Aliases for MAF1 Gene
External Ids for MAF1 Gene
Previous GeneCards Identifiers for MAF1 Gene
This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAF1 Gene
MAF1 (MAF1 Homolog, Negative Regulator Of RNA Polymerase III) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include RNA polymerase III type 1 promoter DNA binding and RNA polymerase III type 3 promoter DNA binding.
UniProtKB/Swiss-Prot for MAF1 Gene
Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.