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MADCAM1 Gene

protein-coding   GIFtS: 56
GCID: GC19P000499

Mucosal Vascular Addressin Cell Adhesion Molecule 1

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mucosal Vascular Addressin Cell Adhesion Molecule 11 2
Mucosal Addressin Cell Adhesion Molecule-11 2
MAdCAM-12 3
hMAdCAM-12 3
MACAM12 5
Mucosal Addressin Cell Adhesion Molecule 12

External Ids:    HGNC: 67651   Entrez Gene: 81742   Ensembl: ENSG000000998667   OMIM: 1026705   UniProtKB: Q134773   
ORGUL members:         

Export aliases for MADCAM1 gene to outside databases

Previous GC identifers: GC19P000507 GC19P000531 GC19P000436 GC19P000448 GC19P000449 GC19P000450 GC19P000266


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MADCAM1 Gene:
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the
leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct
leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1
and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found
for this gene, but the full-length nature of some variants has not been determined. (provided by RefSeq, Jul
2008)

GeneCards Summary for MADCAM1 Gene:
MADCAM1 (mucosal vascular addressin cell adhesion molecule 1) is a protein-coding gene. Diseases associated with MADCAM1 include malt lymphoma, and cholangitis.

UniProtKB/Swiss-Prot: MADCA_HUMAN, Q13477
Function: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into
mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin
alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the
mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening,
independent of L-selectin binding

Gene Wiki entry for MADCAM1 (Addressin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the MADCAM1 gene promoter:
         Tal-1   COUP   Tal-1beta   E47   POU2F1   COUP-TF   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMADCAM1 promoter sequence
   Search Chromatin IP Primers for MADCAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MADCAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MADCAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MADCAM1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000499:  view genomic region     (about GC identifiers)

Start:
489,176 bp from pter      End:
505,347 bp from pter
Size:
16,172 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MADCA_HUMAN, Q13477 (See protein sequence)
Recommended Name: Mucosal addressin cell adhesion molecule 1 precursor  
Size: 382 amino acids; 40155 Da
Subunit: Homodimer (Probable)
6 PDB 3D structures from and Proteopedia for MADCAM1:
1BQS (3D)        1GSM (3D)        4HBQ (3D)        4HC1 (3D)        4HCR (3D)        4HD9 (3D)    
Secondary accessions: A5PKV4 B2RPL9 O60222 O75867 Q5UGI7
Alternative splicing: 4 isoforms:  Q13477-1   Q13477-2   Q13477-3   Q13477-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MADCAM1: NX_Q13477

Explore proteomics data for MADCAM1 at MOPED

Post-translational modifications: 

  • The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation (By similarity)1
  • Glycosylation2 at Asn83

  • See MADCAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_570116.2  NP_570118.1  

    ENSEMBL proteins: 
     ENSP00000475575   ENSP00000304247   ENSP00000215637   ENSP00000372130  
    Reactome Protein details: Q13477

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR015169 Adhes-Ig-like
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q13477

    ProtoNet protein and cluster: Q13477

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: MADCA_HUMAN, Q13477
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    MADCAM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MADCA_HUMAN, Q13477
    Function: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into
    mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin
    alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the
    mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening,
    independent of L-selectin binding

         Genatlas biochemistry entry for MADCAM1:
    mucosal vascular addressin cell adhesion molecule 1,ligand for leukocyte B7 integrin (LPAM-1) L selectin,VLA-4 on
    myeloid cells,with two alternatively spliced forms,homing leukocytes to mucosal inflammed tissues

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MADCAM1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Madcam1):
     hematopoietic system  immune system  no phenotypic analysis 

    MADCAM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Madcam1tm1.2Nwag for MADCAM1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MADCAM1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MADCA_HUMAN, Q13477: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS8502297
    GO:0016021integral component of membrane IEA--

    MADCAM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MADCAM1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Paxillin-dependent events mediated by a4b1
    Paxillin-independent events mediated by a4b1 and a4b70.58
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Allograft rejection
    Intestinal immune network for IgA production0.41
    4Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    5Integrin cell surface interactions
    Integrin cell surface interactions

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MADCAM1
        Paxillin-independent events mediated by a4b1 and a4b7

    2 Reactome Pathways for MADCAM1
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    2 Kegg Pathways  (Kegg details for MADCAM1):
        Cell adhesion molecules (CAMs)
    Intestinal immune network for IgA production


    MADCAM1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MADCAM1
    Interactions:

        GeneGlobe Interaction Network for MADCAM1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MADCAM1 (Q134773 ENSP000002156374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB7P260103, ENSP000002670824I2D: score=1 STRING: ENSP00000267082
    SELLENSP000002361474STRING: ENSP00000236147
    CD44ENSP000002783854STRING: ENSP00000278385
    ITGA4ENSP000003802274STRING: ENSP00000380227
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0006955immune response TAS8502297
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS8502297
    GO:0007568aging IEA--

    MADCAM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MADCAM1 (MADCA)

    9 Novoseek inferred chemical compound relationships for MADCAM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    natalizumab 58.3 1 19707360 (1)
    tripeptide 34.8 2 9873398 (1), 11573247 (1)
    5 aminosalicylic acid 26.8 3 11472325 (2)
    rantes 26.6 1 12537753 (1)
    carbohydrates 8.22 8 19067429 (5), 7650378 (1), 8609404 (1)
    manganese 0.706 3 7512373 (2), 12699089 (1)
    nitric oxide 0 1 11481030 (1)
    sulfate 0 1 9466573 (1)
    aspartate 0 2 9655832 (1), 9700512 (1)



    MADCAM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MADCAM1 gene (2 alternative transcripts): 
    NM_130760.2  NM_130762.2  

    Unigene Cluster for MADCAM1:

    Mucosal vascular addressin cell adhesion molecule 1
    Hs.102598  [show with all ESTs]
    Unigene Representative Sequence: AK092211
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587541 ENST00000346144(uc002lot.3 uc010drq.3) ENST00000215637(uc002los.3)
    ENST00000382683

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      QuantiFast Probe-based Assays in human, mouse, rat MADCAM1

    Additional mRNA sequence: 

    AK092211.1 AY732484.1 AY819760.1 BC136408.1 BC137506.1 BC137507.1 BC142629.1 BC144065.1 
    DQ076657.1 U43628.1 U82483.1 

    4 DOTS entries:

    DT.409211  DT.92360074  DT.99932820  DT.99965995 

    18 AceView cDNA sequences:

    NM_130762 BI821776 AA928768 BM702750 NM_130760 AI131233 U82483 AA678836 
    AW340299 U43628 AK092211 AA705935 NM_130761 AA668527 T54621 AW340202 
    T54705 BE173884 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MADCAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCACGTCT
    MADCAM1 Expression
    About this image


    MADCAM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Spleen (Hematopoietic System)
             Spleen
    MADCAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MADCAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.102598

    UniProtKB/Swiss-Prot: MADCA_HUMAN, Q13477
    Tissue specificity: Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the
    small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas
    and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle,
    kidney or peripheral blood leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MADCAM1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Madcam15 mucosal vascular addressin cell adhesion molecule 1   --   10 (39.72 cM) 79664574 
    chicken
    (Gallus gallus)
    Aves MADCAM16
    mucosal vascular addressin cell adhesion molecule ...
    22(a)
    1 ↔ 1
    28(2603716-2606506)


    ENSEMBL Gene Tree for MADCAM1 (if available)
    TreeFam Gene Tree for MADCAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    MADCA_HUMAN, Q13477: The number of repeats in the mucin domain varies between 5 and 8 repeats


    Selected SNPs for MADCAM1 (see all 323)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1181430431,2
    F--494541(+) CCTGGG/TCCCTC 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs96531341,2
    C,F,A--494574(+) CACCCT/CGGGCC 2 -- us2k19Minor allele frequency- C:0.48NA WA CSA EA 368
    rs1854257531,2
    --494629(+) GCCCCC/TCCTCT 2 -- us2k10--------
    rs1454663201,2
    C--494710(+) CCTCCC/TCTAGG 2 -- us2k10--------
    rs1488118751,2
    --494734(+) CCTTTA/GCACCC 2 -- us2k10--------
    rs1894991781,2
    --495324(+) AGCCCC/GGGCAG 2 -- us2k10--------
    rs7585021,2
    C,F,A,H--495600(+) CAGGCC/TTGCTA 2 -- us2k123Minor allele frequency- T:0.31MN NS EA NA CSA WA 2712
    rs1806870511,2
    --495700(+) CCACGA/GCCAGG 2 -- us2k10--------
    rs7585031,2
    C,F,A,H--495722(+) CAGGGG/TGCCTC 2 -- us2k122Minor allele frequency- T:0.28NS EA NA CSA WA 2524
    rs2014527091,2
    --495750(+) CCTGA-/CCCCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MADCAM1 (489176 - 505347 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MADCAM1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509712CNV Insertion20534489
    nsv470101CNV Loss18288195
    nsv910083CNV Loss21882294
    dgv3498n71CNV Loss21882294
    nsv910109CNV Loss21882294
    dgv3506n71CNV Loss21882294
    dgv3507n71CNV Loss21882294
    nsv910102CNV Loss21882294
    nsv910132CNV Loss21882294
    dgv3505n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 102670    OMIM disorders: --

    Selected diseases for MADCAM1 (see all 28):    
    About MalaCards
    malt lymphoma    cholangitis    acquired immunodeficiency syndrome    sclerosing cholangitis
    cholera    adult t-cell leukemia    primary sclerosing cholangitis    hematopoietic stem cell transplantation
    inflammatory bowel disease    crohn's disease    ulcerative colitis    periodontal disease
    celiac disease    endotheliitis    duodenitis    liver disease
    periodontitis    sinusitis    gastritis    encephalomyelitis

    1 disease from the University of Copenhagen DISEASES database for MADCAM1:
    Inflammatory bowel disease

    MADCAM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for MADCAM1 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory bowel diseases 68.6 21 11472325 (5), 10562584 (2), 11343233 (2), 11481030 (1) (see all 9)
    colitis 50 5 16917232 (2), 12625840 (1), 19847949 (1)
    ileitis 45.1 3 16401463 (2), 15699171 (1)
    inflammation 44 20 10661685 (2), 9036954 (2), 16401463 (2), 10562584 (1) (see all 12)
    cholangitis primary sclerosing 41.8 6 11343233 (3), 16750586 (2), 19233184 (1)
    malt lymphoma 40.6 2 11504840 (1), 14669317 (1)
    lymphoma low-grade 38.9 1 11504840 (1)
    lymphoma t-cell 38.7 1 10508262 (1)
    colitis ulcerative 34.7 4 9212736 (1), 19847949 (1), 19067429 (1), 9214052 (1)
    lymphoma 29.7 2 7517418 (1), 7687523 (1)

    Genetic Association Database (GAD): MADCAM1
    Human Genome Epidemiology (HuGE) Navigator: MADCAM1 (2 documents)

    Export disorders for MADCAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MADCAM1 gene, integrated from 10 sources (see all 141):
    (articles sorted by number of sources associating them with MADCAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences. (PubMed id 8609404)1, 2, 3, 9 Shyjan A.M.... Briskin M.J. (J. Immunol. 1996)
    2. Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene. (PubMed id 9162097)1, 2, 3, 9 Leung E.... Krissansen G.W. (Immunogenetics 1997)
    3. The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. (PubMed id 9655832)1, 2, 9 Tan K....Wang J.H. (Structure 1998)
    4. Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. (PubMed id 16750586)1, 4, 9 Bowlus C.L....Boberg K.M. (J. Hepatol. 2006)
    5. A reassessment of the MAdCAM-1 structure and its role in integrin recognition. (PubMed id 11807247)1, 2, 9 Dando J.... Brady R.L. (Acta Crystallogr. D 2002)
    6. Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts. (PubMed id 8989586)1, 2, 9 Leung E....Krissansen G.W. (Immunol. Cell Biol. 1996)
    7. Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation. (PubMed id 19286444)1, 4, 9 Ambruzova Z....Petrek M. (Hum. Immunol. 2009)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. (PubMed id 15483224)1, 9 Ogawa H....Rafiee P. (Am. J. Physiol., Cell Physiol. 2005)
    10. Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1. (PubMed id 9233649)1, 9 Tidswell M....Erle D.J. (J. Immunol. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8174 HGNC: 6765 AceView: MADCAM1 Ensembl:ENSG00000099866 euGenes: HUgn8174
    ECgene: MADCAM1 Kegg: 8174 H-InvDB: MADCAM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MADCAM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MADCAM1 gene:
    Search GeneIP for patents involving MADCAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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