MAFF Gene
protein-coding GIFtS : 57
GC22P036922
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (Previous names: v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein F )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for MAFF
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases OTTHUMP00000028701 2 U-MAF 2 U-Maf 3 hMafF 1 , 2
Descriptions V-maf musculoaponeurotic fibrosarcoma oncogene homolog F 3 transcription factor MAFF 2 v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F 2 v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein F 1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 2
Search outside databases for aliases for MAFF genePrevious GC identifers: GC22P035212 GC22P036841
Summaries for MAFF (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for MAFF : The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks atransactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocinreceptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteinsto enhance expression of the OTR gene during term pregnancy. The encoded protein can also formhomodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor oftranscription. This gene may also be involved in the cellular stress response. Two transcriptvariants encoding the same protein have been found for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9 Function : Interacts with the upstream promoter region of the oxytocin receptor gene. May be atranscriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Sinceit lacks a putative transactivation domain, it may behave as a transcriptional repressor when itdimerize among himself. May also serve as a transcriptional activator by dimerizing with other(usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May beinvolved in the cellular stress response
Gene Wiki entry for MAFF
Genomic Location for MAFF
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MAFF gene Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1 MAFF Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22P036922:
(about GC identifiers )
Start:
36,927,944 bp from pter
End:
36,942,460 bp from pter
Size:
14,517 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000022.9 NT_011520.11 Proteins for MAFF
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9 (See
protein sequence )Recommended Name: Transcription factor MafF Size : 164 amino acids; 17760 Da
Subunit : Monomer and homo- or heterodimer. Interacts with MIP
Subcellular location : Nucleus
Secondary accessions : Q9Y525
REFSEQ proteins (2 alternative transcripts):
NP_036455.1 NP_690617.1 ENSEMBL proteins: ENSP00000384094 ENSP00000345393 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
About this table Antibodies for MAFF: Assays for MAFF:
Protein
Domains/ Families for MAFF(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9ULX9 ProtoNet protein and cluster: Q9ULX9
1 Blocks protein family : IPB004826 Maf transcription factor UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9 Similarity : Belongs to the bZIP family. Maf subfamilySimilarity : Contains 1 bZIP domain
Gene Function for MAFF
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_152878 Applied Biosystems Silencer ® siRNAs for MAFF Sigma-Aldrich siRNA for MAFF Sigma-Aldrich shRNA for MAFF Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_012323                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_012323                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_012323  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012323 UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9 Function : Interacts with the upstream promoter region of the oxytocin receptor gene. May be atranscriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Sinceit lacks a putative transactivation domain, it may behave as a transcriptional repressor when itdimerize among himself. May also serve as a transcriptional activator by dimerizing with other(usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May beinvolved in the cellular stress response Induction : By oxidative stress
Genatlas biochemistry entry for MAFF :V-maf musculoaponeurotic fibrosarcoma (ovarian) oncogene family protein F, expressed in kidney andin term myometrium where it binds to the oxytocin receptor
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Maff) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 transcription factor activity
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
About this table
Pathways & Interactions for MAFF
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for MAFF (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for MAFF 5/11 Interacting proteins for MAFF (Q9ULX9 2 ENSP00000345393 3 ) via UniProtKB, MINT, and/or STRING (see all 11
)About this table 5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
):
About this table
Drugs & Compounds for MAFF (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MAFF 1 Novoseek chemical compound relationship for MAFF gene
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Transcripts for MAFF(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_152878 Sigma-Aldrich siRNA for MAFF Sigma-Aldrich shRNA for MAFF Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_012323 NM_152878
REFSEQ mRNAs for MAFF gene (2 alternative transcripts): NM_012323.2 NM_152878.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012323 NM_152878
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_012323                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_012323                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_012323  
Additional cDNA sequence: AB025247.1 AJ010857.1 AK002001.1 AK097953.1 AK300932.1 BC015037.1 BC067751.1 CR606348.1 CR611256.1 CR618179.1
10 DOTS entries : DT.203620 DT.97788728 DT.100776324 DT.100780528 DT.100839561 DT.120647699 DT.120647718 DT.100704879 DT.100727449 DT.91680261
24/112 AceView cDNA sequences (see all 112
):NM_152878 BM837671 AW514537 AI580738 BM015626 AL541932 CR606348 NM_012323 CR611256 CR618179 AI654655 BI821412 BX328755 BX344318 BX428336 BX509965 BM014036 BI858984 AW069639 BI860930 CB267489 AU137437 BX094372 BG032829
highest scoring ESTs for MAFF :AB025247 AI580738 AI610651 AI654655 AJ010857 AK002001 AK097953 AU137437 AU139809 AU157175
Unigene Cluster for MAFF: V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) Hs.517617 [show with all ESTs ] Unigene Representative Sequence: BC067751 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for MAFF ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d SP1 :                     SP2 :     -   -   -             SP3 :       -   -             SP4 :         -            
About this scheme ECgene alternative splicing isoforms for MAFF 2 Ensembl transcripts including schematic representations : ENST00000407965
ENST00000338483
Expression for MAFF
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MAFF expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MAFF 1 / 2 / 3
5 probe-sets matching MAFF gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GACTGCTGTGSOURCE GeneReport for Unigene cluster: Hs.517617 Expression variation in blood from EXPOLDB for MAFF
UniProtKB/Swiss-Prot: MAFF_HUMAN, Q9ULX9 Tissue specificity : Expressed in the term myometrium and kidney
Orthologs for MAFF
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MAFF gene from 5/7 species (see all 7
)
About this table Species with no ortholog for MAFF ENSEMBL Gene Tree for MAFF Paralogs for MAFF (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MAFF gene ENSG00000218788 2 MAFG 2 MAFK 2
SNPs/Variants for MAFF (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MAFF (up to first 250kb)
Disorders & Mutations for MAFF
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 604877
Medical News for MAFF (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MAFF (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/20 PubMed articles for MAFF gene (see all 20
): The DNA sequence of human chromosome 22. (PubMed id 10591208) 2, 3, 4 Dunham I....O'Brien K.P. (1999) Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium. (PubMed id 10527846) 1, 3, 4 Kimura T.... Murata Y. (1999) The novel human gene MIP functions as a co-activator of hMafF. (PubMed id 16549056) 1, 3, 4 Ye X....Lu H. (2006) Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators. (PubMed id 11772409) 1, 3, 4 Moran J.A.... Mulcahy R.T. (2002) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation. (PubMed id 12490281) 1, 3 Marini M.G....Moi P. (2002) Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells. (PubMed id 16371591) 1, 3 Massrieh W....Blank V. (2006) Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. (PubMed id 8107826) 1, 3 Igarashi K....Yamamoto M. (1994) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 3 Stelzl U....Wanker E.E. (2005)
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Genome Databases showing MAFF
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MAFF
(According to HUGE )
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Specialized Databases showing MAFF (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for MAFF (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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