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Aliases for MAD2L1BP Gene

Aliases for MAD2L1BP Gene

  • MAD2L1 Binding Protein 2 3 5
  • Caught By MAD2 Protein 3 4
  • CMT2 3 4
  • KIAA0110 4

External Ids for MAD2L1BP Gene

Previous GeneCards Identifiers for MAD2L1BP Gene

  • GC06P043598
  • GC06P043650
  • GC06P043711
  • GC06P043597
  • GC06P043316

Summaries for MAD2L1BP Gene

Entrez Gene Summary for MAD2L1BP Gene

  • The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAD2L1BP Gene

MAD2L1BP (MAD2L1 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MAD2L1BP Gene

  • May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.

Gene Wiki entry for MAD2L1BP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAD2L1BP Gene

Genomics for MAD2L1BP Gene

Regulatory Elements for MAD2L1BP Gene

Enhancers for MAD2L1BP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAD2L1BP on UCSC Golden Path with GeneCards custom track

Promoters for MAD2L1BP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAD2L1BP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAD2L1BP gene promoter:

Genomic Location for MAD2L1BP Gene

43,629,540 bp from pter
43,640,952 bp from pter
11,413 bases
Plus strand

Genomic View for MAD2L1BP Gene

Genes around MAD2L1BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAD2L1BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAD2L1BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAD2L1BP Gene

Proteins for MAD2L1BP Gene

  • Protein details for MAD2L1BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAD2L1-binding protein
    Protein Accession:
    Secondary Accessions:
    • B4DLV3
    • E9PAT7
    • Q6IBB1

    Protein attributes for MAD2L1BP Gene

    274 amino acids
    Molecular mass:
    31052 Da
    Quaternary structure:
    • Interacts with MAD2L1.
    • Sequence=BAG59665.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAD2L1BP Gene

    Alternative splice isoforms for MAD2L1BP Gene


neXtProt entry for MAD2L1BP Gene

Proteomics data for MAD2L1BP Gene at MOPED

Post-translational modifications for MAD2L1BP Gene

  • Ubiquitination at Lys 95 and Lys 229
  • Modification sites at PhosphoSitePlus

Other Protein References for MAD2L1BP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAD2L1BP Gene

Domains & Families for MAD2L1BP Gene

Protein Domains for MAD2L1BP Gene


Suggested Antigen Peptide Sequences for MAD2L1BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MAD2L1BP family.
  • Belongs to the MAD2L1BP family.
genes like me logo Genes that share domains with MAD2L1BP: view

No data available for Gene Families for MAD2L1BP Gene

Function for MAD2L1BP Gene

Molecular function for MAD2L1BP Gene

UniProtKB/Swiss-Prot Function:
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.

Phenotypes for MAD2L1BP Gene

genes like me logo Genes that share phenotypes with MAD2L1BP: view

Animal Model Products

CRISPR Products

miRNA for MAD2L1BP Gene

miRTarBase miRNAs that target MAD2L1BP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAD2L1BP Gene

Localization for MAD2L1BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAD2L1BP Gene

Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.

Subcellular locations from

Jensen Localization Image for MAD2L1BP Gene COMPARTMENTS Subcellular localization image for MAD2L1BP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MAD2L1BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with MAD2L1BP: view

Pathways & Interactions for MAD2L1BP Gene

SuperPathways for MAD2L1BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAD2L1BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007096 regulation of exit from mitosis IEA,IMP 12456649
genes like me logo Genes that share ontologies with MAD2L1BP: view

No data available for Pathways by source and SIGNOR curated interactions for MAD2L1BP Gene

Drugs & Compounds for MAD2L1BP Gene

No Compound Related Data Available

Transcripts for MAD2L1BP Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MAD2L1BP Gene

No ASD Table

Relevant External Links for MAD2L1BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAD2L1BP Gene

mRNA expression in normal human tissues for MAD2L1BP Gene

Protein differential expression in normal tissues from HIPED for MAD2L1BP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.5) and Lymph node (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAD2L1BP Gene

SOURCE GeneReport for Unigene cluster for MAD2L1BP Gene Hs.122346

genes like me logo Genes that share expression patterns with MAD2L1BP: view

Protein tissue co-expression partners for MAD2L1BP Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAD2L1BP Gene

Orthologs for MAD2L1BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAD2L1BP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAD2L1BP 35
  • 88.2 (n)
  • 85.77 (a)
  • 83 (a)
(Canis familiaris)
Mammalia MAD2L1BP 35
  • 87.59 (n)
  • 87.96 (a)
  • 85 (a)
(Mus musculus)
Mammalia Mad2l1bp 35
  • 81.37 (n)
  • 79.85 (a)
Mad2l1bp 16
Mad2l1bp 36
  • 74 (a)
(Pan troglodytes)
Mammalia MAD2L1BP 35
  • 99.15 (n)
  • 98.91 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mad2l1bp 35
  • 82.45 (n)
  • 82.58 (a)
(Monodelphis domestica)
Mammalia MAD2L1BP 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MAD2L1BP 36
  • 68 (a)
(Gallus gallus)
Aves MAD2L1BP 35
  • 65.28 (n)
  • 64.35 (a)
  • 54 (a)
(Anolis carolinensis)
Reptilia MAD2L1BP 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mad2l1bp 35
  • 61.21 (n)
  • 56.36 (a)
(Danio rerio)
Actinopterygii LOC101886806 35
  • 53.15 (n)
  • 41.47 (a)
  • 26 (a)
Species with no ortholog for MAD2L1BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAD2L1BP Gene

Gene Tree for MAD2L1BP (if available)
Gene Tree for MAD2L1BP (if available)

Paralogs for MAD2L1BP Gene

No data available for Paralogs for MAD2L1BP Gene

Variants for MAD2L1BP Gene

Sequence variations from dbSNP and Humsavar for MAD2L1BP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1214944 -- 43,638,294(+) gcctc(A/G)gcctc intron-variant
rs1214945 -- 43,638,300(+) gcctc(C/T)caaag intron-variant
rs1799726 -- 43,640,828(+) GACAC(A/T)CTATG utr-variant-3-prime
rs1804066 -- 43,640,814(+) AAAAT(A/G)GGTCC utr-variant-3-prime
rs7106 -- 43,640,649(+) CAACT(C/T)TCCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAD2L1BP Gene

Variant ID Type Subtype PubMed ID
nsv5281 CNV Loss 18451855
esv2675471 CNV Deletion 23128226

Variation tolerance for MAD2L1BP Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAD2L1BP Gene

Disorders for MAD2L1BP Gene

Relevant External Links for MAD2L1BP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAD2L1BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAD2L1BP Gene

Publications for MAD2L1BP Gene

  1. Identification of a MAD2-binding protein, CMT2, and its role in mitosis. (PMID: 12456649) Habu T. … Matsumoto T. (EMBO J. 2002) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes. (PMID: 26324890) Miniowitz-Shemtov S. … Hershko A. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MAD2L1BP Gene

Sources for MAD2L1BP Gene