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MACROD1 Gene

protein-coding   GIFtS: 48
GCID: GC11M063767

MACRO Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MACRO Domain Containing 11 2     O-Acetyl-ADP-Ribose Deacetylase MACROD12
LRP162 3     EC 3.2.2.-3
[Protein ADP-Ribosylglutamate] Hydrolase2 3     EC 3.5.1.-3
MACRO Domain-Containing Protein 12 3     Protein LRP163

External Ids:    HGNC: 295981   Entrez Gene: 289922   Ensembl: ENSG000001333157   OMIM: 6104005   UniProtKB: Q9BQ693   

Export aliases for MACROD1 gene to outside databases

Previous GC identifers: GC11M063523 GC11M060094


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MACROD1 Gene:
MACROD1 (MACRO domain containing 1) is a protein-coding gene. Diseases associated with MACROD1 include estrogen resistance, and monocytic leukemia. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and deacetylase activity. An important paralog of this gene is GDAP2.

UniProtKB/Swiss-Prot: MACD1_HUMAN, Q9BQ69
Function: Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive
towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the
deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling.
Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May
play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward
mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback
regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in
endometrial cancer cells. Enhances ESR1-mediated transcription activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MACROD1 gene promoter:
         Sp1   Bach2   NF-kappaB   PPAR-gamma1   POU2F1   c-Myb   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMACROD1 promoter sequence
   Search Chromatin IP Primers for MACROD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MACROD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

MACROD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MACROD1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M063767:  view genomic region     (about GC identifiers)

Start:
63,766,030 bp from pter      End:
63,933,585 bp from pter
Size:
167,556 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MACD1_HUMAN, Q9BQ69 (See protein sequence)
Recommended Name: O-acetyl-ADP-ribose deacetylase MACROD1  
Size: 325 amino acids; 35505 Da
Subunit: Interacts with ESR1; Interacts in a manner that is estrogen independent but is enhanced by estrogen.
Interacts (via macro domain) with AR
Miscellaneous: Overexpression may promote MCF-7 cells proliferation. There is an approximate one-third increase of
the invasive capacity of MACROD1-overexpressing cells. The expression of CDH1 is repressed by MACROD1. Further
analyzes demonstrats that MACROD1 inhibits CDH1 transactivation in a dose dependent manner. Inhibition is
abolished by estrogen deprivation, indicating that the down-regulation of CDH1 transcription by MACROD1 requires
ESR1 mediation. Binding of ESR1 to the CDH1 promoter is antagonized by MACROD1, suggesting that MACROD1 could
interfere with ESR1-mediated transcription. Knockdown of MACROD1 leads to impaired AR function and greatly
attenuates the coactivation of AR by other AR coactivators such as UXT and NCOA1. This interference also markedly
inhibits the androgen-stimulated proliferation of androgen-sensitive LNCaP prostate cancer cells. MACROD1
knockdown does not significantly affect the growth rate of AR-negative PC-3 prostate cancer cells
Sequence caution: Sequence=AAH03188.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH03188.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for MACROD1:
2X47 (3D)    
Secondary accessions: Q9UH96

Explore the universe of human proteins at neXtProt for MACROD1: NX_Q9BQ69

Explore proteomics data for MACROD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MACROD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054786.2  
    ENSEMBL proteins: 
     ENSP00000255681  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002589 Macro_dom

    Graphical View of Domain Structure for InterPro Entry Q9BQ69

    ProtoNet protein and cluster: Q9BQ69

    1 Blocks protein domain: IPB002589 Protein of unknown function Appr-1

    UniProtKB/Swiss-Prot: MACD1_HUMAN, Q9BQ69
    Similarity: Contains 1 Macro domain


    MACROD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MACD1_HUMAN, Q9BQ69
    Function: Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive
    towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the
    deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling.
    Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May
    play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward
    mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback
    regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in
    endometrial cancer cells. Enhances ESR1-mediated transcription activity
    Enzyme regulation: Subject to competitive inhibition by the product ADP-ribose
    Biophysicochemical properties: Kinetic parameters: KM=373 uM for O-acetyl-ADP-ribose;
    Induction: Overexpressed by estrogens in breast cancer MCF-7 cells, probably via an activation of nuclear
    receptors for steroids (ESR1 but not ESR2). Significantly increased by estrogens in ESR1-positive Ishikawa
    endometrial cancer cells. Up-regulated in 17-beta-estradiol-responsive BG-1 ovarian cancer cells but
    down-regulated in estrogen-resistant SKOV3 ovarian cancer cells. Induced by androgen

         Enzyme Numbers (IUBMB): EC 3.5.1.-1 EC 3.2.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17914104
    GO:0016798hydrolase activity, acting on glycosyl bonds IDA--
    GO:0019213deacetylase activity IDA--
         
    MACROD1 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MACD1_HUMAN, Q9BQ69: Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    peroxisome2
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005739mitochondrion IEA--

    MACROD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MACROD1
    Interactions:

        GeneGlobe Interaction Network for MACROD1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MACROD1 (Q9BQ691, 3 ENSP000002556814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPB41P111713, ENSP000002901004I2D: score=1 STRING: ENSP00000290100
    ESR1P033721, ENSP000002062494EBI-5324932,EBI-78473 STRING: ENSP00000206249
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006974cellular response to DNA damage stimulus IMP--
    GO:0042278purine nucleoside metabolic process IDA--
    GO:0051725protein de-ADP-ribosylation IDA--

    MACROD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MACROD1 (MACD1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MACROD1 gene: 
    NM_014067.3  

    Unigene Cluster for MACROD1:

    MACRO domain containing 1
    Hs.602898  [show with all ESTs]
    Unigene Representative Sequence: AL833017
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255681(uc001nyh.3) ENST00000542105 ENST00000538042 ENST00000541041
    ENST00000543422 ENST00000545464 ENST00000542359 ENST00000538595
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MACROD1
      QuantiFast Probe-based Assays in human, mouse, rat MACROD1

    Additional mRNA sequence: 

    AF086206.1 AF202922.2 AL833017.1 BC000270.1 BC003188.1 BC007297.1 BC008316.1 

    15 DOTS entries:

    DT.91762287  DT.112929  DT.120741840  DT.75100064  DT.95335120  DT.40132281  DT.100751626  DT.75154589 
    DT.91762269  DT.120741897  DT.40316156  DT.446438  DT.97805164  DT.97825025  DT.97770464 

    Selected AceView cDNA sequences (see all 136):

    AI801852 BM920848 BF939311 BM710028 BE219954 BC003188 BM821256 AI215091 
    AI300099 BC000270 AF202922 BM740794 BE501142 BQ637198 BE466565 BE550014 
    BM785075 BF590037 BQ772767 AI469181 NM_014067 BM781625 AI479573 BC007297 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MACROD1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                      -                                 
    SP2:                          -                                             


    ECgene alternative splicing isoforms for MACROD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MACROD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGAGATG
    MACROD1 Expression
    About this image

    MACROD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MACROD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.602898
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MACROD1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Macrod11 , 5 MACRO domain containing 11, 5 86.17(n)1
    86.07(a)1
      19 (5.17 cM)5
    1072271  NM_134147.41  NP_598908.21 
     70567685 
    lizard
    (Anolis carolinensis)
    Reptilia MACROD16
    MACRO domain containing 1
    70(a)
    1 ↔ 1
    GL343555.1(31825-110517)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686972 hypothetical protein MGC68697 73.63(n)    BC060026.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc659602 hypothetical protein MGC65960 71.86(n)   393521  BC056529.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0035.36
    Protein B0035.3 (B0035.3) mRNA, complete cds
    43(a)
    1 → many
    IV(11314077-11315050) WBGene00007106


    ENSEMBL Gene Tree for MACROD1 (if available)
    TreeFam Gene Tree for MACROD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MACROD1 gene
    GDAP22  MACROD22  
    1 SIMAP similar gene for MACROD1 using alignment to 1 protein entry:     MACD1_HUMAN:
    MACROD2

    MACROD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MACROD1 (see all 2707)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503203671,2
    C--63766462(+) GGTAGA/CTGTCC 2 S I mis11Minor allele frequency- C:0.00NA 2668
    rs1115751821,2
    C--63766469(+) GTCCTC/G/TGTCCT 3 K Q E mis11CSA 1
    rs1483178441,2
    C--63766544(+) GCTGCC/GACGCC 1 -- int10--------
    rs1414304421,2
    --63766698(+) AAGGGA/GCGGGC 1 -- int10--------
    rs1503989431,2
    --63766720(+) CTCTGC/TACCCT 1 -- int10--------
    rs3201511,2
    C--63766764(-) CATCCC/TGGCCA 1 -- int12Minor allele frequency- T:0.00NA 4
    rs1496393711,2
    C--63766772(+) ATGCGA/GACCCC 1 -- int10--------
    rs753474161,2
    C--63766819(+) GCTGCC/TCCAGC 2 E G mis10--------
    rs116067571,2
    C,H--63766907(+) TCCTAG/TGCTCT 1 -- int10--------
    rs2021420141,2
    --63767002(+) CTCACC/TAAACA 2 S G mis10--------

    HapMap Linkage Disequilibrium report for MACROD1 (63766030 - 63933585 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MACROD1 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744613CNV Deletion23290073
    esv2666053CNV Deletion23128226
    esv2669519CNV Deletion23128226
    nsv354CNV Insertion18451855
    esv29993CNV Loss17803354
    dgv15n68CNV Loss17160897
    dgv1156n71CNV Loss21882294
    nsv897663CNV Loss21882294
    dgv1160n71CNV Loss21882294
    dgv1155n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610400    OMIM disorders: --

    UniProtKB/Swiss-Prot: MACD1_HUMAN, Q9BQ69
  • Note=A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation
    t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein

  • 13 diseases for MACROD1:    
    About MalaCards
    estrogen resistance    monocytic leukemia    acute leukemia    t-cell leukemia
    leukemia    ovarian cancer    retinitis    tuberculosis
    prostate cancer    prostatitis    breast cancer    multiple myeloma
    myeloma


    MACROD1 for disorders           About GeneDecksing


    Export disorders for MACROD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MACROD1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with MACROD1)
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    1. Differential induction of LRP16 by liganded and unliganded estrogen receptor alpha in SKOV3 ovarian carcinoma cells. (PubMed id 19403568)1, 2 Tian L.... Han W. (J. Endocrinol. 2009)
    2. The single-macro domain protein LRP16 is an essential cofactor of androgen receptor. (PubMed id 19022849)1, 2 Yang J....Han W.-D. (Endocr. Relat. Cancer 2009)
    3. Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity. (PubMed id 17914104)1, 2 Han W.-D.... Mu Y.-M. (Endocr. Relat. Cancer 2007)
    4. LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). (PubMed id 17532767)1, 2 Imagama S.... Naoe T. (Eur. J. Haematol. 2007)
    5. Mechanism of transcriptional regulation of LRP16 gene expression by 17-beta estradiol in MCF-7 human breast cancer cells. (PubMed id 15691879)1, 3 Zhao Y.L....Pan C.Y. (J. Mol. Endocrinol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion of human breast cancer MCF-7 cell proliferation: a preliminary report. (PubMed id 12790785)1, 2 Han W.-D.... Pan C.-Y. (Endocr. Relat. Cancer 2003)
    8. The application of RACE technique to clone the full-length cDNA of a novel leukemia associated gene LRP16. (PubMed id 12578638)1, 2 Han W.-D.... Jin H.J. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2001)
    9. A family of macrodomain proteins reverses cellular mono-ADP- ribosylation. (PubMed id 23474712)2 Jankevicius G.... Ladurner A.G. (Nat. Struct. Mol. Biol. 2013)
    10. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28992 HGNC: 29598 AceView: LRP16 Ensembl:ENSG00000133315 euGenes: HUgn28992
    ECgene: MACROD1 H-InvDB: MACROD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MACROD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MACROD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MACROD1 gene:
    Search GeneIP for patents involving MACROD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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