MAD2L2 Gene
protein-coding GIFtS: 59
GCID: GC01M011734
|
|
MAD2 mitotic arrest deficient-like 2 (yeast)(Previous names: MAD2 (mitotic arrest deficient, yeast, homolog)-like 2...)
| |
Aliases
for MAD2L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAD2 Mitotic Arrest Deficient-Like 2 (Yeast)1 2 | | HREV71 | | MAD2B1 2 3 5 | | MAD2-Like Protein 22 3 | | REV71 2 3 | | REV7 Homolog2 3 | | POLZ21 2 | | Mitotic Arrest Deficient Homolog-Like 22 | | MAD2 (Mitotic Arrest Deficient, Yeast, Homolog)-Like 21 2 | | Mitotic Spindle Assembly Checkpoint Protein MAD2B2 | | Mitotic Arrest Deficient 2-Like Protein 22 3 | | Polymerase (DNA-Directed), Zeta 2, Accessory Subunit2 |
Export aliases for MAD2L2 gene to outside databasesPrevious GC identifers: GC01M011695 GC01M011578 GC01M011343 GC01M011444 GC01M011668 GC01M010888 |
Summaries
for MAD2L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAD2L2:
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset ofanaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar toMAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MD2L2_HUMAN, Q9UI95Function: Adapter protein able to interact with different proteins and involved in different biological processes.Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserterpolymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNAsynthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May alsoregulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation andactivation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of theanaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated genetranscription and may play a role in epithelial-mesenchymal transdifferentiation
Gene Wiki entry for MAD2L2
|
Genomic Views
for MAD2L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAD2L2 gene promoter:
Bach1 AP-1 ATF-2 c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAD2L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAD2L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36MAD2L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M011734: view genomic region
(about GC identifiers)
Start:
|
11,734,537 bp from pter |
End:
|
11,751,707 bp from pter |
Size:
|
17,171 bases |
Orientation:
|
minus strand |
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Proteins
for MAD2L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MD2L2_HUMAN, Q9UI95 (See
protein sequence)Recommended Name: Mitotic spindle assembly checkpoint protein MAD2B Size: 211 amino acids; 24334 Da
Subunit: Homooligomer (Probable). Interacts with REV1. Interacts with ADAM9. Interacts with CHAMP1. Interacts withREV3L. Interacts with FZR1 (in complex with the anaphase promoting complex APC). Interacts with CDC20; PubMed:11459825could not detect the interaction. Interacts with RAN. Interacts with ELK1; the interaction is direct and recruitsMAD2L2 to ELK1-specific promoters. May interact with the JNK kinases MAPK8 and/or MAPK9 to stimulate ELK1phosphorylation and transcriptional activity upon DNA damage. Interacts with TCF7L2; prevents its binding to promotersand negatively modulates its transcriptional activity. Interacts with YY1AP1. Interacts with S.flexneri protein ipaB;prevents the interaction of MAD2L2 with FZR1 and CDC20 resulting in an activation of the anaphase-promoting complexAPC and a cell cycle arrest. Interacts with PRCC; the interaction is direct. Interacts with POGZ
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm
3 PDB 3D structures from  and Proteopedia  for MAD2L2:3ABD (3D)
3ABE (3D)
3VU7 (3D)
Secondary accessions: B3KNE3 Q5TGW7 Q9UNA7 Q9Y6I6Explore the universe of human proteins at neXtProt for MAD2L2: NX_Q9UI95
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UI95
MAD2L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001120797.1 NP_006332.3
ENSEMBL proteins: ENSP00000235310 ENSP00000365860 ENSP00000365857 ENSP00000365855 ENSP00000365852 ENSP00000411807 ENSP00000400982 ENSP00000365843 ENSP00000365882 Reactome Protein details: Q9UI95
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
MAD2L2 for ontologies About GeneDecksing
MAD2L2 Antibody Products:
Assay Products for MAD2L2: |
Protein
Domains /
Families
for MAD2L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAD2L2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UI95ProtoNet protein and cluster: Q9UI95 1 Blocks protein family: IPB003511 DNA-binding HORMA
UniProtKB/Swiss-Prot: MD2L2_HUMAN, Q9UI95Similarity: Contains 1 HORMA domain |
Function
for MAD2L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MD2L2_HUMAN, Q9UI95Function: Adapter protein able to interact with different proteins and involved in different biological processes.Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserterpolymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNAsynthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May alsoregulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation andactivation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of theanaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated genetranscription and may play a role in epithelial-mesenchymal transdifferentiation Genatlas biochemistry entry for MAD2L2:mitotic arrest deficient protein 2-like 2,yeast homolog,component of the mitotic spindle assembly checkpoint,preventingthe onset of anaphase until all chromosomes are properly aligned at the metaphase plate
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAD2L2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAD2L2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MAD2L2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MAD2L2:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Mad2l2):
MAD2L2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAD2L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translesion synthesis by DNA polymerases bypassing lesion on DNA template | | | 2 | Cell cycle Role of APC in cell cycle regulation | | | 3 | Oocyte meiosis | | | 4 | Cell cycle | | | 5 | Shigellosis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MAD2L2
1  GeneGo (Thomson Reuters) Pathway for MAD2L2
1  BioSystems Pathway for MAD2L2
4 
Reactome Pathways for MAD2L2
5 
Kegg Pathways (Kegg details for MAD2L2):
MAD2L2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAD2L2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/48 Interacting proteins for MAD2L2 (Q9UI951, 2, 3 ENSP000002353104) via UniProtKB, MINT, STRING, and/or I2D (see all 48)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ADAM9 | Q134431, 2, 3 | EBI-77889,EBI-77903 MINT-15197 MINT-15198 I2D:
score=5 | | PRRC2A | P486342, 3, ENSP000003651754 | MINT-62729 MINT-62805 MINT-62631 I2D:
score=5 STRING: ENSP00000365175 | | CHAMP1 | Q96JM32, 3, ENSP000003547304 | MINT-8091847 MINT-8091996 MINT-8092017 I2D:
score=1 STRING: ENSP00000354730 | | CDC27 | P302601, 3 | EBI-77889,EBI-994813 I2D:
score=1 | | REV3L | O606732, 3, ENSP000003516974 | MINT-8385495 MINT-8385803 MINT-8385849 MINT-8385833 MINT-8385442 I2D:
score=3 STRING: ENSP00000351697 |
About this table
Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table
MAD2L2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAD2L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAD2L2
Search CenterWatch for drugs/clinical trials and news about MAD2L2 / MD2L2
|
Transcripts
for MAD2L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAD2L2 gene (2 alternative transcripts): NM_001127325.1 NM_006341.3 Unigene Cluster for MAD2L2: MAD2 mitotic arrest deficient-like 2 (yeast) Hs.19400 [show with all ESTs]Unigene Representative Sequence: AK0943169 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000235310(uc001asp.3 uc009vnc.3 uc001asq.4) ENST00000376672
ENST00000376669 ENST00000376667 ENST00000376664 ENST00000445656 ENST00000456915
ENST00000376655 ENST00000376692
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAD2L2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAD2L2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MAD2L2 (NM_006341) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAD2L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAD2L2 |
Additional cDNA sequence: AF072933.1 AF080398.1 AF139365.1 AF157482.1 AK027327.1 AK094316.1 BC015244.1 8 DOTS entries: DT.443868 DT.86847012 DT.97839435 DT.97845161 DT.97845160 DT.121397208 DT.121397233 DT.91765968 24/198 AceView cDNA sequences (see all 198): BE268098 BM739532 AF157482 BM465188 BQ720995 BG060101 AI346937 BC015244 BM760440 BQ933191 BM847429 BQ959482 BG746845 BM841551 CR626073 AI202349 AU102348 CB117704 F20535 AK094316 BG575420 AI636880 CR604773 BM841256
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAD2L2 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAD2L2
|
Expression
for MAD2L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAD2L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGCCCTGA
About this image
See MAD2L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAD2L2
SOURCE GeneReport for Unigene cluster: Hs.19400
UniProtKB/Swiss-Prot: MD2L2_HUMAN, Q9UI95Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including MAD2L2: | Cell Cycle in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAD2L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAD2L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAD2L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAD2L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAD2L2 |
Orthologs
for MAD2L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MAD2L2 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mad2l21 , 5 |
MAD2 mitotic arrest deficient-like 2 (yeast)5
MAD2 mitotic arrest deficient-like 21 |
89.26(n)1
98.58(a)1 |
|
4 (78.67 cM)5
718901 NM_027985.21 NP_082261.21
1481303845 |
chicken
(Gallus gallus) |
Aves |
MAD2L21 |
MAD2 mitotic arrest deficient-like 2 (yeast) |
82.31(n)
96.68(a) |
|
419493 NM_001025578.1 NP_001020749.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
mad2l2-A2 |
MAD2 mitotic arrest deficient-like 2 (yeast) |
77.83(n) |
|
AJ318530.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.177062 |
Transcribed sequence with moderate similarity to protein more |
76.85(n) |
|
57052403 |
fruit fly
(Drosophila melanogaster) |
Insecta |
rev76 |
rev7 |
27(a) |
1 ↔ 1 |
3R(1414595-1415425) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
REV71 |
mitotic spindle assembly checkpoint protein MAD2B |
43.81(n)
34.02(a) |
|
838228 NM_101522.3 NP_564002.1 |
ENSEMBL Gene Tree for MAD2L2 (if available)
TreeFam Gene Tree for MAD2L2 (if available) |
Paralogs
for MAD2L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MAD2L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAD2L2 (11734537 - 11751707 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAD2L2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAD2L2 |
|
Disorders
/ Diseases
for MAD2L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAD2L2 for disorders About GeneDecksing
OMIM gene information: 604094
OMIM disorders: --
12  diseases for MAD2L2: About MalaCardsrenal cell carcinoma papillary renal cell carcinoma familial renal cell carcinoma familial breast cancer
shigellosis breast cancer hepatocellular carcinoma carcinoma
colon cancer nasopharyngitis prostate cancer prostatitis
4 Novoseek disease relationships for MAD2L2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| colorectal tumors |
49.1 |
1 |
17044027 (1) |
| carcinoma renal cell |
34.1 |
2 |
17333263 (1) |
| cancer |
11.5 |
1 |
17044027 (1) |
| tumors |
3.84 |
17 |
17044027 (3), 17333263 (2), 10660610 (1) |
Human Genome Epidemiology (HuGE) Navigator: MAD2L2 (2 documents)
Export disorders for MAD2L2 gene to outside databases
|
Publications
for MAD2L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAD2L2 gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with MAD2L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of MAD2B and other mitotic spindle checkpoint genes. (PubMed id 10366450)1, 2, 3, 9 Cahill D.P.... Lengauer C. (1999)
- Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. (PubMed id 11485998)1, 2, 9 Murakumo Y.... Takahashi M. (2001)
- Crystal structure of human REV7 in complex with a hum an REV3 fragment and structural implication of the interaction between DNA poly merase zeta and REV1. (PubMed id 20164194)1, 2, 9 Hara K....Sato M. (2010)
- A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. (PubMed id 10660610)1, 2, 9 Murakumo Y....Fishel R. (2000)
- Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. (PubMed id 17541814)1, 2, 9 Li L....Huo K. (2007)
- Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. (PubMed id 11717438)1, 2, 9 Weterman M.A....van Kessel A.G. (2001)
- MAD2B, a novel TCF4-binding protein, modulates TCF4-m ediated epithelial-mesenchymal transdifferentiation. (PubMed id 19443654)1, 2 Hong C.F....Wu C.W. (2009)
- The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle. (PubMed id 19753112)1, 2 Medendorp K....van Kessel A.G. (2009)
- A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. (PubMed id 17719540)1, 2 Iwai H....Sasakawa C. (2007)
- Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. (PubMed id 17296730)1, 2 Zhang L....Sharrocks A.D. (2007)
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External Searches for MAD2L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MAD2L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MAD2L2 gene
(According to HUGE)
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Specialized Databases showing MAD2L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for MAD2L2 gene:
Search GeneIP for patents involving MAD2L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MAD2L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAD2L2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAD2L2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAD2L2 | | | OriGene Protein Over-expression Lysate for MAD2L2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAD2L2 | | OriGene 3'-UTR Clone for MAD2L2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAD2L2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAD2L2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MAD2L2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAD2L2 | | OriGene Custom Protein Services for MAD2L2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAD2L2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAD2L2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAD2L2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAD2L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAD2L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAD2L2 |
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| | | | Search Tocris compounds for MAD2L2 |
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 | | | MAD2L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAD2L2 |
|  |  |  | | | | ThermoFisher Antibodies for MAD2L2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAD2L2 |
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