Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAEA Gene

protein-coding   GIFtS: 54
GCID: GC04P001273

Macrophage Erythroblast Attacher

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Macrophage Erythroblast Attacher1 2     GID Complex Subunit 91
EMP2 3 5     EMLP2
Cell Proliferation-Inducing Gene 5 Protein2 3     GID92
Erythroblast Macrophage Protein2 3     PIG52
Human Lung Cancer Oncogene 10 Protein2 3     GID Complex Subunit 9, FYV10 Homolog2
HLC-102 3     Lung Cancer-Related Protein 102
FYV10 Homolog (S. Cerevisiae)1     Proliferation-Inducing Gene 52

External Ids:    HGNC: 137311   Entrez Gene: 102962   Ensembl: ENSG000000903167   OMIM: 6068015   UniProtKB: Q7L5Y93   

Export aliases for MAEA gene to outside databases

Previous GC identifer: GC04P001289


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAEA Gene:
This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal
maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral
membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the
cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of
33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple
alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the
biological validity of some variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAEA Gene: 
MAEA (macrophage erythroblast attacher) is a protein-coding gene. Diseases associated with MAEA include extramedullary plasmacytoma, and lung cancer. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the
attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of
mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic
island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate
actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division
events




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_037622.5  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAEA gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAEA promoter sequence
   Search SABiosciences Chromatin IP Primers for MAEA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAEA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

MAEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAEA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P001273:  view genomic region     (about GC identifiers)

Start:
1,283,639 bp from pter      End:
1,333,935 bp from pter
Size:
50,297 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9 (See protein sequence)
Recommended Name: Macrophage erythroblast attacher  
Size: 396 amino acids; 45287 Da
Subunit: Forms a complex with F-actin
Subcellular location: Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear
speckled-like pattern
Developmental stage: Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at
metaphase and in the contractile ring during telophase and cytokinesis
Sequence caution: Sequence=AAC67543.1; Type=Erroneous termination; Positions=397; Note=Translated as stop;
Sequence=AAC67543.1; Type=Frameshift; Positions=253, 327; Sequence=AAC67543.1; Type=Miscellaneous discrepancy;
Note=Sequence differs at N-terminus; Sequence=AAO85220.1; Type=Erroneous initiation; Sequence=AK128302;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: O95285 Q5JB54 Q6ZRD6 Q9BQ11 Q9H9V6 Q9H9Z4 Q9NW84
Alternative splicing: 5 isoforms:  Q7L5Y9-1   Q7L5Y9-2   Q7L5Y9-3   Q7L5Y9-4   Q7L5Y9-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MAEA: NX_Q7L5Y9

Explore proteomics data for MAEA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L5Y9

  • MAEA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAEA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001017405.1  NP_005873.2  

    ENSEMBL proteins: 
     ENSP00000302830   ENSP00000422215   ENSP00000423056   ENSP00000422235   ENSP00000421644  
     ENSP00000264750   ENSP00000426326   ENSP00000426903   ENSP00000427512   ENSP00000426966  
     ENSP00000426807   ENSP00000427460   ENSP00000424436   ENSP00000411415  

    Human Recombinant Protein Products for MAEA: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MAEA
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MAEA
    GenScript Custom Purified and Recombinant Proteins Services for MAEA
    Novus Biologicals MAEA Proteins
    Novus Biologicals MAEA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAEA 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005819spindle IDA16510120
    GO:0005826actomyosin contractile ring IDA16510120
    GO:0005856cytoskeleton IDA16510120
    GO:0005887integral to plasma membrane IDA9763581

    MAEA for ontologies           About GeneDecksing



    MAEA Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MAEA (EMP/MAEA)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MAEA
    GenScript Custom Superior Antibodies Services for MAEA
    Novus Biologicals MAEA Antibodies
    Abcam antibodies for MAEA
    Cloud-Clone Corp. Antibodies for MAEA 
    ThermoFisher Antibodies for MAEA
    LSBio Antibodies in human, mouse, rat for MAEA 

    Assay Products for MAEA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAEA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAEA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAEA 
    Cloud-Clone Corp. CLIAs for MAEA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR027370 zf-RING_LisH
     IPR006594 LisH_dimerisation
     IPR013144 CRA_dom
     IPR024964 CTLH/CRA
     IPR006595 CTLH_C

    Graphical View of Domain Structure for InterPro Entry Q7L5Y9

    ProtoNet protein and cluster: Q7L5Y9

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB006595 CTLH


    UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain


    MAEA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAEA_HUMAN, Q7L5Y9
    Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the
    attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of
    mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic
    island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate
    actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division
    events

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA16510120
    GO:0005515protein binding ----
         
    MAEA for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Maea):
     growth/size  hematopoietic system  immune system  integument  mortality/aging 

    MAEA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAEA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAEA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAEA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAEA 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAEA
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MAEA (see all 23):
    hsa-miR-498 hsa-miR-1178 hsa-miR-539 hsa-miR-181c hsa-miR-520d-5p hsa-miR-548k hsa-miR-496 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidMAEA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAEA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAEA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAEA
    Sirion Biotech Customized adenovirus for overexpression of MAEA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAEA (see all 14)
    OriGene ORF clones in mouse, rat for MAEA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAEA (NM_005882)
    Sino Biological Human cDNA Clone for MAEA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAEA
    Sirion Biotech Customized lentivirus for stable overexpression of MAEA 
                         Customized lentivirus expression plasmids for stable overexpression of MAEA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAEA
    Search LifeMap BioReagents cell lines for MAEA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAEA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAEA

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/44 Interacting proteins for MAEA (Q7L5Y93 ENSP000003028304) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RMND5AQ9H8713, ENSP000002836324I2D: score=5 STRING: ENSP00000283632
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    ALG5Q9Y6733I2D: score=5 
    GID8Q9NWU23I2D: score=5 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IEA--
    GO:0007049cell cycle IEA--
    GO:0007155cell adhesion IDA9763581
    GO:0007346regulation of mitotic cell cycle NAS16510120
    GO:0033033negative regulation of myeloid cell apoptotic process IDA9763581

    MAEA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAEA

    Search CenterWatch for drugs/clinical trials and news about MAEA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAEA gene (2 alternative transcripts): 
    NM_001017405.1  NM_005882.3  

    Unigene Cluster for MAEA:

    Macrophage erythroblast attacher
    Hs.139896  [show with all ESTs]
    Unigene Representative Sequence: AB208907
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000303400(uc003gda.3 uc003gdb.3 uc011bvb.2 uc003gdc.3 uc003gdd.3 uc011bvc.2 uc011bvd.2 uc010ibt.3)
    ENST00000505177 ENST00000513301 ENST00000512308 ENST00000503653 ENST00000264750
    ENST00000509254 ENST00000502558 ENST00000514708 ENST00000508634 ENST00000503693(uc010ibs.1)
    ENST00000509531 ENST00000510862 ENST00000510794 ENST00000512842 ENST00000505839
    ENST00000512289 ENST00000506530
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAEA
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MAEA (see all 23):
    hsa-miR-498 hsa-miR-1178 hsa-miR-539 hsa-miR-181c hsa-miR-520d-5p hsa-miR-548k hsa-miR-496 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidMAEA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAEA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAEA
    Clone
    Products:
         
    OriGene clones in human, mouse for MAEA (see all 14)
    OriGene ORF clones in mouse, rat for MAEA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAEA (NM_005882)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAEA
    Sirion Biotech Customized lentivirus for stable overexpression of MAEA 
                         Customized lentivirus expression plasmids for stable overexpression of MAEA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAEA
    OriGene qSTAR qPCR primer pairs in human, mouse for MAEA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAEA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAEA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAEA

    Additional mRNA sequence: 

    AB208907.1 AF084928.1 AK001088.1 AK022515.1 AK022586.1 AK091951.1 AK094253.1 AK127875.1 
    AK296174.1 AK298944.1 AK300572.1 AK301155.1 AK308901.1 AY189687.1 AY236486.1 BC001225.1 
    BC006470.1 BT006957.1 

    24/34 DOTS entries (see all 34):

    DT.102828944  DT.100803262  DT.95363778  DT.102828943  DT.100823297  DT.91944969  DT.101981808  DT.99994246 
    DT.445825  DT.121266255  DT.91758643  DT.100823303  DT.121266257  DT.121266296  DT.100823305  DT.91982110 
    DT.100823310  DT.121266305  DT.100823300  DT.121266128  DT.121266139  DT.100823295  DT.100823296  DT.121266151 

    24/468 AceView cDNA sequences (see all 468):

    CB147498 AA890207 BQ652414 AA314645 BE263550 CB126311 BM765152 AI285206 
    BQ232210 BU859620 BM741737 BQ945575 BE550620 AA291394 BE256789 AK091951 
    CB129034 BU156696 AU124409 BQ942851 BI488420 AA782788 AA626253 CR606463 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAEA (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:        -                       -     -     -                                                   
    SP2:                                                                                                
    SP3:        -           -     -     -     -                                                         
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MAEA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAEA expression in normal human tissues (normalized intensities)      MAEA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAATAAAAT
    MAEA Expression
    About this image


    MAEA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Erythroblasts Hematopoietic Bone Marrow
             leukocytes   

    See MAEA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAEA

    SOURCE GeneReport for Unigene cluster: Hs.139896

    UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for MAEA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAEA
    OriGene qSTAR qPCR primer pairs in human, mouse for MAEA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAEA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAEA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAEA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAEA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAEA gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Maea1 , 5 macrophage erythroblast attacher1, 5 89.39(n)1
    98.74(a)1
      5 (17.55 cM)5
    590031  NM_021500.21  NP_067475.21 
     333355725 
    chicken
    (Gallus gallus)
    Aves MAEA1 macrophage erythroblast attacher 80.39(n)
    96.72(a)
      426024  NM_001012604.1  NP_001012622.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAEA6
    macrophage erythroblast attacher
    96(a)
    1 ↔ 1
    GL343447.1(356341-390495)
    African clawed frog
    (Xenopus laevis)
    Amphibia maea-prov2 macrophage erythroblast attacher 81.16(n)    BC053803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb20a092 wufb20a09 77.67(n)   321575  BC055388.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG313571 CG31357 58.71(n)
    48.82(a)
      326135  NM_170171.1  NP_733044.1 
    worm
    (Caenorhabditis elegans)
    Secernentea maea-16
    Protein MAEA-1
    25(a)
    1 ↔ 1
    I(13806917-13812268)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FYV10(YIL097W)4 Protein of unknown function, required for survival more   --   9(180427-181977) 854710  NP_012169.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G550701 LisH/CRA/RING-U-box domain-containing protein 48.28(n)
    38.46(a)
      824673  NM_115365.1  NP_191067.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01601001 hypothetical protein 50.81(n)
    37.1(a)
      4337882  NM_001061254.1  NP_001054719.1 


    ENSEMBL Gene Tree for MAEA (if available)
    TreeFam Gene Tree for MAEA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1550 SNPs in MAEA are shown (see all 1550)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs16800721,2
    C,F,A--1281695(-) GTTTCC/ATATCT 2 -- us2k111Minor allele frequency- A:0.47NA WA CSA EA 372
    rs17321001,2
    C,F,A,H--1281761(-) CCAACA/GTTCTT 2 -- us2k115Minor allele frequency- G:0.47NS EA NA WA CSA 790
    rs1458491781,2
    --1281883(+) TGGAAG/TCCCCG 2 -- us2k10--------
    rs112479831,2
    C,F,A,H--1281951(+) GATGCC/GTACAT 2 -- us2k1 tfbs310Minor allele frequency- G:0.25NS EA NA 670
    rs760842451,2
    F--1282131(+) AATACA/CGTTTT 2 -- us2k10--------
    rs737952821,2
    C,F--1282212(+) TGCAAA/TCCTCT 2 -- us2k12Minor allele frequency- T:0.02WA 120
    rs1429392571,2
    C--1282238(+) AGTATG/TTCTGA 2 -- us2k10--------
    rs737952831,2
    C,F--1282259(+) TACTAG/CGATAG 2 -- us2k11Minor allele frequency- C:0.50WA 2
    rs798453291,2
    F--1282383(+) GCTCCC/TGTGTA 2 -- us2k10--------
    rs1424744561,2
    --1282440(+) AAGGAC/TGCAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAEA (1283639 - 1333935 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/36 variations for MAEA (see all 36):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726779CNV Deletion23290073
    esv2726781CNV Deletion23290073
    esv2726786CNV Deletion23290073
    esv1108812CNV Deletion17803354
    esv2726785CNV Deletion23290073
    esv2726787CNV Deletion23290073
    esv1006767CNV Deletion20482838
    esv1011456CNV Deletion17803354
    esv2726782CNV Deletion23290073
    esv2726778CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAEA
    DNA2.0 Custom Variant and Variant Library Synthesis for MAEA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606801    OMIM disorders: --

    6 diseases for MAEA:    About MalaCards
    extramedullary plasmacytoma    lung cancer    plasmacytoma    lissencephaly
    myeloma    multiple myeloma

    3 diseases from the University of Copenhagen DISEASES database for MAEA:
    Plasmacytoma     Multiple myeloma     Prostate cancer

    MAEA for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAEA

    Export disorders for MAEA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAEA gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with MAEA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. (PubMed id 9763581)1, 2, 3, 9 Hanspal M.... Uong Q. (1998)
    2. Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1, 4 Cho Y.S....Seielstad M. (2012)
    3. Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division. (PubMed id 16510120)1, 2 Bala S.... Hanspal M. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    6. Evaluation of erythroblast macrophage protein related to erythroblastic islands in patients with hematopoietic stem cell transplantati on. (PubMed id 23566571)1 Mao X....Hu L. (2013)
    7. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10296 HGNC: 13731 AceView: MAEA Ensembl:ENSG00000090316 euGenes: HUgn10296
    ECgene: MAEA H-InvDB: MAEA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAEA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAEA gene:
    Search GeneIP for patents involving MAEA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for MAEA (EMP/MAEA)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MAEA  
     OriGene qPCR primer pairs and template standards for MAEA   OriGene Protein Over-expression Lysate for MAEA  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MAEA  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAEA   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MAEA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAEA   OriGene Custom Protein Services for MAEA  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAEA
     QIAGEN SeqTarget long-range PCR primers for resequencing MAEA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAEA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAEA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAEA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAEA
     GenScript Custom Purified and Recombinant Proteins Services for MAEA GenScript cDNA clones with any tag delivered in your preferred vector for MAEA
     GenScript Custom Assay Services for MAEA GenScript Custom Superior Antibodies Services for MAEA
     GenScript Custom overexpressing Cell Line Services for MAEA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MAEA promoter
     Search Chromatin IP Primers for MAEA
     RT2 qPCR Primer Assay in human, mouse, rat MAEA
     Search GNC Networks for MAEA
     SABiosciences Custom PCR Arrays for MAEA
     Search Tocris compounds for MAEA
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for MAEA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MAEA antibodies
     MAEA proteins
     MAEA lysates
     Antibodies for MAEA
     See all of Abcam's Antibodies, Kits and Proteins for MAEA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MAEA
     Antibodies for MAEA
     ELISAs for MAEA
     CLIAs for MAEA
     Search LifeMap BioReagents cell lines for MAEA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAEA
     SwitchGear 3'UTR luciferase reporter plasmids for MAEA
     SwitchGear Promoter luciferase reporter plasmids for MAEA
     ThermoFisher Antibodies for MAEA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAEA
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MAEA
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAEA
    Customized:
     lentivirus for stable overexpression of MAEA
     lentivirus expression plasmids for stable overexpression of MAEA
     adenovirus for overexpression of MAEA
     LSBio Antibodies in human, mouse, rat for MAEA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAEA gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4