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Aliases for MAD1L1 Gene

Aliases for MAD1L1 Gene

  • MAD1 Mitotic Arrest Deficient-Like 1 (Yeast) 2 3
  • TXBP181 3 4 6
  • Mitotic Arrest Deficient 1-Like Protein 1 3 4
  • Mitotic Checkpoint MAD1 Protein Homolog 3 4
  • Tax-Binding Protein 181 3 4
  • MAD1-Like Protein 1 3 4
  • MAD1 3 4
  • MAD1 (Mitotic Arrest Deficient, Yeast, Homolog)-Like 1 2
  • Mitotic-Arrest Deficient 1, Yeast, Homolog-Like 1 3
  • Mitotic Spindle Assembly Checkpoint Protein MAD1 3
  • Tumor Protein P53 Inducible Protein 9 3
  • TP53I9 3
  • HsMAD1 4
  • HMAD1 4
  • PIG9 3

External Ids for MAD1L1 Gene

Summaries for MAD1L1 Gene

Entrez Gene Summary for MAD1L1 Gene

  • MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for MAD1L1 Gene

MAD1L1 (MAD1 Mitotic Arrest Deficient-Like 1 (Yeast)) is a Protein Coding gene. Diseases associated with MAD1L1 include prostate cancer. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for MAD1L1 Gene

  • Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Gene Wiki entry for MAD1L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAD1L1 Gene

Genomics for MAD1L1 Gene

Genomic Location for MAD1L1 Gene

Start:
1,815,792 bp from pter
End:
2,233,243 bp from pter
Size:
417,452 bases
Orientation:
Minus strand

Genomic View for MAD1L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAD1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAD1L1 Gene

Regulatory Elements for MAD1L1 Gene

Proteins for MAD1L1 Gene

  • Protein details for MAD1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6D9-MD1L1_HUMAN
    Recommended name:
    Mitotic spindle assembly checkpoint protein MAD1
    Protein Accession:
    Q9Y6D9
    Secondary Accessions:
    • B3KR41
    • Q13312
    • Q75MI0
    • Q86UM4
    • Q9UNH0

    Protein attributes for MAD1L1 Gene

    Size:
    718 amino acids
    Molecular mass:
    83067 Da
    Quaternary structure:
    • Homodimer. Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20. Also able to interact with the BUB1/BUB3 complex and the viral Tax protein. Interacts with NEK2. Interacts with TPR; the interactions occurs in a microtubule-independent manner.
    SequenceCaution:
    • Sequence=AAC52059.1; Type=Frameshift; Positions=663; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAD1L1 Gene

    Alternative splice isoforms for MAD1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAD1L1 Gene

Proteomics data for MAD1L1 Gene at MOPED

Post-translational modifications for MAD1L1 Gene

  • Phosphorylated; by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic spindle damage.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys625

No data available for DME Specific Peptides for MAD1L1 Gene

Domains for MAD1L1 Gene

Protein Domains for MAD1L1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y6D9

UniProtKB/Swiss-Prot:

MD1L1_HUMAN
Family:
  • Belongs to the MAD1 family.:
    • Q9Y6D9
genes like me logo Genes that share domains with MAD1L1: view

No data available for Gene Families for MAD1L1 Gene

Function for MAD1L1 Gene

Molecular function for MAD1L1 Gene

GENATLAS Biochemistry: mitotic arrest deficient protein 1-like 1,yeast homolog induced by TP53,essential component of the mitotic spindle assembly checkpoint,preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate,interacting as a homodimer with MAD2L1,involved in cell cycle control
UniProtKB/Swiss-Prot Function: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
UniProtKB/Swiss-Prot Induction: Increased by p53/TP53.

Gene Ontology (GO) - Molecular Function for MAD1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12006501
genes like me logo Genes that share ontologies with MAD1L1: view
genes like me logo Genes that share phenotypes with MAD1L1: view

Animal Models for MAD1L1 Gene

MGI Knock Outs for MAD1L1:

miRNA for MAD1L1 Gene

miRTarBase miRNAs that target MAD1L1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MAD1L1 Gene

Localization for MAD1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAD1L1 Gene

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAD1L1 Gene COMPARTMENTS Subcellular localization image for MAD1L1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 4

Gene Ontology (GO) - Cellular Components for MAD1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IDA 17363900
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005643 colocalizes_with nuclear pore IDA 18981471
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MAD1L1: view

Pathways for MAD1L1 Gene

genes like me logo Genes that share pathways with MAD1L1: view

Pathways by source for MAD1L1 Gene

1 GeneGo (Thomson Reuters) pathway for MAD1L1 Gene
2 BioSystems pathways for MAD1L1 Gene

Gene Ontology (GO) - Biological Process for MAD1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007093 mitotic cell cycle checkpoint NAS 9546394
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with MAD1L1: view

Compounds for MAD1L1 Gene

(2) Novoseek inferred chemical compound relationships for MAD1L1 Gene

Compound -log(P) Hits PubMed IDs
nocodazole 62.3 1
serine 0 2

(2) PharmGKB related drug/compound annotations for MAD1L1 Gene

Drug/compound Annotation
carboplatin CA
paclitaxel CA
genes like me logo Genes that share compounds with MAD1L1: view

Transcripts for MAD1L1 Gene

mRNA/cDNA for MAD1L1 Gene

Unigene Clusters for MAD1L1 Gene

MAD1 mitotic arrest deficient-like 1 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAD1L1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12: - - - - - -
SP13: - - - -
SP14: -
SP15: - - - - -
SP16:
SP17:
SP18:

ExUns: 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c · 33d · 33e
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5:
SP6: - - - - - -
SP7: - -
SP8:
SP9:
SP10: -
SP11: - -
SP12: - -
SP13: - -
SP14: - -
SP15:
SP16:
SP17: -
SP18:

Relevant External Links for MAD1L1 Gene

GeneLoc Exon Structure for
MAD1L1
ECgene alternative splicing isoforms for
MAD1L1

Expression for MAD1L1 Gene

mRNA expression in normal human tissues for MAD1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAD1L1 Gene

SOURCE GeneReport for Unigene cluster for MAD1L1 Gene Hs.654838

mRNA Expression by UniProt/SwissProt for MAD1L1 Gene

Q9Y6D9-MD1L1_HUMAN
Tissue specificity: Expressed weakly at G0/G1 and highly at late S and G2/M phase
genes like me logo Genes that share expressions with MAD1L1: view

No data available for mRNA differential expression in normal tissues for MAD1L1 Gene

Orthologs for MAD1L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAD1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAD1L1 35
  • 99.44 (n)
  • 99.44 (a)
MAD1L1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAD1L1 35
  • 85.45 (n)
  • 84.66 (a)
MAD1L1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAD1L1 35
  • 84.29 (n)
  • 83.96 (a)
MAD1L1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mad1l1 35
  • 81.45 (n)
  • 81.4 (a)
Mad1l1 16
Mad1l1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MAD1L1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mad1l1 35
  • 82.28 (n)
  • 83.36 (a)
chicken
(Gallus gallus)
Aves MAD1L1 35
  • 73.18 (n)
  • 70.01 (a)
MAD1L1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAD1L1 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mad1-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mad1l1 35
  • 64.99 (n)
  • 63.04 (a)
zebrafish
(Danio rerio)
Actinopterygii mad1l1 35
  • 60.6 (n)
  • 54.06 (a)
mad1l1 36
  • 53 (a)
OneToOne
zgc56571 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006632 35
  • 47.69 (n)
  • 28.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mad1 35
  • 44.97 (n)
  • 28.93 (a)
Mad1 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAD1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToOne
Species with no ortholog for MAD1L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAD1L1 Gene

ENSEMBL:
Gene Tree for MAD1L1 (if available)
TreeFam:
Gene Tree for MAD1L1 (if available)

Paralogs for MAD1L1 Gene

Pseudogenes.org Pseudogenes for MAD1L1 Gene

genes like me logo Genes that share paralogs with MAD1L1: view

No data available for Paralogs for MAD1L1 Gene

Variants for MAD1L1 Gene

Sequence variations from dbSNP and Humsavar for MAD1L1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7680 -- 1,815,895(-) AGCAC(C/T)CTCTC utr-variant-3-prime
rs731140 -- 2,112,366(+) cctaa(A/G)ggaac intron-variant
rs733611 -- 2,217,144(-) TCACA(C/T)GTGCT intron-variant
rs735932 -- 2,105,834(-) GAGCG(C/G)GGTGG intron-variant
rs745528 -- 2,094,179(+) AAGGG(A/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAD1L1 Gene

Variant ID Type Subtype PubMed ID
nsv887241 CNV Loss 21882294
nsv830881 CNV Loss 17160897
dgv7106n71 CNV Gain 21882294
nsv830883 CNV Loss 17160897
dgv7107n71 CNV Loss 21882294
dgv7108n71 CNV Loss 21882294
nsv5616 CNV Loss 18451855
esv29771 CNV Loss 19812545
esv2666795 CNV Deletion 23128226
nsv471193 CNV Loss 18288195
nsv887250 CNV Loss 21882294
esv2733782 CNV Deletion 23290073
esv2733784 CNV Deletion 23290073
nsv509186 CNV Insertion 20534489
dgv7109n71 CNV Loss 21882294
dgv7110n71 CNV Loss 21882294
esv2733785 CNV Deletion 23290073
esv1790768 CNV Insertion 17803354
esv2665376 CNV Deletion 23128226
esv1651495 CNV Deletion 17803354
esv1002584 CNV Deletion 20482838
esv2733786 CNV Deletion 23290073
nsv887257 CNV Loss 21882294
esv2657037 CNV Deletion 23128226
esv2733787 CNV Deletion 23290073
esv2733788 CNV Deletion 23290073
esv1621443 CNV Deletion 17803354
nsv365724 CNV Loss 16902084
esv2733789 CNV Deletion 23290073
esv2733790 CNV Deletion 23290073
esv1008479 CNV Deletion 20482838
esv1051273 CNV Deletion 17803354
esv2733791 CNV Deletion 23290073
esv1699347 CNV Deletion 17803354
esv1002751 CNV Insertion 20482838
esv1004176 CNV Insertion 20482838
esv2733792 CNV Deletion 23290073
esv2733793 CNV Deletion 23290073
esv2083782 CNV Deletion 18987734
esv2733795 CNV Deletion 23290073
nsv366131 CNV Loss 16902084
esv4844 CNV Deletion 18987735
esv2662272 CNV Deletion 23128226
nsv511941 CNV Loss 21212237
esv22857 CNV Loss 19812545
esv2312132 CNV Deletion 18987734
esv2733796 CNV Deletion 23290073
esv2674584 CNV Deletion 23128226
esv2733797 CNV Deletion 23290073
dgv1179e199 CNV Deletion 23128226
dgv1114e201 CNV Deletion 23290073
dgv7111n71 CNV Loss 21882294
esv2733799 CNV Deletion 23290073
esv1021970 CNV Deletion 17803354
esv1064342 CNV Deletion 17803354
dgv1115e201 CNV Deletion 23290073
esv1309588 CNV Insertion 17803354
esv2733800 CNV Deletion 23290073
esv2353291 CNV Deletion 18987734
esv2678786 CNV Deletion 23128226
nsv5617 CNV Loss 18451855
esv28954 CNV Gain 19812545
esv2733801 CNV Deletion 23290073
esv1734258 CNV Deletion 17803354
esv2733802 CNV Deletion 23290073
esv2568241 CNV Insertion 19546169
esv1280895 CNV Insertion 17803354
nsv830884 CNV Loss 17160897
nsv511366 CNV Loss 21212237
nsv887263 CNV Loss 21882294
esv26649 CNV Gain+Loss 19812545
esv2654648 CNV Deletion 19546169
nsv511942 CNV Loss 21212237
esv3905 CNV Deletion 18987735
esv999994 CNV Gain 20482838
esv2733803 CNV Deletion 23290073
esv1086937 CNV Deletion 17803354
esv2733804 CNV Deletion 23290073
esv2733807 CNV Deletion 23290073
esv1260882 CNV Insertion 17803354
nsv366600 CNV Insertion 16902084
esv2733808 CNV Deletion 23290073
esv2733809 CNV Deletion 23290073
esv2304578 CNV Deletion 18987734
esv3528 CNV Deletion 18987735
nsv366761 CNV Loss 16902084
dgv796n27 CNV Loss 19166990
esv1660511 CNV Insertion 17803354
esv2733810 CNV Deletion 23290073
esv2733811 CNV Deletion 23290073
dgv7112n71 CNV Loss 21882294
nsv830885 CNV Loss 17160897
esv2458937 CNV Deletion 19546169
esv2733812 CNV Deletion 23290073
esv2733813 CNV Deletion 23290073
esv24890 CNV Loss 19812545
dgv1116e201 CNV Deletion 23290073
esv1656328 CNV Deletion 17803354
esv2733816 CNV Deletion 23290073
dgv1117e201 CNV Deletion 23290073
esv2733819 CNV Deletion 23290073
nsv365970 CNV Loss 16902084
nsv471204 CNV Loss 18288195
dgv7113n71 CNV Loss 21882294
esv2733821 CNV Deletion 23290073
nsv464252 CNV Loss 19166990
esv2733822 CNV Deletion 23290073
nsv887269 CNV Loss 21882294
nsv464253 CNV Loss 19166990
esv2733823 CNV Deletion 23290073
dgv7114n71 CNV Loss 21882294
esv2733824 CNV Deletion 23290073
esv2733825 CNV Deletion 23290073
esv2733826 CNV Deletion 23290073
esv2733827 CNV Deletion 23290073
nsv887272 CNV Loss 21882294
nsv887273 CNV Loss 21882294
esv2733829 CNV Deletion 23290073
esv2733830 CNV Deletion 23290073
esv2733831 CNV Deletion 23290073
nsv830886 CNV Loss 17160897
esv2733832 CNV Deletion 23290073
nsv887274 CNV Loss 21882294
nsv464254 CNV Loss 19166990
esv2733833 CNV Deletion 23290073
esv1587480 CNV Deletion 17803354
esv2164289 CNV Deletion 18987734
dgv7115n71 CNV Loss 21882294
nsv887277 CNV Loss 21882294
esv2733834 CNV Deletion 23290073
esv995598 CNV Deletion 20482838
esv2674509 CNV Deletion 23128226
esv2733835 CNV Deletion 23290073
nsv887278 CNV Loss 21882294
esv2733836 CNV Deletion 23290073
esv2218091 CNV Deletion 18987734
esv2733837 CNV Deletion 23290073
esv2733838 CNV Deletion 23290073
nsv365745 CNV Insertion 16902084
esv2733840 CNV Deletion 23290073
nsv887279 CNV Loss 21882294
esv2733841 CNV Deletion 23290073
esv2733842 CNV Deletion 23290073
esv2332356 CNV Deletion 18987734
esv1005388 CNV Deletion 20482838

Relevant External Links for MAD1L1 Gene

HapMap Linkage Disequilibrium report
MAD1L1
Human Gene Mutation Database (HGMD)
MAD1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAD1L1 Gene

Disorders for MAD1L1 Gene

(1) OMIM Diseases for MAD1L1 Gene (602686)

UniProtKB/Swiss-Prot

MD1L1_HUMAN
  • Note=Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.

(1) MalaCards Diseases for MAD1L1 Gene

Search for MAD1L1 Gene in MalaCards »

(3) Novoseek inferred disease relationships for MAD1L1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma renal cell 19.8 1
cancer 5.15 2
tumors 0 4

Relevant External Links for MAD1L1

Genetic Association Database (GAD)
MAD1L1
Human Genome Epidemiology (HuGE) Navigator
MAD1L1
genes like me logo Genes that share disorders with MAD1L1: view

Publications for MAD1L1 Gene

  1. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. (PMID: 9546394) Jin D.-Y. … Jeang K.-T. (Cell 1998) 2 3 4 23
  2. Phosphorylation of human MAD1 by the BUB1 kinase in vitro. (PMID: 10198256) Seeley T.W. … Zhen J.Y. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. (PMID: 12006501) Sironi L. … Musacchio A. (EMBO J. 2002) 3 4 23
  4. NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling. (PMID: 14978040) Lou Y. … Yao X. (J. Biol. Chem. 2004) 3 4 23
  5. Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5. (PMID: 10049595) Jin D.-Y. … Jeang K.-T. (Genomics 1999) 2 3 4

Products for MAD1L1 Gene

Sources for MAD1L1 Gene

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