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Aliases & Descriptions for MAEL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ14904 1, 2 | | OTTHUMP00000032343 2 | | RP11-102C16.1 2 |
| | | Descriptions |
|---|
| maelstrom homolog 2 | | maelstrom homolog (Drosophila) 2 |
|
| | Search outside databases for aliases for MAEL genePrevious GC identifer: GC01P163691 |
Summaries for MAEL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: MAEL_HUMAN, Q96JY0Function: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity) |
Genomic Location for MAEL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the MAEL gene 
Entrez Gene cytogenetic band: 1q24.1 Ensembl cytogenetic band: 1q24.1 HGNC cytogenetic band: 1q24.1MAEL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P165224:
(about GC identifiers)
Start:
|
165,224,975 bp from pter |
End:
|
165,258,071 bp from pter |
Size:
|
33,097 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for MAEL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MAEL_HUMAN, Q96JY0 (See
protein sequence)Recommended Name: Protein maelstrom homolog Size: 434 amino acids; 49219 Da
Subunit: Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA-associated proteins TDRD1, PIWIL1 and PIWIL2 (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis (By similarity)
Sequence caution: Sequence=CAH69955.1; Type=Erroneous gene model prediction;
PDB structures from and Proteopedia :2CTO (3D)
 
Secondary accessions: B4DY43 Q49AP9 Q5VZP8 Q9UIW6Alternative splicing: 3 isoforms: Q96JY0-1 Q96JY0-2 Q96JY0-3 REFSEQ proteins: NP_116247.1
ENSEMBL proteins: ENSP00000356846 ENSP00000356844
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: MAEL 
Antibodies for MAEL: Assays for MAEL: | Protein
Domains/ Families for MAEL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96JY0
ProtoNet protein and cluster: Q96JY0 UniProtKB/Swiss-Prot: MAEL_HUMAN, Q96JY0Similarity: Belongs to the maelstrom familySimilarity: Contains 1 HMG box DNA-binding domain | Gene Function for MAEL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032858
Applied Biosystems Silencer® siRNAs for MAEL
Sigma-Aldrich siRNA for MAEL  Sigma-Aldrich shRNA for MAEL  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032858                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032858                                  untagged cDNA clones in CMV expression vector (see all 2): NM_032858 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_032858
UniProtKB/Swiss-Prot: MAEL_HUMAN, Q96JY0Function: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity)3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mael):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | About this table | Pathways & Interactions for MAEL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for MAEL (ENSP000003568463) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for MAEL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for MAEL
|
Transcripts for MAEL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032858
Sigma-Aldrich siRNA for MAEL  Sigma-Aldrich shRNA for MAEL  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_032858 REFSEQ mRNAs for MAEL gene: NM_032858.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_032858               OriGene GFP tagged cDNA clone in CMV expression vector: NM_032858                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032858                                  untagged cDNA clones in CMV expression vector (see all 2): NM_032858  Additional cDNA sequence: AK027810.1 AK131066.1 AK302253.1 AL133073.1 BC028595.2 BC034310.1 CR597287.1 CR614428.1 CR624981.1 DQ076156.2 7 DOTS entries: DT.413784 DT.91818096 DT.97837568 DT.100790988 DT.121440223 DT.99946801 DT.100020079 24/147 AceView cDNA sequences (see all 147
):BP369150 BP370827 AK027810 AI769054 BP369432 BP369922 BI829160 AL133073 AA446073 BP369554 BP371250 BI825432 CR624981 AW134538 AA398518 BP371654 AA470046 AI365191 BP369667 AA412123 NM_032858 BP370327 AA446177 BC028595
highest scoring ESTs for MAEL:AI026927 AA229169 AA229204 AA383613 AA393102 AA398518 AA412123 AA416548 AA416959 AA421199 Unigene Cluster for MAEL: Maelstrom homolog (Drosophila) Hs.651245 [show with all ESTs]Unigene Representative Sequence: BC034310
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MAEL (see all 9
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for MAEL
2 Ensembl transcripts including schematic representations: ENST00000367872
ENST00000367870
|
Expression for MAEL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MAEL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MAEL
1 / 2 / 3 3 probe-sets matching MAEL gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGAAAATGA
SOURCE GeneReport for Unigene cluster: Hs.651245 UniProtKB/Swiss-Prot: MAEL_HUMAN, Q96JY0Tissue specificity: Testis specific |
Orthologs for MAEL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MAEL gene from 5/6 species (see all 6
)
About this table Species with no ortholog for MAEL
ENSEMBL Gene Tree for MAEL | Paralogs for MAEL(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for MAEL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for MAEL (up to first 250kb)
|
Disorders & Mutations for MAEL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611368
Human Genome Epidemiology Navigator: MAEL (1 document)
|
Medical News for MAEL(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for MAEL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for MAEL gene: |
Search for MAEL
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MAEL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MAEL
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAEL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for MAEL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for MAEL:

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| | Recombinant Proteins (Mael) | | Antibodies (Mael) |
| | | Search Tocris compounds for MAEL |
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Incremental update: 13 Oct 2009
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