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Aliases for MAEA Gene

Aliases for MAEA Gene

  • Macrophage Erythroblast Attacher 2 3
  • EMP 3 4 6
  • Cell Proliferation-Inducing Gene 5 Protein 3 4
  • Human Lung Cancer Oncogene 10 Protein 3 4
  • Erythroblast Macrophage Protein 3 4
  • HLC-10 3 4
  • GID Complex Subunit 9, FYV10 Homolog 3
  • Lung Cancer-Related Protein 10 3
  • FYV10 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 9 2
  • EMLP 3
  • GID9 3
  • PIG5 3

External Ids for MAEA Gene

Summaries for MAEA Gene

Entrez Gene Summary for MAEA Gene

  • This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MAEA Gene

MAEA (Macrophage Erythroblast Attacher) is a Protein Coding gene. Diseases associated with MAEA include lung cancer. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for MAEA Gene

  • Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAEA Gene

Genomics for MAEA Gene

Genomic Location for MAEA Gene

Start:
1,251,817 bp from pter
End:
1,340,147 bp from pter
Size:
88,331 bases
Orientation:
Plus strand

Genomic View for MAEA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAEA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAEA Gene

Regulatory Elements for MAEA Gene

Proteins for MAEA Gene

  • Protein details for MAEA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5Y9-MAEA_HUMAN
    Recommended name:
    Macrophage erythroblast attacher
    Protein Accession:
    Q7L5Y9
    Secondary Accessions:
    • O95285
    • Q5JB54
    • Q6ZRD6
    • Q9BQ11
    • Q9H9V6
    • Q9H9Z4
    • Q9NW84

    Protein attributes for MAEA Gene

    Size:
    396 amino acids
    Molecular mass:
    45287 Da
    Quaternary structure:
    • Forms a complex with F-actin.
    SequenceCaution:
    • Sequence=AAC67543.1; Type=Erroneous termination; Positions=397; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=AAC67543.1; Type=Frameshift; Positions=253, 327; Evidence={ECO:0000305}; Sequence=AAC67543.1; Type=Miscellaneous discrepancy; Note=Sequence differs at N-terminus.; Evidence={ECO:0000305}; Sequence=AAO85220.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK128302; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAEA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAEA Gene

Proteomics data for MAEA Gene at MOPED

Post-translational modifications for MAEA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys23, Lys31, Lys84, Lys97, Lys100, Lys144, Lys186, Lys223, Lys304, and Lys323

No data available for DME Specific Peptides for MAEA Gene

Domains for MAEA Gene

UniProtKB/Swiss-Prot:

MAEA_HUMAN
Domain:
  • Contains 1 CTLH domain.:
    • Q7L5Y9
  • Contains 1 LisH domain.:
    • Q7L5Y9
genes like me logo Genes that share domains with MAEA: view

No data available for Gene Families for MAEA Gene

Function for MAEA Gene

Molecular function for MAEA Gene

UniProtKB/Swiss-Prot Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.

Gene Ontology (GO) - Molecular Function for MAEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 16510120
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MAEA: view
genes like me logo Genes that share phenotypes with MAEA: view

miRNA for MAEA Gene

miRTarBase miRNAs that target MAEA

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAEA Gene

Localization for MAEA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAEA Gene

Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like pattern.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAEA Gene COMPARTMENTS Subcellular localization image for MAEA gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for MAEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005819 spindle IDA 16510120
GO:0005826 actomyosin contractile ring IDA 16510120
genes like me logo Genes that share ontologies with MAEA: view

Pathways for MAEA Gene

SuperPathways for MAEA Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007049 cell cycle IEA --
GO:0007155 cell adhesion IDA 9763581
GO:0007346 regulation of mitotic cell cycle NAS 16510120
GO:0033033 negative regulation of myeloid cell apoptotic process IDA 9763581
genes like me logo Genes that share ontologies with MAEA: view

No data available for Pathways by source for MAEA Gene

Transcripts for MAEA Gene

Unigene Clusters for MAEA Gene

Macrophage erythroblast attacher:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAEA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:

Relevant External Links for MAEA Gene

GeneLoc Exon Structure for
MAEA
ECgene alternative splicing isoforms for
MAEA

Expression for MAEA Gene

mRNA expression in normal human tissues for MAEA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAEA Gene

SOURCE GeneReport for Unigene cluster for MAEA Gene Hs.139896

mRNA Expression by UniProt/SwissProt for MAEA Gene

Q7L5Y9-MAEA_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with MAEA: view

Orthologs for MAEA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAEA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAEA 36
  • 99.33 (n)
  • 99.75 (a)
MAEA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAEA 36
  • 91.58 (n)
  • 99.24 (a)
MAEA 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAEA 36
  • 90.99 (n)
  • 97.9 (a)
MAEA 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Maea 36
  • 89.39 (n)
  • 98.74 (a)
Maea 16
Maea 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAEA 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 77 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Maea 36
  • 89.98 (n)
  • 98.74 (a)
chicken
(Gallus gallus)
Aves MAEA 36
  • 80.39 (n)
  • 96.72 (a)
MAEA 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAEA 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia maea-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia maea 36
  • 81.13 (n)
  • 95.11 (a)
Str.2513 36
zebrafish
(Danio rerio)
Actinopterygii maea 36
  • 77.66 (n)
  • 93.77 (a)
maea 37
  • 94 (a)
OneToOne
wufb20a09 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004332 36
  • 58.97 (n)
  • 53.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31357 36
  • 58.71 (n)
  • 48.82 (a)
CG31357 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea maea-1 37
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FYV10 37
  • 20 (a)
OneToOne
FYV10 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55070 36
  • 48.3 (n)
  • 39.52 (a)
rice
(Oryza sativa)
Liliopsida Os05g0160100 36
  • 50.81 (n)
  • 37.1 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09000 36
  • 49.45 (n)
  • 39.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC106.13 36
  • 40.07 (n)
  • 30.85 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4076 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToOne
Species with no ortholog for MAEA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAEA Gene

ENSEMBL:
Gene Tree for MAEA (if available)
TreeFam:
Gene Tree for MAEA (if available)

Paralogs for MAEA Gene

No data available for Paralogs for MAEA Gene

Variants for MAEA Gene

Sequence variations from dbSNP and Humsavar for MAEA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs900027 -- 1,285,572(-) ggtga(C/T)ggctg intron-variant
rs900028 -- 1,285,374(-) GGAGC(A/T)CCCAA intron-variant
rs900029 -- 1,285,357(-) TCTGC(A/G)CGGCA intron-variant
rs922698 -- 1,288,934(-) AAAGT(A/G)TTATT upstream-variant-2KB, intron-variant
rs1128427 -- 1,336,971(+) CAGGC(C/T)GGCCT synonymous-codon, reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MAEA Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
nsv829835 CNV Gain 17160897
nsv878328 CNV Loss 21882294
nsv878330 CNV Loss 21882294
nsv508988 CNV Insertion 20534489
nsv461156 CNV Loss 19166990
dgv5404n71 CNV Loss 21882294
dgv5405n71 CNV Loss 21882294
esv22192 CNV Loss 19812545
esv1006767 CNV Deletion 20482838
esv2726778 CNV Deletion 23290073
esv1108812 CNV Deletion 17803354
nsv878344 CNV Loss 21882294
nsv878345 CNV Loss 21882294
nsv461157 CNV Loss 19166990
nsv878347 CNV Loss 21882294
esv267600 CNV Insertion 20981092
esv274069 CNV Insertion 20981092
esv1413945 CNV Insertion 17803354
esv2726779 CNV Deletion 23290073
esv2726780 CNV Deletion 23290073
esv1007469 CNV Insertion 20482838
esv1714696 CNV Insertion 17803354
nsv290178 CNV Insertion 16902084
esv2726781 CNV Deletion 23290073
esv2726782 CNV Deletion 23290073
nsv878349 CNV Loss 21882294
esv2726783 CNV Deletion 23290073
esv2726785 CNV Deletion 23290073
esv2726786 CNV Deletion 23290073
esv23351 CNV Loss 19812545
nsv292086 CNV Loss 16902084
esv2726787 CNV Deletion 23290073
esv1011456 CNV Deletion 17803354
nsv878350 CNV Loss 21882294
nsv878351 CNV Loss 21882294

Relevant External Links for MAEA Gene

HapMap Linkage Disequilibrium report
MAEA

Disorders for MAEA Gene

(1) MalaCards Diseases for MAEA Gene

Search for MAEA Gene in MalaCards »

(3) University of Copenhagen DISEASES for MAEA Gene

Relevant External Links for MAEA

Genetic Association Database (GAD)
MAEA
genes like me logo Genes that share disorders with MAEA: view

No data available for UniProtKB/Swiss-Prot for MAEA Gene

Publications for MAEA Gene

  1. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. (PMID: 9763581) Hanspal M. … Uong Q. (Blood 1998) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division. (PMID: 16510120) Bala S. … Hanspal M. (Biochem. Biophys. Res. Commun. 2006) 3 4
  4. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho Y.S. … Seielstad M. (Nat. Genet. 2012) 3 49
  5. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. (PMID: 22456796) Imamura M. … Kadowaki T. (Hum. Mol. Genet. 2012) 3

Products for MAEA Gene

Sources for MAEA Gene

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