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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MADD Gene

protein-coding   GIFtS: 63
GCID: GC11P047290

MAP-Kinase Activating Death Domain

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MAP-Kinase Activating Death Domain1 2     Rab3 GDP/GTP Exchange Factor2 3
DENN2 3 5     RAB3GEP2
Differentially Expressed In Normal And Neoplastic Cells2 3     MAP Kinase-Activating Death Domain Protein2
Insulinoma Glucagonoma Clone 202 3     KIAA03583
IG202 3     

External Ids:    HGNC: 67661   Entrez Gene: 85672   Ensembl: ENSG000001105147   OMIM: 6035845   UniProtKB: Q8WXG63   

Export aliases for MADD gene to outside databases

Previous GC identifers: GC11P049230 GC11P048168 GC11P047322 GC11P047255 GC11P047247 GC11P046990


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MADD Gene:
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells
targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins.
The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death
domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic
signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several
transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MADD Gene: 
MADD (MAP-kinase activating death domain) is a protein-coding gene. Diseases associated with MADD include glucagonoma, and insulinoma, and among its related super-pathways are DR3 Signaling and Apoptosis and survival Caspase cascade. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity and death receptor binding.

UniProtKB/Swiss-Prot: MADD_HUMAN, Q8WXG6
Function: Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA
splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive
form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD
links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death
(TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is
resistant and isoform 3 and isoform 4 have no effect

Gene Wiki entry for MADD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MADD gene promoter:
         AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MADD promoter sequence
   Search SABiosciences Chromatin IP Primers for MADD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MADD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

MADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MADD gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P047290:  view genomic region     (about GC identifiers)

Start:
47,290,712 bp from pter      End:
47,351,582 bp from pter
Size:
60,871 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MADD_HUMAN, Q8WXG6 (See protein sequence)
Recommended Name: MAP kinase-activating death domain protein  
Size: 1647 amino acids; 183303 Da
Subunit: Interacts with the death domain of TNFRSF1A through its own death domain
Subcellular location: Membrane. Cytoplasm
Miscellaneous: Overexpression of MADD activates the mitogen-activated protein (MAP) kinase extracellular
signal-regulated kinase (ERK). Expression of the MADD death domain stimulates both the ERK and c-JUN N-terminal
kinase MAP kinases and induces the phosphorylation of cytosolic phospholipase A2
Sequence caution: Sequence=BAA20814.2; Type=Erroneous initiation;
Secondary accessions: A8K8S7 B5MEE5 D3DQR4 O15065 O15293 Q15732 Q15741 Q8IWD7 Q8WXG3 Q8WXG4
Q8WXG5 Q8WZ63
Alternative splicing: 8 isoforms:  Q8WXG6-1   Q8WXG6-2   Q8WXG6-3   Q8WXG6-4   Q8WXG6-5   Q8WXG6-6   Q8WXG6-7   Q8WXG6-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MADD: NX_Q8WXG6

Explore proteomics data for MADD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WXG6

  • MADD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MADD Protein Expression
    REFSEQ proteins (10 alternative transcripts): 
    NP_001129415.1  NP_001129416.1  NP_003673.3  NP_569826.2  NP_569827.2  NP_569828.2  NP_569829.2  NP_569830.2  
    NP_569831.1  NP_569832.2  

    ENSEMBL proteins: 
     ENSP00000388255   ENSP00000343902   ENSP00000398167   ENSP00000385585   ENSP00000384435  
     ENSP00000304505   ENSP00000310933   ENSP00000384204   ENSP00000378753   ENSP00000413116  
     ENSP00000378745   ENSP00000384287   ENSP00000402364   ENSP00000384483  

    Human Recombinant Protein Products for MADD: 
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    Novus Biologicals MADD Protein
    Novus Biologicals MADD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MADD 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA--
    GO:0016021integral to membrane IDA8988362

    MADD for ontologies           About GeneDecksing



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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MADD 
    Cloud-Clone Corp. CLIAs for MADD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DENND: DENN/MADD domain containing

    3 InterPro protein domains:
     IPR005112 dDENN_dom
     IPR005113 uDENN_dom
     IPR001194 DENN_dom

    Graphical View of Domain Structure for InterPro Entry Q8WXG6

    ProtoNet protein and cluster: Q8WXG6

    UniProtKB/Swiss-Prot: MADD_HUMAN, Q8WXG6
    Similarity: Belongs to the MADD family
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 death domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 uDENN domain


    MADD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MADD_HUMAN, Q8WXG6
    Function: Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA
    splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive
    form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD
    links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death
    (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is
    resistant and isoform 3 and isoform 4 have no effect

         Genatlas biochemistry entry for MADD:
    Map kinase-activating death domain protein homolog and similar to C elegans AEX3,differentially expressed in
    normal and neoplastic cell,linkingTNFR1 with MAP kinase activation and arachidonic acid release and provide
    further insight into the mechanisms by which TNF exerts its pleiotropic effects

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005123death receptor binding TAS9115275
    GO:0005515protein binding IPI16273344
    GO:0017112Rab guanyl-nucleotide exchange factor activity IMP9115275
    GO:0030295protein kinase activator activity TAS9115275
         
    MADD for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Madd):
     behavior/neurological  integument  mortality/aging  nervous system  respiratory system 

    MADD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Maddtm1Ytk for MADD

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MADD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MADD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MADD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MADD 

    miRNA
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    hsa-miR-3678-3p hsa-miR-181c hsa-miR-3166 hsa-miR-1197 hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidMADD 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MADD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MADD About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TNFR1 Pathway0.56
    TNF Signaling0.55
    2Apoptosis and survival Caspase cascade
    Caspase cascade in apoptosis0.42
    3TRAF Pathway
    TRAF Pathway0.42
    4Apoptosis Modulation and Signaling
    Apoptosis Modulation and Signaling0.38
    5TNF receptor signaling pathway
    TNF receptor signaling pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MADD
        TNF Signaling
    TRAF Pathway
    TNFR1 Pathway

    5 BioSystems Pathways for MADD
        Apoptosis Modulation and Signaling
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Ceramide signaling pathway
    TNF receptor signaling pathway
    Caspase cascade in apoptosis


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MADD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/18 Interacting proteins for MADD (Q8WXG61, 3 ENSP000003109334) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRNQ168491, 3, ENSP000002957184EBI-310528,EBI-728153 I2D: score=3 STRING: ENSP00000295718
    VPS13DQ5THJ43, ENSP000003508544I2D: score=2 STRING: ENSP00000350854
    NPDC1Q9NQX53, ENSP000003606604I2D: score=1 STRING: ENSP00000360660
    PIDDQ9HB753, ENSP000003377974I2D: score=2 STRING: ENSP00000337797
    TNFRSF10AO002203, ENSP000002211324I2D: score=1 STRING: ENSP00000221132
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IMP9115275
    GO:0007166cell surface receptor signaling pathway TAS9115275
    GO:0032483regulation of Rab protein signal transduction IDA--
    GO:0042981regulation of apoptotic process IMP11577081
    GO:0051726regulation of cell cycle IMP14735464

    MADD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MADD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MADD

    2 HMDB Compounds for MADD    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    4 Novoseek inferred chemical compound relationships for MADD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 66.9 4 12410563 (1), 11563850 (1), 15464446 (1), 9796103 (1)
    gtp 56.4 4 12410563 (1), 11563850 (1), 15464446 (1), 9796103 (1)
    vinblastine 46.1 1 14695193 (1)
    etoposide 31.8 1 14695193 (1)

    Search CenterWatch for drugs/clinical trials and news about MADD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MADD gene (10 alternative transcripts): 
    NM_001135943.1  NM_001135944.1  NM_003682.3  NM_130470.2  NM_130471.2  NM_130472.2  NM_130473.2  NM_130474.2  
    NM_130475.2  NM_130476.2  

    Unigene Cluster for MADD:

    MAP-kinase activating death domain
    Hs.82548  [show with all ESTs]
    Unigene Representative Sequence: NM_003682
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000453571 ENST00000342922(uc001neq.2) ENST00000428807 ENST00000402799(uc009yln.1 uc001neu.1)
    ENST00000406482(uc001nev.1) ENST00000349238(uc001net.1) ENST00000311027(uc001ner.1)
    ENST00000407859(uc001nes.1) ENST00000534808 ENST00000395344 ENST00000444117
    ENST00000395336(uc001nex.2) ENST00000526603 ENST00000402192(uc001nez.2 uc001new.2)
    ENST00000422579 ENST00000489415 ENST00000524530 ENST00000524686

    miRNA
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    hsa-miR-3678-3p hsa-miR-181c hsa-miR-3166 hsa-miR-1197 hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB002356.1 AF440100.1 AF440101.1 AF440102.1 AF440103.1 AF440434.1 AK292442.1 BC040484.1 
    U44953.1 U77352.1 

    20 DOTS entries:

    DT.95196710  DT.100824108  DT.95196696  DT.95196704  DT.91680541  DT.95196665  DT.75126953  DT.100029601 
    DT.100824110  DT.100824109  DT.100646688  DT.87015779  DT.120754723  DT.40213898  DT.120754703  DT.120754733 
    DT.120754744  DT.91894316  DT.97848210  DT.91739600 

    24/268 AceView cDNA sequences (see all 268):

    CB115976 CD242691 AU130871 NM_130474 BM757184 CA487563 NM_130473 AB002356 
    AL041084 BM743699 CB130946 AA771933 CA435662 NM_130472 AA731365 BQ216930 
    BQ640625 AX747807 AA376927 NM_130476 BM547742 CD722967 BM699383 BQ434951 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for MADD (see all 21)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:              -     -     -     -     -                                               -                                                                     
    SP2:                                      -                                               -                                                                     
    SP3:              -     -     -     -     -                                               -                                                                 -   
    SP4:              -     -     -     -     -                                               -                                                                     
    SP5:        -     -     -     -     -     -                                               -                                                                     

    ExUns: 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c · 23d ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^
    SP1:  -                                                                                                                                                         
    SP2:  -                                                                                                                                                         
    SP3:  -                                                                       -                                         -                                       
    SP4:  -                                                                       -                                         -                                       
    SP5:  -                 -                                                     -                                         -                                       

    ExUns: 37 ^ 38a · 38b ^ 39a · 39b ^ 40a · 40b
    SP1:              -     -                     
    SP2:        -     -     -                     
    SP3:              -     -                     
    SP4:              -     -                     
    SP5:              -     -                     


    ECgene alternative splicing isoforms for MADD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MADD expression in normal human tissues (normalized intensities)      MADD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGGGCGCC
    MADD Expression
    About this image


    MADD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             cerebellum   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Neural Crest (Sensory Organs)
             sensory organ/nose/vomeronasal organ   

    See MADD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MADD

    SOURCE GeneReport for Unigene cluster: Hs.82548

    UniProtKB/Swiss-Prot: MADD_HUMAN, Q8WXG6
    Tissue specificity: Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is
    constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including MADD: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MADD gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Madd1 , 5 MAP-kinase activating death domain1, 5 89.74(n)1
    95.81(a)1
      2 (50.46 cM)5
    2283551  NM_001177720.11  NP_001171191.11 
     911373605 
    chicken
    (Gallus gallus)
    Aves MADD1 MAP-kinase activating death domain 76.57(n)
    85.18(a)
      423184  XM_421109.3  XP_421109.3 
    lizard
    (Anolis carolinensis)
    Reptilia MADD6
    MAP-kinase activating death domain
    82(a)
    1 ↔ 1
    1(43825831-43891618)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16132 Xenopus laevis transcribed sequence with moderate similarity more 77.37(n)    CD255867.1 
    zebrafish
    (Danio rerio)
    Actinopterygii madd1 MAP-kinase activating death domain 70.14(n)
    75.62(a)
      100150917  XM_001923953.3  XP_001923988.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta rab3-GEF1 , 3 neurotransmitter secretion RAB
    guanyl-nucleotide more3
    CG5627-PC1
    41(a)3
    52.73(n)1
    50(a)1
      324421  NM_001103513.21  NP_001096983.21 
    worm
    (Caenorhabditis elegans)
    Secernentea aex-31 , 3 Expression: neurons3
    Protein AEX-31
    41(a)3
    51.85(n)1
    47.36(a)1
      X(786832-795009)3
    1804201  NM_171618.21  NP_741710.11 


    ENSEMBL Gene Tree for MADD (if available)
    TreeFam Gene Tree for MADD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MADD gene
    3 SIMAP similar genes for MADD using alignment to 6 protein entries:     MADD_HUMAN (see all proteins):
    DENN    DENND5B    DENND3

    MADD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1515 SNPs in MADD are shown (see all 1515)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429600701,2
    C--46990794(+) CCGGT-/GGGGGT 10 -- int10--------
    rs2010729071,2
    C--46992257(+) AATTC-/TTTTTT 10 -- int10--------
    rs113188341,2
    C--46993868(+) CTACA-/T/TT  
            
    TTTTT
    10 -- int1 trp32NA CSA 4
    rs1504788001,2
    C--46993869(+) CTACA-/TTTTTTT 10 -- int10--------
    rs802702791,2
    C--46993879(+) TTTTTC/TTCTTG 10 -- int11Minor allele frequency- T:0.00NA 2
    rs1130123341,2
    C--47015671(+) TTTTTT/-GAGAC 10 -- int11Minor allele frequency- -:0.00CSA 2
    rs1490259051,2
    --47020238(+) TAGGG-/CT    
       TTTTT
    TTTTT
    10 -- int10--------
    rs1414737741,2
    --47020276(+) AACCA-/CCAC  
      CTCCCG
    GGCTC
    10 -- int10--------
    rs355949041,2
    C--47021114(+) CGCCC-/TGCCCC 10 -- int10--------
    rs1382263731,2
    C--47021596(+) TTTTT-/TGTTTT 10 -- int10--------

    HapMap Linkage Disequilibrium report for MADD (47290712 - 47351582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MADD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897323CNV Loss21882294
    nsv832141CNV Loss17160897
    nsv825870CNV Gain20364138


    Human Gene Mutation Database (HGMD): MADD
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MADD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603584    OMIM disorders: --

    15 diseases for MADD:    About MalaCards
    glucagonoma    insulinoma    brown-vialetto-van laere syndrome    diastolic heart failure
    thyroid cancer    coronary heart disease    lung adenocarcinoma    thyroiditis
    neuroblastoma    hepatitis b    alzheimer's disease    hepatitis
    adenocarcinoma    leukemia    neuronitis


    MADD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for MADD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 41 14 11577081 (2), 19289468 (2), 17314102 (1), 14695193 (1) (see all 7)
    cancer 29.2 16 12410563 (3), 17314102 (2), 16682944 (2), 19289468 (2) (see all 6)
    tumors 25.9 22 19190106 (3), 11577081 (2), 14695193 (2), 19289468 (2) (see all 9)

    Genetic Association Database (GAD): MADD
    Human Genome Epidemiology (HuGE) Navigator: MADD (19 documents)

    Export disorders for MADD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MADD gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with MADD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22. (PubMed id 9796103)1, 2, 3, 9 Chow V.T.K.... Lim D. (1998)
    2. MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase. (PubMed id 9115275)1, 2, 3 Schievella A.R.... Lin L.-L. (1997)
    3. IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs. (PubMed id 14716293)1, 2, 9 Efimova E.V.... Prabhakar B.S. (2004)
    4. Contrasting effects of IG20 and its splice isoforms, MADD and DENN- SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3. (PubMed id 11577081)1, 2, 9 Al-Zoubi A.M.... Prabhakar B.S. (2001)
    5. Genome-wide association identifies nine common variant s associated with fasting proinsulin levels and provides new insights into the p athophysiology of type 2 diabetes. (PubMed id 21873549)1, 4 Strawbridge R.J....Florez J.C. (2011)
    6. Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (2010)
    7. New genetic loci implicated in fasting glucose homeos tasis and their impact on type 2 diabetes risk. (PubMed id 20081858)1, 4 Dupuis J....Zillikens M.C. (2010)
    8. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B lo ci are associated with reduced glucose-stimulated beta cell function in middle- aged Danish people. (PubMed id 20419449)1, 4 Boesgaard T.W....Borch-Johnsen K. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PubMed id 19060911)1, 4 Aulchenko Y.S....Peltonen L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8567 HGNC: 6766 AceView: MADD Ensembl:ENSG00000110514 euGenes: HUgn8567
    ECgene: MADD H-InvDB: MADD

    (According to HUGE)
    About This Section
    HUGE: KIAA0358

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MADD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MADD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MADD gene:
    Search GeneIP for patents involving MADD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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