Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAG Gene

protein-coding GIFtS: 63
GCID: GC19P035783

myelin associated glycoprotein

(Previous symbol: GMA)

Explore 42 diseases affiliated with
MAG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myelin Associated Glycoprotein¹ ²		Myelin-Associated Glycoprotein²
GMA¹ ² ³ ⁵		Sialic Acid Binding Ig-Like Lectin 4A²
S-MAG¹ ²		Sialic Acid-Binding Immunoglobulin-Like Lectin 4A²
SIGLEC-4A¹ ²		Siglec-4a³
SIGLEC4A¹ ²

External Ids:	HGNC: 6783¹	Entrez Gene: 4099²	Ensembl: ENSG00000105695⁷	OMIM: 159460⁵	UniProtKB: P20916³

Export aliases for MAG gene to outside databases

Previous GC identifers: GC19P036400 GC19P036231 GC19P040459 GC19P040474 GC19P032291

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAG:

The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is

thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and

mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different

isoforms have been described for this gene. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: MAG_HUMAN, P20916

Function: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions

between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAG gene promoter:
COUP-TF1 p300 COUP HNF-4alpha2 GATA-2 HNF-4alpha1 COUP-TF STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAG promoter sequence

Search SABiosciences Chromatin IP Primers for MAG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1

MAG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAG gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P035783: view genomic region (about GC identifiers)

Start:	35,783,037 bp from pter	End:	35,804,707 bp from pter
Size:	21,671 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAG_HUMAN, P20916 (See protein sequence)

Recommended Name: Myelin-associated glycoprotein precursor

Size: 626 amino acids; 69069 Da

Subunit: Binds to RTN4R (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: B7Z2E5 F5GYC0 Q567S4

Alternative splicing: 3 isoforms: P20916-1 P20916-2 P20916-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAG: NX_P20916

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20916

MAG Protein expression data from MOPED and PaxDb: --

REFSEQ proteins (3 alternative transcripts):

NP_001186145.1 NP_002352.1 NP_542167.1

ENSEMBL proteins:

ENSP00000376048 ENSP00000355234 ENSP00000440695

Reactome Protein details: P20916
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MAG OriGene Custom Protein Services for MAG
	GenScript Custom Purified and Recombinant Proteins Services for MAG
	Novus Biologicals MAG Proteins Novus Biologicals MAG Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAG

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0033270	paranode region of axon	IEA	--
GO:0043209	myelin sheath	--	--

MAG for ontologies About GeneDecksing

MAG Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MAG
	R&D Systems Antibodies for MAG (MAG/Siglec-4a)
	Cell Signaling Technology (CST) Antibodies for MAG
	OriGene Antibodies: MAG OriGene Custom Antibody Services for MAG
	GenScript Superior Antibodies for MAG
	Novus Biologicals MAG Antibodies
	Abcam antibodies for MAG
	Uscn Antibodies for MAG
	Search ThermoFisher Antibodies for MAG

Assay Products for MAG:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MAG
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAG for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003598 Ig_sub2

IPR013162 CD80_C2-set

IPR013098 Ig_I-set

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry P20916

ProtoNet protein and cluster: P20916

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: MAG_HUMAN, P20916

Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family

Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MAG_HUMAN, P20916

Function: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions

between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity)

Genatlas biochemistry entry for MAG:

myelin associated glycoprotein,expressed on oligodendrocytes in the CNS and Schwann cells in the peripheral nervous

system,interacting with neuronal processes,sialoadhesin family,Ig superfamily

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MAG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAG
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate MAG:
		hsa-miR-544b hsa-miR-3942-5p hsa-miR-3202 hsa-miR-1324
		SwitchGear 3'UTR luciferase reporter plasmid: MAG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAG (see all 7) OriGene shRNA RFP: MAG OriGene siRNA: MAG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAG

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MAG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAG (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAG (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MAG (NM_002361)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAG
		Search LifeMap BioReagents cell lines for MAG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAG

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030246	carbohydrate binding	--	--

MAG for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for MAG:

Decreased number of cells in m

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for MAG: Mag^tm1Mtg Mag^tm1Pop Mag^tm1Rod
2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mag):

behavior/neurological

nervous system

MAG for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axonal growth inhibition (RHOA activation)

Axonal growth inhibition (RHOA activation)

1.00

p75NTR regulates axonogenesis

0.90

Development MAG-dependent inhibition of neurite outgrowth

Development MAG-dependent inhibition of neurite outgrowth

1.00

Development_MAG-dependent inhibition of neurite outgrowth

0.87

Neuroscience

Neuroscience

1.00

Basigin interactions

Basigin interactions

1.00

Glial Cell Differentiation

Glial Cell Differentiation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MAG

Development MAG-dependent inhibition of neurite outgrowth

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAG

	Guidance Cues and Growth Cone Motility
	NgR-p75(NTR)-Mediated Signaling

1 Cell Signaling Technology (CST) Pathway for MAG

Neuroscience

1 GeneGo (Thomson Reuters) Pathway for MAG

Development MAG-dependent inhibition of neurite outgrowth

2 BioSystems Pathways for MAG

	Glial Cell Differentiation
	p75(NTR)-mediated signaling

5/8 Reactome Pathways for MAG (see all 8)

	Hemostasis
	Axonal growth inhibition (RHOA activation)
	Signal Transduction
	p75NTR regulates axonogenesis
	Signalling by NGF

1 Kegg Pathway (Kegg details for MAG):

Cell adhesion molecules (CAMs)

MAG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAG

5/20 Interacting proteins for MAG (P20916³) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RTN4R	Q9BZR6³	I2D: score=4
COL2A1	P02458³	I2D: score=3
COL3A1	P02461³	I2D: score=3
COL9A1	P20849³	I2D: score=3
FN1	P02751³	I2D: score=3

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0048011	nerve growth factor receptor signaling pathway	TAS	--
GO:0050770	regulation of axonogenesis	TAS	--
GO:0050771	negative regulation of axonogenesis	TAS	--

MAG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MAG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAG
10/40 Novoseek chemical compound relationships for MAG gene (see all 40) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sglpg	92.7	12	16829480 (3), 11602387 (3), 9920969 (2), 1695241 (1) (see all 5)
gq1balpha	90	6	20095613 (1), 17870542 (1), 19175312 (1), 17507233 (1) (see all 5)
gt1aalpha	79.1	2	10608819 (1)
2',3'-cyclic nucleotide	76.7	10	7509848 (1), 10417810 (1), 18496213 (1), 1383426 (1) (see all 9)
sulfatide	76.1	16	1282933 (3), 17915254 (2), 11160960 (2), 1706491 (1) (see all 11)
gangliotetraose	69.2	1	8570640 (1)
sialic acid	64	35	9298990 (5), 9874234 (4), 10570219 (3), 9084450 (2) (see all 15)
ammonium metavanadate	54.4	2	1697896 (1), 8562321 (1)
ganglioside	50.8	7	1966017 (1), 12161033 (1), 10420586 (1), 19822144 (1)
neurocan	47.1	1	10483914 (1)

Search CenterWatch for drugs/clinical trials and news about MAG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAG gene (3 alternative transcripts):

NM_001199216.1 NM_002361.3 NM_080600.2

Unigene Cluster for MAG:

Myelin associated glycoprotein

Hs.643440 [show with all ESTs]

Unigene Representative Sequence: NM_080600

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392213 ENST00000361922(uc002nyx.2 uc002nyy.2 uc002nyz.2)

ENST00000537831(uc010eds.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MAG Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAG
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate MAG:
		hsa-miR-544b hsa-miR-3942-5p hsa-miR-3202 hsa-miR-1324
		SwitchGear 3'UTR luciferase reporter plasmid: MAG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAG (see all 7) OriGene shRNA RFP: MAG OriGene siRNA: MAG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAG

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAG (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAG (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MAG (NM_002361)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAG

Additional cDNA sequence:

AK094545.1 AK222649.1 AK222680.1 AK223562.1 AK294644.1 AK308976.1 BC034042.1 BC053347.1

BC093045.1 M29273.1 X98405.1

13 DOTS entries:

DT.100777832 DT.95116020 DT.121497014 DT.100777830 DT.121497027 DT.100020126 DT.95116022 DT.100775956

DT.121497045 DT.121497048 DT.91763583 DT.100775960 DT.95128281

24/286 AceView cDNA sequences (see all 286):

NM_002361 BE267684 CR614873 BQ642447 BG685870 BQ057725 BX350637 F04235

BQ057104 BC053347 AW500201 BQ059060 AW337790 BM478063 BQ055275 BU727996

CD514856 BM475659 AW408631 F09020 BQ890637 BG176660 X52785 BF111811

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MAG (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b
SP1:													-																																		-
SP2:													-																																-		-
SP3:													-						-		-
SP4:													-										-		-		-		-		-		-		-										-		-
SP5:													-								-		-

ECgene alternative splicing isoforms for MAG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATAAATGC

About this image

MAG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for MAG

SOURCE GeneReport for Unigene cluster: Hs.643440

SABiosciences Expression via Pathway-Focused PCR Arrays including MAG:

Multiple Sclerosis in human mouse rat

Necrosis in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Cell Death PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAG

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MAG gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	MAG⁶	--	52(a)	1 ↔ 1	GL343514.1(420765-437830)
zebrafish (Danio rerio)	Actinopterygii	mag¹	myelin associated glycoprotein	52.02(n) 42.31(a)		474346 NM_001007062.1 NP_001007063.1

ENSEMBL Gene Tree for MAG (if available)
TreeFam Gene Tree for MAG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAG gene

CD33² SIGLEC17P² SIGLEC8² SIGLEC5² SIGLEC11² SIGLEC16² SIGLEC6² SIGLEC14²

SIGLEC12² SIGLEC10² SIGLEC7² SIGLEC9²

MAG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190157704^1,2		--	35780997(+)	`AGTGGC/TGCAAT`	3	--	us2k¹		0	--	--	--	--
rs62109573^1,2	C,	--	35781030(+)	`CTCCCA/GGGTTC`	3	--	us2k¹		2		NA	4
rs182263386^1,2		--	35781064(+)	`CCTGAA/GTAGCT`	3	--	us2k¹		0	--	--	--	--
rs12608838^1,2	C,F,H,	--	35781085(+)	`gcgccT/Cgccac`	3	--	us2k¹		6		NA CSA	11
rs12608839^1,2	C,F,H,	--	35781093(+)	`caccaT/Cgcccg`	3	--	us2k¹		6		NA CSA	11
rs187243775^1,2	C,	--	35781127(+)	`GAGACA/GGGGTT`	3	--	us2k¹		0	--	--	--	--
rs12609882^1,2	C,F,H,	--	35781138(+)	`TCACCG/ATGTTA`	3	--	us2k¹		5		NA	10
rs12608841^1,2	C,F,A,H,	--	35781148(+)	`AGCCAG/TGATGG`	3	--	us2k¹		8		NA WA CSA	15
rs12609984^1,2	C,F,A,H,	--	35781157(+)	`GGTCTC/TGATCT`	3	--	us2k¹		3		NA	6
rs190868826^1,2		--	35781178(+)	`TGATCC/TGCCCG`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAG (35783037 - 35804707 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MAG
2 CNVs: 4078 32248
1 Indel: 26266
Human Gene Mutation Database (HGMD): MAG

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAG

DNA2.0 Custom Variant and Variant Library Synthesis for MAG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAG for disorders           About GeneDecksing

OMIM gene information: 159460    OMIM disorders: --

20/42 diseases for MAG (see all 42):    About MalaCards

charcot-marie-tooth disease monoclonal gammopathy of uncertain significance central pontine myelinolysis niemann-pick disease

acid sphingomyelinase deficiency wallerian degeneration chronic inflammatory demyelinating polyneuropathy demyelinating polyneuropathy

optic neuritis amyotrophic lateral sclerosis osteosclerotic myeloma polyneuropathy

lateral sclerosis tooth disease macroglobulinemia neuritis

paraproteinemia hereditary neuropathies b-cell lymphomas pick's disease

6 diseases from the University of Copenhagen DISEASES database for MAG:

Polyneuropathy Neuropathy Macroglobulinemia Multiple sclerosis

POEMS syndrome Osteosclerotic myeloma

10/31 Novoseek disease relationships for MAG gene (see all 31) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
monoclonal gammopathy	83.1	34	8383189 (2), 10229128 (1), 7681445 (1), 12407306 (1) (see all 24)
polyneuropathy	82.7	42	7516055 (3), 7691993 (2), 7543988 (2), 11985632 (2) (see all 26)
gammopathy	77.1	11	16829480 (1), 1371150 (1), 9600601 (1), 16546215 (1) (see all 7)
demyelination	68.8	12	16421127 (2), 1706491 (1), 16969155 (1), 1694384 (1) (see all 9)
polyneuropathy motor	65.8	1	1706491 (1)
myelin degeneration	61.9	1	12528815 (1)
sensory neuropathy	54	2	1706491 (1), 20120390 (1)
charcot-marie-tooth disease	52.6	1	10848494 (1)
multiple sclerosis	52	17	7515411 (3), 1705050 (1), 12020971 (1), 9001700 (1) (see all 13)
waldenstrom macroglobulinemia	49.3	3	8383189 (1), 7504399 (1)

Genetic Association Database (GAD): MAG
Human Genome Epidemiology (HuGE) Navigator: MAG (17 documents)

Export disorders for MAG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MAG gene, integrated from 9 sources (see all 326):
(articles sorted by number of sources associating them with MAG)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning and amino acid sequence for human myelin-associated glycoprotein. (PubMed id 2476987)^{1, 2, 3} Sato S....Miyatake T. (1989)
Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the Chinese Han population. (PubMed id 16039057)^{1, 4, 9} Wan C....Wang L. (2005)
Identification of the glycosylated sequons of human myelin-associated glycoprotein. (PubMed id 7505568)^{1, 2, 9} Burger D.... Steck A.J. (1993)
Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene and study of their association with multiple sclerosis. (PubMed id 12020971)^{1, 4, 9} D'Alfonso S....Momigliano-Richiardi P. (2002)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Fluorescence in situ hybridization mapping of human c hromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA mark ers. (PubMed id 8432525)^{1, 3} Trask B....Carrano A. (1993)
Molecular cloning of human myelin-associated glycoprotein. (PubMed id 2479762)^{1, 2} Spagnol G.... Latov N. (1989)
MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. (PubMed id 17974963)^{1, 9} Swanson B.J....Hollingsworth M.A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4099	HGNC: 6783	AceView: CD22andMAG	Ensembl:ENSG00000105695	euGenes: HUgn4099
ECgene: MAG	Kegg: 4099	H-InvDB: MAG

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MAG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MAG	Genetics and Cytogenetics in Oncology and Haematology
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_271

Intellectual Property for MAG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MAG gene:
Search GeneIP for patents involving MAG

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of MAG
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for MAG (MAG/Siglec-4a)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for MAG		OriGene shRNA RFP for MAG
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAG		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAG
	OriGene Protein Over-expression Lysate for MAG		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MAG		OriGene 3'-UTR Clone for MAG
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAG		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAG
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MAG		OriGene Custom Protein Services for MAG
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAG
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAG
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAG
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAG
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAG
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAG

	GenScript Custom Purified and Recombinant Proteins Services for MAG		GenScript cDNA clones with any tag delivered in your preferred vector for MAG
	GenScript Custom Assay Services for MAG		GenScript Superior Antibodies for MAG
	GenScript Custom overexpressing Cell Line Services for MAG		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for MAG

	Regulatory tfbs in MAG promoter
	Search Chromatin IP Primers for MAG
	RT² qPCR Primer Assay in human, mouse, rat MAG
	GNC Network for MAG
	SABiosciences PCR Arrays including human, mouse, rat MAG

Search Tocris compounds for MAG

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MAG antibodies
	MAG proteins
	MAG lysates

	Antibodies for MAG
	See all of Abcam's Antibodies, Kits and Proteins for MAG
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

MAG Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MAG

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAG

	SwitchGear 3'UTR luciferase reporter plasmids for MAG
	SwitchGear Promoter luciferase reporter plasmids for MAG

Search ThermoFisher Antibodies for MAG

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAG

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MAG gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

MAG Gene

myelin associated glycoprotein

Aliases
for MAG gene

Summaries
for MAG gene

Genomic Views
for MAG gene

Proteins
for MAG gene

Protein Domains /
Families
for MAG gene

Function
for MAG gene

Pathways & Interactions
for MAG gene

Drugs & Compounds
for MAG gene

Transcripts
for MAG gene

Expression
for MAG gene

Orthologs
for MAG gene

Paralogs
for MAG gene

Genomic Variants
for MAG gene

Disorders / Diseases
for MAG gene

Publications
for MAG gene

External Searches for MAG gene

Genome Databases showing MAG gene

Other Databases showing MAG gene

Specialized Databases showing MAG gene

Intellectual Property
for MAG gene

Products
for MAG gene

View Random Gene

Polyneuropathy Motor
Melanoma
myelin degeneration
hereditary neuropathy
Glioma
Scar
Multiple Sclerosis
Demyelination
Waldenstrom Macroglobulinemia
Demyelinating Diseases
Wallerian Degeneration
gammopathy
Paralysis
immunodeficiency
sensory neuropathy
Autoimmune Response
Schwannoma
Polyneuropathy
MYELOMA
Myasthenia Gravis
Optic Neuritis
Charcot-Marie-Tooth Disease
Polyradiculoneuritis
Tumors
Schizophrenia
Neurofibroma
mimicry
Cholera
Autoimmunity
Amyotrophic Lateral Sclerosis
Monoclonal gammopathy

Advanced Search

Export list of displayed genes

MAG Gene

myelin associated glycoprotein

Aliasesfor MAG gene

Summariesfor MAG gene

Genomic Viewsfor MAG gene

Proteinsfor MAG gene

Protein Domains /Familiesfor MAG gene

Functionfor MAG gene

Pathways & Interactionsfor MAG gene

Drugs & Compoundsfor MAG gene

Transcriptsfor MAG gene

Expression for MAG gene

Orthologsfor MAG gene

Paralogsfor MAG gene

Genomic Variantsfor MAG gene

Disorders / Diseasesfor MAG gene

Publicationsfor MAG gene

External Searches for MAG gene

Genome Databases showing MAG gene

Other Databases showing MAG gene

Specialized Databases showing MAG gene

Intellectual Propertyfor MAG gene

Productsfor MAG gene

View Random Gene

Aliases
for MAG gene

Summaries
for MAG gene

Genomic Views
for MAG gene

Proteins
for MAG gene

Protein Domains /
Families
for MAG gene

Function
for MAG gene

Pathways & Interactions
for MAG gene

Drugs & Compounds
for MAG gene

Transcripts
for MAG gene

Expression
for MAG gene

Orthologs
for MAG gene

Paralogs
for MAG gene

Genomic Variants
for MAG gene

Disorders / Diseases
for MAG gene

Publications
for MAG gene

Intellectual Property
for MAG gene

Products
for MAG gene