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MAG Gene

protein-coding   GIFtS: 64
GCID: GC19P035956

Myelin Associated Glycoprotein


(Previous symbol: GMA)
  See MAG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myelin Associated Glycoprotein1 2     SIGLEC4A2
GMA1 2 3 5     Myelin-Associated Glycoprotein2
Sialic Acid Binding Ig-Like Lectin 4A1 2     Sialic Acid-Binding Immunoglobulin-Like Lectin 4A2
S-MAG2     Siglec-4a3
SIGLEC-4A2     

External Ids:    HGNC: 67831   Entrez Gene: 40992   Ensembl: ENSG000001056957   OMIM: 1594605   UniProtKB: P209163   

Export aliases for MAG gene to outside databases

Previous GC identifers: GC19P036400 GC19P036231 GC19P040459 GC19P040474 GC19P035783 GC19P032291 GC19P035787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAG Gene:
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is
thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and
mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different
isoforms have been described for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for MAG Gene:
MAG (myelin associated glycoprotein) is a protein-coding gene. Diseases associated with MAG include central pontine myelinolysis, and monoclonal gammopathy of uncertain significance. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: MAG_HUMAN, P20916
Function: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell
interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAG gene promoter:
         COUP-TF1   p300   COUP   HNF-4alpha2   GATA-2   HNF-4alpha1   COUP-TF   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAG promoter sequence
   Search Chromatin IP Primers for MAG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

MAG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAG gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035956:  view genomic region     (about GC identifiers)

Start:
35,782,989 bp from pter      End:
35,804,710 bp from pter
Size:
21,722 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAG_HUMAN, P20916 (See protein sequence)
Recommended Name: Myelin-associated glycoprotein precursor  
Size: 626 amino acids; 69069 Da
Subunit: Binds to RTN4R (By similarity)
Secondary accessions: B7Z2E5 F5GYC0 Q567S4
Alternative splicing: 3 isoforms:  P20916-1   P20916-2   P20916-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAG: NX_P20916

Explore proteomics data for MAG at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn99, Asn223, Asn246, Asn315, Asn406, Asn450, Asn454
  • Modification sites at PhosphoSitePlus

  • See MAG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186145.1  NP_002352.1  NP_542167.1  

    ENSEMBL proteins: 
     ENSP00000470772   ENSP00000376048   ENSP00000355234   ENSP00000473125   ENSP00000473245  
     ENSP00000440695  
    Reactome Protein details: P20916

    MAG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAG
    GenScript Custom Purified and Recombinant Proteins Services for MAG
    Novus Biologicals MAG Proteins
    Novus Biologicals MAG Lysates
    Sino Biological Recombinant Protein for MAG
    Sino Biological Cell Lysate for MAG
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAG

     
    Search eBioscience for Proteins for MAG 

    MAG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAG
    R&D Systems Antibodies for MAG (MAG/Siglec-4a)
    Cell Signaling Technology (CST) Antibodies for MAG 
    OriGene Antibodies for MAG
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    Abcam antibodies for MAG
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    MAG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAG
    Cloud-Clone Corp. CLIAs for MAG
    Search eBioscience for ELISAs for MAG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P20916

    ProtoNet protein and cluster: P20916

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: MAG_HUMAN, P20916
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with MAG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAG_HUMAN, P20916
    Function: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell
    interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By
    similarity)

         Genatlas biochemistry entry for MAG:
    myelin associated glycoprotein,expressed on oligodendrocytes in the CNS and Schwann cells in the peripheral
    nervous system,interacting with neuronal processes,sialoadhesin family,Ig superfamily

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MAG           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAG:
     Decreased number of cells in m  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mag):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with MAG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAG: Magtm1Mtg Magtm1Pop Magtm1Rod

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAG

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MAG using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MAG:
    hsa-miR-544b hsa-miR-3942-5p hsa-miR-3202 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidMAG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAG
    Predesigned siRNA for gene silencing in human, mouse, rat MAG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAG

    Clone
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    OriGene clones in human, mouse for MAG (see all 11)
    OriGene ORF clones in mouse, rat for MAG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAG (NM_002361)
    Sino Biological Human cDNA Clone for MAG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAG

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAG
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAG_HUMAN, P20916: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0033270paranode region of axon IEA--
    GO:0043209myelin sheath ----
    GO:0043220Schmidt-Lanterman incisure IEA--

    Find genes that share ontologies with MAG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAG About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    Axonal growth inhibition (RHOA activation)0.00
    p75NTR regulates axonogenesis0.00
    2Signaling by FGFR
    Signalling by NGF0.71
    3Signaling by GPCR
    Signal Transduction0.58
    4Cell adhesion Integrin mediated cell adhesion and migration
    Development MAG dependent inhibition of neurite outgrowth0.46
    5Hemostasis
    Hemostasis0.43


    Find genes that share SuperPaths with MAG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAG
        Guidance Cues and Growth Cone Motility
    NgR-p75(NTR)-Mediated Signaling

    1 Cell Signaling Technology (CST) Pathway for MAG
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for MAG
        Development MAG-dependent inhibition of neurite outgrowth

    3 BioSystems Pathways for MAG
        Spinal Cord Injury
    Glial Cell Differentiation
    p75(NTR)-mediated signaling


    2 Reactome Pathways for MAG
        Axonal growth inhibition (RHOA activation)
    Basigin interactions


    1 Kegg Pathway  (Kegg details for MAG):
        Cell adhesion molecules (CAMs)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAG: 
              Multiple Sclerosis in human mouse rat
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAG

    Selected Interacting proteins for MAG (P209163) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RTN4RQ9BZR63I2D: score=4 
    COL2A1P024583I2D: score=3 
    COL3A1P024613I2D: score=3 
    COL9A1P208493I2D: score=3 
    FN1P027513I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007596blood coagulation TAS--
    GO:0021762substantia nigra development IEP--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--
    GO:0050770regulation of axonogenesis TAS--

    Find genes that share ontologies with MAG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAG

    Selected Novoseek inferred chemical compound relationships for MAG gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sglpg 92.7 12 16829480 (3), 11602387 (3), 9920969 (2), 1695241 (1) (see all 5)
    gq1balpha 90 6 20095613 (1), 17870542 (1), 19175312 (1), 17507233 (1) (see all 5)
    gt1aalpha 79.1 2 10608819 (1)
    2',3'-cyclic nucleotide 76.7 10 7509848 (1), 10417810 (1), 18496213 (1), 1383426 (1) (see all 9)
    sulfatide 76.1 16 1282933 (3), 17915254 (2), 11160960 (2), 1706491 (1) (see all 11)
    gangliotetraose 69.2 1 8570640 (1)
    sialic acid 64 35 9298990 (5), 9874234 (4), 10570219 (3), 9084450 (2) (see all 15)
    ammonium metavanadate 54.4 2 1697896 (1), 8562321 (1)
    ganglioside 50.8 7 1966017 (1), 12161033 (1), 10420586 (1), 19822144 (1)
    neurocan 47.1 1 10483914 (1)



    Find genes that share compounds with MAG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAG gene (3 alternative transcripts): 
    NM_001199216.1  NM_002361.3  NM_080600.2  

    Unigene Cluster for MAG:

    Myelin associated glycoprotein
    Hs.643440  [show with all ESTs]
    Unigene Representative Sequence: NM_080600
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600291 ENST00000392213 ENST00000361922(uc002nyx.2 uc002nyy.2 uc002nyz.2)
    ENST00000595791 ENST00000597035 ENST00000537831(uc010eds.2) ENST00000593348
    ENST00000597162
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate MAG:
    hsa-miR-544b hsa-miR-3942-5p hsa-miR-3202 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidMAG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAG
    Predesigned siRNA for gene silencing in human, mouse, rat MAG
    Clone
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    OriGene clones in human, mouse for MAG (see all 11)
    OriGene ORF clones in mouse, rat for MAG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAG (NM_002361)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAG
    OriGene qSTAR qPCR primer pairs in human, mouse for MAG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAG
      QuantiTect SYBR Green Assays in human, mouse, rat MAG
      QuantiFast Probe-based Assays in human, mouse, rat MAG

    Additional mRNA sequence: 

    AK094545.1 AK222649.1 AK222680.1 AK223562.1 AK294644.1 AK308976.1 BC034042.1 BC053347.1 
    BC093045.1 M29273.1 X98405.1 

    13 DOTS entries:

    DT.100777832  DT.95116020  DT.121497014  DT.100777830  DT.121497027  DT.100020126  DT.95116022  DT.100775956 
    DT.121497045  DT.121497048  DT.91763583  DT.100775960  DT.95128281 

    Selected AceView cDNA sequences (see all 286):

    F09020 BG176660 AW500201 X52785 BU192138 AI859588 BQ642447 AW408631 
    BF111811 BQ055275 BQ632310 BQ057725 CR614873 BE874674 BM664837 AW337790 
    BQ055266 BM478063 BQ890637 BC053347 BQ057104 BU727996 CD514856 BX280770 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAG (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                                      -                                                                                                     -               
    SP2:                                      -                                                                                               -     -               
    SP3:                                      -                 -     -                                                                                             
    SP4:                                      -                             -     -     -     -     -     -     -                             -     -               
    SP5:                                      -                       -     -                                                                                       


    ECgene alternative splicing isoforms for MAG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAAATGC
    MAG Expression
    About this image


    MAG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             Myelinating Schwann Cells Peripheral Nerve Domain
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Spinal Cord White Matter
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)
             Oligodendrocyte-like cells
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    MAG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643440
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAG: 
              Multiple Sclerosis in human mouse rat
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAG
    OriGene qSTAR qPCR primer pairs in human, mouse for MAG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAG
    QuantiTect SYBR Green Assays in human, mouse, rat MAG
    QuantiFast Probe-based Assays in human, mouse, rat MAG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for MAG gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mag1 , 5 myelin-associated glycoprotein1, 5 87.26(n)1
    94.24(a)1
      7 (19.26 cM)5
    171361  NM_010758.21  NP_034888.11 
     308991835 
    lizard
    (Anolis carolinensis)
    Reptilia MAG6
    myelin associated glycoprotein
    59(a)
    1 ↔ 1
    GL343514.1(418293-440864)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mag1 myelin associated glycoprotein 60.04(n)
    52.02(a)
      100494147  XM_002943089.2  XP_002943135.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mag1 myelin associated glycoprotein 51.97(n)
    42.65(a)
      474346  NM_001007062.1  NP_001007063.1 


    ENSEMBL Gene Tree for MAG (if available)
    TreeFam Gene Tree for MAG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAG gene
    CD332  SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC62  SIGLEC142  SIGLEC122  
    SIGLEC102  SIGLEC72  SIGLEC92  
    1 SIMAP similar gene for MAG using alignment to 4 protein entries:     MAG_HUMAN (see all proteins):
    SIGLEC12

    Find genes that share paralogs with MAG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAG (see all 731)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901577041,2
    --35780997(+) AGTGGC/TGCAAT 3 -- us2k10--------
    rs621095731,2
    C--35781030(+) CTCCCA/GGGTTC 3 -- us2k12Minor allele frequency- G:0.25NA 4
    rs1822633861,2
    C--35781064(+) CCTGAA/GTAGCT 3 -- us2k10--------
    rs126088381,2
    C,F,H--35781085(+) gcgccT/Cgccac 3 -- us2k16Minor allele frequency- C:0.45NA CSA 11
    rs126088391,2
    C,F,H--35781093(+) caccaT/Cgcccg 3 -- us2k16Minor allele frequency- C:0.45NA CSA 11
    rs1872437751,2
    C--35781127(+) GAGACA/GGGGTT 3 -- us2k10--------
    rs126098821,2
    C,F,H--35781138(+) TCACCG/ATGTTA 3 -- us2k15Minor allele frequency- A:0.40NA 10
    rs126088411,2
    C,F,A,H--35781148(+) AGCCAA/G/TGATGG 3 -- us2k18NA WA CSA 15
    rs126099841,2
    C,F,A,H--35781157(+) GGTCTC/TGATCT 3 -- us2k13Minor allele frequency- T:0.33NA 6
    rs1908688261,2
    --35781178(+) TGATCC/TGCCCG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAG (35782989 - 35804710 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MAG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1763084CNV Deletion17803354
    esv1006379CNV Deletion20482838
    nsv510765CNV Loss20534489
    nsv911618CNV Loss21882294
    nsv9711CNV Loss18304495
    nsv833810CNV Gain17160897
    dgv1080e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAG
    DNA2.0 Custom Variant and Variant Library Synthesis for MAG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159460    OMIM disorders: --

    6 diseases for MAG:    
    About MalaCards
    central pontine myelinolysis    monoclonal gammopathy of uncertain significance    wallerian degeneration    kearns-sayre syndrome
    amyotrophic lateral sclerosis    schizophrenia

    6 diseases from the University of Copenhagen DISEASES database for MAG:
    Polyneuropathy     Neuropathy     Monoclonal gammopathy of uncertain significance     POEMS syndrome
    Macroglobulinemia     Multiple sclerosis

    Find genes that share disorders with MAG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MAG gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monoclonal gammopathy 83.1 34 8383189 (2), 10229128 (1), 7681445 (1), 12407306 (1) (see all 24)
    polyneuropathy 82.7 42 7516055 (3), 7691993 (2), 7543988 (2), 11985632 (2) (see all 26)
    gammopathy 77.1 11 16829480 (1), 1371150 (1), 9600601 (1), 16546215 (1) (see all 7)
    demyelination 68.8 12 16421127 (2), 1706491 (1), 16969155 (1), 1694384 (1) (see all 9)
    polyneuropathy motor 65.8 1 1706491 (1)
    myelin degeneration 61.9 1 12528815 (1)
    sensory neuropathy 54 2 1706491 (1), 20120390 (1)
    charcot-marie-tooth disease 52.6 1 10848494 (1)
    multiple sclerosis 52 17 7515411 (3), 1705050 (1), 12020971 (1), 9001700 (1) (see all 13)
    waldenstrom macroglobulinemia 49.3 3 8383189 (1), 7504399 (1)

    Genetic Association Database (GAD): MAG
    Human Genome Epidemiology (HuGE) Navigator: MAG (17 documents)

    Export disorders for MAG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAG gene, integrated from 10 sources (see all 330):
    (articles sorted by number of sources associating them with MAG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and amino acid sequence for human myelin-associated glycoprotein. (PubMed id 2476987)1, 2, 3 Sato S....Miyatake T. (Biochem. Biophys. Res. Commun. 1989)
    2. Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the Chinese Han population. (PubMed id 16039057)1, 4, 9 Wan C....Wang L. (Neurosci. Lett. 2005)
    3. Identification of the glycosylated sequons of human myelin-associated glycoprotein. (PubMed id 7505568)1, 2, 9 Burger D.... Steck A.J. (Biochem. Biophys. Res. Commun. 1993)
    4. A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. (PubMed id 18496213)1, 4, 9 Voineskos A.N....Kennedy J.L. (Psychiatr. Genet. 2008)
    5. Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene and study of their association with multiple sclerosis. (PubMed id 12020971)1, 4, 9 D'Alfonso S....Momigliano-Richiardi P. (J. Neuroimmunol. 2002)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. (PubMed id 8432525)1, 3 Trask B....Carrano A. (Genomics 1993)
    10. Molecular cloning of human myelin-associated glycoprotein. (PubMed id 2479762)1, 2 Spagnol G.... Latov N. (J. Neurosci. Res. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4099 HGNC: 6783 AceView: CD22andMAG Ensembl:ENSG00000105695 euGenes: HUgn4099
    ECgene: MAG Kegg: 4099 H-InvDB: MAG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAG Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_271

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAG gene:
    Search GeneIP for patents involving MAG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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