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Aliases for MAEA Gene

Aliases for MAEA Gene

  • Macrophage Erythroblast Attacher 2 3 5
  • Cell Proliferation-Inducing Gene 5 Protein 3 4
  • Human Lung Cancer Oncogene 10 Protein 3 4
  • Erythroblast Macrophage Protein 3 4
  • HLC-10 3 4
  • EMP 3 4
  • GID Complex Subunit 9, FYV10 Homolog 3
  • Lung Cancer-Related Protein 10 3
  • FYV10 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 9 2
  • PIG5 3
  • EMLP 3
  • GID9 3

External Ids for MAEA Gene

Previous GeneCards Identifiers for MAEA Gene

  • GC04P001273
  • GC04P001252

Summaries for MAEA Gene

Entrez Gene Summary for MAEA Gene

  • This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MAEA Gene

MAEA (Macrophage Erythroblast Attacher) is a Protein Coding gene. Diseases associated with MAEA include Epiglottis Neoplasm and Solitary Osseous Plasmacytoma. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for MAEA Gene

  • Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAEA Gene

Genomics for MAEA Gene

Regulatory Elements for MAEA Gene

Enhancers for MAEA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAEA on UCSC Golden Path with GeneCards custom track

Promoters for MAEA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAEA on UCSC Golden Path with GeneCards custom track

Genomic Location for MAEA Gene

Chromosome:
4
Start:
1,289,851 bp from pter
End:
1,340,148 bp from pter
Size:
50,298 bases
Orientation:
Plus strand

Genomic View for MAEA Gene

Genes around MAEA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAEA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAEA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAEA Gene

Proteins for MAEA Gene

  • Protein details for MAEA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5Y9-MAEA_HUMAN
    Recommended name:
    Macrophage erythroblast attacher
    Protein Accession:
    Q7L5Y9
    Secondary Accessions:
    • O95285
    • Q5JB54
    • Q6ZRD6
    • Q9BQ11
    • Q9H9V6
    • Q9H9Z4
    • Q9NW84

    Protein attributes for MAEA Gene

    Size:
    396 amino acids
    Molecular mass:
    45287 Da
    Quaternary structure:
    • Forms a complex with F-actin.
    SequenceCaution:
    • Sequence=AAC67543.1; Type=Erroneous termination; Positions=397; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=AAC67543.1; Type=Frameshift; Positions=253, 327; Evidence={ECO:0000305}; Sequence=AAC67543.1; Type=Miscellaneous discrepancy; Note=Sequence differs at N-terminus.; Evidence={ECO:0000305}; Sequence=AAO85220.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK128302; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAEA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAEA Gene

Proteomics data for MAEA Gene at MOPED

Post-translational modifications for MAEA Gene

  • Ubiquitination at Lys 23, Lys 31, Lys 84, Lys 97, Lys 100, Lys 144, Lys 186, Lys 223, Lys 304, and Lys 323
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MAEA

No data available for DME Specific Peptides for MAEA Gene

Domains & Families for MAEA Gene

Graphical View of Domain Structure for InterPro Entry

Q7L5Y9

UniProtKB/Swiss-Prot:

MAEA_HUMAN :
  • Contains 1 CTLH domain.
Domain:
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with MAEA: view

No data available for Gene Families for MAEA Gene

Function for MAEA Gene

Molecular function for MAEA Gene

UniProtKB/Swiss-Prot Function:
Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.

Gene Ontology (GO) - Molecular Function for MAEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 16510120
genes like me logo Genes that share ontologies with MAEA: view
genes like me logo Genes that share phenotypes with MAEA: view

Animal Models for MAEA Gene

MGI Knock Outs for MAEA:
  • Maea tm1b(EUCOMM)Wtsi

Animal Model Products

miRNA for MAEA Gene

miRTarBase miRNAs that target MAEA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAEA Gene

Localization for MAEA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAEA Gene

Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like pattern.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAEA Gene COMPARTMENTS Subcellular localization image for MAEA gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005819 spindle IDA 16510120
GO:0015629 actin cytoskeleton IEA --
GO:0016363 nuclear matrix IDA 16510120
genes like me logo Genes that share ontologies with MAEA: view

Pathways & Interactions for MAEA Gene

SuperPathways for MAEA Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007155 cell adhesion IDA 9763581
GO:0048821 erythrocyte development IEA --
genes like me logo Genes that share ontologies with MAEA: view

No data available for Pathways by source and SIGNOR curated interactions for MAEA Gene

Drugs & Compounds for MAEA Gene

(1) Drugs for MAEA Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WF10 Approved, Investigational Pharma Target 0
genes like me logo Genes that share compounds with MAEA: view

Transcripts for MAEA Gene

Unigene Clusters for MAEA Gene

Macrophage erythroblast attacher:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAEA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:

Relevant External Links for MAEA Gene

GeneLoc Exon Structure for
MAEA
ECgene alternative splicing isoforms for
MAEA

Expression for MAEA Gene

mRNA expression in normal human tissues for MAEA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAEA Gene

This gene is overexpressed in Lavage (47.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAEA Gene



SOURCE GeneReport for Unigene cluster for MAEA Gene Hs.139896

mRNA Expression by UniProt/SwissProt for MAEA Gene

Q7L5Y9-MAEA_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MAEA: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MAEA Gene

Orthologs for MAEA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAEA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAEA 35
  • 91.58 (n)
  • 99.24 (a)
MAEA 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAEA 35
  • 90.99 (n)
  • 97.9 (a)
MAEA 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Maea 35
  • 89.39 (n)
  • 98.74 (a)
Maea 16
Maea 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAEA 35
  • 99.33 (n)
  • 99.75 (a)
MAEA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Maea 35
  • 89.98 (n)
  • 98.74 (a)
oppossum
(Monodelphis domestica)
Mammalia MAEA 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAEA 35
  • 80.39 (n)
  • 96.72 (a)
MAEA 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAEA 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia maea 35
  • 81.13 (n)
  • 95.11 (a)
Str.2513 35
African clawed frog
(Xenopus laevis)
Amphibia maea-prov 35
zebrafish
(Danio rerio)
Actinopterygii maea 35
  • 77.66 (n)
  • 93.77 (a)
wufb20a09 35
maea 36
  • 94 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004332 35
  • 58.97 (n)
  • 53.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31357 35
  • 58.71 (n)
  • 48.82 (a)
CG31357 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea maea-1 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FYV10 36
  • 20 (a)
OneToOne
FYV10 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55070 35
  • 48.3 (n)
  • 39.52 (a)
rice
(Oryza sativa)
Liliopsida Os05g0160100 35
  • 50.81 (n)
  • 37.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4076 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09000 35
  • 49.45 (n)
  • 39.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC106.13 35
  • 40.07 (n)
  • 30.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for MAEA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAEA Gene

ENSEMBL:
Gene Tree for MAEA (if available)
TreeFam:
Gene Tree for MAEA (if available)

Paralogs for MAEA Gene

No data available for Paralogs for MAEA Gene

Variants for MAEA Gene

Sequence variations from dbSNP and Humsavar for MAEA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs34082974 - 1,312,011(-) GCGGC(A/G)CGAAA nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1128427 -- 1,336,971(+) CAGGC(C/T)GGCCT nc-transcript-variant, reference, synonymous-codon, missense
rs1128597 -- 1,340,013(+) GAACC(A/C)CCGTA nc-transcript-variant, utr-variant-3-prime
rs1316393 -- 1,321,831(+) CTAGC(A/G)GAGAC intron-variant
rs1316394 -- 1,322,032(+) TGGGG(A/G)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAEA Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
nsv829835 CNV Gain 17160897
nsv878328 CNV Loss 21882294
nsv878330 CNV Loss 21882294
nsv508988 CNV Insertion 20534489
nsv461156 CNV Loss 19166990
dgv5404n71 CNV Loss 21882294
dgv5405n71 CNV Loss 21882294
esv22192 CNV Loss 19812545
esv1006767 CNV Deletion 20482838
esv2726778 CNV Deletion 23290073
esv1108812 CNV Deletion 17803354
nsv878344 CNV Loss 21882294
nsv878345 CNV Loss 21882294
nsv461157 CNV Loss 19166990
nsv878347 CNV Loss 21882294
esv267600 CNV Insertion 20981092
esv274069 CNV Insertion 20981092
esv1413945 CNV Insertion 17803354
esv2726779 CNV Deletion 23290073
esv2726780 CNV Deletion 23290073
esv1007469 CNV Insertion 20482838
esv1714696 CNV Insertion 17803354
nsv290178 CNV Insertion 16902084
esv2726781 CNV Deletion 23290073
esv2726782 CNV Deletion 23290073
nsv878349 CNV Loss 21882294
esv2726783 CNV Deletion 23290073
esv2726785 CNV Deletion 23290073
esv2726786 CNV Deletion 23290073
esv23351 CNV Loss 19812545
nsv292086 CNV Loss 16902084
esv2726787 CNV Deletion 23290073
esv1011456 CNV Deletion 17803354
nsv878350 CNV Loss 21882294
nsv878351 CNV Loss 21882294

Variation tolerance for MAEA Gene

Residual Variation Intolerance Score: 9.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAEA Gene

Disorders for MAEA Gene

MalaCards: The human disease database

(8) MalaCards diseases for MAEA Gene - From: DISEASES

Disorder Aliases PubMed IDs
epiglottis neoplasm
  • epiglottic tumor
solitary osseous plasmacytoma
  • isolated osseous plasmacytoma
chronic frontal sinusitis
mature b-cell neoplasm
  • mature b-cell lymphocytic neoplasm
frontal sinusitis
- elite association - COSMIC cancer census association via MalaCards
Search MAEA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAEA

Genetic Association Database (GAD)
MAEA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAEA
genes like me logo Genes that share disorders with MAEA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAEA Gene

Publications for MAEA Gene

  1. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. (PMID: 9763581) Hanspal M. … Uong Q. (Blood 1998) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Genome-wide association study identifies three novel loci for type 2 diabetes. (PMID: 23945395) Hara K. … Kadowaki T. (Hum. Mol. Genet. 2014) 3

Products for MAEA Gene

Sources for MAEA Gene

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