V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

MADD Gene

protein-coding GIFtS: 59

GC11P047247

MAP-kinase activating death domain
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DENN ^¹, ², ³, ⁵
FLJ35600 ^²
FLJ36300 ^²
IG20 ^², ³
KIAA0358 ^¹, ², ³
RAB3GEP ^¹, ²

Descriptions
Differentially expressed in normal and neoplastic cells ^², ³
Insulinoma glucagonoma clone 20 ^³
MAP-kinase activating death domain ^²
MAP-kinase activating death domain-containing protein ^²
Rab3 GDP/GTP exchange factor ^², ³
insulinoma-glucagonoma protein 20 ^²

External Ids
HGNC: 6766¹
Entrez Gene: 8567²
UniProtKB: Q8WXG6³
Ensembl: ENSG00000110514⁷

Search outside databases for aliases for MADD gene

Previous GC identifers: GC11P049230 GC11P048168 GC11P047322 GC11P047255

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MADD:

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two

receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells

by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing

adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate

mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound

and expressed at a higher level in neoplastic cells than in normal cells. Several transcript

variants encoding different isoforms have been described for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MADD_HUMAN, Q8WXG6

Function: Plays a significant role in regulating cell proliferation, survival and death through

alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows

decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active

forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase

activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced,

caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is

resistant and isoform 3 and isoform 4 have no effect

Gene Wiki entry for MADD

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MADD gene

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2

MADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P047247: (about GC identifiers)

Start:	47,247,535 bp from pter
End:	47,314,521 bp from pter
Size:	66,987 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MADD_HUMAN, Q8WXG6 (See protein sequence)

Recommended Name: MAP kinase-activating death domain protein

Size: 1647 amino acids; 183303 Da

Subunit: Interacts with the death domain of TNFRSF1A through its own death domain

Subcellular location: Membrane; Multi-pass membrane protein

Miscellaneous: Overexpression of MADD activates the mitogen-activated protein (MAP) kinase

extracellular signal-regulated kinase (ERK). Expression of the MADD death domain stimulates both

the ERK and c-JUN N-terminal kinase MAP kinases and induces the phosphorylation of cytosolic

phospholipase A2

Secondary accessions: O15065 O15293 Q15732 Q15741 Q8IWD7 Q8WXG3 Q8WXG4 Q8WXG5 Q8WZ63

Alternative splicing: 7 isoforms: Q8WXG6-1 Q8WXG6-2 Q8WXG6-3 Q8WXG6-4 Q8WXG6-5 Q8WXG6-6 Q8WXG6-7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (10 alternative transcripts):

NP_001129415.1 NP_001129416.1 NP_003673.3 NP_569826.2 NP_569827.2 NP_569828.2 NP_569829.2 NP_569830.2

NP_569831.1 NP_569832.2

ENSEMBL proteins:

ENSP00000384483 ENSP00000384435 ENSP00000343902 ENSP00000385585 ENSP00000384204 ENSP00000384287

ENSP00000378745 ENSP00000310933 ENSP00000304505 ENSP00000378751 ENSP00000378753 ENSP00000378758

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	8988362
GO:0005886	plasma membrane	TAS	8988362
GO:0016021	integral to membrane	IDA	8988362

About this table

Antibodies for MADD:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for MADD
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for MADD

Assays for MADD:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8WXG6

ProtoNet protein and cluster: Q8WXG6

UniProtKB/Swiss-Prot: MADD_HUMAN, Q8WXG6

Similarity: Belongs to the MADD family

Similarity: Contains 1 dDENN domain

Similarity: Contains 1 death domain

Similarity: Contains 1 DENN domain

Similarity: Contains 1 uDENN domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MADD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MADD)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 10): NM_003682

Applied Biosystems Silencer® siRNAs for MADD

Sigma-Aldrich siRNA for MADD

Sigma-Aldrich shRNA Panels and shRNA for MADD

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 10): NM_001135943
Myc/DDK tagged cDNA clones in CMV expression vector (see all 10): NM_001135943
untagged cDNA clones in CMV expression vector (see all 10): NM_001135943

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003682

UniProtKB/Swiss-Prot: MADD_HUMAN, Q8WXG6

Function: Plays a significant role in regulating cell proliferation, survival and death through

alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows

decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active

forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase

activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced,

caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is

resistant and isoform 3 and isoform 4 have no effect

Genatlas biochemistry entry for MADD:

Map kinase-activating death domain protein homolog and similar to C elegans AEX3,differentially

expressed in normal and neoplastic cell,linkingTNFR1 with MAP kinase activation and arachidonic

acid release and provide further insight into the mechanisms by which TNF exerts its pleiotropic

effects

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Madd):

behavior/neurological

lethality-prenatal/perinatal

nervous system

respiratory system

touch/vibrissae

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005123	death receptor binding	TAS	9115275
GO:0005515	protein binding	IPI	9115275
GO:0017112	Rab guanyl-nucleotide exchange factor activity	IMP	9115275
GO:0030295	protein kinase activator activity	TAS	9115275

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MADD

5/28 Interacting proteins for MADD (Q8WXG6¹ ENSP00000310933³) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPRN	Q16849¹, ENSP00000295718³	EBI-310528, EBI-728153 STRING (score=.759)
TNFRSF1A	ENSP00000162749³	STRING (score=.978)
CASP8	ENSP00000351273³	STRING (score=.977)
MAP4K4	ENSP00000313644³	STRING (score=.952)
FADD	ENSP00000301838³	STRING (score=.951)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IMP	9115275
GO:0007166	cell surface receptor linked signal transduction	TAS	9115275
GO:0042981	regulation of apoptosis	IMP	9115275 11577081 14735464
GO:0051726	regulation of cell cycle	IMP	14735464

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MADD
2 Novoseek chemical compound relationships for MADD gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	67.45	4	12410563 (1), 11563850 (1), 15464446 (1), 9796103 (1)
gtp	56.88	4	12410563 (1), 11563850 (1), 15464446 (1), 9796103 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MADD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MADD)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 10): NM_003682

Sigma-Aldrich siRNA for MADD

Sigma-Aldrich shRNA Panels and shRNA for MADD

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001135943 NM_001135944 NM_003682 NM_130470 NM_130471 NM_130472 NM_130473 NM_130474

NM_130475 NM_130476

REFSEQ mRNAs for MADD gene (10 alternative transcripts):

NM_001135943.1 NM_001135944.1 NM_003682.3 NM_130470.2 NM_130471.2 NM_130472.2 NM_130473.2 NM_130474.2

NM_130475.2 NM_130476.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001135943 NM_001135944 NM_003682 NM_130470 NM_130471 NM_130472 NM_130473 NM_130474

NM_130475 NM_130476

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 10): NM_001135943
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 10): NM_001135943
                                 untagged cDNA clones in CMV expression vector (see all 10): NM_001135943

Additional cDNA sequence:

AB002356.1 AF440100.1 AF440101.1 AF440102.1 AF440103.1 AF440434.1 AK292442.1 BC040484.1

U44953.1 U77352.1

20 DOTS entries:

DT.95196710 DT.100824108 DT.95196696 DT.95196704 DT.91680541 DT.95196665 DT.75126953 DT.100029601

DT.100824110 DT.100824109 DT.100646688 DT.87015779 DT.120754723 DT.40213898 DT.120754703 DT.120754733

DT.120754744 DT.91894316 DT.97848210 DT.91739600

24/268 AceView cDNA sequences (see all 268 ):

AW999775 NM_130474 CB164318 AU130871 BM699383 NM_130472 NM_130476 AA768186

BM547742 BQ434951 CA435662 AA731365 AX747807 AA771933 NM_130475 BM708070

AA376927 NM_003682 CD722967 AL041084 BQ216930 BQ640625 BM743699 BM757184

highest scoring ESTs for MADD:

AB002356 AA135118 AA181266 AA181397 AA281945 AA282445 AA349852 AA357581 AA365684 AA376927

Unigene Cluster for MADD:

MAP-kinase activating death domain

Hs.82548 [show with all ESTs]

Unigene Representative Sequence: NM_003682

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for MADD (see all 21 )

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^
SP1:					-		-		-		-		-																-
SP2:													-																-
SP3:					-		-		-		-		-																-																						-
SP4:					-		-		-		-		-																-
SP5:			-		-		-		-		-		-																-

ExUns:	18a	·	18b	^	19	^	20	^	21	^	22a	·	22b	^	23a	·	23b	·	23c	·	23d	^	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^
SP1:	-
SP2:	-
SP3:	-																								-														-
SP4:	-																								-														-
SP5:	-						-																		-														-

ExUns:	37	^	38a	·	38b	^	39a	·	39b	^	40a	·	40b
SP1:					-		-
SP2:			-		-		-
SP3:					-		-
SP4:					-		-
SP5:					-		-

About this scheme

ECgene alternative splicing isoforms for MADD

12 Ensembl transcripts including schematic representations:

ENST00000405573 ENST00000406482 ENST00000342922 ENST00000402799 ENST00000407859 ENST00000402192

ENST00000395336 ENST00000311027 ENST00000349238 ENST00000395342 ENST00000395344 ENST00000395349

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MADD expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MADD

¹ / ² / ³

5 probe-sets matching MADD gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38398_at²^{, 3}	U133-A	1	1.00	1.00	1.00	1.00	AB002356	1.00	1.00	1.00	1
210252_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB002356	1.00	1.00	1.00	1
38398_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB002356	1.00	1.00	1.00	1
210252_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
38398_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTGGGCGCC

SOURCE GeneReport for Unigene cluster: Hs.82548
Expression variation in blood from EXPOLDB for MADD
UniProtKB/Swiss-Prot: MADD_HUMAN, Q8WXG6
Tissue specificity: Highly expressed in fetal brain and kidney; adult testis, ovary, brain and
heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver
and in several cancer cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MADD gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MADD¹	--	MAP-kinase activating death domain	92.7(n) 96.35(a)	475982 XM_855751.1 XP_860844.1
cow (Bos taurus)	MADD¹	--	MAP-kinase activating death domain	88.83(n) 93.51(a)	534306 XM_001252418.1 XP_001252419.1
rat (Rattus norvegicus)	Madd¹	--	MAP-kinase activating death domain	89.31(n) 95.57(a)	94193 NM_053585.1 NP_446037.1
mouse (Mus musculus)	Madd^{1, 5}	2⁵	MAP-kinase activating death domain^{1, 5}	89.45(n)¹ 95.5(a)¹	228355¹ NM_145527.3¹ NP_663502.3¹ AA982471⁵ AK035777⁵ (see all 25)
chicken (Gallus gallus)	MADD¹	--	MAP-kinase activating death domain	76.57(n) 85.06(a)	423184 XM_421109.2 XP_421109.2

About this table Species with no ortholog for MADD

ENSEMBL Gene Tree for MADD

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/326 NCBI SNPs in MADD are shown (see all 326 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 159)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1449627^1,2	A,C,F,H	47247560(+)	`CTTGGT/GTTTTC`	8	--	ng5¹ ut5¹ trp³		7	MN EA EU WA	948
	rs1051006^1,2	A,C,F,H	47263161(+)	`CGAACG/ATGGAC`	10	M/V	mis¹ ese³		16	EA NA EU WA	2896
	rs10838694^1,2	C,F,H	47308336(+)	`CTAGAG/ACAAGG`	8	--	ng3¹		15	NS EU EA WA	1648
--	rs3736101^1,2	C,F	47263204(-)	`TTCGCC/TGGCGC`	8	R/Q	mis¹ int¹ ese³		5	NA EU EA WA	456
	rs11570126^1,2	F,H	47307826(-)	`CACTGC/TGGGCC`	10	--	ut3¹ ese³		5	NS EU EA WA	594
	rs34534575^1,2	C,F	47302402(-)	`AGTACA/GGCTCC`	10	L/P	mis¹		5	NA EU EA WA	496
	rs1051094^1,2	F	47308101(+)	`GCCCCA/CCATTA`	10	--	ut3¹		1	MN	184
	rs326215^1,2	C	47247676(+)	`TCCTGC/AGGCGG`	8	--	ng5¹ ut5¹ ese³		1	MN	184
	rs3021055^1,2	C	47307896(-)	`AAGGCG/ATGGCA`	10	--	ut3¹		1	NS	176
	rs11570125^1,2	H	47307875(-)	`AATTCG/ACCGCT`	10	--	ut3¹ ese³		5	NS EU EA WA	596

About this table

HapMap Linkage Disequilibrium images for MADD (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603584

3 Novoseek disease relationships for MADD gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	41.94	12	11577081 (2), 19289468 (2), 17314102 (1), 14695193 (1) (see all 7)
cancer	30.63	14	12410563 (3), 17314102 (2), 16682944 (2), 19289468 (2) (see all 6)
tumors	27.00	20	19190106 (3), 11577081 (2), 14695193 (2), 19289468 (2) (see all 9)

About this table

Human Genome Epidemiology Navigator: MADD (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/36 PubMed articles for MADD gene (see all 36 ):

The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22. (PubMed id 9796103)^{1, 2, 3, 4} Chow V.T....Lim D. (1998)
MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase. (PubMed id 9115275)^{2, 3, 4} Schievella A.R.... Lin L.-L. (1997)
IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs. (PubMed id 14716293)^{1, 3, 4} Efimova E.V.... Prabhakar B.S. (2004)
Contrasting effects of IG20 and its splice isoforms, MADD and DENN- SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3. (PubMed id 11577081)^{1, 3, 4} Al-Zoubi A.M.... Prabhakar B.S. (2001)
Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle. (PubMed id 14735464)^{3, 4} Lim K.M.... Chow V.T.K. (2004)
Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. (PubMed id 15007167)^{3, 4} Del Villar K. and Miller C.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{3, 4} Nagase T....Ohara O. (1997)
DENN, a novel human gene differentially expressed in normal and neoplastic cells. (PubMed id 8988362)^{3, 4} Chow V.T.K. and Lee S.S. (1996)
IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth. (PubMed id 14695193)^{1, 3} Efimova E....Prabhakar B.S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8567	HGNC: 6766	AceView: MADD	Ensembl:ENSG00000110514	euGenes: HUgn8567
ECgene: MADD	H-InvDB: MADD

(According to HUGE)
About This Section

HUGE: KIAA0358

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MADD	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MADD
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MADD:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MADD-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MADD		Antibodies for MADD
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MADD		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (MADD)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for MADD

Search Tocris compounds for MADD

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for MADD

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MADD Gene at Home site.
Version 2.41.1
server5.xennexinc.com

MADD Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for MADD

Summaries
for MADD

Genomic Location
for MADD

Proteins
for MADD

Protein Domains/
Families
for MADD

Gene Function
for MADD

Pathways & Interactions
for MADD

Drugs & Compounds
for MADD

Transcripts
for MADD

Expression
for MADD

Orthologs
for MADD

Paralogs
for MADD

SNPs/Variants
for MADD

Disorders & Mutations
for MADD

Medical News
for MADD

Publications
for MADD

Search for MADD

Genome Databases showing MADD

Other Databases showing MADD

Specialized Databases showing MADD

Licensable Technologies
for MADD

Services
for MADD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MADD Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor MADD

Summariesfor MADD

Genomic Locationfor MADD

Proteinsfor MADD

Protein Domains/Familiesfor MADD

Gene Functionfor MADD

Pathways & Interactionsfor MADD

Drugs & Compoundsfor MADD

Transcriptsfor MADD

Expression for MADD

Orthologsfor MADD

Paralogsfor MADD

SNPs/Variantsfor MADD

Disorders & Mutationsfor MADD

Medical Newsfor MADD

Publicationsfor MADD

Search for MADD

Genome Databases showing MADD

Other Databases showing MADD

Specialized Databases showing MADD

Licensable Technologiesfor MADD

Servicesfor MADD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MADD

Summaries
for MADD

Genomic Location
for MADD

Proteins
for MADD

Protein Domains/
Families
for MADD

Gene Function
for MADD

Pathways & Interactions
for MADD

Drugs & Compounds
for MADD

Transcripts
for MADD

Expression
for MADD

Orthologs
for MADD

Paralogs
for MADD

SNPs/Variants
for MADD

Disorders & Mutations
for MADD

Medical News
for MADD

Publications
for MADD

Licensable Technologies
for MADD

Services
for MADD