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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAFA Gene

protein-coding   GIFtS: 52
GCID: GC08M144511

V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog A1 2     hMafA2
Pancreatic Beta-Cell-Specific Transcriptional Activator2 3     Transcription Factor MafA2
Transcription Factor RIPE3b12 3     V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A3
RIPE3b12     RIPE3B15

External Ids:    HGNC: 231451   Entrez Gene: 3896922   Ensembl: ENSG000001827597   OMIM: 6103035   UniProtKB: Q8NHW33   

Export aliases for MAFA gene to outside databases

Previous GC identifers: GC08U900345 GC08M144617 GC08M144582 GC08M139764


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAFA Gene:
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta
cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 (PubMed 12011435)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for MAFA Gene: 
MAFA (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A) is a protein-coding gene. Diseases associated with MAFA include pancreatitis, and fibrosarcoma, and among its related super-pathways are Type II diabetes mellitus and Regulation of beta-cell development. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NRL.

UniProtKB/Swiss-Prot: MAFA_HUMAN, Q8NHW3
Function: Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates
insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its
transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor
suppressor, depending on the cell context

Gene Wiki entry for MAFA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAFA gene promoter:
         E2F-3a   E2F-4   E2F-5   Lmo2   E2F-2   YY1   GATA-2   c-Ets-1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAFA promoter sequence
   Search SABiosciences Chromatin IP Primers for MAFA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

MAFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAFA gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M144511:  view genomic region     (about GC identifiers)

Start:
144,501,352 bp from pter      End:
144,512,602 bp from pter
Size:
11,251 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAFA_HUMAN, Q8NHW3 (See protein sequence)
Recommended Name: Transcription factor MafA  
Size: 353 amino acids; 36982 Da
Subunit: Binds DNA as a homodimer. Interacts with NEUROD1, PCAF and PDX1
Subcellular location: Nucleus. Note=Detected in nuclei of pancreas islet beta cells (By similarity)
1 PDB 3D structure from and Proteopedia for MAFA:
4EOT (3D)    

Explore the universe of human proteins at neXtProt for MAFA: NX_Q8NHW3

Explore proteomics data for MAFA at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated, leading to its degradation by the proteasome
  • UniProtKB: Ser-14 and Ser-65 appear to be the major phosphorylation sites. Phosphorylated by MAPK13 on serine and threonine
    residues (Probable). Phosphorylation by GSK3 requires prior phosphorylation of Ser-65 by another kinase.
    Phosphorylation proceeds then from Ser-61 to Thr-57, Thr-53 and Ser-49. GSK3-mediated phosphorylation increases
    its transcriptional activity through the recruitment of the coactivator PCAF, is required for its transforming
    activity and leads to its degradation through an ubiquitin/proteasome-dependent pathway
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NHW3

  • MAFA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAFA Protein Expression
    REFSEQ proteins: NP_963883.2  
    ENSEMBL proteins: 
     ENSP00000328364  

    Human Recombinant Protein Products for MAFA: 
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    Novus Biologicals MAFA Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAFA 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12368292

    MAFA for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for MAFA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR004827 bZIP
     IPR024874 Transciption_factor_Maf
     IPR008917 Euk_TF_DNA-bd
     IPR004826 bZIP_Maf
     IPR013592 Maf_TF_N

    Graphical View of Domain Structure for InterPro Entry Q8NHW3

    ProtoNet protein and cluster: Q8NHW3

    2 Blocks protein domains:
    IPB004826 Maf transcription factor
    IPB013592 Maf transcription factor


    UniProtKB/Swiss-Prot: MAFA_HUMAN, Q8NHW3
    Similarity: Belongs to the bZIP family. Maf subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    MAFA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAFA_HUMAN, Q8NHW3
    Function: Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates
    insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its
    transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor
    suppressor, depending on the cell context
    Induction: Up-regulated by glucose

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA12368292
    GO:0003700sequence-specific DNA binding transcription factor activity TAS12368292
    GO:0042803protein homodimerization activity TAS12368292
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046982protein heterodimerization activity NAS12368292
         
    MAFA for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mafa):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  no phenotypic analysis  normal 
     renal/urinary system 

    MAFA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAFA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAFA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAFA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAFA 

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MAFA (see all 13):
    hsa-miR-548p hsa-miR-576-5p hsa-miR-4328 hsa-miR-429 hsa-miR-4299 hsa-miR-877* hsa-miR-153 hsa-miR-942
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAFA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Type II diabetes mellitus
    Type II diabetes mellitus0.38
    Type II diabetes mellitus0.35
    Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics0.38
    2Regulation of beta-cell development
    Maturity onset diabetes of the young0.56
    3Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MAFA
        Type II diabetes mellitus

    2 PharmGKB Pathways for MAFA
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for MAFA):
        Type II diabetes mellitus
    Maturity onset diabetes of the young


    MAFA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for MAFA (Q8NHW33 ENSP000003283644) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEUROD1Q135623, ENSP000002951084I2D: score=2 STRING: ENSP00000295108
    PDX1P529453, ENSP000003704214I2D: score=2 STRING: ENSP00000370421
    MAPK1P284823, ENSP000002158324I2D: score=1 STRING: ENSP00000215832
    MAFO754443, ENSP000003270484I2D: score=1 STRING: ENSP00000327048
    MAPK14Q165393, ENSP000002297944I2D: score=1 STRING: ENSP00000229794
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS12368292
    GO:0007263nitric oxide mediated signal transduction IDA17941991
    GO:0009749response to glucose stimulus IDA12368292
    GO:0030073insulin secretion IDA17941991

    MAFA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAFA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAFA

    1 Novoseek inferred chemical compound relationship for MAFA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 41.6 39 8613527 (4), 17682063 (4), 12368292 (3), 8289826 (2) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about MAFA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAFA gene: 
    NM_201589.3  

    Unigene Cluster for MAFA:

    V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
    Hs.521914  [show with all ESTs]
    Unigene Representative Sequence: NM_201589
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528185 ENST00000333480(uc003yyc.2)
    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MAFA (see all 13):
    hsa-miR-548p hsa-miR-576-5p hsa-miR-4328 hsa-miR-429 hsa-miR-4299 hsa-miR-877* hsa-miR-153 hsa-miR-942
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAFA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAFA

    2 DOTS entries:

    DT.422260  DT.97838907 

    1 AceView cDNA sequence:

    AI761030 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAFA expression in normal human tissues (normalized intensities)      MAFA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGTGCGCG
    MAFA Expression
    About this image


    MAFA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 8 entries
             Immature Beta Progenitor Cells Ventral Pancreatic Bud
             Beta-like cells ( Derivation of beta cells including an expansion step )
     
     Spinal Cord (Nervous System)
             spinal cord/lateral wall   
     
     Neural Tube (Nervous System)
             spinal cord/lateral wall   
     
     Skeletal Muscle (Muscoskeletal System)

    See MAFA Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.521914
        SABiosciences Expression via Pathway-Focused PCR Array including MAFA: 
              Terminal Differentiation Markers in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAFA gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mafa1 , 5 v-maf musculoaponeurotic fibrosarcoma oncogene family, more1, 5 91.93(n)1
    95.16(a)1
      15 (34.82 cM)5
    3784351  NM_194350.11  NP_919331.11 
     757468435 
    chicken
    (Gallus gallus)
    Aves MAFA1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog more 76.81(n)
    83.22(a)
      395881  NM_205025.1  NP_990356.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mafl2 v-maf musculoaponeurotic fibrosarcoma (avian) oncogene more 82.63(n)   114468  AB006324.2 
    worm
    (Caenorhabditis elegans)
    Secernentea maf-16
    Protein MAF-1
    28(a)
    possible ortholog
    I(10382746-10384222)


    ENSEMBL Gene Tree for MAFA (if available)
    TreeFam Gene Tree for MAFA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAFA gene
    NRL2  MAFF2  MAFG2  MAFK2  MAF2  MAFB2  
    6 SIMAP similar genes for MAFA using alignment to 2 protein entries:     MAFA_HUMAN (see all proteins):
    MAFK    MAFG    MAFF    MAFB    MAF    NRL

    MAFA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/94 SNPs in MAFA are shown (see all 94)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559810351,2
    C,F--144509784(+) GGCCCT/CGTGAA 1 -- ds50012Minor allele frequency- C:0.35NA EA 240
    rs759346961,2
    F--144509804(+) CTGGGG/TTACTG 1 -- ds50011Minor allele frequency- T:0.07WA 118
    rs104480871,2
    C--144509865(+) AAGGGC/TAGGCT 1 -- ds500111Minor allele frequency- T:0.03NA WA CSA EA 372
    rs1869456271,2
    --144510010(+) CCCTCA/GGCCTT 1 -- ds50010--------
    rs22809301,2
    C,F,H--144510023(-) GCCCTC/TGGCAA 1 -- ds500116Minor allele frequency- T:0.21NS EA NA 2214
    rs104480881,2
    C--144510059(+) GGTGCG/AGGCCG 1 -- ds500111Minor allele frequency- A:0.02NA WA CSA EA 373
    rs1396383241,2
    C--144510103(+) TCCTG-/CCGTCACC
    CAGGGCCCGT
    CCGTC
    1 -- cds10--------
    rs22809291,2
    C,F--144510132(-) TGGCCC/GTGGGT 1 -- ds500114Minor allele frequency- G:0.16EA NA WA CSA 2234
    rs1463834871,2
    --144510190(+) AACACA/GGCAAA 1 -- ds50010--------
    rs1916930971,2
    --144510231(+) GCGGTA/GACTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MAFA (144501352 - 144512602 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for MAFA (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668424CNV Deletion23128226
    dgv7920n71CNV Loss21882294
    nsv891682CNV Loss21882294
    dgv7924n71CNV Loss21882294
    dgv7927n71CNV Loss21882294
    nsv891687CNV Loss21882294
    dgv7929n71CNV Loss21882294
    dgv7928n71CNV Loss21882294
    dgv7925n71CNV Loss21882294
    nsv891675CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610303    OMIM disorders: --

    9 diseases for MAFA:    About MalaCards
    pancreatitis    fibrosarcoma    monogenic diabetes    insulinoma
    hyperglycemia    maturity-onset diabetes of the young    diabetes mellitus    neuronitis
    hepatitis


    MAFA for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MAFA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosarcoma 61.9 5 19785038 (1), 18778246 (1), 17131142 (1), 17149590 (1) (see all 5)
    insulinoma 45 1 14765989 (1)
    hyperglycemia 29.9 1 19393272 (1)

    Genetic Association Database (GAD): MAFA
    Human Genome Epidemiology (HuGE) Navigator: MAFA (3 documents)

    Export disorders for MAFA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAFA gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with MAFA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. (PubMed id 12368292)1, 2, 9 Kataoka K.... Handa H. (2002)
    2. Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1. (PubMed id 15993959)1, 2, 9 Aramata S.... Kataoka K. (2005)
    3. Mutations in MAFA and IAPP are not a common cause of monogenic diabetes. (PubMed id 19573128)1, 4, 9 Garin I....Perez de Nanclares G. (2009)
    4. GSK-3-mediated phosphorylation enhances Maf-transforming activity. (PubMed id 18042454)1, 2 Rocques N....Pouponnot C. (2007)
    5. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. (PubMed id 15665000)1, 2 Zhao L....Stein R. (2005)
    6. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. (PubMed id 12011435)1, 2 Olbrot M.... Sharma A. (2002)
    7. Phosphorylation of MafA is essential for its transcriptional and biological properties. (PubMed id 11416124)1, 2 Benkhelifa S....Felder-Schmittbuhl M.-P. (2001)
    8. Role of MafA in pancreatic beta-cells. (PubMed id 19393272)1, 9 Kaneto H....Matsuhisa M. (2009)
    9. FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. (PubMed id 16847327)1, 9 Raum J.C....Stein R. (2006)
    10. PDX-1 functions as a master factor in the pancreas. (PubMed id 18508668)1, 9 Kaneto H....Matsuhisa M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 389692 HGNC: 23145 AceView: MAFA Ensembl:ENSG00000182759 euGenes: HUgn389692
    ECgene: MAFA Kegg: 389692 H-InvDB: MAFA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAFA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAFA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAFA gene:
    Search GeneIP for patents involving MAFA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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