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Aliases for MAF1 Gene

Aliases for MAF1 Gene

  • MAF1 Homolog (S. Cerevisiae) 2 3

External Ids for MAF1 Gene

Previous GeneCards Identifiers for MAF1 Gene

  • GC00U990992
  • GC08M145276
  • GC08P144934
  • GC08P145265
  • GC08P145231
  • GC08P145160
  • GC08P140435
  • GC08P145161

Summaries for MAF1 Gene

Entrez Gene Summary for MAF1 Gene

  • This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAF1 Gene

MAF1 (MAF1 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase III type 1 promoter DNA binding and RNA polymerase III type 3 promoter DNA binding.

UniProtKB/Swiss-Prot for MAF1 Gene

  • Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.

Gene Wiki entry for MAF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAF1 Gene

Genomics for MAF1 Gene

Regulatory Elements for MAF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAF1 Gene

Start:
144,104,402 bp from pter
End:
144,107,612 bp from pter
Size:
3,211 bases
Orientation:
Plus strand

Genomic View for MAF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAF1 Gene

Proteins for MAF1 Gene

  • Protein details for MAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H063-MAF1_HUMAN
    Recommended name:
    Repressor of RNA polymerase III transcription MAF1 homolog
    Protein Accession:
    Q9H063
    Secondary Accessions:
    • D3DWL4

    Protein attributes for MAF1 Gene

    Size:
    256 amino acids
    Molecular mass:
    28771 Da
    Quaternary structure:
    • Interacts with BRF2.

    Three dimensional structures from OCA and Proteopedia for MAF1 Gene

neXtProt entry for MAF1 Gene

Proteomics data for MAF1 Gene at MOPED

Post-translational modifications for MAF1 Gene

  • Phosphorylated at Ser-60, Ser-68 and Ser-75; the major sites of phosphorylation. Nuclear accumulation correlates with a concomitant dephosphorylation. Phosphorylation may attenuate its RNA polymerase III-repressive function.
  • Sumoylated with SUMO1 and SUMO2, mainly on Lys-35. Desumoylated by SENP1. SUMOylation promotes the ability of MAF1 to repress transcription and suppress colony formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAF1 Gene

No data available for DME Specific Peptides for MAF1 Gene

Domains for MAF1 Gene

Protein Domains for MAF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H063

UniProtKB/Swiss-Prot:

MAF1_HUMAN :
  • Q9H063
Family:
  • Belongs to the MAF1 family.
genes like me logo Genes that share domains with MAF1: view

No data available for Gene Families for MAF1 Gene

Function for MAF1 Gene

Molecular function for MAF1 Gene

UniProtKB/Swiss-Prot Function: Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.

Gene Ontology (GO) - Molecular Function for MAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000994 RNA polymerase III core binding IBA --
GO:0001030 RNA polymerase III type 1 promoter DNA binding IDA 20233713
GO:0001031 RNA polymerase III type 2 promoter DNA binding IDA 20233713
GO:0001032 RNA polymerase III type 3 promoter DNA binding IDA 20233713
genes like me logo Genes that share ontologies with MAF1: view

Phenotypes for MAF1 Gene

MGI mutant phenotypes for MAF1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with MAF1: view

Animal Models for MAF1 Gene

MGI Knock Outs for MAF1:

Animal Model Products

CRISPR Products

miRNA for MAF1 Gene

miRTarBase miRNAs that target MAF1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MAF1 Gene

Localization for MAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAF1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAF1 Gene COMPARTMENTS Subcellular localization image for MAF1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MAF1: view

Pathways for MAF1 Gene

SuperPathways for MAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016480 negative regulation of transcription from RNA polymerase III promoter IDA 20233713
GO:0070217 transcription factor TFIIIB complex assembly IBA --
genes like me logo Genes that share ontologies with MAF1: view

No data available for Pathways by source for MAF1 Gene

Transcripts for MAF1 Gene

Unigene Clusters for MAF1 Gene

MAF1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAF1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5:

Relevant External Links for MAF1 Gene

GeneLoc Exon Structure for
MAF1
ECgene alternative splicing isoforms for
MAF1

Expression for MAF1 Gene

mRNA expression in normal human tissues for MAF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAF1 Gene

SOURCE GeneReport for Unigene cluster for MAF1 Gene Hs.19673

genes like me logo Genes that share expressions with MAF1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAF1 Gene

Orthologs for MAF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAF1 35
  • 99.22 (n)
  • 100 (a)
MAF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAF1 35
  • 90.94 (n)
  • 99.03 (a)
MAF1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAF1 35
  • 89.45 (n)
  • 93.36 (a)
mouse
(Mus musculus)
Mammalia Maf1 35
  • 87.24 (n)
  • 94.53 (a)
Maf1 16
Maf1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAF1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAF1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Maf1 35
  • 87.11 (n)
  • 95.31 (a)
chicken
(Gallus gallus)
Aves MAF1 35
  • 85.28 (n)
  • 93.2 (a)
MAF1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAF1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia maf1-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20177 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5208 35
zebrafish
(Danio rerio)
Actinopterygii maf1 35
  • 70.63 (n)
  • 72.95 (a)
MAF1 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008411 35
  • 64.24 (n)
  • 61.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Maf1 35
  • 55.23 (n)
  • 59.42 (a)
Maf1 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C43H8.2 35
  • 45.6 (n)
  • 35.85 (a)
mafr-1 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAF1 36
  • 17 (a)
OneToOne
MAF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13240 35
  • 48.31 (n)
  • 41.18 (a)
corn
(Zea mays)
Liliopsida Zm.17804 35
rice
(Oryza sativa)
Liliopsida Os04g0662900 35
  • 49.38 (n)
  • 43.92 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04597 35
  • 51.44 (n)
  • 38.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes maf1 35
  • 45.24 (n)
  • 39.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3101 36
  • 54 (a)
OneToOne
Species with no ortholog for MAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAF1 Gene

ENSEMBL:
Gene Tree for MAF1 (if available)
TreeFam:
Gene Tree for MAF1 (if available)

Paralogs for MAF1 Gene

Pseudogenes.org Pseudogenes for MAF1 Gene

genes like me logo Genes that share paralogs with MAF1: view

No data available for Paralogs for MAF1 Gene

Variants for MAF1 Gene

Sequence variations from dbSNP and Humsavar for MAF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
VAR_060408 -

Structural Variations from Database of Genomic Variants (DGV) for MAF1 Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
nsv891766 CNV Loss 21882294
dgv906n27 CNV Loss 19166990
nsv470249 CNV Loss 18288195
dgv7948n71 CNV Loss 21882294
dgv7949n71 CNV Loss 21882294
dgv7950n71 CNV Loss 21882294
nsv515809 CNV Gain+Loss 19592680
dgv7954n71 CNV Loss 21882294
nsv466014 CNV Loss 19166990
dgv7955n71 CNV Loss 21882294
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891809 CNV Loss 21882294
esv29971 CNV Loss 17803354
dgv2263e1 CNV Complex 17122850
dgv7956n71 CNV Loss 21882294
nsv891812 CNV Loss 21882294
nsv6448 CNV Insertion 18451855
nsv891814 CNV Loss 21882294
nsv824802 CNV Gain 20364138

Relevant External Links for MAF1 Gene

HapMap Linkage Disequilibrium report
MAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAF1 Gene

Disorders for MAF1 Gene

No disorders were found for MAF1 Gene.

No data available for UniProtKB/Swiss-Prot for MAF1 Gene

Publications for MAF1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae. (PMID: 11438659) Pluta K. … Boguta M. (Mol. Cell. Biol. 2001) 2 3
  3. Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases. (PMID: 17499043) Johnson S.S. … Johnson D.L. (Mol. Cell 2007) 3 23
  4. Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. (PMID: 20233713) Shor B. … Yu K. (J. Biol. Chem. 2010) 3 4
  5. mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. (PMID: 20543138) Kantidakis T. … White R.J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4

Products for MAF1 Gene

Sources for MAF1 Gene

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