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Aliases for MAD2L2 Gene

Aliases for MAD2L2 Gene

  • MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) 2 3
  • MAD2B 3 4 6
  • MAD2 (Mitotic Arrest Deficient, Yeast, Homolog)-Like 2 2 3
  • Mitotic Arrest Deficient 2-Like Protein 2 3 4
  • Mitotic Arrest Deficient Homolog-Like 2 2 3
  • MAD2-Like Protein 2 3 4
  • REV7 Homolog 3 4
  • HREV7 3 4
  • REV7 3 4
  • Polymerase (DNA-Directed), Zeta 2, Accessory Subunit 3
  • Mitotic Spindle Assembly Checkpoint Protein MAD2B 3
  • Polymerase (DNA-Directed) 2
  • Accessory Subunit 2
  • Zeta 2 2
  • POLZ2 3

External Ids for MAD2L2 Gene

Summaries for MAD2L2 Gene

Entrez Gene Summary for MAD2L2 Gene

  • The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAD2L2 Gene

MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (Yeast)) is a Protein Coding gene. Diseases associated with MAD2L2 include renal cell carcinoma. Among its related pathways are Salmonella infection (KEGG) and Bacterial invasion of epithelial cells. GO annotations related to this gene include RNA polymerase II activating transcription factor binding and JUN kinase binding.

UniProtKB/Swiss-Prot for MAD2L2 Gene

  • Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

Gene Wiki entry for MAD2L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAD2L2 Gene

Genomics for MAD2L2 Gene

Genomic Location for MAD2L2 Gene

Start:
11,674,480 bp from pter
End:
11,691,650 bp from pter
Size:
17,171 bases
Orientation:
Minus strand

Genomic View for MAD2L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAD2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAD2L2 Gene

Regulatory Elements for MAD2L2 Gene

Proteins for MAD2L2 Gene

  • Protein details for MAD2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI95-MD2L2_HUMAN
    Recommended name:
    Mitotic spindle assembly checkpoint protein MAD2B
    Protein Accession:
    Q9UI95
    Secondary Accessions:
    • B3KNE3
    • Q5TGW7
    • Q9UNA7
    • Q9Y6I6

    Protein attributes for MAD2L2 Gene

    Size:
    211 amino acids
    Molecular mass:
    24334 Da
    Quaternary structure:
    • Homooligomer (Probable). Interacts with REV1. Interacts with ADAM9. Interacts with CHAMP1. Interacts with REV3L. Interacts with FZR1 (in complex with the anaphase promoting complex APC). Interacts with CDC20; PubMed:11459825 could not detect the interaction. Interacts with RAN. Interacts with ELK1; the interaction is direct and recruits MAD2L2 to ELK1-specific promoters. May interact with the JNK kinases MAPK8 and/or MAPK9 to stimulate ELK1 phosphorylation and transcriptional activity upon DNA damage. Interacts with TCF7L2; prevents its binding to promoters and negatively modulates its transcriptional activity. Interacts with YY1AP1. Interacts with S.flexneri protein ipaB; prevents the interaction of MAD2L2 with FZR1 and CDC20 resulting in an activation of the anaphase-promoting complex APC and a cell cycle arrest. Interacts with PRCC; the interaction is direct. Interacts with POGZ.

    Three dimensional structures from OCA and Proteopedia for MAD2L2 Gene

neXtProt entry for MAD2L2 Gene

Proteomics data for MAD2L2 Gene at MOPED

Post-translational modifications for MAD2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys90 and Lys190

Other Protein References for MAD2L2 Gene

No data available for DME Specific Peptides for MAD2L2 Gene

Domains for MAD2L2 Gene

Gene Families for MAD2L2 Gene

HGNC:
  • POL :DNA polymerases

Protein Domains for MAD2L2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAD2L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI95

UniProtKB/Swiss-Prot:

MD2L2_HUMAN
Domain:
  • Contains 1 HORMA domain.:
    • Q9UI95
genes like me logo Genes that share domains with MAD2L2: view

Function for MAD2L2 Gene

Molecular function for MAD2L2 Gene

GENATLAS Biochemistry: mitotic arrest deficient protein 2-like 2,yeast homolog,component of the mitotic spindle assembly checkpoint,preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate
UniProtKB/Swiss-Prot Function: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

Gene Ontology (GO) - Molecular Function for MAD2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 19443654
GO:0005515 protein binding IPI 10527948
GO:0008432 JUN kinase binding IDA 17296730
genes like me logo Genes that share ontologies with MAD2L2: view
genes like me logo Genes that share phenotypes with MAD2L2: view

Animal Models for MAD2L2 Gene

MGI Knock Outs for MAD2L2:

miRNA for MAD2L2 Gene

miRTarBase miRNAs that target MAD2L2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MAD2L2 Gene

Localization for MAD2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAD2L2 Gene

Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAD2L2 Gene COMPARTMENTS Subcellular localization image for MAD2L2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAD2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17541814
GO:0005654 nucleoplasm TAS --
GO:0005680 colocalizes_with anaphase-promoting complex IDA 11459825
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IDA 21063390
genes like me logo Genes that share ontologies with MAD2L2: view

Pathways for MAD2L2 Gene

genes like me logo Genes that share pathways with MAD2L2: view

Pathways by source for MAD2L2 Gene

Gene Ontology (GO) - Biological Process for MAD2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 19443654
GO:0001558 regulation of cell growth IGI 15988022
GO:0006281 DNA repair TAS --
GO:0006302 double-strand break repair IGI 15988022
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MAD2L2: view

Transcripts for MAD2L2 Gene

Unigene Clusters for MAD2L2 Gene

MAD2 mitotic arrest deficient-like 2 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAD2L2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for MAD2L2 Gene

GeneLoc Exon Structure for
MAD2L2
ECgene alternative splicing isoforms for
MAD2L2

Expression for MAD2L2 Gene

mRNA expression in normal human tissues for MAD2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAD2L2 Gene

SOURCE GeneReport for Unigene cluster for MAD2L2 Gene Hs.19400

mRNA Expression by UniProt/SwissProt for MAD2L2 Gene

Q9UI95-MD2L2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with MAD2L2: view

No data available for mRNA differential expression in normal tissues for MAD2L2 Gene

Orthologs for MAD2L2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAD2L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAD2L2 35
  • 99.21 (n)
  • 100 (a)
MAD2L2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAD2L2 35
  • 91.79 (n)
  • 99.05 (a)
MAD2L2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAD2L2 35
  • 90.26 (n)
  • 94.87 (a)
MAD2L2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mad2l2 35
  • 89.26 (n)
  • 98.58 (a)
Mad2l2 16
Mad2l2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAD2L2 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAD2L2 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAD2L2 35
  • 82.31 (n)
  • 96.68 (a)
MAD2L2 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mad2l2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mad2l2 35
  • 77.09 (n)
  • 93.36 (a)
Str.12948 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9617 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17706 35
LOC557968 35
  • 75.83 (n)
  • 84.83 (a)
MAD2L2 (1 of 2) 36
  • 85 (a)
OneToMany
MAD2L2 (2 of 2) 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta rev7 36
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons REV7 35
  • 43.99 (n)
  • 34.54 (a)
Species with no ortholog for MAD2L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAD2L2 Gene

ENSEMBL:
Gene Tree for MAD2L2 (if available)
TreeFam:
Gene Tree for MAD2L2 (if available)

Paralogs for MAD2L2 Gene

No data available for Paralogs for MAD2L2 Gene

Variants for MAD2L2 Gene

Sequence variations from dbSNP and Humsavar for MAD2L2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs746218 -- 11,683,067(+) AGGCA(A/G)TGGCA intron-variant, upstream-variant-2KB
rs878778 -- 11,675,188(+) GAGAC(A/C)AAGGT intron-variant
rs909933 -- 11,683,514(-) CCCCC(A/C)GAGTC intron-variant
rs2143296 -- 11,686,443(-) AAAAA(A/G)GAGCA intron-variant
rs2233004 -- 11,682,017(-) TTTTA(A/G)TAATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAD2L2 Gene

Variant ID Type Subtype PubMed ID
nsv832758 CNV Loss 17160897
nsv871014 CNV Gain 21882294

Relevant External Links for MAD2L2 Gene

HapMap Linkage Disequilibrium report
MAD2L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAD2L2 Gene

Disorders for MAD2L2 Gene

(1) MalaCards Diseases for MAD2L2 Gene

Search for MAD2L2 Gene in MalaCards »

(4) Novoseek inferred disease relationships for MAD2L2 Gene

Disease -log(P) Hits PubMed IDs
colorectal tumors 49.1 1
carcinoma renal cell 34.1 1
cancer 11.5 1
tumors 3.84 6

Relevant External Links for MAD2L2

Genetic Association Database (GAD)
MAD2L2
Human Genome Epidemiology (HuGE) Navigator
MAD2L2
genes like me logo Genes that share disorders with MAD2L2: view

No data available for UniProtKB/Swiss-Prot for MAD2L2 Gene

Publications for MAD2L2 Gene

  1. Characterization of MAD2B and other mitotic spindle checkpoint genes. (PMID: 10366450) Cahill D.P. … Lengauer C. (Genomics 1999) 2 3 4 23
  2. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. (PMID: 10660610) Murakumo Y. … Fishel R. (J. Biol. Chem. 2000) 3 4 23
  3. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. (PMID: 11485998) Murakumo Y. … Takahashi M. (J. Biol. Chem. 2001) 3 4 23
  4. Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. (PMID: 11717438) Weterman M.A. … van Kessel A.G. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  5. Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. (PMID: 17541814) Li L. … Huo K. (Mol. Cell. Biochem. 2007) 3 4 23

Products for MAD2L2 Gene

Sources for MAD2L2 Gene

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