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MAD1L1 Gene

protein-coding GIFtS: 68

GC07M001821

MAD1 mitotic arrest deficient-like 1 (yeast)
(Previous names: MAD1 (mitotic arrest deficient, yeast, homolog)-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HsMAD1 ^¹, ², ³
MAD1 ^¹, ², ³
PIG9 ^¹, ²
TP53I9 ^¹, ²
TXBP181 ^¹, ², ³, ⁵
hMAD1 ^³

Descriptions
MAD1 (mitotic arrest deficient, yeast, homolog)-like 1 ^¹
MAD1 mitotic arrest deficient-like 1 (yeast) ^²
MAD1-like 1 ^³
MAD1-like 1 protein ^²
Mitotic arrest deficient-like protein 1 ^³
Mitotic checkpoint MAD1 protein homolog ^³
Tax-binding protein 181 ^³
mitotic-arrest deficient 1, yeast, homolog-like 1 ^²
tumor protein p53 inducible protein 9 ^²

External Ids
HGNC: 6762¹
Entrez Gene: 8379²
UniProtKB: Q9Y6D9³
Ensembl: ENSG00000002822⁷

Search outside databases for aliases for MAD1L1 gene

Previous GC identifers: GC07M001499 GC07M001599 GC07M001628

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAD1L1:

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of

anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a

homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor

suppression. Three transcript variants encoding the same protein have been found for this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: MD1L1_HUMAN, Q9Y6D9

Function: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until

all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached

kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1

to the nuclear periphery

Gene Wiki entry for MAD1L1 (Mad1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAD1L1 gene

Entrez Gene cytogenetic band: 7p22 Ensembl cytogenetic band: 7p22.2 HGNC cytogenetic band: 7p22

MAD1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M001821: (about GC identifiers)

Start:	1,821,954 bp from pter
End:	2,239,404 bp from pter
Size:	417,451 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 1,908,333-2,321,257

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MD1L1_HUMAN, Q9Y6D9 (See protein sequence)

Recommended Name: Mitotic spindle assembly checkpoint protein MAD1

Size: 718 amino acids; 83067 Da

Subunit: Homodimer. Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core

complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may

decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the

attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to

CDC20. Also able to interact with the BUB1/BUB3 complex and the viral Tax protein. Interacts with

TPR

Subcellular location: Nucleus. Kinetochore. Note=From the beginning to the end of mitosis, it is

seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and

finally to the midbody

Sequence caution: Sequence=AAC52059.1; Type=Frameshift; Positions=663;

PDB structures from and Proteopedia :

1GO4 (3D)

Secondary accessions: Q13312 Q75MI0 Q86UM4 Q9UNH0

Post-translational modifications:

Phosphorylated; by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic

spindle damage. Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001013858.1 NP_001013859.1 NP_003541.2

ENSEMBL proteins:

ENSP00000384155 ENSP00000385334 ENSP00000382562 ENSP00000265854

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAD1)
	Human Recombinant Proteins from Abnova (MAD1L1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	18029348
GO:0005813	centrosome	NAS	9546394
GO:0005819	spindle	NAS	9546394
GO:0005829	cytosol	EXP	11181178 11804586 12006501

About this table

Antibodies for MAD1L1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for MAD1L1
	R&D Systems Antibodies for MAD1L1
	Antibodies from Abcam (MAD1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAD1L1)
	Novus Biologicals Antibodies for MAD1L1

Assays for MAD1L1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y6D9

ProtoNet protein and cluster: Q9Y6D9

1 Blocks protein family: IPB008672 Mitotic checkpoint

UniProtKB/Swiss-Prot: MD1L1_HUMAN, Q9Y6D9

Similarity: Belongs to the MAD1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAD1L1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003550

Applied Biosystems Silencer® siRNAs for MAD1L1

Sigma-Aldrich siRNA for MAD1L1

Sigma-Aldrich shRNA Panels and shRNA for MAD1L1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAD1L1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001013836
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001013836
untagged cDNA clones in CMV expression vector (see all 3): NM_001013836

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001013836

UniProtKB/Swiss-Prot: MD1L1_HUMAN, Q9Y6D9

Function: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until

all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached

kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1

to the nuclear periphery

Induction: Increased by TP53

Genatlas biochemistry entry for MAD1L1:

mitotic arrest deficient protein 1-like 1,yeast homolog induced by TP53,essential component of the

mitotic spindle assembly checkpoint,preventing the onset of anaphase until all chromosomes are

properly aligned at the metaphase plate,interacting as a homodimer with MAD2L1,involved in cell

cycle control

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mad1l1):

cellular

lethality-prenatal/perinatal

no phenotypic analysis

tumorigenesis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IPI	17418410 18692475

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MAD1L1

5/99 Interacting proteins for MAD1L1 (Q9Y6D9^{1, 2} ENSP00000265854³) via UniProtKB, MINT, and/or STRING (see all 99 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAD2L1	Q13257¹, ENSP00000296509³	EBI-742610, EBI-78203 STRING (score=.998)
MAX	P61244¹, ENSP00000284165³	EBI-742610, EBI-878388 STRING (score=.97)
COIL	P38432²	MINT-2864955
MAD1L1	Q9Y6D9²	MINT-68457
NINL	Q9Y2I6²	MINT-66346

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000089	mitotic metaphase	NAS	9546394
GO:0000090	mitotic anaphase	NAS	9546394
GO:0000093	mitotic telophase	NAS	9546394
GO:0007049	cell cycle	IEA	--
GO:0007093	mitotic cell cycle checkpoint	NAS	9546394

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAD1L1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAD1L1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003550

Sigma-Aldrich siRNA for MAD1L1

Sigma-Aldrich shRNA Panels and shRNA for MAD1L1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001013836 NM_001013837 NM_003550

REFSEQ mRNAs for MAD1L1 gene (3 alternative transcripts):

NM_001013836.1 NM_001013837.1 NM_003550.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001013836 NM_001013837 NM_003550

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001013836
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001013836
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001013836

Additional cDNA sequence:

AF083811.1 AF123318.1 AK090959.1 AK310481.1 AK310831.1 AK314227.1 BC009964.2 BC018870.2

CR600439.1 U33822.1

24 DOTS entries:

DT.100820801 DT.100719823 DT.101980030 DT.100708775 DT.95178583 DT.95178581 DT.95178584 DT.95258931

DT.100724625 DT.97859201 DT.100685376 DT.100820802 DT.121112843 DT.95155934 DT.100699863 DT.91898481

DT.95202769 DT.100711653 DT.100820800 DT.121112836 DT.91771885 DT.97795020 DT.97821456 DT.97859202

7 AceView cDNA sequences:

AI806304 AW183144 AW272458 AW628827 BQ429811 BQ429773 BG200630

highest scoring ESTs for MAD1L1:

U33822 AA077508 AA338765 AF083811 AF123318 AK090959 AL709177 AU100549 AU279508 BC009964

Unigene Cluster for MAD1L1:

MAD1 mitotic arrest deficient-like 1 (yeast)

Hs.654838 [show with all ESTs]

Unigene Representative Sequence: AK310831

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for MAD1L1 (see all 18 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	·	18c	^	19	^	20	^
SP1:			-		-												-														-		-		-		-				-		-		-		-		-
SP2:																	-														-		-		-		-				-		-		-		-		-
SP3:			-		-		-		-		-																				-		-		-		-				-		-		-		-		-
SP4:
SP5:

ExUns:	21	^	22	^	23a	·	23b	·	23c	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33a	·	33b	·	33c	·	33d	·	33e
SP1:	-		-										-						-						-		-
SP2:	-		-										-						-						-		-
SP3:	-		-										-						-						-		-
SP4:	-		-										-
SP5:

About this scheme

ECgene alternative splicing isoforms for MAD1L1

4 Ensembl transcripts including schematic representations:

ENST00000402746 ENST00000406869 ENST00000399654 ENST00000265854

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MAD1L1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAD1L1

¹ / ² / ³

3 probe-sets matching MAD1L1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
499_at²^{, 3}	U95-A	2	1.00	0.72	1.00	1.00	U33822	1.00	1.00	1.00	1
204857_at²^{, 3}	U133-A	2	1.00	0.91	--	--	NM_003550	0.60	1.00	0.82	1
204857_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

GeneDecks MAD1L1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGTCCCGGAG

SOURCE GeneReport for Unigene cluster: Hs.654838
Expression variation in blood from EXPOLDB for MAD1L1
UniProtKB/Swiss-Prot: MD1L1_HUMAN, Q9Y6D9
Tissue specificity: Expressed weakly at G0/G1 and highly at late S and G2/M phase

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAD1L1 gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAD1L1¹	--	MAD1 mitotic arrest deficient-like 1 (yeast)	84.29(n) 83.96(a)	609673 XM_846973.1 XP_852066.1
chimpanzee (Pan troglodytes)	MAD1L1¹	--	MAD1 mitotic arrest deficient-like 1 (yeast)	99.44(n) 99.44(a)	463223 XM_518933.2 XP_518933.2
cow (Bos taurus)	MAD1L1¹	--	MAD1 mitotic arrest deficient-like 1 (yeast)	85.45(n) 84.66(a)	517837 XM_596016.3 XP_596016.3
rat (Rattus norvegicus)	Mad1l1¹	--	MAD1 mitotic arrest deficient-like 1 (yeast)	82.28(n) 83.36(a)	680006 XM_001055286.1 XP_001055286.1
mouse (Mus musculus)	Mad1l1^{1, 5}	5 (81.00 cM)⁵	mitotic arrest deficient 1-like 1^{1, 5}	81.45(n)¹ 81.4(a)¹	17120¹ NM_010752.3¹ NP_034882.2¹ AF083812⁵ AF083813⁵ (see all 17)

About this table Species with no ortholog for MAD1L1

ENSEMBL Gene Tree for MAD1L1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/3210 NCBI SNPs in MAD1L1 are shown (see all 3210 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 601)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3757440^1,2	A,C,F,H	2239462(+)	`TAGAAA/GTGCAA`	3	--	ng3¹		5		EA EU WA	1904
--	rs7680^1,2	A,H	1822057(-)	`AGCACC/TCTCTC`	3	--	ut3¹ ese³		3		MN EU	488
	rs1801368^1,2	C,F	1942983(-)	`CCTGCG/ACGAGG`	3	H/R	mis¹ ese³		4		EA NA	1742
--	rs11771972^1,2	C	1821918(+)	`CCCTGA/CTAGGG`	3	--	ng5¹		0	--	--	--	--
--	rs11771971^1,2	C	1821915(+)	`CCACCA/CTGCTA`	3	--	ng5¹		0	--	--	--	--
	rs1004643^1,2	A,C,F,H,O	2151850(-)	`CCGTGC/GAACCT`	3	--	int¹		6		MN EU EA WA	2038
	rs1637759^1,2	A,C,F,H,O	2186579(-)	`TAGATA/GCTCGG`	3	--	int¹		12		MN EU EA WA NA	1106
	rs1639910^1,2	A,C,F,H,O	2210509(+)	`TGATCC/TGCGCA`	3	--	int¹		9		MN EU EA WA NA	814
--	rs1637751^1,2	A,C,F,H,O	2192233(-)	`GTTGTT/CAGTGT`	3	--	int¹		8		MN EU EA WA NA	722
	rs1860827^1,2	A,C,F,H,O	2079853(+)	`TGTTCC/TGCAGC`	3	--	int¹		5		MN EU EA WA	602

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HapMap Linkage Disequilibrium images for MAD1L1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602686

UniProtKB/Swiss-Prot: MD1L1_HUMAN, Q9Y6D9

Defects in MAD1L1 are involved in the development and/or progression of various types of

cancer

3 Novoseek disease relationships for MAD1L1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma renal cell	22.07	2	17333263 (1)
cancer	4.24	2	16157026 (1), 11980658 (1)
tumors	0.00	10	17333263 (2), 18791270 (1), 11490301 (1)

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Human Genome Epidemiology Navigator: MAD1L1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/99 PubMed articles for MAD1L1 gene (see all 99 ):

Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. (PubMed id 9546394)^{1, 2, 3, 4} Jin D.Y....Jeang K.T. (1998)
Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5. (PubMed id 10049595)^{2, 3, 4} Jin D.-Y....Jeang K.-T. (1999)
Phosphorylation of human MAD1 by the BUB1 kinase in vitro. (PubMed id 10198256)^{1, 3, 4} Seeley T.W.... Zhen J.Y. (1999)
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. (PubMed id 12006501)^{1, 3, 4} Sironi L....Musacchio A. (2002)
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. (PubMed id 18981471)^{3, 4} Lee S.H....McCormick F. (2008)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8379	HGNC: 6762	AceView: MAD1L1	Ensembl:ENSG00000002822	euGenes: HUgn8379
ECgene: MAD1L1	H-InvDB: MAD1L1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MAD1L1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MAD1L1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAD1L1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAD1L1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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Antibodies for MAD1L1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MAD1L1 Gene at Home site.
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MAD1L1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for MAD1L1

Summaries
for MAD1L1

Genomic Location
for MAD1L1

Proteins
for MAD1L1

Protein Domains/
Families
for MAD1L1

Gene Function
for MAD1L1

Pathways & Interactions
for MAD1L1

Drugs & Compounds
for MAD1L1

Transcripts
for MAD1L1

Expression
for MAD1L1

Orthologs
for MAD1L1

Paralogs
for MAD1L1

SNPs/Variants
for MAD1L1

Disorders & Mutations
for MAD1L1

Medical News
for MAD1L1

Publications
for MAD1L1

Search for MAD1L1

Genome Databases showing MAD1L1

Other Databases showing MAD1L1

Specialized Databases showing MAD1L1

Licensable Technologies
for MAD1L1

Services
for MAD1L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAD1L1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor MAD1L1

Summariesfor MAD1L1

Genomic Locationfor MAD1L1

Proteinsfor MAD1L1

Protein Domains/Familiesfor MAD1L1

Gene Functionfor MAD1L1

Pathways & Interactionsfor MAD1L1

Drugs & Compoundsfor MAD1L1

Transcriptsfor MAD1L1

Expression for MAD1L1

Orthologsfor MAD1L1

Paralogsfor MAD1L1

SNPs/Variantsfor MAD1L1

Disorders & Mutationsfor MAD1L1

Medical Newsfor MAD1L1

Publicationsfor MAD1L1

Search for MAD1L1

Genome Databases showing MAD1L1

Other Databases showing MAD1L1

Specialized Databases showing MAD1L1

Licensable Technologiesfor MAD1L1

Servicesfor MAD1L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAD1L1

Summaries
for MAD1L1

Genomic Location
for MAD1L1

Proteins
for MAD1L1

Protein Domains/
Families
for MAD1L1

Gene Function
for MAD1L1

Pathways & Interactions
for MAD1L1

Drugs & Compounds
for MAD1L1

Transcripts
for MAD1L1

Expression
for MAD1L1

Orthologs
for MAD1L1

Paralogs
for MAD1L1

SNPs/Variants
for MAD1L1

Disorders & Mutations
for MAD1L1

Medical News
for MAD1L1

Publications
for MAD1L1

Licensable Technologies
for MAD1L1

Services
for MAD1L1