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Aliases & Descriptions for MAEA
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EMLP 2 EMP 1 , 2 , 3 , 5 HLC-10 2 , 3 PIG5 2
Descriptions Cell proliferation-inducing gene 5 protein 3 Erythroblast macrophage protein 2 , 3 Human lung cancer oncogene 10 protein 3 lung cancer-related protein 10 2 macrophage erythroblast attacher 2 proliferation-inducing gene 5 2
Search outside databases for aliases for MAEA genePrevious GC identifer: GC04P001289
Summaries for MAEA (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for MAEA : This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotesterminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. Thisprotein is an integral membrane protein with the N-terminus on the extracellular side and theC-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms oferythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detectedin macrophage membranes; this gene encodes the larger isoform. Multiple alternatively splicedtranscript variants encoding distinct isoforms have been found for this gene, but the biologicalvalidity of some variants has not been determined. [provided by RefSeq] UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9 Function : Play a role in erythroblast enucleation and in the development of the mature macrophages.Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presenceof MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cellsapoptosis. Participates to erythroblastic island formation, which is the functional unit ofdefinitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblastsand macrophages. May contribute to nuclear architecture and cells division events
Genomic Location for MAEA
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MAEA gene Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3 MAEA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P001273:
(about GC identifiers )
Start:
1,273,672 bp from pter
End:
1,323,925 bp from pter
Size:
50,254 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000004.10 NT_037622.5 Proteins for MAEA
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9 (See
protein sequence )Recommended Name: Macrophage erythroblast attacher Size : 396 amino acids; 45287 Da
Subunit : Form a complex with F-actin
Subcellular location : Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized asnuclear speckled-like pattern
Developmental stage : Localized with condensed chromatin at prophase; Detected in nuclear spindlepoles at metaphase and in the contractile ring during telophase and cytokinesis
Sequence caution : Sequence=AAC67543.1; Type=Frameshift; Positions=252, 327;
Secondary accessions : O95285 Q5JB54 Q6ZRD6 Q9BQ11 Q9H9V6 Q9H9Z4 Q9NW84Alternative splicing : 6 isoforms : Q7L5Y9-1 Q7L5Y9-2 Q7L5Y9-3 Q7L5Y9-4 Q7L5Y9-5 Q7L5Y9-6
REFSEQ proteins (2 alternative transcripts):
NP_001017405.1 NP_005873.2 ENSEMBL proteins: ENSP00000302830 ENSP00000264750 ENSP00000372405 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: MAEA 5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9
):
About this table Antibodies for MAEA: Assays for MAEA:
Protein
Domains/ Families for MAEA(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q7L5Y9 ProtoNet protein and cluster: Q7L5Y9
2 Blocks protein families : IPB006594 Lissencephaly type-1-like homology motif IPB006595 CTLH UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9 Similarity : Contains 1 CTLH domainSimilarity : Contains 1 LisH domain
Gene Function for MAEA
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001017405 Applied Biosystems Silencer ® siRNAs for MAEA Sigma-Aldrich siRNA and siRNA Panels for MAEA Sigma-Aldrich shRNA Panels and shRNA for MAEA Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001017405                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001017405                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001017405  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001017405 UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9 Function : Play a role in erythroblast enucleation and in the development of the mature macrophages.Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presenceof MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cellsapoptosis. Participates to erythroblastic island formation, which is the functional unit ofdefinitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblastsand macrophages. May contribute to nuclear architecture and cells division events
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Maea) :1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for MAEA
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/8 Interacting proteins for MAEA (ENSP00000302830 3 ) via UniProtKB, MINT, and/or STRING (see all 8
)About this table 5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
):
About this table
Drugs & Compounds for MAEA (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MAEA
Transcripts for MAEA(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001017405 Sigma-Aldrich siRNA and siRNA Panels for MAEA Sigma-Aldrich shRNA Panels and shRNA for MAEA Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001017405 NM_005882
REFSEQ mRNAs for MAEA gene (2 alternative transcripts): NM_001017405.1 NM_005882.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001017405 NM_005882
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001017405                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001017405                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001017405  
Additional cDNA sequence: AB208907.1 AF084928.1 AK001088.1 AK022515.1 AK022586.1 AK091951.1 AK094253.1 AK127875.1 AK296174.1 AK298944.1 AK300572.1 AK301155.1 AK308901.1 AY189687.1 AY236486.1 BC001225.1 BC006470.1 BT006957.1 CR601639.1 CR606463.1 CR615926.1
24/34 DOTS entries (see all 34
): DT.102828944 DT.100803262 DT.95363778 DT.102828943 DT.100823297 DT.91944969 DT.101981808 DT.99994246 DT.445825 DT.121266255 DT.91758643 DT.100823303 DT.121266257 DT.121266296 DT.100823305 DT.91982110 DT.100823310 DT.121266305 DT.97825508 DT.100823300 DT.121266128 DT.121266139 DT.100823295 DT.100823296
24/468 AceView cDNA sequences (see all 468
):AL599051 BG674252 BQ643464 AY189687 AK091951 BU622852 CA407470 AA890207 AI468871 AI078734 BX380184 BG116905 BM752947 BU846328 AA291394 BQ942851 BC001225 CA440896 AI421773 BU931849 AL521008 BM763749 BE550620 CA444845
highest scoring ESTs for MAEA :AA025521 AA041297 AA069148 AA079028 AA149893 AA150393 AA159350 AA215452 AA224400 AA291394
Unigene Cluster for MAEA: Macrophage erythroblast attacher Hs.139896 [show with all ESTs ] Unigene Representative Sequence: AB208907 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAEA (see all 6
) ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 SP1 :   -         -   -   -                   SP2 :                                 SP3 :   -     -   -   -   -                     SP4 :                                 SP5 :                                
About this scheme ECgene alternative splicing isoforms for MAEA 3 Ensembl transcripts including schematic representations : ENST00000303400
ENST00000264750
ENST00000382947
Expression for MAEA
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MAEA expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MAEA 1 / 2 / 3
3 probe-sets matching MAEA gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CGAATAAAATSOURCE GeneReport for Unigene cluster: Hs.139896 Expression variation in blood from EXPOLDB for MAEA
UniProtKB/Swiss-Prot: MAEA_HUMAN, Q7L5Y9 Tissue specificity : Ubiquitous
Orthologs for MAEA
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MAEA gene from 5/20 species (see all 20
)
About this table Species with no ortholog for MAEA ENSEMBL Gene Tree for MAEA Paralogs for MAEA (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MAEA gene RMND5B 2 RMND5A 2
SNPs/Variants for MAEA (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MAEA (up to first 250kb)
Disorders & Mutations for MAEA
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 606801
Medical News for MAEA (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MAEA (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for MAEA gene : Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. (PubMed id 9763581) 1, 2, 3, 4 Hanspal M.... Uong Q. (1998) Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division. (PubMed id 16510120) 3, 4 Bala S.... Hanspal M. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. (PubMed id 17467196) 3 Kobayashi N....Ishigatsubo Y. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 4 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 4 Aoki H.... Hino O. (2000) Changing pattern of the subcellular distribution of erythroblast macrophage protein (Emp) during macrophage differentiation. (PubMed id 17071116) 1 Soni S....Hanspal M. (2007) Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion. (PubMed id 16707498) 1 Soni S....Hanspal M. (2006)
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Genome Databases showing MAEA
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MAEA
(According to HUGE )
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Specialized Databases showing MAEA (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for MAEA (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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