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Aliases for MAG Gene

Aliases for MAG Gene

  • Myelin Associated Glycoprotein 2 3 5
  • Sialic Acid Binding Ig-Like Lectin 4A 2 3
  • SIGLEC-4A 3 4
  • GMA 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 4A 3
  • SIGLEC4A 3
  • S-MAG 3
  • SPG75 3

External Ids for MAG Gene

Previous HGNC Symbols for MAG Gene

  • GMA

Previous GeneCards Identifiers for MAG Gene

  • GC19P036400
  • GC19P036231
  • GC19P040459
  • GC19P040474
  • GC19P035783
  • GC19P032291
  • GC19P035787
  • GC19P035956

Summaries for MAG Gene

Entrez Gene Summary for MAG Gene

  • The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for MAG Gene

MAG (Myelin Associated Glycoprotein) is a Protein Coding gene. Diseases associated with MAG include Spastic Paraplegia 75 and Chronic Polyneuropathy. Among its related pathways are p75 NTR receptor-mediated signalling and Platelet activation, signaling and aggregation. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC10.

UniProtKB/Swiss-Prot for MAG Gene

  • Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAG Gene

Genomics for MAG Gene

Regulatory Elements for MAG Gene

Enhancers for MAG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAG on UCSC Golden Path with GeneCards custom track

Genomic Location for MAG Gene

Chromosome:
19
Start:
35,292,086 bp from pter
End:
35,313,807 bp from pter
Size:
21,722 bases
Orientation:
Plus strand

Genomic View for MAG Gene

Genes around MAG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAG Gene

Proteins for MAG Gene

  • Protein details for MAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20916-MAG_HUMAN
    Recommended name:
    Myelin-associated glycoprotein
    Protein Accession:
    P20916
    Secondary Accessions:
    • B7Z2E5
    • F5GYC0
    • Q567S4

    Protein attributes for MAG Gene

    Size:
    626 amino acids
    Molecular mass:
    69069 Da
    Quaternary structure:
    • Binds to RTN4R.

    Alternative splice isoforms for MAG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAG Gene

Proteomics data for MAG Gene at MOPED

Post-translational modifications for MAG Gene

  • Glycosylation at Asn 99, Asn 106, Asn 223, Asn 246, Asn 315, Asn 406, Asn 450, and Asn 454
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAG (MAG)

No data available for DME Specific Peptides for MAG Gene

Domains & Families for MAG Gene

Suggested Antigen Peptide Sequences for MAG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20916

UniProtKB/Swiss-Prot:

MAG_HUMAN :
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with MAG: view

Function for MAG Gene

Molecular function for MAG Gene

GENATLAS Biochemistry:
myelin associated glycoprotein,expressed on oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system,interacting with neuronal processes,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function:
Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).

Gene Ontology (GO) - Molecular Function for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with MAG: view
genes like me logo Genes that share phenotypes with MAG: view

Animal Models for MAG Gene

MGI Knock Outs for MAG:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAG Gene

Localization for MAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAG Gene COMPARTMENTS Subcellular localization image for MAG gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MAG Gene

Pathways & Interactions for MAG Gene

genes like me logo Genes that share pathways with MAG: view

Pathways by source for MAG Gene

Gene Ontology (GO) - Biological Process for MAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0021762 substantia nigra development IEP 22926577
GO:0048711 positive regulation of astrocyte differentiation IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with MAG: view

No data available for SIGNOR curated interactions for MAG Gene

Drugs & Compounds for MAG Gene

(17) Drugs for MAG Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
rituximab Approved Pharma Therapeutic Antibodies 1593
Antibodies Pharma 5531
Antibodies, Monoclonal Pharma 3413
Antirheumatic Agents Pharma 10210
Immunoglobulins Pharma 5531

(28) Additional Compounds for MAG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAG: view

Transcripts for MAG Gene

Unigene Clusters for MAG Gene

Myelin associated glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for MAG Gene

GeneLoc Exon Structure for
MAG
ECgene alternative splicing isoforms for
MAG

Expression for MAG Gene

mRNA expression in normal human tissues for MAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAG Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x17.1), Brain - Substantia nigra (x8.5), Brain - Hippocampus (x4.5), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for MAG Gene

This gene is overexpressed in Frontal cortex (29.9), Spinal cord (27.3), and Brain (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAG Gene



SOURCE GeneReport for Unigene cluster for MAG Gene Hs.643440

genes like me logo Genes that share expression patterns with MAG: view

Protein tissue co-expression partners for MAG Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MAG Gene

Orthologs for MAG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAG 35
  • 89.7 (n)
  • 94.31 (a)
MAG 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAG 35
  • 92.39 (n)
  • 96.65 (a)
MAG 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mag 35
  • 87.26 (n)
  • 94.24 (a)
Mag 16
Mag 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mag 35
  • 88.66 (n)
  • 95.37 (a)
oppossum
(Monodelphis domestica)
Mammalia MAG 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MAG 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAG 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mag 35
  • 60.04 (n)
  • 52.02 (a)
zebrafish
(Danio rerio)
Actinopterygii mag 35
  • 51.97 (n)
  • 42.65 (a)
mag 36
  • 37 (a)
OneToOne
Species with no ortholog for MAG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAG Gene

ENSEMBL:
Gene Tree for MAG (if available)
TreeFam:
Gene Tree for MAG (if available)

Paralogs for MAG Gene

(1) SIMAP similar genes for MAG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAG: view

Variants for MAG Gene

Sequence variations from dbSNP and Humsavar for MAG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11084810 - 35,299,742(+) CACTG(A/C)TGCAC reference, missense
rs12976524 -- 35,294,906(+) accac(C/T)gcatt intron-variant
rs12980281 -- 35,306,036(+) TCCCA(C/G/T)CCCCC intron-variant
rs12980353 -- 35,290,897(+) GAAGC(C/G)TGGGG upstream-variant-2KB
rs12980495 -- 35,306,083(+) CCCCC(C/T)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAG Gene

Variant ID Type Subtype PubMed ID
nsv510765 CNV Loss 20534489
dgv1080e1 CNV Complex 17122850
nsv911618 CNV Loss 21882294
nsv833810 CNV Gain 17160897
esv1763084 CNV Deletion 17803354
nsv9711 CNV Loss 18304495
esv1006379 CNV Deletion 20482838

Variation tolerance for MAG Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAG Gene

Human Gene Mutation Database (HGMD)
MAG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAG Gene

Disorders for MAG Gene

MalaCards: The human disease database

(30) MalaCards diseases for MAG Gene - From: ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia 75
  • spg75
chronic polyneuropathy
polyneuropathy
  • polyneuropathy unspecified
osteosclerotic myeloma
peripheral nervous system disease
  • peripheral neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search MAG in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAG

Genetic Association Database (GAD)
MAG
Human Genome Epidemiology (HuGE) Navigator
MAG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAG
genes like me logo Genes that share disorders with MAG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAG Gene

Publications for MAG Gene

  1. cDNA cloning and amino acid sequence for human myelin-associated glycoprotein. (PMID: 2476987) Sato S. … Miyatake T. (Biochem. Biophys. Res. Commun. 1989) 2 3 4 67
  2. Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. (PMID: 19720975) Kuijf M.L. … Jacobs B.C. (Neurology 2009) 3 23
  3. Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia. (PMID: 17964117) Mitkus S.N. … Lipska B.K. (Schizophr. Res. 2008) 3 23
  4. A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. (PMID: 18496213) Voineskos A.N. … Kennedy J.L. (Psychiatr. Genet. 2008) 3 23
  5. MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. (PMID: 17974963) Swanson B.J. … Hollingsworth M.A. (Cancer Res. 2007) 3 23

Products for MAG Gene

Sources for MAG Gene

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