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MAEA Gene

protein-coding   GIFtS: 57
GCID: GC04P001273

Macrophage Erythroblast Attacher

  See MAEA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Macrophage Erythroblast Attacher1 2     GID Complex Subunit 91
EMP2 3 5     EMLP2
Cell Proliferation-Inducing Gene 5 Protein2 3     GID92
Erythroblast Macrophage Protein2 3     PIG52
Human Lung Cancer Oncogene 10 Protein2 3     GID Complex Subunit 9, FYV10 Homolog2
HLC-102 3     Lung Cancer-Related Protein 102
FYV10 Homolog (S. Cerevisiae)1     Proliferation-Inducing Gene 52

External Ids:    HGNC: 137311   Entrez Gene: 102962   Ensembl: ENSG000000903167   OMIM: 6068015   UniProtKB: Q7L5Y93   

Export aliases for MAEA gene to outside databases

Previous GC identifer: GC04P001289


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAEA Gene:
This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal
maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral
membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the
cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of
33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple
alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the
biological validity of some variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAEA Gene:
MAEA (macrophage erythroblast attacher) is a protein-coding gene. Diseases associated with MAEA include lung cancer. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the
attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of
mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic
island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate
actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division
events




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAEA gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAEA promoter sequence
   Search Chromatin IP Primers for MAEA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAEA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

MAEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAEA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P001273:  view genomic region     (about GC identifiers)

Start:
1,283,639 bp from pter      End:
1,333,935 bp from pter
Size:
50,297 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9 (See protein sequence)
Recommended Name: Macrophage erythroblast attacher  
Size: 396 amino acids; 45287 Da
Subunit: Forms a complex with F-actin
Developmental stage: Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at
metaphase and in the contractile ring during telophase and cytokinesis
Sequence caution: Sequence=AAC67543.1; Type=Erroneous termination; Positions=397; Note=Translated as stop;
Sequence=AAC67543.1; Type=Frameshift; Positions=253, 327; Sequence=AAC67543.1; Type=Miscellaneous discrepancy;
Note=Sequence differs at N-terminus; Sequence=AAO85220.1; Type=Erroneous initiation; Sequence=AK128302;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: O95285 Q5JB54 Q6ZRD6 Q9BQ11 Q9H9V6 Q9H9Z4 Q9NW84
Alternative splicing: 5 isoforms:  Q7L5Y9-1   Q7L5Y9-2   Q7L5Y9-3   Q7L5Y9-4   Q7L5Y9-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MAEA: NX_Q7L5Y9

Explore proteomics data for MAEA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23, Lys31, Lys84, Lys97, Lys100, Lys144, Lys186, Lys223, Lys304, Lys323
  • Modification sites at PhosphoSitePlus

  • See MAEA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017405.1  NP_005873.2  

    ENSEMBL proteins: 
     ENSP00000302830   ENSP00000422215   ENSP00000423056   ENSP00000422235   ENSP00000421644  
     ENSP00000264750   ENSP00000426326   ENSP00000426903   ENSP00000427512   ENSP00000426966  
     ENSP00000426807   ENSP00000427460   ENSP00000424436   ENSP00000411415  

    MAEA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAEA
    OriGene Protein Over-expression Lysate for MAEA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAEA
    GenScript Custom Purified and Recombinant Proteins Services for MAEA
    Novus Biologicals MAEA Proteins
    Novus Biologicals MAEA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAEA
    Cloud-Clone Corp. Proteins for MAEA

     
    Search eBioscience for Proteins for MAEA 

    MAEA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MAEA (EMP/MAEA)
    OriGene Antibodies for MAEA
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    Novus Biologicals MAEA Antibodies
    Abcam antibodies for MAEA
    Cloud-Clone Corp. Antibodies for MAEA
    ThermoFisher Antibodies for MAEA
    LSBio Antibodies in human, mouse, rat for MAEA

    MAEA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MAEA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAEA
    Cloud-Clone Corp. CLIAs for MAEA
    Search eBioscience for ELISAs for MAEA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR006594 LisH_dimerisation
     IPR013144 CRA_dom
     IPR024964 CTLH/CRA
     IPR006595 CTLH_C

    Graphical View of Domain Structure for InterPro Entry Q7L5Y9

    ProtoNet protein and cluster: Q7L5Y9

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB006595 CTLH


    UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain


    Find genes that share domains with MAEA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAEA_HUMAN, Q7L5Y9
    Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the
    attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of
    mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic
    island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate
    actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division
    events

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA16510120
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MAEA           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Maea):
     growth/size/body  hematopoietic system  immune system  integument  mortality/aging 

    Find genes that share phenotypes with MAEA           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAEA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAEA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAEA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAEA

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAEA:
    hsa-mir-455-3p (MIRT037862)

    Block miRNA regulation of human, mouse, rat MAEA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAEA (see all 23):
    hsa-miR-498 hsa-miR-1178 hsa-miR-539 hsa-miR-181c hsa-miR-520d-5p hsa-miR-548k hsa-miR-496 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidMAEA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAEA
    Predesigned siRNA for gene silencing in human, mouse, rat MAEA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAEA

    Clone
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    OriGene clones in human, mouse for MAEA (see all 13)
    OriGene ORF clones in mouse, rat for MAEA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAEA (NM_005882)
    Sino Biological Human cDNA Clone for MAEA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAEA

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAEA
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAEA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAEA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAEA_HUMAN, Q7L5Y9: Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear
    speckled-like pattern
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane5
    cytosol2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005819spindle IDA16510120
    GO:0005826actomyosin contractile ring IDA16510120
    GO:0005856cytoskeleton IDA16510120
    GO:0005887integral component of plasma membrane IDA9763581

    Find genes that share ontologies with MAEA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAEA
    Interactions:

        Search GeneGlobe Interaction Network for MAEA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for MAEA (Q7L5Y93 ENSP000003028304) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GID8Q9NWU23, ENSP000002660694I2D: score=5 STRING: ENSP00000266069
    PSMC3P179803, ENSP000002988524I2D: score=5 STRING: ENSP00000298852
    RMND5AQ9H8713, ENSP000002836324I2D: score=5 STRING: ENSP00000283632
    WDR26Q9H7D73, ENSP000002950244I2D: score=4 STRING: ENSP00000295024
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IEA--
    GO:0007049cell cycle IEA--
    GO:0007155cell adhesion IDA9763581
    GO:0007346regulation of mitotic cell cycle NAS16510120
    GO:0033033negative regulation of myeloid cell apoptotic process IDA9763581

    Find genes that share ontologies with MAEA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAEA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAEA gene (2 alternative transcripts): 
    NM_001017405.1  NM_005882.3  

    Unigene Cluster for MAEA:

    Macrophage erythroblast attacher
    Hs.139896  [show with all ESTs]
    Unigene Representative Sequence: AB208907
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000303400(uc003gda.3 uc003gdb.3 uc011bvb.2 uc003gdc.3 uc003gdd.3 uc011bvc.2 uc011bvd.2 uc010ibt.3)
    ENST00000505177 ENST00000513301 ENST00000512308 ENST00000503653 ENST00000264750
    ENST00000509254 ENST00000502558 ENST00000514708 ENST00000508634 ENST00000503693(uc010ibs.1)
    ENST00000509531 ENST00000510862 ENST00000510794 ENST00000512842 ENST00000505839
    ENST00000512289 ENST00000506530
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAEA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAEA (see all 23):
    hsa-miR-498 hsa-miR-1178 hsa-miR-539 hsa-miR-181c hsa-miR-520d-5p hsa-miR-548k hsa-miR-496 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidMAEA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAEA
    Predesigned siRNA for gene silencing in human, mouse, rat MAEA
    Clone
    Products:
         
    OriGene clones in human, mouse for MAEA (see all 13)
    OriGene ORF clones in mouse, rat for MAEA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAEA (NM_005882)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAEA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAEA
    OriGene qSTAR qPCR primer pairs in human, mouse for MAEA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAEA
      QuantiTect SYBR Green Assays in human, mouse, rat MAEA
      QuantiFast Probe-based Assays in human, mouse, rat MAEA

    Additional mRNA sequence: 

    AB208907.1 AF084928.1 AK001088.1 AK022515.1 AK022586.1 AK091951.1 AK094253.1 AK127875.1 
    AK296174.1 AK298944.1 AK300572.1 AK301155.1 AK308901.1 AY189687.1 AY236486.1 BC001225.1 
    BC006470.1 BT006957.1 

    Selected DOTS entries (see all 34):

    DT.102828944  DT.100803262  DT.95363778  DT.102828943  DT.100823297  DT.91944969  DT.101981808  DT.99994246 
    DT.445825  DT.121266255  DT.91758643  DT.100823303  DT.121266257  DT.121266296  DT.100823305  DT.91982110 
    DT.100823310  DT.121266305  DT.100823300  DT.121266128  DT.121266139  DT.100823295  DT.100823296  DT.121266151 

    Selected AceView cDNA sequences (see all 468):

    BM765152 AA890207 BF477339 BU846328 BU931849 AI349437 BE273395 AI955907 
    BM763749 BU195110 AI468871 AL521008 CB147498 CA407470 BM469314 CA941613 
    BQ002815 BU557106 AI744481 CR601639 BU622852 AI349433 BI757533 BI768726 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAEA (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:        -                       -     -     -                                                   
    SP2:                                                                                                
    SP3:        -           -     -     -     -                                                         
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MAEA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAEA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAATAAAAT
    MAEA Expression
    About this image


    MAEA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Erythroblasts Hematopoietic Bone Marrow
             leukocytes   
    MAEA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAEA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.139896

    UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for MAEA
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAEA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAEA
    QuantiTect SYBR Green Assays in human, mouse, rat MAEA
    QuantiFast Probe-based Assays in human, mouse, rat MAEA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAEA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAEA gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Maea1 , 5 macrophage erythroblast attacher1, 5 89.39(n)1
    98.74(a)1
      5 (17.55 cM)5
    590031  NM_021500.21  NP_067475.21 
     333355725 
    chicken
    (Gallus gallus)
    Aves MAEA1 macrophage erythroblast attacher 80.39(n)
    96.72(a)
      426024  NM_001012604.1  NP_001012622.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAEA6
    macrophage erythroblast attacher
    96(a)
    1 ↔ 1
    GL343447.1(356341-390495)
    African clawed frog
    (Xenopus laevis)
    Amphibia maea-prov2 macrophage erythroblast attacher 81.16(n)    BC053803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb20a092 wufb20a09 77.67(n)   321575  BC055388.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG313571 CG31357 58.71(n)
    48.82(a)
      326135  NM_170171.1  NP_733044.1 
    worm
    (Caenorhabditis elegans)
    Secernentea maea-16
    Protein MAEA-1 (maea-1) mRNA, complete cds
    25(a)
    1 ↔ 1
    I(13806917-13812268) WBGene00012366
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FYV10(YIL097W)4 Protein of unknown function, required for survival more   --   9(180427-181977) 854710  NP_012169.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G550701 AT3G55070 48.3(n)
    39.52(a)
      824673  NM_115365.1  NP_191067.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01601001 Os05g0160100 50.81(n)
    37.1(a)
      4337882  NM_001061254.1  NP_001054719.1 


    ENSEMBL Gene Tree for MAEA (if available)
    TreeFam Gene Tree for MAEA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAEA (see all 1550)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs16800721,2
    C,F,A--1281695(-) GTTTCC/ATATCT 2 -- us2k111Minor allele frequency- A:0.47NA WA CSA EA 372
    rs17321001,2
    C,F,A,H--1281761(-) CCAACA/GTTCTT 2 -- us2k115Minor allele frequency- G:0.47NS EA NA WA CSA 790
    rs1458491781,2
    --1281883(+) TGGAAG/TCCCCG 2 -- us2k10--------
    rs112479831,2
    C,F,A,H--1281951(+) GATGCC/GTACAT 2 -- us2k1 tfbs310Minor allele frequency- G:0.25NS EA NA 670
    rs760842451,2
    F--1282131(+) AATACA/CGTTTT 2 -- us2k10--------
    rs737952821,2
    C,F--1282212(+) TGCAAA/TCCTCT 2 -- us2k12Minor allele frequency- T:0.02WA 120
    rs1429392571,2
    C--1282238(+) AGTATG/TTCTGA 2 -- us2k10--------
    rs737952831,2
    C,F--1282259(+) TACTAG/CGATAG 2 -- us2k11Minor allele frequency- C:0.50WA 2
    rs798453291,2
    F--1282383(+) GCTCCC/TGTGTA 2 -- us2k10--------
    rs1424744561,2
    --1282440(+) AAGGAC/TGCAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAEA (1283639 - 1333935 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAEA (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726779CNV Deletion23290073
    esv2726781CNV Deletion23290073
    esv2726786CNV Deletion23290073
    esv1108812CNV Deletion17803354
    esv2726785CNV Deletion23290073
    esv2726787CNV Deletion23290073
    esv1006767CNV Deletion20482838
    esv1011456CNV Deletion17803354
    esv2726782CNV Deletion23290073
    esv2726778CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAEA
    DNA2.0 Custom Variant and Variant Library Synthesis for MAEA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606801    OMIM disorders: --

    1 disease for MAEA:    
    About MalaCards
    lung cancer

    3 diseases from the University of Copenhagen DISEASES database for MAEA:
    Plasmacytoma     Multiple myeloma     Prostate cancer

    Find genes that share disorders with MAEA           About GenesLikeMe

    Genetic Association Database (GAD): MAEA

    Export disorders for MAEA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAEA gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with MAEA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. (PubMed id 9763581)1, 2, 3, 9 Hanspal M.... Uong Q. (Blood 1998)
    2. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1, 4 Cho Y.S....Seielstad M. (Nat. Genet. 2012)
    3. Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division. (PubMed id 16510120)1, 2 Bala S.... Hanspal M. (Biochem. Biophys. Res. Commun. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genome-wide association study identifies three novel loci for type 2 diabetes. (PubMed id 23945395)1 Hara K....Kadowaki T. (Hum. Mol. Genet. 2014)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. Evaluation of erythroblast macrophage protein related to erythroblastic islands in patients with hematopoietic stem cell transplantation. (PubMed id 23566571)1 Mao X....Hu L. (Eur. J. Med. Res. 2013)
    8. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10296 HGNC: 13731 AceView: MAEA Ensembl:ENSG00000090316 euGenes: HUgn10296
    ECgene: MAEA H-InvDB: MAEA

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAEA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAEA gene:
    Search GeneIP for patents involving MAEA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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