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MAFF Gene

protein-coding   GIFtS: 57

GC22P036922
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
(Previous names: v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein F )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
OTTHUMP00000028701 2
U-MAF 2
U-Maf 3
hMafF 1, 2
Descriptions
V-maf musculoaponeurotic fibrosarcoma oncogene homolog F 3
transcription factor MAFF 2
v-maf avian musculoaponeurotic fibrosarcoma oncogene family
protein F 2
v-maf musculoaponeurotic fibrosarcoma (avian) oncogene
family, protein F 1
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F
(avian) 2
External Ids
HGNC: 67801
Entrez Gene: 237642
UniProtKB: Q9ULX93
Ensembl: ENSG000001850227
Search outside databases for aliases for MAFF gene

Previous GC identifers: GC22P035212 GC22P036841

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAFF:
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a
transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin
receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins
to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form
homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of
transcription. This gene may also be involved in the cellular stress response. Two transcript
variants encoding the same protein have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9
Function: Interacts with the upstream promoter region of the oxytocin receptor gene. May be a
transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since
it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it
dimerize among himself. May also serve as a transcriptional activator by dimerizing with other
(usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be
involved in the cellular stress response

Gene Wiki entry for MAFF

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAFF gene  

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

MAFF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P036922:     (about GC identifiers)

Start:
36,927,944 bp from pter
End:
36,942,460 bp from pter
Size:
14,517 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000022.9  NT_011520.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9 (See protein sequence)
Recommended Name: Transcription factor MafF  
Size: 164 amino acids; 17760 Da
Subunit: Monomer and homo- or heterodimer. Interacts with MIP
Subcellular location: Nucleus
Secondary accessions: Q9Y525

REFSEQ proteins (2 alternative transcripts): 
NP_036455.1  NP_690617.1  


ENSEMBL proteins: 
ENSP00000384094 ENSP00000345393 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (MAFF)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
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Antibodies for MAFF: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for MAFF
R&D Systems Antibodies for MAFF
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for MAFF

Assays for MAFF: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR004827 TF_bZIP
 IPR004826 TF_Maf


   GeneDecks  MAFF for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9ULX9

ProtoNet protein and cluster: Q9ULX9

1 Blocks protein family: IPB004826 Maf transcription factor

UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9
Similarity: Belongs to the bZIP family. Maf subfamily
Similarity: Contains 1 bZIP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (MAFF)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (MAFF)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_152878

              Applied Biosystems Silencer® siRNAs for MAFF

              Sigma-Aldrich siRNA for MAFF  
                     Sigma-Aldrich shRNA for MAFF  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for MAFF
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_012323
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_012323
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012323 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_012323

UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9
Function: Interacts with the upstream promoter region of the oxytocin receptor gene. May be a
transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since
it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it
dimerize among himself. May also serve as a transcriptional activator by dimerizing with other
(usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be
involved in the cellular stress response
Induction: By oxidative stress

Genatlas biochemistry entry for MAFF:
V-maf musculoaponeurotic fibrosarcoma (ovarian) oncogene family protein F, expressed in kidney and
in term myometrium where it binds to the oxytocin receptor

1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Maff):

normal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity IEA--
GO:0043565 sequence-specific DNA binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Sigma-Aldrich "Your Favorite Gene" Pathway for  MAFF  (Your Favorite Gene powered by Ingenuity) 
 NRF2-mediated Oxidative Stress Response

   GeneDecks  MAFF for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  MAFF 


5/11 Interacting proteins for MAFF (Q9ULX92 ENSP000003453933) via UniProtKB, MINT, and/or STRING (see all 11 )
InteractantInteraction Details
GeneCardExternal ID(s)
PSAPP076022MINT-65765
NFE2ENSP000003124363STRING (score=.981)
C16orf35ENSP000002623133STRING (score=.927)
NFE2L1ENSP000003548553STRING (score=.905)
MAFGENSP000003503693STRING (score=.904)
About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0001701 in utero embryonic development IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0006366 transcription from RNA polymerase II promoter TAS10527846
GO:0006950 response to stress IEA--
GO:0007567 parturition TAS10527846
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAFF
1 Novoseek chemical compound relationship for MAFF gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
leucine 51.46 3 9224592 (1), 10527846 (1), 18201722 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (MAFF)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (MAFF)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_152878

              Sigma-Aldrich siRNA for MAFF  
                     Sigma-Aldrich shRNA for MAFF  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_012323  NM_152878  

REFSEQ mRNAs for MAFF gene (2 alternative transcripts): 

NM_012323.2   NM_152878.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_012323  NM_152878  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_012323
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_012323
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012323 

Additional cDNA sequence: 

AB025247.1 AJ010857.1 AK002001.1 AK097953.1 AK300932.1 BC015037.1 BC067751.1 CR606348.1 
CR611256.1 CR618179.1 

10 DOTS entries:

DT.203620  DT.97788728  DT.100776324  DT.100780528  DT.100839561  DT.120647699  DT.120647718  DT.100704879 
DT.100727449  DT.91680261 

24/112 AceView cDNA sequences (see all 112 ):

NM_152878 BM837671 AW514537 AI580738 BM015626 AL541932 CR606348 NM_012323 
CR611256 CR618179 AI654655 BI821412 BX328755 BX344318 BX428336 BX509965 
BM014036 BI858984 AW069639 BI860930 CB267489 AU137437 BX094372 BG032829 

highest scoring ESTs for MAFF:

AB025247 AI580738 AI610651 AI654655 AJ010857 AK002001 AK097953 AU137437 AU139809 AU157175 

Unigene Cluster for MAFF:

V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
Hs.517617  [show with all ESTs]
Unigene Representative Sequence: BC067751


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MAFF

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:                                                            
SP2:              -     -     -                                 
SP3:                    -     -                                 
SP4:                          -                                 

About this scheme

ECgene alternative splicing isoforms for MAFF

2 Ensembl transcripts including schematic representations:
ENST00000407965  ENST00000338483  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAFF expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for MAFF

1 / 2 / 3

5 probe-sets matching MAFF gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
36711_at2, 3 U133-A 1 1.00 1.00 1.00 1.00 AL021977 0.20 1.00 0.72 1
36711_at2, 3 U133-A 1 1.00 1.00 -- -- AL021977 0.20 1.00 0.72 1

205193_at2, 3 U133-A 1 1.00 1.00 -- -- NM_012323 0.60 1.00 0.82 1
36711_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

205193_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  MAFF for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GACTGCTGTG

SOURCE GeneReport for Unigene cluster: Hs.517617

Expression variation in blood from EXPOLDB for MAFF

UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9
Tissue specificity: Expressed in the term myometrium and kidney

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for MAFF gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
MAFF1   -- v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 93.33(n)
96.13(a)
481255  XM_538376.2  XP_538376.2 
chimpanzee
(Pan troglodytes)
MAFF1   -- v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 99.8(n)
99.39(a)
743669  XM_001147709.1  XP_001147709.1 
cow
(Bos taurus)
MAFF1   -- v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 95.54(n)
100(a)
617914  XM_870246.2  XP_875339.2 
rat
(Rattus norvegicus)
Maff1   -- v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 89.96(n)
94.87(a)
366960  XM_345857.3  XP_345858.3 
mouse
(Mus musculus)
Maff1, 5 15 (46.00 cM)5
v-maf musculoaponeurotic fibrosarcoma oncogene family, more1, 5 91.24(n)1
94.23(a)1
171331  NM_010755.31  NP_034885.11 
 AA0605085  AB0096945  (see all 9)
About this table        Species with no ortholog for MAFF

ENSEMBL Gene Tree for MAFF
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for MAFF gene
ENSG000002187882  MAFG2  MAFK2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/125 NCBI SNPs in MAFF are shown (see all 125 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 39)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 22 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs46086231,2
A,C,F,H36927324(+) AGGTGG/TTGAGA 1 -- ng514Minor allele frequency- T:0.48EU EA WA 412
rs24135081,2
A,F,H36927120(+) GGACAG/CAAAGA 1 -- ng51 trp34Minor allele frequency- C:0.35EU EA WA 416
--
rs48217661,2
A,C,F36942157(+) accccG/Atctct 2 -- ut311Minor allele frequency- A:0.09EA 176
rs72863221,2
A,C,F36938333(+) CATGGC/TGGAGA 2 -- ng51 int11Minor allele frequency- T:0.23NA 90
--
rs20641031,2
A,C36938173(+) GGTCTC/TGAACT 2 -- ng51 int10--------
--
rs96075171,2
A,C36926046(+) GTTGCA/GATGTA 1 -- ng510--------
--
rs59955501,2
A36942318(+) gcaaaA/Ctcctg 2 -- ut31 ese30--------
--
rs43744561,2
A36927323(+) GAGGTC/GGTGAG 1 -- ng510--------
--
rs20641041,2
C36938187(+) gaactC/Gaggtg 2 -- int1 ng510--------
rs117036011,2
C36927987(+) CTCGGC/TCCCCT 1 -- ut51 ese30--------
About this table

HapMap Linkage Disequilibrium images for MAFF (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604877

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/20 PubMed articles for MAFF gene (see all 20 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23764 HGNC: 6780 AceView: MAFF Ensembl:ENSG00000185022 euGenes: HUgn23764
ECgene: MAFF H-InvDB: MAFF
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for MAFF Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for MAFF:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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 Predesigned and custom siRNAs for MAFF Antibodies for MAFF
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for MAFF Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search Novus for antibodies for MAFF

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