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Aliases for MAG Gene

Aliases for MAG Gene

  • Myelin Associated Glycoprotein 2 3 5
  • Sialic Acid Binding Ig-Like Lectin 4A 2 3
  • SIGLEC-4A 3 4
  • GMA 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 4A 3
  • Myelin-Associated Glycoprotein 3
  • SIGLEC4A 3
  • S-MAG 3
  • SPG75 3

External Ids for MAG Gene

Previous HGNC Symbols for MAG Gene

  • GMA

Previous GeneCards Identifiers for MAG Gene

  • GC19P036400
  • GC19P036231
  • GC19P040459
  • GC19P040474
  • GC19P035783
  • GC19P032291
  • GC19P035787
  • GC19P035956

Summaries for MAG Gene

Entrez Gene Summary for MAG Gene

  • The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for MAG Gene

MAG (Myelin Associated Glycoprotein) is a Protein Coding gene. Diseases associated with MAG include Spastic Paraplegia 75 and Demyelinating Polyneuropathy. Among its related pathways are Platelet activation, signaling and aggregation and p75 NTR receptor-mediated signalling. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC10.

UniProtKB/Swiss-Prot for MAG Gene

  • Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAG Gene

Genomics for MAG Gene

Regulatory Elements for MAG Gene

Enhancers for MAG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MAG on UCSC Golden Path with GeneCards custom track

Genomic Location for MAG Gene

Chromosome:
19
Start:
35,292,086 bp from pter
End:
35,313,807 bp from pter
Size:
21,722 bases
Orientation:
Plus strand

Genomic View for MAG Gene

Genes around MAG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAG Gene

Proteins for MAG Gene

  • Protein details for MAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20916-MAG_HUMAN
    Recommended name:
    Myelin-associated glycoprotein
    Protein Accession:
    P20916
    Secondary Accessions:
    • B7Z2E5
    • F5GYC0
    • Q567S4

    Protein attributes for MAG Gene

    Size:
    626 amino acids
    Molecular mass:
    69069 Da
    Quaternary structure:
    • Binds to RTN4R.

    Alternative splice isoforms for MAG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAG Gene

Post-translational modifications for MAG Gene

  • N-glycosylated.
  • Glycosylation at Asn 99, Asn 106, Asn 223, Asn 246, Asn 315, Asn 406, Asn 450, and Asn 454
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAG (MAG)

No data available for DME Specific Peptides for MAG Gene

Domains & Families for MAG Gene

Protein Domains for MAG Gene

Suggested Antigen Peptide Sequences for MAG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20916

UniProtKB/Swiss-Prot:

MAG_HUMAN :
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with MAG: view

Function for MAG Gene

Molecular function for MAG Gene

GENATLAS Biochemistry:
myelin associated glycoprotein,expressed on oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system,interacting with neuronal processes,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function:
Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).

Gene Ontology (GO) - Molecular Function for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IEA --
GO:0019901 protein kinase binding IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with MAG: view
genes like me logo Genes that share phenotypes with MAG: view

Animal Models for MAG Gene

MGI Knock Outs for MAG:

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAG Gene

Localization for MAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAG Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAG Gene COMPARTMENTS Subcellular localization image for MAG gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0033270 paranode region of axon IEA --
GO:0035749 myelin sheath adaxonal region IEA --
genes like me logo Genes that share ontologies with MAG: view

Pathways & Interactions for MAG Gene

genes like me logo Genes that share pathways with MAG: view

Pathways by source for MAG Gene

Gene Ontology (GO) - Biological Process for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007399 nervous system development IEA --
GO:0010977 negative regulation of neuron projection development IEA --
GO:0031643 positive regulation of myelination IEA --
GO:0045665 negative regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with MAG: view

No data available for SIGNOR curated interactions for MAG Gene

Drugs & Compounds for MAG Gene

(13) Drugs for MAG Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
rituximab Approved Pharma Therapeutic Antibodies 1611

(30) Additional Compounds for MAG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAG: view

Transcripts for MAG Gene

Unigene Clusters for MAG Gene

Myelin associated glycoprotein:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for MAG Gene

GeneLoc Exon Structure for
MAG
ECgene alternative splicing isoforms for
MAG

Expression for MAG Gene

mRNA expression in normal human tissues for MAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAG Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x17.1), Brain - Substantia nigra (x8.5), Brain - Hippocampus (x4.5), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for MAG Gene

This gene is overexpressed in Frontal cortex (29.9), Spinal cord (27.3), and Brain (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAG Gene



Protein tissue co-expression partners for MAG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAG Gene:

MAG

SOURCE GeneReport for Unigene cluster for MAG Gene:

Hs.643440
genes like me logo Genes that share expression patterns with MAG: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MAG Gene

Orthologs for MAG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAG 34
  • 89.7 (n)
  • 94.31 (a)
MAG 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAG 34
  • 92.39 (n)
  • 96.65 (a)
MAG 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mag 34
  • 87.26 (n)
  • 94.24 (a)
Mag 16
Mag 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mag 34
  • 88.66 (n)
  • 95.37 (a)
oppossum
(Monodelphis domestica)
Mammalia MAG 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MAG 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAG 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mag 34
  • 60.04 (n)
  • 52.02 (a)
zebrafish
(Danio rerio)
Actinopterygii mag 34
  • 51.97 (n)
  • 42.65 (a)
mag 35
  • 37 (a)
OneToOne
Species where no ortholog for MAG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAG Gene

ENSEMBL:
Gene Tree for MAG (if available)
TreeFam:
Gene Tree for MAG (if available)

Paralogs for MAG Gene

(1) SIMAP similar genes for MAG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAG: view

Variants for MAG Gene

Sequence variations from dbSNP and Humsavar for MAG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11084810 - 35,299,742(+) CACTG(A/C)TGCAC reference, missense
rs3214111 -- 35,294,118(+) TGGGA(-/G)GGCCA intron-variant
rs3214112 -- 35,307,899(+) GAAGT(-/G)GGGGG intron-variant
rs3746248 -- 35,299,600(+) ACGGA(A/G)GTGGA reference, synonymous-codon
rs3746249 -- 35,299,741(+) TCACT(A/G)CTGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MAG Gene

Variant ID Type Subtype PubMed ID
dgv2010e59 CNV duplication 20981092
esv1006379 CNV deletion 20482838
esv1763084 CNV deletion 17803354
esv2758758 CNV loss 17122850
nsv510765 CNV deletion 20534489
nsv833810 CNV gain 17160897
nsv953283 CNV deletion 24416366
nsv9711 CNV loss 18304495

Variation tolerance for MAG Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAG Gene

Human Gene Mutation Database (HGMD)
MAG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAG Gene

Disorders for MAG Gene

MalaCards: The human disease database

(27) MalaCards diseases for MAG Gene - From: ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia 75
  • spg75
demyelinating polyneuropathy
  • peripheral demyelinating neuropathy
chronic polyneuropathy
peripheral nervous system disease
  • peripheral nerve disease
pelizaeus-merzbacher disease
  • leukodystrophy, sudanophilic
- elite association - COSMIC cancer census association via MalaCards
Search MAG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MAG_HUMAN
  • Spastic paraplegia 75, autosomal recessive (SPG75) [MIM:616680]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG75 is characterized by onset in early childhood and is associated with mild to moderate cognitive impairment. {ECO:0000269 PubMed:24482476, ECO:0000269 PubMed:26179919}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MAG

Genetic Association Database (GAD)
MAG
Human Genome Epidemiology (HuGE) Navigator
MAG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAG
genes like me logo Genes that share disorders with MAG: view

No data available for Genatlas for MAG Gene

Publications for MAG Gene

  1. A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. (PMID: 18496213) Voineskos A.N. … Kennedy J.L. (Psychiatr. Genet. 2008) 3 22 46 65
  2. Identification of the glycosylated sequons of human myelin-associated glycoprotein. (PMID: 7505568) Burger D. … Steck A.J. (Biochem. Biophys. Res. Commun. 1993) 3 4 22 65
  3. cDNA cloning and amino acid sequence for human myelin-associated glycoprotein. (PMID: 2476987) Sato S. … Miyatake T. (Biochem. Biophys. Res. Commun. 1989) 2 3 4 65
  4. Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. (PMID: 26179919) Lossos A. … Peles E. (Brain 2015) 3 4 65
  5. Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. (PMID: 19720975) Kuijf M.L. … Jacobs B.C. (Neurology 2009) 3 22 65

Products for MAG Gene

Sources for MAG Gene

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