MAFB Gene
protein-coding GIFtS: 56
GC20M038747
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v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
(Previous name: Kreisler (mouse) maf-related leucine zipper homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: KRML)
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Aliases &
Descriptions
for MAFB
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| KRML 2, 3, 5 | | MGC43127 2 | | Maf-B 3 | | OTTHUMP00000031698 2 |
| | | Descriptions |
|---|
| Kreisler (mouse) maf-related leucine zipper homolog 1 | | Kreisler maf-related leucine zipper homolog 2 | MAFB/Kreisler basic region/leucine zipper transcription
factor 2 | | V-maf musculoaponeurotic fibrosarcoma oncogene homolog B 3 | | transcription factor MAFB 2 | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B
(avian) 2 |
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Search outside databases for aliases for MAFB genePrevious GC identifers: GC20M039043 GC20M039952 GC20M039999 |
Summaries
for MAFB(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for MAFB:
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays
an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein
represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene
contains no introns. [provided by RefSeq]
UniProtKB/Swiss-Prot: MAFB_HUMAN, Q9Y5Q3Function: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating
lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific
genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell
differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and
glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through
the G1 element. SUMO modification controls its transcriptional activity and ability to specify
macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an
oncogene or as a tumor suppressor, depending on the cell contextGene Wiki entry for MAFB |
Genomic Location
for MAFB
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the MAFB gene 
Entrez Gene cytogenetic band: 20q11.2-q13.1 Ensembl cytogenetic band: 20q12 HGNC cytogenetic band: 20q11.1-q13.1MAFB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M038747:
(about GC identifiers)
Start:
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38,747,902 bp from pter |
End:
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38,751,294 bp from pter |
Size:
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3,393 bases |
Orientation:
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minus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011362.9
| Proteins
for MAFB
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MAFB_HUMAN, Q9Y5Q3 (See
protein sequence)Recommended Name: Transcription factor MafB Size: 323 amino acids; 35792 Da
Subunit: Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a
homodimer or a heterodimer. Forms homo- and heterodimers with FOS, FOSB and FOSL2, but not with
JUN proteins (JUN, JUNB and JUND). Interacts with PAX6; the interaction is direct. Interacts with
ETS1 and LRP1 (By similarity). Interacts with the intracellular cytoplasmic domain of LRP1
(LRPICD); the interaction results in a moderate reduction of MAFB transcriptional potential
Subcellular location: Nucleus (By similarity)
Secondary accessions: B3KNE1 Q9H1F1Post-translational modifications:
Phosphorylated by GSK3 and MAPK13 on serine and threonine residues (Probable)1
Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity
and promotes macrophage differentiation from myeloid progenitors (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005452.2
ENSEMBL proteins: ENSP00000362410 ENSP00000380167
Human Recombinant Proteins  OriGene Purified Recombinant Human Protein: MAFB
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for MAFB:
Assays for MAFB: | Protein
Domains/
Families
for MAFB(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y5Q3
ProtoNet protein and cluster: Q9Y5Q3 2 Blocks protein families: IPB004826 Maf transcription factor IPB013592 Maf transcription factor
UniProtKB/Swiss-Prot: MAFB_HUMAN, Q9Y5Q3Domain: The leucine-zipper domain is involved in the interaction with LRPICDSimilarity: Belongs to the bZIP family. Maf subfamilySimilarity: Contains 1 bZIP domain | Gene Function
for MAFB
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005461
 Applied Biosystems Silencer® siRNAs for MAFB
 Sigma-Aldrich siRNA for MAFB
Sigma-Aldrich shRNA for MAFB
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005461
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005461
untagged cDNA clone in CMV expression vector: NM_005461
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_005461
UniProtKB/Swiss-Prot: MAFB_HUMAN, Q9Y5Q3Function: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating
lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific
genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell
differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and
glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through
the G1 element. SUMO modification controls its transcriptional activity and ability to specify
macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an
oncogene or as a tumor suppressor, depending on the cell context10 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Mafb):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for MAFB
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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Gene Network CentralTM Interacting Genes and Proteins Network for MAFB
5/19 Interacting proteins for MAFB (ENSP000003624103) via UniProtKB, MINT, and/or STRING (see all 19
)About this table
5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9
): About this table
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Drugs & Compounds
for MAFB(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MAFB
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Transcripts
for MAFB(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005461
Sigma-Aldrich siRNA for MAFB
Sigma-Aldrich shRNA for MAFB
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_005461 REFSEQ mRNAs for MAFB gene: NM_005461.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005461
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005461
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005461
untagged cDNA clone in CMV expression vector: NM_005461
Additional cDNA sequence: AF086178.1 AF134157.1 AK027324.1 BC028098.1 BC036689.1 CR611755.1 7 DOTS entries: DT.100752412 DT.416351 DT.100752413 DT.120797989 DT.120797963 DT.92042090 DT.120797961 24/178 AceView cDNA sequences (see all 178
):AL544306 BQ129935 AW140037 BF437137 AA725480 CA776398 BU741148 NM_005461 BQ710402 AA975289 AA384636 BI962692 AI417601 C02406 BU783903 CA842975 AK027324 BU790225 CA771895 BM719823 BQ576290 BQ631848 BU072400 AI092862
 highest scoring ESTs for MAFB:AI869550 N90926 AA037402 AA347212 AA347213 AA379134 AA379135 AA384636 AA505246 AA725480 Unigene Cluster for MAFB: V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) Hs.169487 [show with all ESTs]Unigene Representative Sequence: NM_005461
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000373313
ENST00000396967
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Expression
for MAFB
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MAFB expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MAFB
1 / 2 / 3 6 probe-sets matching MAFB gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TAAAATAAGG
SOURCE GeneReport for Unigene cluster: Hs.169487
UniProtKB/Swiss-Prot: MAFB_HUMAN, Q9Y5Q3Tissue specificity: Ubiquitous |
Orthologs
for MAFB
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MAFB gene from 5/8 species (see all 8
)
About this table Species with no ortholog for MAFB
ENSEMBL Gene Tree for MAFB | Paralogs
for MAFB(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MAFB gene
- NRL2 MAFA2 MAF2
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SNPs/Variants
for MAFB(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for MAFB (up to first 250kb)
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Disorders & Mutations
for MAFB
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608968
Human Genome Epidemiology Navigator: MAFB (2 documents)
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Medical News
for MAFB(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MAFB (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/35 PubMed articles for MAFB gene (see all 35
):- Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (PubMed id 10444328)1, 2, 3, 4 Wang P.W....Le Beau M.M. (1999)
- Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. (PubMed id 15135046)3, 4 Petersen H.H....Willnow T.E. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate. (PubMed id 15598817)1, 3 Bakri Y....Sieweke M.H. (2005)
- Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells. (PubMed id 16456583)1, 3 Gemelli C....Ferrari S. (2006)
- Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis. (PubMed id 18615156)1, 3 Liu C....Gregersen P.K. (2008)
- The vitamin D3/Hox-A10 pathway supports MafB function during the monocyte differentiation of human CD34+ hemopoietic progenitors. (PubMed id 18832725)1, 3 Gemelli C....Ferrari S. (2008)
- Identification of primary MAFB target genes in multiple myeloma. (PubMed id 19013005)3 van Stralen E....Bast B.J. (2009)
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Search for MAFB
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MAFB
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MAFB
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAFB(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for MAFB(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for MAFB:
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(MafB) | | | Antibodies (MafB) |
| | | | Search Tocris compounds for MAFB |
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Incremental update: 13 Oct 2009
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