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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAEA Gene

protein-coding   GIFtS: 50
GCID: GC04P001273

macrophage erythroblast attacher
 Explore 7 diseases affiliated with
MAEA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAEA    

Aliases
for MAEA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Macrophage Erythroblast Attacher1 2     HLC-102 3
EMP1 2 3 5     EMLP2
GID91 2     PIG52
Cell Proliferation-Inducing Gene 5 Protein2 3     GID Complex Subunit 9, FYV10 Homolog2
Erythroblast Macrophage Protein2 3     Lung Cancer-Related Protein 102
Human Lung Cancer Oncogene 10 Protein2 3     Proliferation-Inducing Gene 52

External Ids:    HGNC: 137311   Entrez Gene: 102962   Ensembl: ENSG000000903167   OMIM: 6068015   UniProtKB: Q7L5Y93   

Export aliases for MAEA gene to outside databases

Previous GC identifer: GC04P001289


Summaries
for MAEA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAEA:
This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation
and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein
with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two
immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD
were detected in macrophage membranes; this gene encodes the larger isoform. Multiple alternatively spliced transcript
variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has
not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the
attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature
macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island
formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin
distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events




Genomic Views
for MAEA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_037622.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAEA gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAEA promoter sequence
   Search SABiosciences Chromatin IP Primers for MAEA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAEA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

MAEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAEA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P001273:  view genomic region     (about GC identifiers)

Start:
 1,283,639 bp from pter      End:
 1,333,935 bp from pter
Size:
 50,297 bases      Orientation:
 plus strand

Proteins
for MAEA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9 (See protein sequence)
Recommended Name: Macrophage erythroblast attacher  
Size: 396 amino acids; 45287 Da
Subunit: Forms a complex with F-actin
Subcellular location: Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like
pattern
Developmental stage: Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and
in the contractile ring during telophase and cytokinesis
Sequence caution: Sequence=AAC67543.1; Type=Erroneous termination; Positions=397; Note=Translated as stop;
Sequence=AAC67543.1; Type=Frameshift; Positions=253, 327; Sequence=AAC67543.1; Type=Miscellaneous discrepancy;
Note=Sequence differs at N-terminus; Sequence=AAO85220.1; Type=Erroneous initiation; Sequence=AK128302;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: O95285 Q5JB54 Q6ZRD6 Q9BQ11 Q9H9V6 Q9H9Z4 Q9NW84
Alternative splicing: 5 isoforms:  Q7L5Y9-1   Q7L5Y9-2   Q7L5Y9-3   Q7L5Y9-4   Q7L5Y9-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MAEA: NX_Q7L5Y9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7L5Y9

    • MAEA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017405.1  NP_005873.2  

    ENSEMBL proteins: 
     ENSP00000302830   ENSP00000422215   ENSP00000423056   ENSP00000422235   ENSP00000421644  
     ENSP00000264750   ENSP00000426326   ENSP00000426903   ENSP00000427512   ENSP00000426966  
     ENSP00000426807   ENSP00000427460   ENSP00000424436   ENSP00000411415  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): MAEA
    OriGene Custom Protein Services for MAEA 
    GenScript Custom Purified and Recombinant Proteins Services for MAEA
    Novus Biologicals MAEA Proteins
    Novus Biologicals MAEA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAEA

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005819spindle IDA16510120
    GO:0005826actomyosin contractile ring IDA16510120
    GO:0005856cytoskeleton IDA16510120
    GO:0005887integral to plasma membrane IDA9763581


    MAEA for ontologies           About GeneDecksing



    MAEA Antibody Products: 
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    Protein Domains /
    Families
    for MAEA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAEA for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006594 LisH_dimerisation
     IPR013144 CRA_dom
     IPR024964 CTLH/CRA
     IPR006595 CTLH_C

    Graphical View of Domain Structure for InterPro Entry Q7L5Y9

    ProtoNet protein and cluster: Q7L5Y9

    2 Blocks protein families:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB006595 CTLH


    UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain


    Function
    for MAEA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
    Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the
    attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature
    macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island
    formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin
    distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAEA
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    hsa-miR-498 hsa-miR-1178 hsa-miR-539 hsa-miR-181c hsa-miR-520d-5p hsa-miR-548k hsa-miR-496 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmid: MAEA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAEA (see all 7)
    OriGene shRNA RFP: MAEA
    OriGene siRNA: MAEA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAEA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAEA

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAEA (see all 5)
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAEA 

    Cell Line
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    Search LifeMap BioReagents cell lines for MAEA

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA16510120


    MAEA for ontologies           About GeneDecksing


    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Maea):
     growth/size  hematopoietic system  immune system  integument  mortality/aging 

    MAEA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAEA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAEA

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/44 Interacting proteins for MAEA (Q7L5Y93 ENSP000003028304) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RMND5AQ9H8713, ENSP000002836324I2D: score=5 STRING: ENSP00000283632
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    ALG5Q9Y6733I2D: score=5 
    GID8Q9NWU23I2D: score=5 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IEA--
    GO:0007049cell cycle IEA--
    GO:0007155cell adhesion IDA9763581
    GO:0007346regulation of mitotic cell cycle NAS16510120
    GO:0033033negative regulation of myeloid cell apoptotic process IDA9763581


    MAEA for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAEA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAEA
    Search CenterWatch for drugs/clinical trials and news about MAEA 

    Transcripts
    for MAEA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAEA gene (2 alternative transcripts): 
    NM_001017405.1  NM_005882.3  

    Unigene Cluster for MAEA:

    Macrophage erythroblast attacher
    Hs.139896  [show with all ESTs]
    Unigene Representative Sequence: AB208907
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000303400(uc003gda.3 uc003gdb.3 uc011bvb.2 uc003gdc.3 uc003gdd.3 uc011bvc.2 uc011bvd.2 uc010ibt.3)
    ENST00000505177 ENST00000513301 ENST00000512308 ENST00000503653 ENST00000264750
    ENST00000509254 ENST00000502558 ENST00000514708 ENST00000508634 ENST00000503693(uc010ibs.1)
    ENST00000509531 ENST00000510862 ENST00000510794 ENST00000512842 ENST00000505839
    ENST00000512289 ENST00000506530

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAEA
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MAEA (see all 23):
    hsa-miR-498 hsa-miR-1178 hsa-miR-539 hsa-miR-181c hsa-miR-520d-5p hsa-miR-548k hsa-miR-496 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmid: MAEA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAEA (see all 7)
    OriGene shRNA RFP: MAEA
    OriGene siRNA: MAEA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAEA
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): MAEA (NM_005882)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAEA 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAEA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAEA

    Additional cDNA sequence: 

    AB208907.1 AF084928.1 AK001088.1 AK022515.1 AK022586.1 AK091951.1 AK094253.1 AK127875.1 
    AK296174.1 AK298944.1 AK300572.1 AK301155.1 AK308901.1 AY189687.1 AY236486.1 BC001225.1 
    BC006470.1 BT006957.1 

    24/34 DOTS entries (see all 34):

    DT.102828944  DT.100803262  DT.95363778  DT.102828943  DT.100823297  DT.91944969  DT.101981808  DT.99994246 
    DT.445825  DT.121266255  DT.91758643  DT.100823303  DT.121266257  DT.121266296  DT.100823305  DT.91982110 
    DT.100823310  DT.121266305  DT.100823300  DT.121266128  DT.121266139  DT.100823295  DT.100823296  DT.121266151 

    24/468 AceView cDNA sequences (see all 468):

    AI078734 AW273056 AI468871 CA444845 BC001225 BM710201 CB147498 AK022586 
    AA890207 BQ645132 BC006470 AK127875 BF477339 BU736142 AU121881 BU185965 
    AU143472 BM562893 BU859620 CA440896 CA421761 CB126311 AI349437 BG674252 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAEA (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:        -                       -     -     -                                                   
    SP2:                                                                                                
    SP3:        -           -     -     -     -                                                         
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MAEA

    Expression
    for MAEA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAEA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGAATAAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MAEA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAEA

    SOURCE GeneReport for Unigene cluster: Hs.139896

    UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for MAEA
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAEA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAEA

    Orthologs
    for MAEA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAEA gene from 8/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAEA1 macrophage erythroblast attacher 80.39(n)
    96.72(a)    		   426024  NM_001012604.1  NP_001012622.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAEA6
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343447.1(361453-390490)
    African clawed frog
    (Xenopus laevis)    		 Amphibia maea-prov2 macrophage erythroblast attacher 81.16(n)    BC053803.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb20a092 wufb20a09 77.67(n)   321575  BC055388.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG313571 CG31357 58.71(n)
    48.82(a)    		   326135  NM_170171.1  NP_733044.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea maea-16
    		 Protein MAEA-1
    		 23(a)
    		 1 ↔ 1
    		 I(13806905-13812256)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G550701 LisH/CRA/RING-U-box domain-containing protein 48.28(n)
    38.46(a)    		   824673  NM_115365.1  NP_191067.1 
    rice
    (Oryza sativa)    		 Liliopsida Os05g01601001 hypothetical protein 50.81(n)
    37.1(a)    		   4337882  NM_001061254.1  NP_001054719.1 


    ENSEMBL Gene Tree for MAEA (if available)
    TreeFam Gene Tree for MAEA (if available) 

    Paralogs
    for MAEA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MAEA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for MAEA
         1 CNV: 68603
         5 Indels: 27444 68605 68607 68604 27448
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MAEA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAEA for disorders           About GeneDecksing

    OMIM gene information: 606801    OMIM disorders: --

    7 diseases for MAEA:    About MalaCards
    lung cancer    extramedullary plasmacytoma    plasmacytoma    lissencephaly
    multiple myeloma    myeloma    malaria

    3 diseases from the University of Copenhagen DISEASES database for MAEA:
    Plasmacytoma     Multiple myeloma     Prostate cancer

    Export disorders for MAEA gene to outside databases

    Publications
    for MAEA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAEA gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with MAEA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. (PubMed id 9763581)1, 2, 3, 9 Hanspal M.... Uong Q. (1998)
    2. Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division. (PubMed id 16510120)1, 2 Bala S.... Hanspal M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1 Cho Y.S....Seielstad M. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for MAEA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAEA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10296 HGNC: 13731 AceView: MAEA Ensembl:ENSG00000090316 euGenes: HUgn10296
    ECgene: MAEA H-InvDB: MAEA

    Other Databases showing MAEA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAEA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAEA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAEA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAEA gene:
    Search GeneIP for patents involving MAEA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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