(Danio rerio)
Actinopterygii mag 36
  • 51.97 (n)
  • 42.65 (a)
mag 37
  • 37 (a)
OneToOne
Species with no ortholog for MAG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAG Gene

ENSEMBL:
Gene Tree for MAG (if available)
TreeFam:
Gene Tree for MAG (if available)

Paralogs for MAG Gene

Selected SIMAP similar genes for MAG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAG: view

Variants for MAG Gene

Sequence variations from dbSNP and Humsavar for MAG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs720307 -- 35,307,048(+) CGTTC(C/T)GCCGA intron-variant
rs720308 -- 35,307,157(+) TATTA(A/G)TGTAC intron-variant
rs720309 -- 35,307,013(+) AAAGA(A/T)ACTAA intron-variant
rs1034597 -- 35,308,297(+) AAACG(C/T)ACAGA intron-variant
rs1126770 -- 35,302,686(+) GCCAC(C/T)GCCTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MAG Gene

Variant ID Type Subtype PubMed ID
nsv510765 CNV Loss 20534489
dgv1080e1 CNV Complex 17122850
nsv911618 CNV Loss 21882294
nsv833810 CNV Gain 17160897
esv1763084 CNV Deletion 17803354
nsv9711 CNV Loss 18304495
esv1006379 CNV Deletion 20482838

Relevant External Links for MAG Gene

HapMap Linkage Disequilibrium report
MAG
Human Gene Mutation Database (HGMD)
MAG

Disorders for MAG Gene

(31) Novoseek inferred disease relationships for MAG Gene

Disease -log(P) Hits PubMed IDs
monoclonal gammopathy 83.1 25
polyneuropathy 82.7 32
gammopathy 77.1 7
demyelination 68.8 10
polyneuropathy motor 65.8 1

Relevant External Links for MAG

Genetic Association Database (GAD)
MAG
Human Genome Epidemiology (HuGE) Navigator
MAG
genes like me logo Genes that share disorders with MAG: view

No data available for UniProtKB/Swiss-Prot for MAG Gene

Publications for MAG Gene

  1. Identification of the glycosylated sequons of human myelin-associated glycoprotein. (PMID: 7505568) Burger D. … Steck A.J. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  2. Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene and study of their association with multiple sclerosis. (PMID: 12020971) D'Alfonso S. … Momigliano-Richiardi P. (J. Neuroimmunol. 2002) 3 23 49
  3. Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the Chinese Han population. (PMID: 16039057) Wan C. … Wang L. (Neurosci. Lett. 2005) 3 23 49
  4. A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. (PMID: 18496213) Voineskos A.N. … Kennedy J.L. (Psychiatr. Genet. 2008) 3 23 49
  5. cDNA cloning and amino acid sequence for human myelin-associated glycoprotein. (PMID: 2476987) Sato S. … Miyatake T. (Biochem. Biophys. Res. Commun. 1989) 2 3 4

Products for MAG Gene

Sources for MAG Gene

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