Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MAD2L1BP Gene

protein-coding   GIFtS: 51
GCID: GC06P043597

MAD2L1 Binding Protein

  Search for MAD2L1BP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
MAD2L1 Binding Protein1 2
Caught By MAD2 Protein2 3
CMT22 3
MAD2L1-Binding Protein2
KIAA01103

External Ids:    HGNC: 210591   Entrez Gene: 95872   Ensembl: ENSG000001246887   UniProtKB: Q150133   

Export aliases for MAD2L1BP gene to outside databases

Previous GC identifers: GC06P043598 GC06P043650 GC06P043711 GC06P043316


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MAD2L1BP Gene:
The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1
(MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the
kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate
cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been
observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAD2L1BP Gene:
MAD2L1BP (MAD2L1 binding protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: MD2BP_HUMAN, Q15013
Function: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding
MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex

Gene Wiki entry for MAD2L1BP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAD2L1BP gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAD2L1BP promoter sequence
   Search Chromatin IP Primers for MAD2L1BP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAD2L1BP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

MAD2L1BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAD2L1BP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043597:  view genomic region     (about GC identifiers)

Start:
43,597,277 bp from pter      End:
43,608,689 bp from pter
Size:
11,413 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MD2BP_HUMAN, Q15013 (See protein sequence)
Recommended Name: MAD2L1-binding protein  
Size: 274 amino acids; 31052 Da
Subunit: Interacts with MAD2L1
Developmental stage: During the cell cycle, levels increase and then remain constant until late mitosis after
which they drop
Sequence caution: Sequence=BAG59665.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for MAD2L1BP:
2QYF (3D)    
Secondary accessions: B4DLV3 E9PAT7 Q6IBB1
Alternative splicing: 2 isoforms:  Q15013-1   Q15013-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAD2L1BP: NX_Q15013

Explore proteomics data for MAD2L1BP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys95, Lys229
  • Modification sites at PhosphoSitePlus

  • See MAD2L1BP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001003690.1  NP_055443.1  

    ENSEMBL proteins: 
     ENSP00000410818   ENSP00000361244  

    MAD2L1BP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAD2L1BP
    OriGene Protein Over-expression Lysate for MAD2L1BP
    OriGene MassSpec for MAD2L1BP
    OriGene Custom Protein Services for MAD2L1BP
    GenScript Custom Purified and Recombinant Proteins Services for MAD2L1BP
    Novus Biologicals MAD2L1BP Proteins
    Novus Biologicals MAD2L1BP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAD2L1BP
    Cloud-Clone Corp. Proteins for MAD2L1BP

     
    Search eBioscience for Proteins for MAD2L1BP 

    MAD2L1BP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MAD2L1BP
    OriGene Custom Antibody Services for MAD2L1BP
    Novus Biologicals MAD2L1BP Antibodies
    Abcam antibodies for MAD2L1BP
    Cloud-Clone Corp. Antibodies for MAD2L1BP
    ThermoFisher Antibodies for MAD2L1BP
    LSBio Antibodies in human, mouse, rat for MAD2L1BP

    MAD2L1BP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAD2L1BP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAD2L1BP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAD2L1BP
    Cloud-Clone Corp. CLIAs for MAD2L1BP
    Search eBioscience for ELISAs for MAD2L1BP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR009511 MAD1/Cdc20-bound-Mad2-bd

    Graphical View of Domain Structure for InterPro Entry Q15013

    ProtoNet protein and cluster: Q15013

    UniProtKB/Swiss-Prot: MD2BP_HUMAN, Q15013
    Similarity: Belongs to the MAD2L1BP family


    Find genes that share domains with MAD2L1BP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MD2BP_HUMAN, Q15013
    Function: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding
    MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16169070
         
    Find genes that share ontologies with MAD2L1BP           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAD2L1BP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAD2L1BP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAD2L1BP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAD2L1BP

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAD2L1BP:
    hsa-mir-615-3p (MIRT039833), hsa-mir-151a-5p (MIRT038190)

    Block miRNA regulation of human, mouse, rat MAD2L1BP using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MAD2L1BP:
    hsa-miR-4314 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAD2L1BP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAD2L1BP
    Predesigned siRNA for gene silencing in human, mouse, rat MAD2L1BP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAD2L1BP

    Clone
    Products:
         
    OriGene clones in human, mouse for MAD2L1BP (see all 12)
    OriGene ORF clones in mouse, rat for MAD2L1BP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAD2L1BP (NM_001003690)
    Sino Biological Human cDNA Clone for MAD2L1BP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAD2L1BP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAD2L1BP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAD2L1BP
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAD2L1BP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAD2L1BP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MD2BP_HUMAN, Q15013: Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed
    throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA10942595
    GO:0005819spindle IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with MAD2L1BP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAD2L1BP
    Interactions:

        Search GeneGlobe Interaction Network for MAD2L1BP

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for MAD2L1BP (Q150131, 2, 3 ENSP000004108184) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGOL2Q562F61, 2, 3EBI-712181,EBI-989213 MINT-8211808 MINT-8211761 I2D: score=1 
    KRT15P190122, 3, ENSP000002540434MINT-68374 I2D: score=5 STRING: ENSP00000254043
    KAT5Q929932, 3MINT-64193 I2D: score=5 
    KIAA1377Q9P2H02, 3MINT-64195 I2D: score=5 
    PTNP212462, 3MINT-64189 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007093mitotic cell cycle checkpoint IMP18022368
    GO:0007096regulation of exit from mitosis IMP12456649

    Find genes that share ontologies with MAD2L1BP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAD2L1BP (MD2BP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MAD2L1BP gene (2 alternative transcripts): 
    NM_001003690.1  NM_014628.2  

    Unigene Cluster for MAD2L1BP:

    MAD2L1 binding protein
    Hs.122346  [show with all ESTs]
    Unigene Representative Sequence: NM_001003690
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451025(uc003ovu.3) ENST00000372171(uc003ovv.3) ENST00000508232

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAD2L1BP using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MAD2L1BP:
    hsa-miR-4314 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAD2L1BP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAD2L1BP
    Predesigned siRNA for gene silencing in human, mouse, rat MAD2L1BP
    Clone
    Products:
         
    OriGene clones in human, mouse for MAD2L1BP (see all 12)
    OriGene ORF clones in mouse, rat for MAD2L1BP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAD2L1BP (NM_001003690)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAD2L1BP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAD2L1BP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAD2L1BP
    OriGene qSTAR qPCR primer pairs in human, mouse for MAD2L1BP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAD2L1BP
      QuantiTect SYBR Green Assays in human, mouse, rat MAD2L1BP
      QuantiFast Probe-based Assays in human, mouse, rat MAD2L1BP

    Additional mRNA sequence: 

    BC002904.2 CR456893.1 D14811.1 

    9 DOTS entries:

    DT.101957052  DT.100787342  DT.317149  DT.100787337  DT.100787341  DT.100787338  DT.121405644  DT.121405365 
    DT.95373520 

    Selected AceView cDNA sequences (see all 229):

    BF314371 BM717160 BU185707 CR605087 BM559214 NM_014628 CR601298 AI017834 
    BE254750 BG388904 BM915708 BM800396 BU157165 BQ183719 BX282156 BM558599 
    CR618196 BQ432145 BF941669 AA503234 AI470833 AA828361 BM793738 BM701447 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MAD2L1BP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTGTGAC
    MAD2L1BP Expression
    About this image

    MAD2L1BP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAD2L1BP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.122346
        Custom PCR Arrays for MAD2L1BP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAD2L1BP
    OriGene qSTAR qPCR primer pairs in human, mouse for MAD2L1BP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAD2L1BP
    QuantiTect SYBR Green Assays in human, mouse, rat MAD2L1BP
    QuantiFast Probe-based Assays in human, mouse, rat MAD2L1BP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAD2L1BP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for MAD2L1BP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mad2l1bp1 , 5 MAD2L1 binding protein1, 5 81.37(n)1
    79.85(a)1
      17 (22.88 cM)5
    665911  NM_025649.31  NP_079925.21 
     461473905 
    chicken
    (Gallus gallus)
    Aves MAD2L1BP1 MAD2L1 binding protein 65.28(n)
    64.35(a)
      421448  XM_419498.4  XP_419498.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAD2L1BP6
    MAD2L1 binding protein
    55(a)
    1 ↔ 1
    1(230920800-230926257)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mad2l1bp1 MAD2L1 binding protein 61.21(n)
    56.36(a)
      100486914  XM_002942149.2  XP_002942195.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018868061 MAD2L1-binding protein-like 53.15(n)
    41.47(a)
      101886806  XM_005173022.1  XP_005173079.1 


    ENSEMBL Gene Tree for MAD2L1BP (if available)
    TreeFam Gene Tree for MAD2L1BP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MAD2L1BP (see all 231)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832484931,2
    --43505962(+) TGACCA/GAGAAG 1 -- us2k10--------
    rs1879543371,2
    --43505969(+) GAAGAC/TCTAGG 1 -- us2k10--------
    rs1913127131,2
    --43506018(+) AACAGA/CAAAAC 1 -- us2k10--------
    rs1132560431,2
    C,F--43599061(+) ACTAGG/AGAACT 1 -- int12Minor allele frequency- A:0.14CSA WA 120
    rs1145019601,2
    F--43599086(+) AAGAAG/TGATGA 1 -- int11Minor allele frequency- T:0.02WA 118
    rs69385761,2
    C,A,H--43599394(+) tttttG/Attttt 1 -- int16Minor allele frequency- A:0.17WA CSA NA EA 363
    rs1999056801,2
    C--43599448(+) TTGAA-/CTCCTGGG 1 -- cds10--------
    rs121955471,2
    F,H--43599635(+) TGTTGT/CTGttt 1 -- int14Minor allele frequency- C:0.01NS EA 412
    rs1878460431,2
    --43599760(+) GCCTTC/TTGAGT 1 -- int10--------
    rs1923222381,2
    --43599817(+) TTTTAA/GTAGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MAD2L1BP (43597277 - 43608689 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MAD2L1BP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675471CNV Deletion23128226
    nsv5281CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAD2L1BP
    DNA2.0 Custom Variant and Variant Library Synthesis for MAD2L1BP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MAD2L1BP gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with MAD2L1BP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a MAD2-binding protein, CMT2, and its role in mitosis. (PubMed id 12456649)1, 2, 3, 9 Habu T.... Matsumoto T. (EMBO J. 2002)
    2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. p31comet blocks Mad2 activation through structural mimicry. (PubMed id 18022368)1, 2 Yang M.... Luo X. (Cell 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Role of phosphorylation of Cdc20 in p31(comet)-stimulated disassembly of the mitotic checkpoint complex. (PubMed id 22566641)1 Miniowitz-Shemtov S....Hershko A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Depletion of p31comet protein promotes sensitivity to antimitotic drugs. (PubMed id 22544748)1 Ma H.T....Poon R.Y. (J. Biol. Chem. 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9587 HGNC: 21059 AceView: MAD2L1BP Ensembl:ENSG00000124688 euGenes: HUgn9587
    ECgene: MAD2L1BP H-InvDB: MAD2L1BP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0110

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MAD2L1BP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAD2L1BP gene:
    Search GeneIP for patents involving MAD2L1BP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MAD2L1BP   OriGene RNAi products in human, mouse, rat for MAD2L1BP  
     OriGene qPCR primer pairs and template standards for MAD2L1BP   OriGene Protein Over-expression Lysate for MAD2L1BP  
     OriGene MassSpec something-or-other for MAD2L1BP   OriGene clones in human, mouse for MAD2L1BP  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAD2L1BP   OriGene Purified Protein for MAD2L1BP  
     OriGene ORF clones in mouse, rat for MAD2L1BP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAD2L1BP   OriGene Custom Protein Services for MAD2L1BP  

     
     
     Block miRNA regulation of human, mouse, rat MAD2L1BP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MAD2L1BP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAD2L1BP Predesigned siRNA for gene silencing in human, mouse, rat MAD2L1BP
     QuantiFast Probe-based Assays in human, mouse, rat MAD2L1BP QuantiTect SYBR Green Assays in human, mouse, rat MAD2L1BP
     Custom PCR Arrays for MAD2L1BP Search Chromatin IP Primers for MAD2L1BP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAD2L1BP  Search GeneGlobe Interaction Network for MAD2L1BP
     Regulatory tfbs in MAD2L1BP promoter
     GenScript Custom Purified and Recombinant Proteins Services for MAD2L1BP GenScript cDNA clones with any tag delivered in your preferred vector for MAD2L1BP
     GenScript Custom Assay Services for MAD2L1BP GenScript Custom overexpressing Cell Line Services for MAD2L1BP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MAD2L1BP (MD2BP)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MAD2L1BP
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MAD2L1BP antibodies
     MAD2L1BP proteins
     MAD2L1BP lysates
     Antibodies for MAD2L1BP
     See all of Abcam's Antibodies, Kits and Proteins for MAD2L1BP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MAD2L1BP
     Proteins for MAD2L1BP
     Antibodies for MAD2L1BP
     ELISAs for MAD2L1BP
     CLIAs for MAD2L1BP



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAD2L1BP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAD2L1BP
     SwitchGear 3'UTR luciferase reporter plasmids for MAD2L1BP
     SwitchGear Promoter luciferase reporter plasmids for MAD2L1BP
     ThermoFisher Antibodies for MAD2L1BP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAD2L1BP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAD2L1BP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAD2L1BP
     LSBio Antibodies in human, mouse, rat for MAD2L1BP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MAD2L1BP
      Search eBioscience for proteins for MAD2L1BP
      Search eBioscience for elisas for MAD2L1BP
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAD2L1BP gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4