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MAD2L1 Gene

protein-coding GIFtS: 69

GC04M121260

MAD2 mitotic arrest deficient-like 1 (yeast)
(Previous names: MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HSMAD2 ^¹, ²
HsMAD2 ^³
MAD2 ^¹, ², ³

Descriptions
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 ^¹, ²
MAD2 mitotic arrest deficient-like 1 (yeast) ^²
MAD2-like 1 ^², ³
MAD2-like protein 1 ^²
mitotic arrest deficient, yeast, homolog-like 1 ^²

External Ids
HGNC: 6763¹
Entrez Gene: 4085²
UniProtKB: Q13257³
Ensembl: ENSG00000164109⁷

Search outside databases for aliases for MAD2L1 gene

Previous GC identifers: GC04M121738 GC04M121373 GC04M121439 GC04M121338

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAD2L1:

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of

anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to

the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

[provided by RefSeq]

UniProtKB/Swiss-Prot: MD2L1_HUMAN, Q13257

Function: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until

all chromosomes are properly aligned at the metaphase plate. Required for the execution of the

mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the

activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned

at the metaphase plate

Gene Wiki entry for MAD2L1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAD2L1 gene

Entrez Gene cytogenetic band: 4q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q27

MAD2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M121260: (about GC identifiers)

Start:	121,200,037 bp from pter
End:	121,207,411 bp from pter
Size:	7,375 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MD2L1_HUMAN, Q13257 (See protein sequence)

Recommended Name: Mitotic spindle assembly checkpoint protein MAD2A

Size: 205 amino acids; 23510 Da

Subunit: Monomer and homodimer. Heterotetramer with MAD1L1. Formation of a heterotetrameric core

complex containing two molecules each of MAD1L1 and of MAD2L1 promotes binding of another molecule

of MAD2L1 to each MAD2L1, resulting in a heterohexamer. Interacts with CDC20, MAD2L1BP and with

ADAM17/TACE. Dimeric MAD2L1 in the closed conformation interacts with CDC20. Monomeric MAD2L1 in

the open conformation does not interact with CDC20. CDC20 competes with MAD1L1 for MAD2L1 binding.

Interacts with TPR

Subcellular location: Nucleus. Kinetochore. Cytoplasm. Note=Recruited by MAD1L1 to unattached

kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase

PDB structures from and Proteopedia :

1DUJ (3D)

1GO4 (3D)

1KLQ (3D)

1S2H (3D)

2QYF (3D)

2V64 (3D)

2VFX (3D)

Secondary accessions: Q53F56 Q548X9 Q6IRW7

Post-translational modifications:

Phosphorylated on multiple serine residues. The level of phosphorylation varies during the cell

cycle and is highest during mitosis. Phosphorylation abolishes interaction with MAD1L1 and reduces

interaction with CDC20¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002349.1

ENSEMBL proteins:

ENSP00000296509 ENSP00000332295

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for MAD2L1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAD2, Mad2L1)
	Human Recombinant Proteins from Abnova (MAD2L1)

OriGene Purified Recombinant Human Protein: MAD2L1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000776	kinetochore	TAS	8824189
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	EXP	11181178 11285280 11535616 11742988 11804586 12006501

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Antibodies for MAD2L1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for MAD2L1
	R&D Systems Antibodies for MAD2L1
	Antibodies from Abcam (MAD2, Mad2L1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAD2L1)
	Novus Biologicals Antibodies for MAD2L1

Assays for MAD2L1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13257

ProtoNet protein and cluster: Q13257

1 Blocks protein family: IPB003511 DNA-binding HORMA

UniProtKB/Swiss-Prot: MD2L1_HUMAN, Q13257

Domain: The protein has two highly different native conformations, an inactive open conformation

that cannot bind CDC20 and that predominates in cytosolic monomers, and an active closed

conformation. The protein in the closed conformation preferentially dimerizes with another

molecule in the open conformation, but can also form a dimer with a molecule in the closed

conformation. Formation of a heterotetrameric core complex containing two molecules of MAD1L1 and

of MAD2L1 in the closed conformation promotes binding of another molecule of MAD2L1 in the open

conformation and the conversion of the open to the closed form, and thereby promotes interaction

with CDC20

Similarity: Belongs to the MAD2 family

Similarity: Contains 1 HORMA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAD2L1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAD2L1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002358

Applied Biosystems Silencer® siRNAs for MAD2L1

Sigma-Aldrich siRNA for MAD2L1

Sigma-Aldrich shRNA Panels and shRNA for MAD2L1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAD2L1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002358
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002358
untagged cDNA clone in CMV expression vector: NM_002358

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002358

UniProtKB/Swiss-Prot: MD2L1_HUMAN, Q13257

Function: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until

all chromosomes are properly aligned at the metaphase plate. Required for the execution of the

mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the

activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned

at the metaphase plate

Genatlas biochemistry entry for MAD2L1:

mitotic arrest deficient protein 2-like 1,yeast homolog in the 5q-syndrome region,involved in the

cell cycle control at mitotic spindle assembly checkpoint,preventing the onset of anaphase until

all chromosomes are properly aligned at the metaphase plate

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mad2l1):

cellular	embryogenesis	growth/size	hematopoietic system	immune system
lethality-prenatal/perinatal	tumorigenesis

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	10527948 17353931 18022367 18022368 18692475

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MAD2L1

5/150 Interacting proteins for MAD2L1 (Q13257^{1, 2} ENSP00000296509³) via UniProtKB, MINT, and/or STRING (see all 150 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAD1L1	Q9Y6D9¹, ENSP00000265854³	EBI-78203, EBI-742610 STRING (score=.998)
MAD2L1BP	Q15013¹, ENSP00000361246³	EBI-78203, EBI-712181 STRING (score=.987)
CDC20	Q12834¹^,², ENSP00000308450³	EBI-78203, EBI-367462 MINT-2211306 EBI-78203, EBI-367462 MINT-2211306 STRING (score=.999)
ADAM17	P78536¹^,²	EBI-78203, EBI-78188 MINT-13999 MINT-13998 EBI-78203, EBI-78188 MINT-13999 MINT-13998
DSTYK	Q6XUX3¹	EBI-78203, EBI-1049520

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0007067	mitosis	TAS	8824189
GO:0007093	mitotic cell cycle checkpoint	TAS	8824189
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	EXP	11285280
GO:0051301	cell division	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAD2L1
1 Novoseek chemical compound relationship for MAD2L1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
monastrol	69.80	1	10973989 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAD2L1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAD2L1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002358

Sigma-Aldrich siRNA for MAD2L1

Sigma-Aldrich shRNA Panels and shRNA for MAD2L1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002358

REFSEQ mRNAs for MAD2L1 gene:

NM_002358.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002358

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002358
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002358
                                 untagged cDNA clone in CMV expression vector: NM_002358

Additional cDNA sequence:

AF394735.1 AJ000186.1 AK223433.1 AK298228.1 AK313827.1 BC000356.2 BC005945.1 BC070283.1

CR605286.1 CR622828.1 CR623744.1 U31278.1 U65410.1

8 DOTS entries:

DT.315367 DT.91760226 DT.100803604 DT.100803606 DT.95142518 DT.95272195 DT.95272196 DT.100761812

24/225 AceView cDNA sequences (see all 225 ):

AI686723 AI250233 BU509241 BQ959603 BQ440642 BF219704 BE270292 BQ428342

BG527529 AF394735 CA489522 CA429116 AJ000186 BM726304 AA749451 BF305710

CR605286 BP370349 CA337564 AI954357 BX092337 BM680911 BM472304 AA548637

highest scoring ESTs for MAD2L1:

AJ000186 AA361458 AU099442 AW411207 AW674988 AW950858 BC000356 BC005945 BC070283 BE270292

Unigene Cluster for MAD2L1:

MAD2 mitotic arrest deficient-like 1 (yeast)

Hs.591697 [show with all ESTs]

Unigene Representative Sequence: U65410

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000296509 ENST00000333047

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAD2L1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAD2L1

¹ / ² / ³

6 probe-sets matching MAD2L1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1721_g_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.11	U65410	0.80	1.00	0.91	1
1720_at²^{, 3}	U95-A	1	1.00	1.00	-0.09	0.45	U65410	0.80	1.00	0.91	1
37282_at²^{, 3}	U95-A	2	1.00	0.97	0.97	0.92	AJ000186	1.00	1.00	1.00	1
203362_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002358	0.60	1.00	0.82	1
203362_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554768_a_at²	U133Plus2	3	1.00	0.67	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTTTTATAA

SOURCE GeneReport for Unigene cluster: Hs.591697
Expression variation in blood from EXPOLDB for MAD2L1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAD2L1 gene from 5/21 species (see all 21 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAD2L1¹	--	MAD2 mitotic arrest deficient-like 1 (yeast)	93.98(n) 97.56(a)	476070 XM_533278.2 XP_533278.2
chimpanzee (Pan troglodytes)	MAD2L1¹	--	MAD2 mitotic arrest deficient-like 1 (yeast)	99.49(n) 99.49(a)	461661 XM_517581.2 XP_517581.2
cow (Bos taurus)	MAD2L1¹	--	MAD2 mitotic arrest deficient-like 1 (yeast)	95.12(n) 98.54(a)	787996 XM_001254565.1 XP_001254566.1
rat (Rattus norvegicus)	Mad2l1¹	--	MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast)	88.46(n) 94.15(a)	297176 XM_216161.3 XP_216161.1
mouse (Mus musculus)	Mad2l1^{1, 5}	6 (30.30 cM)⁵	MAD2 mitotic arrest deficient-like 1 (yeast)⁵ MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast)¹	88.29(n)¹ 94.15(a)¹	56150¹ NM_019499.3¹ NP_062372.2¹ AA673185⁵ AF259902⁵ (see all 19)

About this table Species with no ortholog for MAD2L1

ENSEMBL Gene Tree for MAD2L1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/26 NCBI SNPs in MAD2L1 are shown (see all 26 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs28616785^1,2	C,F,H	121199660(+)	`GTACCA/GGATGA`	1	--	ng5¹		8		EU EA WA	836
--	rs2908990^1,2	O	121200662(-)	`AATCAA/GGTCAT`	1	--	ut3¹		0	--	--	--	--
	rs1972014^1,2	A,C,F,H,O	121203402(-)	`ATCACA/GGCTAG`	1	--	int¹		5		MN EU EA WA	602
	rs2908989^1,2	A,C,F,H,O	121202707(-)	`TTTATG/ATGTTG`	1	--	int¹		16		EA NA EU WA	1466
	rs1546120^1,2	A,C,F,H	121203525(-)	`ACCTAC/TTGCTC`	1	--	int¹		12		NS EU EA WA NA	662
	rs2908988^1,2	A,C,F,H	121203817(-)	`agtcaA/Gctcac`	1	--	int¹		4		EU EA WA	416
	rs13138258^1,2	C,F,H	121204927(+)	`CCTGTG/ATACAC`	1	--	int¹		8		EU EA WA	832
	rs9999978^1,2	C,F,H	121201086(+)	`TGCAAT/CTTagt`	1	--	int¹		11		EU EA WA NA	980
	rs11936153^1,2	C,F,H	121204941(+)	`AGAACA/TGAGGT`	1	--	int¹		4		EU EA WA	408
	rs3752830^1,2	C,F	121202327(-)	`ACAGTA/GTTTAT`	1	--	int¹		3		NA	142

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HapMap Linkage Disequilibrium images for MAD2L1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601467

10/13 Novoseek disease relationships for MAD2L1 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	34.33	20	12527913 (3), 18691855 (3), 16880791 (2), 17222786 (1) (see all 10)
nasopharyngeal carcinoma	23.17	4	12527913 (1), 11133821 (1), 15735033 (1)
tumors	15.85	23	15070740 (3), 18477210 (3), 17333263 (2), 15254432 (2) (see all 10)
gastric cancer	15.85	20	15484292 (4), 16112690 (3), 16714000 (3), 16214181 (2)
retinoblastoma	14.57	2	17456764 (1)
hepatocellular carcinoma	8.94	13	18715617 (4), 15574775 (1)
colorectal cancer	7.05	8	15457580 (3), 12970887 (3), 17297307 (1)
ovarian carcinoma	3.40	1	17234259 (1)
cancer lung	0.00	1	10439037 (1)
chromosomal aberrations	0.00	1	17333263 (1)

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Human Genome Epidemiology Navigator: MAD2L1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/189 PubMed articles for MAD2L1 gene (see all 189 ):

Identification of a human mitotic checkpoint gene: hsMAD2. (PubMed id 8824189)^{1, 2, 3, 4} Li Y. and Benezra R. (1996)
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. (PubMed id 18318601)^{1, 3, 4} Yang M....Luo X. (2008)
p31comet blocks Mad2 activation through structural mimicry. (PubMed id 18022368)^{1, 3, 4} Yang M....Luo X. (2007)
Mad2 phosphorylation regulates its association with Mad1 and the APC/C. (PubMed id 12574116)^{1, 3, 4} Wassmann K....Benezra R. (2003)
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. (PubMed id 11804586)^{1, 3, 4} Luo X....Yu H. (2002)
The Mad2 spindle checkpoint protein has two distinct natively folded states. (PubMed id 15024386)^{1, 3, 4} Luo X....Yu H. (2004)
The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint. (PubMed id 18022367)^{1, 3, 4} Mapelli M....Musacchio A. (2007)
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. (PubMed id 12006501)^{1, 3, 4} Sironi L....Musacchio A. (2002)
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2-beta. (PubMed id 10527948)^{1, 3, 4} Nelson K.K.... Blobel C.P. (1999)
Perturbation of the chromosomal binding of RCC1, Mad2 and survivin causes spindle assembly defects and mitotic catastrophe. (PubMed id 18712773)^{1, 3, 4} Ho C.Y....Li H.Y. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4085	HGNC: 6763	AceView: MAD2L1	Ensembl:ENSG00000164109	euGenes: HUgn4085
ECgene: MAD2L1	H-InvDB: MAD2L1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MAD2L1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MAD2L1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAD2L1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAD2L1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAD2L1		Antibodies for MAD2L1
	Explore super-pooled esiRNAs		Proteins for MAD2L1
	Lentivirus-delivered shRNAs for MAD2L1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Antibodies for MAD2L1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MAD2L1 Gene at Home site.
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MAD2L1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for MAD2L1

Summaries
for MAD2L1

Genomic Location
for MAD2L1

Proteins
for MAD2L1

Protein Domains/
Families
for MAD2L1

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for MAD2L1

Pathways & Interactions
for MAD2L1

Drugs & Compounds
for MAD2L1

Transcripts
for MAD2L1

Expression
for MAD2L1

Orthologs
for MAD2L1

Paralogs
for MAD2L1

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for MAD2L1

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for MAD2L1

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for MAD2L1

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for MAD2L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAD2L1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor MAD2L1

Summariesfor MAD2L1

Genomic Locationfor MAD2L1

Proteinsfor MAD2L1

Protein Domains/Familiesfor MAD2L1

Gene Functionfor MAD2L1

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Drugs & Compoundsfor MAD2L1

Transcriptsfor MAD2L1

Expression for MAD2L1

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Genome Databases showing MAD2L1

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Specialized Databases showing MAD2L1

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Servicesfor MAD2L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAD2L1

Summaries
for MAD2L1

Genomic Location
for MAD2L1

Proteins
for MAD2L1

Protein Domains/
Families
for MAD2L1

Gene Function
for MAD2L1

Pathways & Interactions
for MAD2L1

Drugs & Compounds
for MAD2L1

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for MAD2L1

Expression
for MAD2L1

Orthologs
for MAD2L1

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for MAD2L1

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for MAD2L1

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for MAD2L1

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for MAD2L1

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for MAD2L1

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for MAD2L1

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for MAD2L1