Aliases for MACROD2 Gene
External Ids for MACROD2 Gene
Previous HGNC Symbols for MACROD2 Gene
The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]
GeneCards Summary for MACROD2 Gene
MACROD2 (MACRO Domain Containing 2) is a Protein Coding gene. Diseases associated with MACROD2 include Kabuki Syndrome 1 and Autism Spectrum Disorder. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and deacetylase activity. An important paralog of this gene is MACROD1.
UniProtKB/Swiss-Prot for MACROD2 Gene
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.