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MAFF Gene

protein-coding   GIFtS: 62
GCID: GC22P038597

V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog F1 2     V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Family Protein F2
U-MAF2     U-Maf3
hMafF2     V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog F3
Transcription Factor MafF2     

External Ids:    HGNC: 67801   Entrez Gene: 237642   Ensembl: ENSG000001850227   OMIM: 6048775   UniProtKB: Q9ULX93   

Export aliases for MAFF gene to outside databases

Previous GC identifers: GC22P035212 GC22P036841 GC22P036922 GC22P021564


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAFF Gene:
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a
transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR)
gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the
OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a
transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in
the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for
this gene. (provided by RefSeq, Jun 2009)

GeneCards Summary for MAFF Gene:
MAFF (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F) is a protein-coding gene. Diseases associated with MAFF include ulnar neuropathy, and rhinotracheitis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NRL.

UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9
Function: Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional
enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative
transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also
serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and
recruiting them to specific DNA-binding sites. May be involved in the cellular stress response

Gene Wiki entry for MAFF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAFF gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAFF promoter sequence
   Search Chromatin IP Primers for MAFF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAFF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

MAFF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAFF gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038597:  view genomic region     (about GC identifiers)

Start:
38,597,889 bp from pter      End:
38,612,518 bp from pter
Size:
14,630 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9 (See protein sequence)
Recommended Name: Transcription factor MafF  
Size: 164 amino acids; 17760 Da
Subunit: Monomer and homo- or heterodimer. Interacts with MIP
Secondary accessions: B4DV49 Q9Y525
Alternative splicing: 2 isoforms:  Q9ULX9-1   Q9ULX9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAFF: NX_Q9ULX9

Explore proteomics data for MAFF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAFF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001155044.1  NP_001155045.1  NP_001155046.1  NP_036455.1  

    ENSEMBL proteins: 
     ENSP00000345393   ENSP00000391589   ENSP00000416493   ENSP00000384094   ENSP00000442060  
     ENSP00000388882   ENSP00000441482  
    Reactome Protein details: Q9ULX9

    MAFF Human Recombinant Protein Products:

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    MAFF Assay Products:

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    Cloud-Clone Corp. ELISAs for MAFF
    Cloud-Clone Corp. CLIAs for MAFF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028573 MafF
     IPR004827 bZIP
     IPR024874 Transciption_factor_Maf
     IPR008917 TF_DNA-bd
     IPR004826 bZIP_Maf

    Graphical View of Domain Structure for InterPro Entry Q9ULX9

    ProtoNet protein and cluster: Q9ULX9

    1 Blocks protein domain: IPB004826 Maf transcription factor

    UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9
    Similarity: Belongs to the bZIP family. Maf subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    MAFF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAFF_HUMAN, Q9ULX9
    Function: Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional
    enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative
    transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also
    serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and
    recruiting them to specific DNA-binding sites. May be involved in the cellular stress response
    Induction: By oxidative stress

         Genatlas biochemistry entry for MAFF:
    V-maf musculoaponeurotic fibrosarcoma (ovarian) oncogene family protein F, expressed in kidney and in term
    myometrium where it binds to the oxytocin receptor

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    MAFF for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Maff):
     normal 

    MAFF for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAFF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAFF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAFF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAFF

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  HWWGTCAGCAWWTTT 

    miRNA
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    miRTarBase miRNAs that target MAFF:
    hsa-mir-335-5p (MIRT018523)

    Block miRNA regulation of human, mouse, rat MAFF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAFF (see all 22):
    hsa-miR-3678-3p hsa-miR-142-5p hsa-miR-642a hsa-miR-3190 hsa-miR-340 hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidMAFF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAFF

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): MAFF (NM_012323)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAFF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAFF

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAFF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAFF_HUMAN, Q9ULX9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    golgi apparatus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    MAFF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAFF About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    3Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    4Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MAFF
        Myometrial Relaxation and Contraction Pathways

    1 Reactome Pathway for MAFF
        Factors involved in megakaryocyte development and platelet production

    1 PharmGKB Pathway for MAFF
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics


    MAFF for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MAFF: 
              Estrogen Receptor Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAFF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for MAFF (Q9ULX92, 3 ENSP000003453934) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSAPP076022, 3, ENSP000003783944MINT-65765 I2D: score=5 STRING: ENSP00000378394
    NFE2L1Q144943, ENSP000003551904I2D: score=3 STRING: ENSP00000355190
    NFE2L2Q162363, ENSP000003802524I2D: score=3 STRING: ENSP00000380252
    NRF1Q166563, ENSP000002231904I2D: score=3 STRING: ENSP00000223190
    HOXD12P354523, ENSP000003855864I2D: score=2 STRING: ENSP00000385586
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS10527846
    GO:0007567parturition TAS10527846
    GO:0007596blood coagulation TAS--

    MAFF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAFF

    1 HMDB Compound for MAFF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Oxytocin(Arg8)-Vasopressin (see all 22)50-56-6--

    1 Novoseek inferred chemical compound relationship for MAFF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 50.9 3 9224592 (1), 10527846 (1), 18201722 (1)



    MAFF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAFF gene (5 alternative transcripts): 
    NM_001161572.1  NM_001161573.1  NM_001161574.1  NM_012323.3  NM_152878.1  

    Unigene Cluster for MAFF:

    V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
    Hs.517617  [show with all ESTs]
    Unigene Representative Sequence: NM_001161572
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338483(uc003avc.3 uc011anq.2) ENST00000441709 ENST00000417948
    ENST00000407965(uc003avd.3) ENST00000538320(uc011anp.2) ENST00000426621(uc011anr.2)
    ENST00000538999
    miRNA
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    Block miRNA regulation of human, mouse, rat MAFF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAFF (see all 22):
    hsa-miR-3678-3p hsa-miR-142-5p hsa-miR-642a hsa-miR-3190 hsa-miR-340 hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidMAFF 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): MAFF (NM_012323)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAFF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAFF
    Primer
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    Additional mRNA sequence: 

    AB025247.1 AJ010857.1 AK002001.1 AK097953.1 AK300932.1 BC015037.1 BC067751.1 

    10 DOTS entries:

    DT.203620  DT.97788728  DT.100776324  DT.100780528  DT.100839561  DT.120647699  DT.120647718  DT.100704879 
    DT.100727449  DT.91680261 

    Selected AceView cDNA sequences (see all 112):

    NM_152878 NM_012323 AW514537 CR611256 CR618179 AL541932 CR606348 AI580738 
    BM015626 BM837671 T82306 BI858984 BI821412 AK097953 BM015145 BX453002 
    BX348088 AU137437 AK002001 AU138272 BU177628 AI610651 CB156777 BG540373 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAFF    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                                            
    SP2:              -     -     -                                 
    SP3:                    -     -                                 
    SP4:                          -                                 


    ECgene alternative splicing isoforms for MAFF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAFF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGCTGTG
    MAFF Expression
    About this image

    MAFF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAFF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517617

    UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9
    Tissue specificity: Expressed in the term myometrium and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including MAFF: 
              Estrogen Receptor Signaling in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MAFF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAFF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAFF gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Maff1 , 5 v-maf musculoaponeurotic fibrosarcoma oncogene family, more1, 5 91.24(n)1
    94.23(a)1
      15 (37.70 cM)5
    171331  NM_010755.31  NP_034885.11 
     793476785 
    chicken
    (Gallus gallus)
    Aves MAFF1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 81.32(n)
    85.82(a)
      395519  NM_204757.1  NP_990088.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAFF6
    v-maf avian musculoaponeurotic fibrosarcoma oncoge...
    84(a)
    1 ↔ 1
    GL343460.1(354481-383954)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638682 hypothetical protein MGC63868 72.7(n)   393307  BC053121.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta maf-S6
    maf-S
    41(a)
    1 → many
    2R(16528476-16529173)
    worm
    (Caenorhabditis elegans)
    Secernentea maf-16
    Protein MAF-1 (maf-1) mRNA, complete cds
    25(a)
    1 → many
    I(10382746-10384222) WBGene00077521


    ENSEMBL Gene Tree for MAFF (if available)
    TreeFam Gene Tree for MAFF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAFF gene
    NRL2  MAFG2  MAFA2  MAFK2  MAF2  MAFB2  
    5 SIMAP similar genes for MAFF using alignment to 3 protein entries:     MAFF_HUMAN (see all proteins):
    MAFK    MAFG    MAF    NRL    MAFA

    MAFF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAFF (see all 316)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616650581,2
    C--21572168(+) TCTCA-/A/AA  
            
    AAAAA
    4 -- int11NA 2
    rs731544371,2
    C,F--38596059(+) ACGGCG/ACACAC 3 -- us2k12Minor allele frequency- A:0.08WA EA 238
    rs96075171,2
    C,F,A,H--38596100(+) GTTGCG/AATGTA 3 -- us2k17Minor allele frequency- A:0.47NA CSA WA EA 366
    rs48217621,2
    C,F,H--38596145(+) tggatC/Accaat 3 -- us2k110Minor allele frequency- A:0.15NA WA CSA EA 371
    rs1825288541,2
    --38596223(+) ATGTAC/TTCCTT 3 -- us2k10--------
    rs1155690751,2
    C,F--38596355(+) GGGAGG/ACCGAG 3 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1875162691,2
    --38596367(+) TGGGTA/GGCCTG 3 -- us2k10--------
    rs2012398451,2
    C--38596530(+) AAAAA-/AGAAAA 3 -- us2k10--------
    rs48203221,2
    A--38596588(+) acattC/Ttggtt 3 -- us2k10--------
    rs48217631,2
    A--38596646(+) ACCCTA/CCAGAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAFF (38597889 - 38612518 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MAFF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv989237CNV Deletion20482838
    nsv915060CNV Loss21882294
    nsv519015CNV Loss19592680
    nsv834194CNV Loss17160897
    nsv514970CNV Complex21397061

    Human Gene Mutation Database (HGMD): MAFF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAFF
    DNA2.0 Custom Variant and Variant Library Synthesis for MAFF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604877    OMIM disorders: --

    9 diseases for MAFF:    
    About MalaCards
    ulnar neuropathy    rhinotracheitis    fibrosarcoma    scrapie
    bovine spongiform encephalopathy    placental choriocarcinoma    choriocarcinoma    mouth disease
    neuropathy

    1 disease from the University of Copenhagen DISEASES database for MAFF:
    Ulnar neuropathy

    MAFF for disorders           About GeneDecksing


    Export disorders for MAFF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MAFF gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with MAFF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    2. Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium. (PubMed id 10527846)1, 2, 9 Kimura T.... Murata Y. (Biochem. Biophys. Res. Commun. 1999)
    3. The novel human gene MIP functions as a co-activator of hMafF. (PubMed id 16549056)1, 2, 9 Ye X.... Lu H. (Arch. Biochem. Biophys. 2006)
    4. Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators. (PubMed id 11772409)1, 2, 9 Moran J.A.... Mulcahy R.T. (Biochem. J. 2002)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation. (PubMed id 12490281)1, 9 Marini M.G....Moi P. (amp 2002)
    8. Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells. (PubMed id 16371591)1, 9 Massrieh W....Blank V. (Biol. Reprod. 2006)
    9. Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. (PubMed id 8107826)1, 9 Igarashi K....Yamamoto M. (Nature 1994)
    10. Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. (PubMed id 24140708)1 Wu T....Zhang D.D. (amp 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23764 HGNC: 6780 AceView: MAFF Ensembl:ENSG00000185022 euGenes: HUgn23764
    ECgene: MAFF H-InvDB: MAFF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAFF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAFF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAFF gene:
    Search GeneIP for patents involving MAFF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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