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Aliases for MAFG Gene

Aliases for MAFG Gene

  • MAF BZIP Transcription Factor G 2 3 5
  • V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G 2 3
  • Basic Leucine Zipper Transcription Factor MafG 2 3
  • Transcription Factor MafG 2 3
  • HMAF 3 4
  • V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog G 4

External Ids for MAFG Gene

Previous GeneCards Identifiers for MAFG Gene

  • GC17M079241
  • GC17M9I0116
  • GC17M080415
  • GC17M9I0558
  • GC17M9I7469
  • GC17M077469
  • GC17M079877
  • GC17M075277

Summaries for MAFG Gene

Entrez Gene Summary for MAFG Gene

  • Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

GeneCards Summary for MAFG Gene

MAFG (MAF BZIP Transcription Factor G) is a Protein Coding gene. Diseases associated with MAFG include Fibrosarcoma. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and NRF2 pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is MAFK.

UniProtKB/Swiss-Prot for MAFG Gene

  • Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).

Gene Wiki entry for MAFG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAFG Gene

Genomics for MAFG Gene

Regulatory Elements for MAFG Gene

Enhancers for MAFG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G081908 1.4 ENCODE dbSUPER 13.3 +20.4 20401 6.0 HDGF FOXA2 MLX ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 MAFG ENSG00000235296 PYCR1 MYADML2 ENSG00000262877 CEP131 GCGR PCYT2 PIR61559
GH17G081416 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +511.0 511026 7.6 AGO1 SIN3A GLI4 FEZF1 ZNF2 GLIS2 ZNF143 KLF7 FOS DEK MAFG FSCN2 CCDC137 HGS NPLOC4 MIR4740 GC17M081444
GH17G081884 1.3 ENCODE dbSUPER 11.9 +45.6 45553 3.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 FOS SP3 P4HB SIRT7 MAFG PYCR1 ENSG00000235296 MYADML2 GC17P081887 GC17P081881
GH17G081984 0.9 FANTOM5 12.7 -53.3 -53349 0.2 MXI1 KLF1 ESRRA NFIB ZSCAN4 INSM2 GLI4 CDC5L ZNF2 ZFHX2 MYADML2 PYCR1 ENSG00000235296 MAFG SIRT7 PCYT2 NPB ALYREF ANAPC11 DCXR
GH17G082011 0.9 ENCODE 12 -81.9 -81898 3.3 ELF3 ARID4B THRB RAD21 RARA GLIS2 ZNF143 PCBP1 PAF1 ZNF263 CENPX DCXR ASPSCR1 MYADML2 PYCR1 ENSG00000235296 MAFG SIRT7 PCYT2 NPB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAFG on UCSC Golden Path with GeneCards custom track

Genomic Location for MAFG Gene

Chromosome:
17
Start:
81,918,269 bp from pter
End:
81,931,560 bp from pter
Size:
13,292 bases
Orientation:
Minus strand

Genomic View for MAFG Gene

Genes around MAFG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAFG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAFG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAFG Gene

Proteins for MAFG Gene

  • Protein details for MAFG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15525-MAFG_HUMAN
    Recommended name:
    Transcription factor MafG
    Protein Accession:
    O15525

    Protein attributes for MAFG Gene

    Size:
    162 amino acids
    Molecular mass:
    17850 Da
    Quaternary structure:
    • Homodimer or heterodimer. Homodimerization leads to transcriptional repression. Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3. Interacts with NFE2; the interaction results in transactivation activation. Interacts with CREBBP; the interaction leads to acetylation of the basic region of MAFG and stimulation of NFE2 transcriptional activity through increased DNA binding.

neXtProt entry for MAFG Gene

Post-translational modifications for MAFG Gene

  • Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
  • Sumoylation at Lys-14 is required for active transcriptional repression.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAFG Gene

No data available for DME Specific Peptides for MAFG Gene

Domains & Families for MAFG Gene

Gene Families for MAFG Gene

Protein Domains for MAFG Gene

Suggested Antigen Peptide Sequences for MAFG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15525

UniProtKB/Swiss-Prot:

MAFG_HUMAN :
  • Belongs to the bZIP family. Maf subfamily.
Family:
  • Belongs to the bZIP family. Maf subfamily.
genes like me logo Genes that share domains with MAFG: view

Function for MAFG Gene

Molecular function for MAFG Gene

GENATLAS Biochemistry:
small MAF protein G,dimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor,homolog to v-maf musinloaponeurotic fibrosarcoma (avian) oncogene
UniProtKB/Swiss-Prot Function:
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).

Gene Ontology (GO) - Molecular Function for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 18692475
GO:0043565 sequence-specific DNA binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with MAFG: view
genes like me logo Genes that share phenotypes with MAFG: view

Animal Models for MAFG Gene

MGI Knock Outs for MAFG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAFG Gene

Localization for MAFG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAFG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAFG gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with MAFG: view

Pathways & Interactions for MAFG Gene

genes like me logo Genes that share pathways with MAFG: view

Pathways by source for MAFG Gene

Gene Ontology (GO) - Biological Process for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007596 blood coagulation TAS --
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with MAFG: view

No data available for SIGNOR curated interactions for MAFG Gene

Drugs & Compounds for MAFG Gene

(1) Drugs for MAFG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MAFG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAFG: view

Transcripts for MAFG Gene

Unigene Clusters for MAFG Gene

V-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAFG Gene

No ASD Table

Relevant External Links for MAFG Gene

GeneLoc Exon Structure for
MAFG
ECgene alternative splicing isoforms for
MAFG

Expression for MAFG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAFG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAFG Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for MAFG Gene

This gene is overexpressed in Heart (51.8) and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAFG Gene



Protein tissue co-expression partners for MAFG Gene

NURSA nuclear receptor signaling pathways regulating expression of MAFG Gene:

MAFG

SOURCE GeneReport for Unigene cluster for MAFG Gene:

Hs.252229

mRNA Expression by UniProt/SwissProt for MAFG Gene:

O15525-MAFG_HUMAN
Tissue specificity: Highly expressed in skeletal muscle. Also expressed in heart and brain.

Evidence on tissue expression from TISSUES for MAFG Gene

  • Lung(4.4)
  • Muscle(4.1)
  • Nervous system(3.5)
  • Skin(2)
genes like me logo Genes that share expression patterns with MAFG: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAFG Gene

Orthologs for MAFG Gene

This gene was present in the common ancestor of animals.

Orthologs for MAFG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAFG 35 34
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAFG 34 35
  • 95.27 (n)
cow
(Bos Taurus)
Mammalia MAFG 34 35
  • 94.24 (n)
rat
(Rattus norvegicus)
Mammalia Mafg 34
  • 91.15 (n)
mouse
(Mus musculus)
Mammalia Mafg 34 16 35
  • 90.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAFG 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAFG 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAFG 34 35
  • 87.24 (n)
lizard
(Anolis carolinensis)
Reptilia MAFG 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mafg 34
  • 74.07 (n)
zebrafish
(Danio rerio)
Actinopterygii mafgb 34 35
  • 84.57 (n)
mafga 35
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta maf-S 35
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea maf-1 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for MAFG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAFG Gene

ENSEMBL:
Gene Tree for MAFG (if available)
TreeFam:
Gene Tree for MAFG (if available)

Paralogs for MAFG Gene

Paralogs for MAFG Gene

(5) SIMAP similar genes for MAFG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAFG: view

Variants for MAFG Gene

Sequence variations from dbSNP and Humsavar for MAFG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000041849 -- 81,919,917(+) TGCCA(A/G)CGCAC upstream-variant-2KB, utr-variant-3-prime
rs1000195754 -- 81,925,763(+) AGATC(C/G)CGCCA intron-variant, upstream-variant-2KB
rs1000195845 -- 81,924,020(+) CTCTA(G/T)ACCTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000360344 -- 81,921,536(+) ACGGC(C/T)TTCTG utr-variant-3-prime
rs1000573932 -- 81,923,986(+) GGCCA(G/T)CAGCT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MAFG Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv29964 CNV loss 17803354
esv33468 CNV loss 17666407
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv833571 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for MAFG Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAFG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAFG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAFG Gene

Disorders for MAFG Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAFG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fibrosarcoma
  • fibrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search MAFG in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAFG

Genetic Association Database (GAD)
MAFG
Human Genome Epidemiology (HuGE) Navigator
MAFG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAFG
genes like me logo Genes that share disorders with MAFG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAFG Gene

Publications for MAFG Gene

  1. Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)- mediated acetylation. (PMID: 11154691) Hung H.-L. … Blobel G.A. (J. Biol. Chem. 2001) 3 4 22 64
  2. Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. (PMID: 9763667) Iwata T. … Ito E. (Cytogenet. Cell Genet. 1998) 2 3 22 64
  3. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. (PMID: 9150357) Toki T. … Ito E. (Oncogene 1997) 3 4 22 64
  4. Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. (PMID: 9166829) Blank V. … Andrews N.C. (Blood 1997) 3 4 22 64
  5. hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. (PMID: 9195958) Marini M.G. … Moi P. (J. Biol. Chem. 1997) 3 4 22 64

Products for MAFG Gene

Sources for MAFG Gene

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