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MAFG Gene

protein-coding   GIFtS: 61
GCID: GC17M079877

V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G1 2
Basic Leucine Zipper Transcription Factor MafG1 2
Transcription Factor MafG1 2
hMAF2 3
V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog G3

External Ids:    HGNC: 67811   Entrez Gene: 40972   Ensembl: ENSG000001970637   OMIM: 6020205   UniProtKB: O155253   

Export aliases for MAFG gene to outside databases

Previous GC identifers: GC17M079241 GC17M9I0116 GC17M080415 GC17M9I0558 GC17M9I7469 GC17M077469 GC17M075277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAFG Gene:
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like
locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al.,
1997 (PubMed 9166829)). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf
protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490).
Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins
(see MIM 165160).(supplied by OMIM, Mar 2010)

GeneCards Summary for MAFG Gene:
MAFG (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) is a protein-coding gene. Diseases associated with MAFG include fibrosarcoma, and lung cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NRL.

UniProtKB/Swiss-Prot: MAFG_HUMAN, O15525
Function: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors
when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with
other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf
proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.
Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene
expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By
similarity)

Gene Wiki entry for MAFG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010663.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAFG gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAFG promoter sequence
   Search Chromatin IP Primers for MAFG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAFG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

MAFG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAFG gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079877:  view genomic region     (about GC identifiers)

Start:
79,876,145 bp from pter      End:
79,885,590 bp from pter
Size:
9,446 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MAFG_HUMAN, O15525 (See protein sequence)
Recommended Name: Transcription factor MafG  
Size: 162 amino acids; 17850 Da
Subunit: Homodimer or heterodimer. Homodimerization leads to transcriptional repression. Forms high affinity
heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3.
Interacts with NFE2; the interaction results in transactivation activation. Interacts with CREBBP; the
interaction leads to acetylation of the basic region of MAFG and stimulation of NFE2 transcriptional activity
through increased DNA binding

Explore the universe of human proteins at neXtProt for MAFG: NX_O15525

Explore proteomics data for MAFG at MOPED

Post-translational modifications: 

  • Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of
    NFE2, but has no effect on binding NFE21
  • Sumoylation at Lys-14 is required for active transcriptional repression (By similarity)1
  • Ubiquitination2 at Lys110
  • Modification sites at PhosphoSitePlus

  • See MAFG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002350.1  NP_116100.2  

    ENSEMBL proteins: 
     ENSP00000350369   ENSP00000376173   ENSP00000459634  
    Reactome Protein details: O15525

    MAFG Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028551 MafG
     IPR004827 bZIP
     IPR024874 Transciption_factor_Maf
     IPR008917 TF_DNA-bd
     IPR004826 bZIP_Maf

    Graphical View of Domain Structure for InterPro Entry O15525

    ProtoNet protein and cluster: O15525

    1 Blocks protein domain: IPB004826 Maf transcription factor

    UniProtKB/Swiss-Prot: MAFG_HUMAN, O15525
    Similarity: Belongs to the bZIP family. Maf subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    MAFG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAFG_HUMAN, O15525
    Function: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors
    when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with
    other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf
    proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.
    Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene
    expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By
    similarity)

         Genatlas biochemistry entry for MAFG:
    small MAF protein G,dimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription
    factor,homolog to v-maf musinloaponeurotic fibrosarcoma (avian) oncogene

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    MAFG for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mafg):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  immune system 
     mortality/aging  muscle  nervous system 

    MAFG for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAFG
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAFG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAFG

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAFG:
    hsa-mir-100-5p (MIRT048503), hsa-mir-218-5p (MIRT003711), hsa-mir-93-3p (MIRT038855), hsa-mir-26b-5p (MIRT029000), hsa-mir-92a-3p (MIRT049582)

    Block miRNA regulation of human, mouse, rat MAFG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAFG (see all 121):
    hsa-miR-194* hsa-miR-548j hsa-miR-4254 hsa-miR-1321 hsa-miR-300 hsa-miR-218-1* hsa-miR-128 hsa-miR-3074-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat MAFG

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    GenScript: all cDNA clones in your preferred vector (see all 2): MAFG (NM_032711)
    Sino Biological Human cDNA Clone for MAFG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAFG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAFG

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAFG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAFG_HUMAN, O15525: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    MAFG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAFG About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MAFG
        Factors involved in megakaryocyte development and platelet production

    1 PharmGKB Pathway for MAFG
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics


    MAFG for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAFG
    Interactions:

        GeneGlobe Interaction Network for MAFG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for MAFG (O155252, 3 ENSP000003503694) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-63109 I2D: score=5 
    MED31Q9Y3C72, 3MINT-63108 I2D: score=5 
    VIMP086702, 3MINT-63106 I2D: score=5 
    NFE2L2Q162363, ENSP000003802524I2D: score=4 STRING: ENSP00000380252
    BACH1O148673, ENSP000002868004I2D: score=3 STRING: ENSP00000286800
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007596blood coagulation TAS--
    GO:0030534adult behavior IEA--

    MAFG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAFG

    3 Novoseek inferred chemical compound relationships for MAFG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tbhq 77.6 2 11772409 (1), 11013233 (1)
    pdtc 59.3 2 11772409 (1), 10559251 (1)
    leucine 53.4 3 9195958 (1), 9224592 (1), 18201722 (1)



    MAFG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAFG gene (2 alternative transcripts): 
    NM_002359.3  NM_032711.3  

    Unigene Cluster for MAFG:

    V-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
    Hs.252229  [show with all ESTs]
    Unigene Representative Sequence: BC103722
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357736(uc002kcm.3 uc002kcn.3) ENST00000392366 ENST00000574686

    miRNA
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    Block miRNA regulation of human, mouse, rat MAFG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAFG (see all 121):
    hsa-miR-194* hsa-miR-548j hsa-miR-4254 hsa-miR-1321 hsa-miR-300 hsa-miR-218-1* hsa-miR-128 hsa-miR-3074-3p
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MAFG
      QuantiFast Probe-based Assays in human, mouse, rat MAFG

    Additional mRNA sequence: 

    BC006143.1 BC103722.1 

    4 DOTS entries:

    DT.446479  DT.120932883  DT.95373881  DT.100720919 

    Selected AceView cDNA sequences (see all 669):

    AW167947 BM835741 AL137626 BM563158 BM738182 BE645897 CA411562 AU119053 
    BM127859 CB529263 BM749464 BM927716 AI003999 CR600645 CD243507 AL046493 
    CR617224 BM127837 BX101126 AI873788 BG252558 BU149195 CA424339 AI245466 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAFG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTATTTGT
    MAFG Expression
    About this image


    MAFG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Telencephalon
    MAFG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAFG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.252229

    UniProtKB/Swiss-Prot: MAFG_HUMAN, O15525
    Tissue specificity: Highly expressed in skeletal muscle. Also expressed in heart and brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAFG gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mafg1 , 5 v-maf musculoaponeurotic fibrosarcoma oncogene family, more1, 5 90.95(n)1
    98.77(a)1
      11 (84.35 cM)5
    171341  NM_010756.31  NP_034886.11 
     1206251175 
    chicken
    (Gallus gallus)
    Aves MAFG1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 87.24(n)
    93.83(a)
      769355  NM_001079489.1  NP_001072957.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAFG6
    v-maf avian musculoaponeurotic fibrosarcoma oncoge...
    94(a)
    1 ↔ 1
    2(118464020-118464706)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mafg1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 74.07(n)
    85.8(a)
      100486278  XM_004916372.1  XP_004916429.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mafgb1 v-maf avian musculoaponeurotic fibrosarcoma oncogene more 84.57(n)
    90.74(a)
      405877  NM_212941.1  NP_998106.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta maf-S6
    maf-S
    42(a)
    1 → many
    2R(16528476-16529173)
    worm
    (Caenorhabditis elegans)
    Secernentea maf-16
    Protein MAF-1 (maf-1) mRNA, complete cds
    27(a)
    1 → many
    I(10382746-10384222) WBGene00077521


    ENSEMBL Gene Tree for MAFG (if available)
    TreeFam Gene Tree for MAFG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAFG gene
    NRL2  MAFF2  MAFA2  MAFK2  MAF2  MAFB2  
    5 SIMAP similar genes for MAFG using alignment to 2 protein entries:     MAFG_HUMAN (see all proteins):
    MAFK    MAFF    MAF    NRL    MAFA

    MAFG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAFG (see all 115)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430341821,2
    --75298494(+) GTATAA/CATGTC 1 -- int10--------
    rs1837678191,2
    --75298528(+) CGTCAA/TTGGGG 1 -- int10--------
    rs1481822771,2
    C--75298696(+) GCAACC/TGGACC 1 -- int10--------
    rs1882489351,2
    --75298746(+) CGGCCA/GCCCTC 1 -- int10--------
    rs1920357361,2
    --75298753(+) CCTCAA/GCCGGG 1 -- int10--------
    rs1841009521,2
    --75298761(+) GGGCTC/TCCTCC 1 -- int10--------
    rs1412043471,2
    --75298876(+) GGAACC/TAGGTC 1 -- int10--------
    rs1885268361,2
    --75298940(+) CACCCA/GCGCCA 1 -- int10--------
    rs1462270021,2
    C--75298958(+) CCTGCA/GGAGAC 1 -- int10--------
    rs1914338241,2
    --75299192(+) GGTTCA/GTCTCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MAFG (79876145 - 79885590 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAFG (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909134CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv833569CNV Loss17160897
    nsv909161CNV Loss21882294
    esv29964CNV Loss17803354
    dgv3340n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3342n71CNV Loss21882294
    nsv833571CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602020    OMIM disorders: --

    4 diseases for MAFG:    
    About MalaCards
    fibrosarcoma    lung cancer    cerebritis    hepatitis


    MAFG for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAFG
    Human Genome Epidemiology (HuGE) Navigator: MAFG (1 document)

    Export disorders for MAFG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAFG gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with MAFG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. (PubMed id 9195958)1, 2, 9 Marini M.G.... Moi P. (J. Biol. Chem. 1997)
    2. Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)- mediated acetylation. (PubMed id 11154691)1, 2, 9 Hung H.-L.... Blobel G.A. (J. Biol. Chem. 2001)
    3. Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. (PubMed id 9166829)1, 2, 9 Blank V.... Andrews N.C. (Blood 1997)
    4. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. (PubMed id 9150357)1, 2, 9 Toki T.... Ito E. (Oncogene 1997)
    5. Molecular characterization and localization of the human MAFG gene. (PubMed id 9286713)1, 2, 9 Blank V.... Andrews N.C. (Genomics 1997)
    6. Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. (PubMed id 9763667)1, 3, 9 Iwata T....Ito E. (Cytogenet. Cell Genet. 1998)
    7. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (PLoS ONE 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. (PubMed id 9421508)1, 9 Johnsen O....Kolsto A.B. (Nucleic Acids Res. 1998)
    10. Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements. (PubMed id 16716189)1, 9 Yamamoto T....Yamamoto M. (amp 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4097 HGNC: 6781 AceView: MAFGandPCYT2andSIRT7 Ensembl:ENSG00000197063 euGenes: HUgn4097
    ECgene: MAFG H-InvDB: MAFG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAFG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAFG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAFG gene:
    Search GeneIP for patents involving MAFG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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