Aliases for MAD2L1 Gene
External Ids for MAD2L1 Gene
Previous GeneCards Identifiers for MAD2L1 Gene
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAD2L1 Gene
MAD2L1 (Mitotic Arrest Deficient 2 Like 1) is a Protein Coding gene. Among its related pathways are APC-Cdc20 mediated degradation of Nek2A and Amplification of signal from the kinetochores. GO annotations related to this gene include protein homodimerization activity and identical protein binding.
UniProtKB/Swiss-Prot for MAD2L1 Gene
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.