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MAFIP Gene

pseudogene   GIFtS: 19
GCID: GC04M9U0054

MAFF Interacting Protein (Pseudogene)

(Previous name: MAFF interacting protein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAFF Interacting Protein (Pseudogene)1 2     TEKT4P42
MIP2 3     pp56442
MAFF Interacting Protein1     Tektin-4 Like Protein PP56443
Tektin 4 Pseudogene 41     

External Ids:    HGNC: 311021   Entrez Gene: 7277642   UniProtKB: Q8WZ333   

Export aliases for MAFIP gene to outside databases

Previous GC identifers: GC00M6J0000 GC21M009910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAFIP Gene:
This gene was originally thought to be a protein coding gene. However, the encoded protein sequence is highly
similar to the C-terminal sequence of the tektin-4 protein, and the transcript sequences of this gene are highly
similar to the TEKT4 pseudogenes, which are found on chromosomes 4, 21 and Y, respectively. Therefore, this gene
is thought to be another pseudogene of the TEKT4 gene (GeneID:150483). Multiple alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for MAFIP Gene:
MAFIP (MAFF interacting protein (pseudogene)) is a pseudogene. Diseases associated with MAFIP include cervical cancer, and cervicitis.

UniProtKB/Swiss-Prot: MAFIP_HUMAN, Q8WZ33
Function: Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MAFIP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAFIP promoter sequence
   Search Chromatin IP Primers for MAFIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAFIP


Genomic Location:
Chromosome:4   

HGNC chromosome: 4

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M9U0054:       (about GC identifiers)

Start:
53,589 bp from start of contig NT_113888      End:
115,010 bp from start of contig NT_113888
Size:
61,422 bases      Orientation:
unknown strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAFIP_HUMAN, Q8WZ33 (See protein sequence)
Recommended Name: MaFF-interacting protein  
Size: 124 amino acids; 13947 Da
Subunit: Interacts with MIS18A. Interacts (via its coiled-coil region) with MAFF

Explore the universe of human proteins at neXtProt for MAFIP: NX_Q8WZ33


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR000435 Tektin

Graphical View of Domain Structure for InterPro Entry Q8WZ33

ProtoNet protein and cluster: Q8WZ33

UniProtKB/Swiss-Prot: MAFIP_HUMAN, Q8WZ33
Similarity: Belongs to the tektin family


MAFIP for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MAFIP_HUMAN, Q8WZ33
Function: Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MAFIP_HUMAN, Q8WZ33: Cytoplasm. Nucleus, nucleolus. Note=Interaction with MAFF induces its translocation from the
cytoplasm to the nucleolus

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005730nucleolus IEA--
GO:0005737cytoplasm IEA--
GO:0005874microtubule IEA--

MAFIP for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for MAFIP

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000226microtubule cytoskeleton organization IEA--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

MAFIP for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MAFIP gene: 
NM_001190825.1  

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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

MAFIP Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

UniProtKB/Swiss-Prot: MAFIP_HUMAN, Q8WZ33
Tissue specificity: Strongly expressed in brain, kidney and ovary. Moderately expressed in liver, spleen, thymus,
prostate, testis, small intestine and colon. Weakly expressed in heart, placenta, lung and leukocytes

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MAFIP
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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4 diseases for MAFIP:    
About MalaCards
cervical cancer    cervicitis    hepatitis    prostatitis


MAFIP for disorders           About GeneDecksing


Export disorders for MAFIP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MAFIP gene integrated from 10 sources:
(articles sorted by number of sources associating them with MAFIP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The novel human gene MIP functions as a co-activator of hMafF. (PubMed id 16549056)1, 2, 3 Ye X.... Lu H. (Arch. Biochem. Biophys. 2006)
  2. PP5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1. (PubMed id 15881666)1, 2, 3 Ye X.-X.... Gu J.-R. (Mol. Cell. Biochem. 2005)
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  5. MAFIP is a tumor suppressor in cervical cancer that inhibits activation of the nuclear factor-kappa B pathway. (PubMed id 21834855)1 Li Y....Lu H. (Cancer Sci. 2011)
  6. Finding a novel interacting protein of the hepatic carcinoma related gene MIP: NF-I_B essential modulator (NEMO). (PubMed id 21109981)1 Ye X....Chen D. (Oncol. Rep. 2011)
  7. Establish a recombinant yeast detection system to study the effect of MIP on transactivation function of hMafF in US2-driven gene transcription. (PubMed id 19723544)1 Ye X....Chen D. (J. Microbiol. Methods 2009)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  10. Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450)1 Fortna A....Sikela J.M. (PLoS Biol. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 727764 HGNC: 31102 euGenes: HUgn727764 ECgene: MAFIP H-InvDB: MAFIP

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MAFIP Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MAFIP gene:
Search GeneIP for patents involving MAFIP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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