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MAEL Gene

protein-coding   GIFtS: 49
GCID: GC01P166958

Maelstrom Spermatogenic Transposon Silencer

(Previous name: maelstrom homolog (Drosophila))
  Search for MAEL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Maelstrom Spermatogenic Transposon Silencer1 2     CT1282
Cancer/Testis Antigen 1281 2     SPATA352
Spermatogenesis Associated 351 2     Maelstrom Homolog2
Maelstrom Homolog (Drosophila)1     Protein Maelstrom Homolog2

External Ids:    HGNC: 259291   Entrez Gene: 849442   Ensembl: ENSG000001431947   OMIM: 6113685   UniProtKB: Q96JY03   
ORGUL members:         

Export aliases for MAEL gene to outside databases

Previous GC identifers: GC01P163691 GC01P165224 GC01P138205


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAEL Gene:
MAEL (maelstrom spermatogenic transposon silencer) is a protein-coding gene.

UniProtKB/Swiss-Prot: MAEL_HUMAN, Q96JY0
Function: Plays a central role during spermatogenesis by repressing transposable elements and preventing their
mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates
the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins
and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a
participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to
the meiotic nuage (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAEL gene promoter:
         Pbx1a   FAC1   E2F   E2F-1   CBF-A   CBF-B   CP1A   RSRFC4   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAEL promoter sequence
   Search Chromatin IP Primers for MAEL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAEL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.1   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q24.1

MAEL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAEL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P166958:  view genomic region     (about GC identifiers)

Start:
166,958,346 bp from pter      End:
166,991,451 bp from pter
Size:
33,106 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAEL_HUMAN, Q96JY0 (See protein sequence)
Recommended Name: Protein maelstrom homolog  
Size: 434 amino acids; 49219 Da
Subunit: Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA-associated proteins TDRD1, PIWIL1 and PIWIL2
(By similarity)
Sequence caution: Sequence=CAH69955.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for MAEL:
2CTO (3D)    
Secondary accessions: B4DY43 Q49AP9 Q5VZP8 Q9UIW6
Alternative splicing: 3 isoforms:  Q96JY0-1   Q96JY0-2   Q96JY0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAEL: NX_Q96JY0

Explore proteomics data for MAEL at MOPED


See MAEL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001273306.1  NP_001273307.1  NP_116247.1  

ENSEMBL proteins: 
 ENSP00000356846   ENSP00000402143   ENSP00000356844  

MAEL Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR009071 HMG_box_dom
 IPR024970 Maelstrom

Graphical View of Domain Structure for InterPro Entry Q96JY0

ProtoNet protein and cluster: Q96JY0

UniProtKB/Swiss-Prot: MAEL_HUMAN, Q96JY0
Similarity: Belongs to the maelstrom family
Similarity: Contains 1 HMG box DNA-binding domain


Find genes that share domains with MAEL           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MAEL_HUMAN, Q96JY0
Function: Plays a central role during spermatogenesis by repressing transposable elements and preventing their
mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates
the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins
and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a
participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to
the meiotic nuage (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0005515protein binding ----
     
Find genes that share ontologies with MAEL           About GenesLikeMe


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mael):
 cellular  endocrine/exocrine gland  reproductive system 

Find genes that share phenotypes with MAEL           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAEL
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAEL

miRNA
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1 qRT-PCR Assays for microRNA that regulate MAEL:
hsa-miR-624*
SwitchGear 3'UTR luciferase reporter plasmidMAEL 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat MAEL

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MAEL_HUMAN, Q96JY0: Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a
germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to
piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol1
endoplasmic reticulum1
mitochondrion1
peroxisome1
plasma membrane1

Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000785chromatin IEA--
GO:0001741XY body IEA--
GO:0005634nucleus ISS--
GO:0005737cytoplasm ISS--
GO:0030849autosome IEA--

Find genes that share ontologies with MAEL           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAEL
Interactions:

    Search GeneGlobe Interaction Network for MAEL

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

Selected Interacting proteins for MAEL (Q96JY03 ENSP000003568464) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
SMARCB1Q128243, ENSP000002631214I2D: score=1 STRING: ENSP00000263121
DDX4Q9NQI03, ENSP000003470874I2D: score=1 STRING: ENSP00000347087
TDRD1Q9BXT43, ENSP000002518644I2D: score=1 STRING: ENSP00000251864
PIWIL1Q96J943, ENSP000002452554I2D: score=1 STRING: ENSP00000245255
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Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0000902cell morphogenesis IEA--
GO:0006974cellular response to DNA damage stimulus ----
GO:0007129synapsis IEA--
GO:0007140male meiosis IEA--

Find genes that share ontologies with MAEL           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MAEL



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MAEL gene (3 alternative transcripts): 
NM_001286377.1  NM_001286378.1  NM_032858.2  

Unigene Cluster for MAEL:

Maelstrom spermatogenic transposon silencer
Hs.651245  [show with all ESTs]
Unigene Representative Sequence: BC034310
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000367872(uc021peh.1 uc001gdy.1 uc001gdz.1) ENST00000447624
ENST00000491055(uc009wvf.1) ENST00000487826 ENST00000367870
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MAEL using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate MAEL:
hsa-miR-624*
SwitchGear 3'UTR luciferase reporter plasmidMAEL 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MAEL
Predesigned siRNA for gene silencing in human, mouse, rat MAEL
Clone
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GenScript: all cDNA clones in your preferred vector: MAEL (NM_032858)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAEL
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAEL
Primer
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OriGene qPCR primer pairs and template standards for MAEL
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAEL
  QuantiTect SYBR Green Assays in human, mouse, rat MAEL
  QuantiFast Probe-based Assays in human, mouse, rat MAEL

Additional mRNA sequence: 

AK027810.1 AK131066.1 AK302253.1 AL133073.1 BC028595.2 BC034310.1 DQ076156.2 GU383113.1 
GU383114.1 

7 DOTS entries:

DT.413784  DT.91818096  DT.97837568  DT.100790988  DT.99946801  DT.100020079  DT.121440223 

Selected AceView cDNA sequences (see all 147):

AA393260 AI365191 CR624981 AA446177 AA421199 BI825432 BP371654 BP369922 
AW134538 AA416959 AI769054 BP369554 CR597287 AK027810 CB143823 AA446073 
AA398518 BP370327 AI138893 NM_032858 BP370751 BP369432 AA412123 BP371720 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAEL (see all 9)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1:                                                                                                        -                                             
SP2:                                                                                                        -     -                                       
SP3:                                                                                                        -     -                                       
SP4:                                                                                                        -     -                                       
SP5:                                                                                                        -     -                                       


ECgene alternative splicing isoforms for MAEL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MAEL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGAAAATGA
MAEL Expression
About this image


MAEL expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Gonad
         XY Germ Cells Testis Cord
 
 Testis (Reproductive System)
         XY Germ Cells Testis Cord
 
 Ovary (Reproductive System)
         XX Germ Cells Ovigerous Cord
MAEL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MAEL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.651245

UniProtKB/Swiss-Prot: MAEL_HUMAN, Q96JY0
Tissue specificity: Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its
promoter

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MAEL gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mael1 , 5 maelstrom homolog (Drosophila)1, 5 89.63(n)1
89.86(a)1
  1 (73.56 cM)5
985581  NM_175296.41  NP_780505.11 
 1662013855 
chicken
(Gallus gallus)
Aves MAEL1 maelstrom homolog (Drosophila) 62.04(n)
54.19(a)
  418446  XM_416657.4  XP_416657.2 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
54(a)
47(a)
many → 1
many → 1
1(186884952-186885767)
3(163364802-163389284)
tropical clawed frog
(Xenopus tropicalis)
Amphibia mael1 maelstrom spermatogenic transposon silencer 58.75(n)
50.66(a)
  780102  NM_001079177.1  NP_001072645.1 
fruit fly
(Drosophila melanogaster)
Insecta mael1 maelstrom 37.73(n)
20.13(a)
  40489  NM_079493.4  NP_524217.1 


ENSEMBL Gene Tree for MAEL (if available)
TreeFam Gene Tree for MAEL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MAEL (see all 687)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs64270491,2
C,F,A,H--166956593(+) aatagC/Ttcatt 1 -- us2k18Minor allele frequency- T:0.31NA WA CSA EA 368
rs66698861,2
C,F,H--166956710(+) gctacT/Cctcaa 1 -- us2k110Minor allele frequency- C:0.20NS EA NA CSA WA 738
rs66569991,2
C,F,A--166956807(+) gtcaaC/Gcagtt 1 -- us2k19Minor allele frequency- G:0.37NA WA CSA EA 370
rs1441503261,2
--166956851(+) TTCAGA/TTCCTT 1 -- us2k10--------
rs1840466631,2
--166956931(+) ACAAAA/CATTAG 1 -- us2k10--------
rs1387799811,2
--166957141(+) AAATAC/TCACAA 1 -- us2k10--------
rs109186061,2
C,F,A,H--166957249(+) TACTAA/GGAATG 1 -- us2k111Minor allele frequency- G:0.30NA WA CSA EA 484
rs121214801,2
H--166957258(+) tggtaG/Cgctgc 1 -- us2k14Minor allele frequency- C:0.00NS EA 416
rs1418293131,2
C--166957267(+) GCATCA/GTTAGA 1 -- us2k10--------
rs115787071,2
C,H--166957305(+) aattaG/Agccag 1 -- us2k15Minor allele frequency- A:0.00NS EA NA 404

HapMap Linkage Disequilibrium report for MAEL (166958346 - 166991451 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MAEL:    About this table    
Variant IDTypeSubtypePubMed ID
esv2750815CNV Gain17911159

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MAEL
DNA2.0 Custom Variant and Variant Library Synthesis for MAEL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611368    OMIM disorders: --


Find genes that share disorders with MAEL           About GenesLikeMe

Genetic Association Database (GAD): MAEL
Human Genome Epidemiology (HuGE) Navigator: MAEL (3 documents)

Export disorders for MAEL gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MAEL gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with MAEL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel human cancer/testis gene MAEL that is regulated by DNA methylation. (PubMed id 19693694)1, 2, 3 Xiao L....Zhang J. (Mol. Biol. Rep. 2010)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  3. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
  5. Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. (PubMed id 18694567)1, 3 Soper S.F....Bortvin A. (Dev. Cell 2008)
  6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
  10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84944 HGNC: 25929 AceView: FLJ14904 Ensembl:ENSG00000143194 euGenes: HUgn84944
ECgene: MAEL H-InvDB: MAEL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MAEL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MAEL gene:
Search GeneIP for patents involving MAEL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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