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Aliases for MAFG Gene

Aliases for MAFG Gene

  • V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G 2 3
  • Basic Leucine Zipper Transcription Factor MafG 2 3
  • Transcription Factor MafG 2 3
  • HMAF 3 4
  • V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog G 4

External Ids for MAFG Gene

Previous GeneCards Identifiers for MAFG Gene

  • GC17M079241
  • GC17M9I0116
  • GC17M080415
  • GC17M9I0558
  • GC17M9I7469
  • GC17M077469
  • GC17M079877
  • GC17M075277

Summaries for MAFG Gene

Entrez Gene Summary for MAFG Gene

  • Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

GeneCards Summary for MAFG Gene

MAFG (V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G) is a Protein Coding gene. Diseases associated with MAFG include fibrosarcoma. Among its related pathways are Hemostasis and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is MAFA.

UniProtKB/Swiss-Prot for MAFG Gene

  • Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).

Gene Wiki entry for MAFG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAFG Gene

Genomics for MAFG Gene

Regulatory Elements for MAFG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAFG Gene

Start:
81,918,269 bp from pter
End:
81,927,714 bp from pter
Size:
9,446 bases
Orientation:
Minus strand

Genomic View for MAFG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAFG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAFG Gene

Proteins for MAFG Gene

  • Protein details for MAFG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15525-MAFG_HUMAN
    Recommended name:
    Transcription factor MafG
    Protein Accession:
    O15525
    Secondary Accessions:

    Protein attributes for MAFG Gene

    Size:
    162 amino acids
    Molecular mass:
    17850 Da
    Quaternary structure:
    • Homodimer or heterodimer. Homodimerization leads to transcriptional repression. Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3. Interacts with NFE2; the interaction results in transactivation activation. Interacts with CREBBP; the interaction leads to acetylation of the basic region of MAFG and stimulation of NFE2 transcriptional activity through increased DNA binding.

neXtProt entry for MAFG Gene

Proteomics data for MAFG Gene at MOPED

Post-translational modifications for MAFG Gene

  • Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
  • Sumoylation at Lys-14 is required for active transcriptional repression.
  • Ubiquitination at Lys110
  • Modification sites at PhosphoSitePlus

Other Protein References for MAFG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAFG Gene

Domains for MAFG Gene

Protein Domains for MAFG Gene

Suggested Antigen Peptide Sequences for MAFG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15525

UniProtKB/Swiss-Prot:

MAFG_HUMAN :
  • O15525
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Maf subfamily.
genes like me logo Genes that share domains with MAFG: view

No data available for Gene Families for MAFG Gene

Function for MAFG Gene

Molecular function for MAFG Gene

GENATLAS Biochemistry:
small MAF protein G,dimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor,homolog to v-maf musinloaponeurotic fibrosarcoma (avian) oncogene
UniProtKB/Swiss-Prot Function:
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).

Gene Ontology (GO) - Molecular Function for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 18692475
GO:0043565 sequence-specific DNA binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with MAFG: view
genes like me logo Genes that share phenotypes with MAFG: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAFG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAFG Gene

Localization for MAFG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAFG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAFG Gene COMPARTMENTS Subcellular localization image for MAFG gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with MAFG: view

Pathways for MAFG Gene

genes like me logo Genes that share pathways with MAFG: view

Pathways by source for MAFG Gene

Gene Ontology (GO) - Biological Process for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007596 blood coagulation TAS --
GO:0030534 adult behavior IEA --
genes like me logo Genes that share ontologies with MAFG: view

Compounds for MAFG Gene

(3) Novoseek inferred chemical compound relationships for MAFG Gene

Compound -log(P) Hits PubMed IDs
tbhq 77.6 2
pdtc 59.3 2
leucine 53.4 3
genes like me logo Genes that share compounds with MAFG: view

Transcripts for MAFG Gene

Unigene Clusters for MAFG Gene

V-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAFG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAFG Gene

No ASD Table

Relevant External Links for MAFG Gene

GeneLoc Exon Structure for
MAFG
ECgene alternative splicing isoforms for
MAFG

Expression for MAFG Gene

mRNA expression in normal human tissues for MAFG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAFG Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Protein differential expression in normal tissues for MAFG Gene

This gene is overexpressed in Heart (51.8) and Fetal Brain (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAFG Gene

SOURCE GeneReport for Unigene cluster for MAFG Gene Hs.252229

mRNA Expression by UniProt/SwissProt for MAFG Gene

O15525-MAFG_HUMAN
Tissue specificity: Highly expressed in skeletal muscle. Also expressed in heart and brain
genes like me logo Genes that share expressions with MAFG: view

Expression partners for MAFG Gene

In Situ Assay Products

Orthologs for MAFG Gene

This gene was present in the common ancestor of animals.

Orthologs for MAFG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAFG 35
  • 94.24 (n)
  • 98.77 (a)
MAFG 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAFG 35
  • 95.27 (n)
  • 98.77 (a)
MAFG 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mafg 35
  • 90.95 (n)
  • 98.77 (a)
Mafg 16
Mafg 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAFG 35
  • 99.59 (n)
  • 100 (a)
MAFG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mafg 35
  • 91.15 (n)
  • 98.77 (a)
oppossum
(Monodelphis domestica)
Mammalia MAFG 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAFG 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAFG 35
  • 87.24 (n)
  • 93.83 (a)
MAFG 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAFG 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mafg 35
  • 74.07 (n)
  • 85.8 (a)
zebrafish
(Danio rerio)
Actinopterygii mafgb 35
  • 84.57 (n)
  • 90.74 (a)
mafga 36
  • 68 (a)
OneToMany
mafgb 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta maf-S 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea maf-1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for MAFG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAFG Gene

ENSEMBL:
Gene Tree for MAFG (if available)
TreeFam:
Gene Tree for MAFG (if available)

Paralogs for MAFG Gene

Paralogs for MAFG Gene

Selected SIMAP similar genes for MAFG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAFG: view

Variants for MAFG Gene

Sequence variations from dbSNP and Humsavar for MAFG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1054499 -- 81,922,890(-) AGCTG(C/T)CGCGT reference, synonymous-codon
rs1054500 -- 81,922,591(-) GTCTG(A/C)CCAGG utr-variant-3-prime
rs1879570 -- 81,921,985(+) ACCAG(A/C)GATTT utr-variant-3-prime
rs2376532 -- 81,923,503(-) TCCCC(C/G/T)GCCCC intron-variant, utr-variant-5-prime
rs3064373 -- 81,925,207(-) CTCTG(-/TG)GGAGC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MAFG Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3342n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
esv33468 CNV Loss 17666407
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
nsv833571 CNV Loss 17160897

Relevant External Links for MAFG Gene

HapMap Linkage Disequilibrium report
MAFG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAFG Gene

Disorders for MAFG Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MAFG Gene in MalaCards »

(1) Diseases for MAFG Gene including...

Relevant External Links for MAFG

Genetic Association Database (GAD)
MAFG
Human Genome Epidemiology (HuGE) Navigator
MAFG
genes like me logo Genes that share disorders with MAFG: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MAFG Gene

Publications for MAFG Gene

  1. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. (PMID: 9150357) Toki T. … Ito E. (Oncogene 1997) 3 4 23
  2. Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. (PMID: 9166829) Blank V. … Andrews N.C. (Blood 1997) 3 4 23
  3. hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. (PMID: 9195958) Marini M.G. … Moi P. (J. Biol. Chem. 1997) 3 4 23
  4. Molecular characterization and localization of the human MAFG gene. (PMID: 9286713) Blank V. … Andrews N.C. (Genomics 1997) 3 4 23
  5. Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. (PMID: 9763667) Iwata T. … Ito E. (Cytogenet. Cell Genet. 1998) 2 3 23

Products for MAFG Gene

Sources for MAFG Gene

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