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MAFF interacting protein (pseudogene)(Previous name: MAFF interacting protein )
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Aliases
for MAFIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAFF Interacting Protein (Pseudogene)1 2 | | FLJ354731 | | MIP1 2 3 | | FLJ396331 | | TEKT4P41 2 | | MAFF Interacting Protein1 | | Pp56441 | | Tektin-4 Like Protein PP56443 | | FLJ002191 | | |
Export aliases for MAFIP gene to outside databasesPrevious GC identifers: GC04M9U0054 GC00M6J0000 |
Summaries
for MAFIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAFIP:
This gene was originally thought to be a protein coding gene. However, the encoded protein sequence is highly similarto the C-terminal sequence of the tektin-4 protein, and the transcript sequences of this gene are highly similar tothe TEKT4 pseudogenes, which are found on chromosomes 4, 21 and Y, respectively. Therefore, this gene is thought to beanother pseudogene of the TEKT4 gene (GeneID:150483). Multiple alternatively spliced transcript variants have beenfound for this gene. (provided by RefSeq, Mar 2012)
UniProtKB/Swiss-Prot: MAFIP_HUMAN, Q8WZ33Function: Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency
|
Genomic Views
for MAFIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MAFIP
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAFIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAFIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 21p11.2 HGNC chromosome: 4MAFIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M009910: view genomic region
(about GC identifiers)
Start:
|
9,907,190 bp from pter |
End:
|
9,968,585 bp from pter |
Size:
|
61,396 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr4-,NT_113888 53,589-115,010 |
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Proteins
for MAFIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAFIP_HUMAN, Q8WZ33 (See
protein sequence)Recommended Name: MaFF-interacting protein Size: 124 amino acids; 13947 Da
Subunit: Interacts with MIS18A. Interacts (via its coiled-coil region) with MAFF
Subcellular location: Cytoplasm. Nucleus, nucleolus. Note=Interaction with MAFF induces its translocation from thecytoplasm to the nucleolusExplore the universe of human proteins at neXtProt for MAFIP: NX_Q8WZ33
MAFIP Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MAFIP for ontologies About GeneDecksing
MAFIP Antibody Products:
Assay Products for MAFIP: |
Protein
Domains /
Families
for MAFIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAFIP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WZ33ProtoNet protein and cluster: Q8WZ33 UniProtKB/Swiss-Prot: MAFIP_HUMAN, Q8WZ33Similarity: Belongs to the tektin family |
Function
for MAFIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAFIP_HUMAN, Q8WZ33Function: Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAFIP |
|
Pathways & Interactions
for MAFIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAFIP
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000226 | microtubule cytoskeleton organization |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
MAFIP for ontologies About GeneDecksing
|
Drugs & Compounds
for MAFIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAFIP
Search CenterWatch for drugs/clinical trials and news about MAFIP 
|
Transcripts
for MAFIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAFIP gene: NM_001190825.1 3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000416067(uc002zka.2 uc021wgx.1 uc021wgy.1) ENST00000559466
ENST00000400754
GeneLoc Exon Structure
|
Expression
for MAFIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
Genevestigator expression for MAFIP
UniProtKB/Swiss-Prot: MAFIP_HUMAN, Q8WZ33Tissue specificity: Strongly expressed in brain, kidney and ovary. Moderately expressed in liver, spleen, thymus,prostate, testis, small intestine and colon. Weakly expressed in heart, placenta, lung and leukocytes
SABiosciences Custom PCR Arrays for MAFIP
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MAFIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAFIP | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAFIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAFIP |
Orthologs
for MAFIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for MAFIP (if available)
TreeFam Gene Tree for MAFIP (if available) |
Paralogs
for MAFIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MAFIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MAFIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAFIP for disorders About GeneDecksing
4  diseases for MAFIP: About MalaCardscervical cancer cervicitis hepatitis prostatitis
Export disorders for MAFIP gene to outside databases
|
Publications
for MAFIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAFIP gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAFIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The novel human gene MIP functions as a co-activator of hMafF. (PubMed id 16549056)1, 2, 3 Ye X....Lu H. (2006)
- PP5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1. (PubMed id 15881666)1, 2, 3 Ye X.-X.... Gu J.-R. (2005)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- MAFIP is a tumor suppressor in cervical cancer that i nhibits activation of the nuclear factor-kappa B pathway. (PubMed id 21834855)1 Li Y....Lu H. (2011)
- Finding a novel interacting protein of the hepatic ca rcinoma related gene MIP: NF-I_B essential modulator (NEMO). (PubMed id 21109981)1 Ye X....Chen D. (2011)
- Establish a recombinant yeast detection system to stu dy the effect of MIP on transactivation function of hMafF in US2-driven gene tr anscription. (PubMed id 19723544)1 Ye X....Chen D. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for MAFIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAFIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAFIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAFIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAFIP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAFIP gene:
Search GeneIP for patents involving MAFIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAFIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAFIP | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAFIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAFIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAFIP | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAFIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAFIP |
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 |  |  |  | |
| | | | Search Tocris compounds for MAFIP |
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 | | | MAFIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAFIP |
|  |  |  | | | | Search ThermoFisher Antibodies for MAFIP |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAFIP |
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