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MAFK Gene

protein-coding   GIFtS: 60
GCID: GC07P001570

V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog K1 2     P182
Erythroid Transcription Factor NF-E2 P18 Subunit1 2 3     Nuclear Factor Erythroid-2, Ubiquitous (P18)2
Basic-Leucine Zipper Transcription Factor MafK1 2     Transcription Factor MafK2
NFE2U2 5     V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Family, Protein K2
Nuclear Factor Erythroid-21     V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog K2
Ubiquitous (P18)1     

External Ids:    HGNC: 67821   Entrez Gene: 79752   Ensembl: ENSG000001985177   OMIM: 6001975   UniProtKB: O606753   

Export aliases for MAFK gene to outside databases

Previous GC identifers: GC07P001214 GC07P001314 GC07P001343 GC07P001536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAFK Gene:
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus
control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription
factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme
biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2
DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK)
and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper
(bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.(supplied by OMIM, Nov
2008)

GeneCards Summary for MAFK Gene:
MAFK (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K) is a protein-coding gene. Diseases associated with MAFK include fibrosarcoma, and lyme disease. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NRL.

UniProtKB/Swiss-Prot: MAFK_HUMAN, O60675
Function: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors
when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with
other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf
proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor

Gene Wiki entry for MAFK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAFK gene promoter:
         CREB   NF-1   deltaCREB   NF-kappaB1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAFK promoter sequence
   Search Chromatin IP Primers for MAFK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAFK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

MAFK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAFK gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P001570:  view genomic region     (about GC identifiers)

Start:
1,570,350 bp from pter      End:
1,582,679 bp from pter
Size:
12,330 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 1,622,776-1,635,087     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAFK_HUMAN, O60675 (See protein sequence)
Recommended Name: Transcription factor MafK  
Size: 156 amino acids; 17523 Da
Subunit: Homodimer or heterodimer. It can form high affinity heterodimers with members of the CNC-bZIP family such
as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3
Secondary accessions: A4D214

Explore the universe of human proteins at neXtProt for MAFK: NX_O60675

Explore proteomics data for MAFK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys110
  • Modification sites at PhosphoSitePlus

  • See MAFK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002351.1  
    ENSEMBL proteins: 
     ENSP00000344903   ENSP00000386009   ENSP00000385437  
    Reactome Protein details: O60675

    MAFK Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for MAFK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028574 MafK
     IPR004827 bZIP
     IPR024874 Transciption_factor_Maf
     IPR008917 TF_DNA-bd
     IPR004826 bZIP_Maf

    Graphical View of Domain Structure for InterPro Entry O60675

    ProtoNet protein and cluster: O60675

    1 Blocks protein domain: IPB004826 Maf transcription factor

    UniProtKB/Swiss-Prot: MAFK_HUMAN, O60675
    Similarity: Belongs to the bZIP family. Maf subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    MAFK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAFK_HUMAN, O60675
    Function: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors
    when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with
    other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf
    proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor

         Genatlas biochemistry entry for MAFK:
    small MAF protein K,interacting with BACH1,heterodimerizing with NFE2 to form an erythroid and megakaryocytic cell
    specific transcription factor,also expressed in neurones from an alternative promoter at least in mouse,homolog
    to v-maf fibrosarcoma (avian) oncogene

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    MAFK for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAFK:
     Decreased Salmonella enterica   Decreased viability with pacli  Synthetic lethal with c-Myc af 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mafk):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  immune system 
     mortality/aging  muscle  nervous system  reproductive system 

    MAFK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mafktm1Sho for MAFK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAFK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAFK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAFK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAFK

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GCTGASTCAGCA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAFK:
    hsa-mir-92b-3p (MIRT040737)

    Block miRNA regulation of human, mouse, rat MAFK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAFK (see all 32):
    hsa-miR-15a hsa-miR-25 hsa-miR-570 hsa-miR-548m hsa-miR-424 hsa-miR-92b hsa-miR-15b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidMAFK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAFK

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    GenScript: all cDNA clones in your preferred vector: MAFK (NM_002360)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAFK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAFK

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAFK_HUMAN, O60675: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    MAFK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAFK About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MAFK
        Factors involved in megakaryocyte development and platelet production

    1 PharmGKB Pathway for MAFK
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics


    MAFK for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAFK
    Interactions:

        GeneGlobe Interaction Network for MAFK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAFK (O606753 ENSP000003449034) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFE2L2Q162363, ENSP000003802524I2D: score=5 STRING: ENSP00000380252
    BACH1O148673, ENSP000002868004I2D: score=4 STRING: ENSP00000286800
    NFE2L1Q144943, ENSP000003551904I2D: score=2 STRING: ENSP00000355190
    ASH2LQ9UBL33, ENSP000003408964I2D: score=1 STRING: ENSP00000340896
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007399nervous system development IEA--
    GO:0007596blood coagulation TAS--

    MAFK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAFK

    2 Novoseek inferred chemical compound relationships for MAFK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tbhq 69.6 2 11772409 (1), 11013233 (1)
    leucine 46 3 9224592 (1), 12388604 (1), 18201722 (1)



    MAFK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAFK gene: 
    NM_002360.3  

    Unigene Cluster for MAFK:

    V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
    Hs.520612  [show with all ESTs]
    Unigene Representative Sequence: NM_002360
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343242(uc003skr.3) ENST00000403150(uc003sks.1) ENST00000406174

    miRNA
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    Block miRNA regulation of human, mouse, rat MAFK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAFK (see all 32):
    hsa-miR-15a hsa-miR-25 hsa-miR-570 hsa-miR-548m hsa-miR-424 hsa-miR-92b hsa-miR-15b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidMAFK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAFK
    Clone
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAFK
      QuantiTect SYBR Green Assays in human, mouse, rat MAFK
      QuantiFast Probe-based Assays in human, mouse, rat MAFK

    Additional mRNA sequence: 

    AF059194.1 AK056767.1 AK092414.1 AL831913.1 BC012777.2 BC094871.1 BC143040.1 BC143041.1 
    BC148194.1 BC148265.1 BC152387.1 

    6 DOTS entries:

    DT.95111972  DT.95155752  DT.121047953  DT.121047905  DT.121047936  DT.91870884 

    Selected AceView cDNA sequences (see all 185):

    BC012777 BM770150 AI218199 BM771401 BM771919 BM771454 BM771381 BM770981 
    BG058633 BQ933020 BM770142 BM770184 BM770092 BM771216 BM771195 BM771353 
    BU607533 AI739144 AI076447 BU686073 AI573098 CN481811 BM770991 BM771445 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAFK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGCCCGTG
    MAFK Expression
    About this image

    MAFK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAFK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520612
        Custom PCR Arrays for MAFK
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAFK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAFK gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mafk1 , 5 v-maf musculoaponeurotic fibrosarcoma oncogene family, more1, 5 89.74(n)1
    98.08(a)1
      5 (78.81 cM)5
    171351  NM_010757.21  NP_034887.11 
     1397915135 
    chicken
    (Gallus gallus)
    Aves MAFK1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 84.83(n)
    93.59(a)
      395518  NM_204756.1  NP_990087.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAFK6
    v-maf avian musculoaponeurotic fibrosarcoma oncoge...
    94(a)
    1 ↔ 1
    GL343327.1(913951-916589)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mafk1 v-maf avian musculoaponeurotic fibrosarcoma oncogene more 79.06(n)
    89.74(a)
      100036635  NM_001097194.1  NP_001090663.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mafk1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 78.14(n)
    84.42(a)
      415133  NM_001002044.2  NP_001002044.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta maf-S1 maf-S 62.89(n)
    55.67(a)
      37336  NM_137656.3  NP_611500.1 
    worm
    (Caenorhabditis elegans)
    Secernentea maf-16
    Protein MAF-1 (maf-1) mRNA, complete cds
    28(a)
    1 → many
    I(10382746-10384222) WBGene00077521


    ENSEMBL Gene Tree for MAFK (if available)
    TreeFam Gene Tree for MAFK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for MAFK gene
    NRL2  MAFF2  MAFG2  MAFA2  MAF2  MAFB2  
    18 SIMAP similar genes for MAFK using alignment to 4 protein entries:     MAFK_HUMAN (see all proteins):
    DKFZp434J046    WDR62    MAFF    MAFG    MAF    SEPT3
    MAFA    SEPT1    SEPT7    SEPT6    SEPT5    SEPT8
    SEPT10    SEPT11    SEPT4    MAFB    SEPT2    NRL

    MAFK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAFK (see all 168)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404573851,2
    C--1568430(+) CTAACA/GTGGTG 1 -- us2k10--------
    rs562619521,2
    C--1568459(+) AAAAA-/ATTAGC 1 -- us2k10--------
    rs119727951,2
    C,H--1568593(+) ctccaC/Gcctgg 1 -- us2k10--------
    rs1830315881,2
    --1568670(+) GTGGGC/TACCTG 1 -- us2k10--------
    rs125320981,2
    H--1568691(+) tactcA/Gagggg 1 -- us2k10--------
    rs1476848391,2
    --1568707(+) GGCAGA/GAGAAT 1 -- us2k10--------
    rs1880629611,2
    --1568715(+) AATCAC/TTTGAA 1 -- us2k10--------
    rs1932409381,2
    --1568747(+) TGAGCC/TGAGAT 1 -- us2k10--------
    rs1487398931,2
    --1568778(+) TGGACA/GACAGA 1 -- us2k10--------
    rs77948421,2
    C,F,A,H--1568785(+) cagagC/Tgagac 1 -- us2k15Minor allele frequency- T:0.25NA WA CSA 8

    HapMap Linkage Disequilibrium report for MAFK (1570350 - 1582679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAFK (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830880CNV Loss17160897
    dgv7100n71CNV Loss21882294
    dgv7098n71CNV Loss21882294
    nsv464247CNV Loss19166990
    nsv887223CNV Loss21882294
    nsv887128CNV Loss21882294
    dgv7095n71CNV Loss21882294
    nsv887231CNV Loss21882294
    dgv7102n71CNV Loss21882294
    nsv887233CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600197    OMIM disorders: --

    10 diseases for MAFK:    
    About MalaCards
    fibrosarcoma    lyme disease    burkitt's lymphoma    age related macular degeneration
    parkinson's disease    retinitis    malaria    squamous cell carcinoma
    hepatitis    neuronitis


    MAFK for disorders           About GeneDecksing


    Export disorders for MAFK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAFK gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with MAFK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. (PubMed id 9763667)1, 3, 9 Iwata T....Ito E. (Cytogenet. Cell Genet. 1998)
    2. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. (PubMed id 9150357)1, 2, 9 Toki T.... Ito E. (Oncogene 1997)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene. (PubMed id 11013233)1, 9 Dhakshinamoorthy S. and Jaiswal A.K. (J. Biol. Chem. 2000)
    7. Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. (PubMed id 8355703)1, 9 Ney P.A.... Neinhuis A.W. (Mol. Cell. Biol. 1993)
    8. Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. (PubMed id 24140708)1 Wu T....Zhang D.D. (amp 2014)
    9. Transforming growth factor-I^ induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. (PubMed id 23737527)1 Okita Y....Kato M. (J. Biol. Chem. 2013)
    10. Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. (PubMed id 22855609)1 Ono Y....Matsubara Y. (Blood 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7975 HGNC: 6782 AceView: MAFK Ensembl:ENSG00000198517 euGenes: HUgn7975
    ECgene: MAFK H-InvDB: MAFK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAFK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAFK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAFK gene:
    Search GeneIP for patents involving MAFK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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