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Aliases for MADCAM1 Gene

Aliases for MADCAM1 Gene

  • Mucosal Vascular Addressin Cell Adhesion Molecule 1 2 3
  • Mucosal Addressin Cell Adhesion Molecule-1 2 3
  • HMAdCAM-1 3 4
  • MAdCAM-1 3 4
  • MACAM1 3 6
  • Mucosal Addressin Cell Adhesion Molecule 1 3

External Ids for MADCAM1 Gene

Previous GeneCards Identifiers for MADCAM1 Gene

  • GC19P000507
  • GC19P000531
  • GC19P000436
  • GC19P000448
  • GC19P000449
  • GC19P000450
  • GC19P000266

Summaries for MADCAM1 Gene

Entrez Gene Summary for MADCAM1 Gene

  • The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for MADCAM1 Gene

MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with MADCAM1 include malt lymphoma and ileitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Degradation of the extracellular matrix.

UniProtKB/Swiss-Prot for MADCAM1 Gene

  • Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding

Gene Wiki entry for MADCAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MADCAM1 Gene

Genomics for MADCAM1 Gene

Regulatory Elements for MADCAM1 Gene

Genomic Location for MADCAM1 Gene

Start:
489,176 bp from pter
End:
505,343 bp from pter
Size:
16,168 bases
Orientation:
Plus strand

Genomic View for MADCAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MADCAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MADCAM1 Gene

Proteins for MADCAM1 Gene

  • Protein details for MADCAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13477-MADCA_HUMAN
    Recommended name:
    Mucosal addressin cell adhesion molecule 1
    Protein Accession:
    Q13477
    Secondary Accessions:
    • A5PKV4
    • B2RPL9
    • O60222
    • O75867
    • Q5UGI7

    Protein attributes for MADCAM1 Gene

    Size:
    382 amino acids
    Molecular mass:
    40155 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for MADCAM1 Gene

    Alternative splice isoforms for MADCAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MADCAM1 Gene

Proteomics data for MADCAM1 Gene at MOPED

Post-translational modifications for MADCAM1 Gene

  • The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
  • Glycosylation at Asn83
  • Modification sites at PhosphoSitePlus

Other Protein References for MADCAM1 Gene

No data available for DME Specific Peptides for MADCAM1 Gene

Domains for MADCAM1 Gene

Gene Families for MADCAM1 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for MADCAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13477

UniProtKB/Swiss-Prot:

MADCA_HUMAN :
  • Q13477
Domain:
  • Contains 2 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with MADCAM1: view

Function for MADCAM1 Gene

Molecular function for MADCAM1 Gene

GENATLAS Biochemistry: mucosal vascular addressin cell adhesion molecule 1,ligand for leukocyte B7 integrin (LPAM-1) L selectin,VLA-4 on myeloid cells,with two alternatively spliced forms,homing leukocytes to mucosal inflammed tissues
UniProtKB/Swiss-Prot Function: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding

Gene Ontology (GO) - Molecular Function for MADCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0098640 integrin binding involved in cell-matrix adhesion IDA 23986478
genes like me logo Genes that share ontologies with MADCAM1: view

Phenotypes for MADCAM1 Gene

genes like me logo Genes that share phenotypes with MADCAM1: view

Animal Models for MADCAM1 Gene

MGI Knock Outs for MADCAM1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MADCAM1 Gene

Localization for MADCAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MADCAM1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MADCAM1 Gene COMPARTMENTS Subcellular localization image for MADCAM1 gene
Compartment Confidence
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for MADCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 8502297
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MADCAM1: view

Pathways for MADCAM1 Gene

genes like me logo Genes that share pathways with MADCAM1: view

Interacting Proteins for MADCAM1 Gene

Gene Ontology (GO) - Biological Process for MADCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006955 immune response TAS 8502297
GO:0007155 cell adhesion TAS 8502297
GO:0007160 cell-matrix adhesion IDA 18308860
GO:0007165 signal transduction TAS 8502297
genes like me logo Genes that share ontologies with MADCAM1: view

Compounds for MADCAM1 Gene

(9) Novoseek inferred chemical compound relationships for MADCAM1 Gene

Compound -log(P) Hits PubMed IDs
natalizumab 58.3 1
tripeptide 34.8 2
5 aminosalicylic acid 26.8 2
rantes 26.6 1
carbohydrates 8.22 7
genes like me logo Genes that share compounds with MADCAM1: view

Transcripts for MADCAM1 Gene

mRNA/cDNA for MADCAM1 Gene

Unigene Clusters for MADCAM1 Gene

Mucosal vascular addressin cell adhesion molecule 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MADCAM1 Gene

No ASD Table

Relevant External Links for MADCAM1 Gene

GeneLoc Exon Structure for
MADCAM1
ECgene alternative splicing isoforms for
MADCAM1

Expression for MADCAM1 Gene

mRNA expression in normal human tissues for MADCAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MADCAM1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MADCAM1 Gene

SOURCE GeneReport for Unigene cluster for MADCAM1 Gene Hs.102598

mRNA Expression by UniProt/SwissProt for MADCAM1 Gene

Q13477-MADCA_HUMAN
Tissue specificity: Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
genes like me logo Genes that share expressions with MADCAM1: view

Orthologs for MADCAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MADCAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MADCAM1 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MADCAM1 36
  • 45 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MADCAM1 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Madcam1 16
Madcam1 36
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MADCAM1 36
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves MADCAM1 36
  • 22 (a)
OneToOne
Species with no ortholog for MADCAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MADCAM1 Gene

ENSEMBL:
Gene Tree for MADCAM1 (if available)
TreeFam:
Gene Tree for MADCAM1 (if available)

Paralogs for MADCAM1 Gene

No data available for Paralogs for MADCAM1 Gene

Variants for MADCAM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MADCAM1 Gene

Q13477-MADCA_HUMAN
The number of repeats in the mucin domain varies between 5 and 8 repeats

Sequence variations from dbSNP and Humsavar for MADCAM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs758502 -- 495,600(+) CAGGC(C/T)TGCTA upstream-variant-2KB
rs758503 -- 495,722(+) CAGGG(G/T)GCCTC upstream-variant-2KB
rs1063736 -- 501,738(+) CTCCC(A/C)GGAGT missense, reference, intron-variant
rs1140822 -- 501,743(+) CGGAG(C/T)CTCCC missense, reference, intron-variant
rs1140823 -- 505,071(+) ctctg(C/T)tcaca utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MADCAM1 Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
dgv3498n71 CNV Loss 21882294
nsv910083 CNV Loss 21882294
dgv3500n71 CNV Loss 21882294
dgv3505n71 CNV Loss 21882294
nsv910102 CNV Loss 21882294
nsv910109 CNV Loss 21882294
nsv509712 CNV Insertion 20534489
nsv470101 CNV Loss 18288195
dgv3506n71 CNV Loss 21882294
dgv3507n71 CNV Loss 21882294
nsv910117 CNV Gain 21882294
nsv910119 CNV Gain 21882294
dgv3508n71 CNV Loss 21882294
esv28250 CNV Gain+Loss 19812545
esv33417 CNV Gain+Loss 17666407
nsv516566 CNV Gain 19592680
nsv910132 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294

Relevant External Links for MADCAM1 Gene

HapMap Linkage Disequilibrium report
MADCAM1

Disorders for MADCAM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for MADCAM1 Gene including...

Search for MADCAM1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MADCAM1 Gene

(16) Novoseek inferred disease relationships for MADCAM1 Gene

Disease -log(P) Hits PubMed IDs
inflammatory bowel diseases 68.6 15
colitis 50 4
ileitis 45.1 3
inflammation 44 15
cholangitis primary sclerosing 41.8 6

Relevant External Links for MADCAM1

Genetic Association Database (GAD)
MADCAM1
Human Genome Epidemiology (HuGE) Navigator
MADCAM1
genes like me logo Genes that share disorders with MADCAM1: view

No data available for UniProtKB/Swiss-Prot for MADCAM1 Gene

Publications for MADCAM1 Gene

  1. Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences. (PMID: 8609404) Shyjan A.M. … Briskin M.J. (J. Immunol. 1996) 2 3 4 23
  2. Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene. (PMID: 9162097) Leung E. … Krissansen G.W. (Immunogenetics 1997) 2 3 4 23
  3. A reassessment of the MAdCAM-1 structure and its role in integrin recognition. (PMID: 11807247) Dando J. … Brady R.L. (Acta Crystallogr. D 2002) 3 4 23
  4. The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. (PMID: 9655832) Tan K. … Wang J.H. (Structure 1998) 3 4 23
  5. Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts. (PMID: 8989586) Leung E. … Krissansen G.W. (Immunol. Cell Biol. 1996) 3 4 23

Products for MADCAM1 Gene

Sources for MADCAM1 Gene

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