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Aliases &
Descriptions
for MACROD1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| | | Descriptions |
|---|
| MACRO domain containing 1 2 | | Protein LRP16 3 |
|
| |
Search outside databases for aliases for MACROD1 gene |
Summaries
for MACROD1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location
for MACROD1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q11 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1MACROD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M063523:
(about GC identifiers)
Start:
|
63,522,606 bp from pter |
End:
|
63,690,109 bp from pter |
Size:
|
167,504 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033903.7
| Proteins
for MACROD1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MACD1_HUMAN, Q9BQ69 (See
protein sequence)Recommended Name: MACRO domain-containing protein 1 Size: 325 amino acids; 35505 Da
Miscellaneous: Overexpression may promote MCF-7 cells proliferation
Secondary accessions: Q9UH96REFSEQ proteins: NP_054786.2
ENSEMBL proteins: ENSP00000255681
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
About this table
Antibodies for MACROD1:
Assays for MACROD1: | Protein
Domains/
Families
for MACROD1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BQ69
ProtoNet protein and cluster: Q9BQ69 1 Blocks protein family: IPB002589 Protein of unknown function Appr-1
UniProtKB/Swiss-Prot: MACD1_HUMAN, Q9BQ69Similarity: Contains 1 Macro domain | Gene Function
for MACROD1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC003188
 Applied Biosystems Silencer® siRNAs for MACROD1
 Sigma-Aldrich siRNA for MACROD1
Sigma-Aldrich shRNA for MACROD1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_014067
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014067
untagged cDNA clones in CMV expression vector (see all 2): BC003188
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_014067
UniProtKB/Swiss-Prot: MACD1_HUMAN, Q9BQ69Induction: Overexpressed by estrogens in breast cancer MCF-7 cells, probably via an activation of
nuclear receptors for steroids (ESR1 and ESR2) | Pathways & Interactions
for MACROD1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
 Gene Network CentralTM Interacting Genes and Proteins Network for MACROD1
3 Interacting proteins for MACROD1 (ENSP000002556813) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds
for MACROD1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MACROD1
|
Transcripts
for MACROD1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC003188
Sigma-Aldrich siRNA for MACROD1
Sigma-Aldrich shRNA for MACROD1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_014067 REFSEQ mRNAs for MACROD1 gene: NM_014067.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014067
OriGene GFP tagged cDNA clone in CMV expression vector: NM_014067
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014067
untagged cDNA clones in CMV expression vector (see all 2): BC003188
Additional cDNA sequence: AF086206.1 AF202922.2 AL833017.1 BC000270.1 BC003188.1 BC007297.1 BC008316.1 16 DOTS entries: DT.91762287 DT.112929 DT.120741840 DT.75100064 DT.95335120 DT.40132281 DT.100751626 DT.75154589 DT.91762269 DT.97770464 DT.120741897 DT.446438 DT.97805164 DT.97825025 DT.210792 DT.40316156 24/136 AceView cDNA sequences (see all 136
):BC003188 NM_014067 BC008316 AI802616 BQ637198 AF202922 BQ012354 AF086206 AI401080 BM544048 BM781625 BC007297 BE466565 BM918888 BM710028 BF939311 BQ772767 AI469181 AI801852 BC000270 BM821256 BM920848 BF590037 BU072540 Unigene Cluster for MACROD1: MACRO domain containing 1 Hs.602898 [show with all ESTs]Unigene Representative Sequence: AL833017
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MACROD1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for MACROD1
1 Ensembl transcript including schematic representation: ENST00000255681
|
Expression
for MACROD1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MACROD1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MACROD1
1 / 2 3 probe-sets matching MACROD1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAAGGAGATG
SOURCE GeneReport for Unigene cluster: Hs.602898
|
Orthologs
for MACROD1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MACROD1 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for MACROD1
ENSEMBL Gene Tree for MACROD1 | Paralogs
for MACROD1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MACROD1 gene
- GDAP22 MACROD22
|
SNPs/Variants
for MACROD1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for MACROD1 (up to first 250kb)
|
Disorders & Mutations
for MACROD1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610400
|
Medical News
for MACROD1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MACROD1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for MACROD1 gene:- Mechanism of transcriptional regulation of LRP16 gene expression by 17-beta estradiol in MCF-7 human breast cancer cells. (PubMed id 15691879)2, 3 Zhao Y.L....Pan C.Y. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion of human breast cancer MCF-7 cell proliferation: a preliminary report. (PubMed id 12790785)3, 4 Han W.-D.... Pan C.-Y. (2003)
- The application of RACE technique to clone the full-length cDNA of a novel leukemia associated gene LRP16. (PubMed id 12578638)3, 4 Han W.-D.... Jin H.J. (2001)
- The single-macro domain protein LRP16 is an essential cofactor of androgen receptor. (PubMed id 19022849)3 Yang J....Han W.D. (2009)
- Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity. (PubMed id 17914104)3 Han W.D....Mu Y.M. (2007)
- LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). (PubMed id 17532767)3 Imagama S....Naoe T. (2007)
- New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. (PubMed id 16368544)3 Calinisan V....Gascard P. (2006)
- Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)3 Wistow G.... Peterson K. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for MACROD1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MACROD1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MACROD1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MACROD1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for MACROD1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for MACROD1:
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