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Aliases for MACROD1 Gene

Aliases for MACROD1 Gene

  • MACRO Domain Containing 1 2 3 5
  • [Protein ADP-Ribosylglutamate] Hydrolase 3 4
  • MACRO Domain-Containing Protein 1 3 4
  • LRP16 3 4
  • Protein LRP16 4
  • EC 3.2.2.- 4
  • EC 3.5.1.- 4

External Ids for MACROD1 Gene

Previous GeneCards Identifiers for MACROD1 Gene

  • GC11M063523
  • GC11M063767
  • GC11M060094

Summaries for MACROD1 Gene

GeneCards Summary for MACROD1 Gene

MACROD1 (MACRO Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and deacetylase activity. An important paralog of this gene is MACROD2.

UniProtKB/Swiss-Prot for MACROD1 Gene

  • Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MACROD1 Gene

Genomics for MACROD1 Gene

Regulatory Elements for MACROD1 Gene

Promoters for MACROD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MACROD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MACROD1 Gene

Chromosome:
11
Start:
63,998,556 bp from pter
End:
64,166,130 bp from pter
Size:
167,575 bases
Orientation:
Minus strand

Genomic View for MACROD1 Gene

Genes around MACROD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MACROD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MACROD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MACROD1 Gene

Proteins for MACROD1 Gene

  • Protein details for MACROD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ69-MACD1_HUMAN
    Recommended name:
    O-acetyl-ADP-ribose deacetylase MACROD1
    Protein Accession:
    Q9BQ69
    Secondary Accessions:
    • Q9UH96

    Protein attributes for MACROD1 Gene

    Size:
    325 amino acids
    Molecular mass:
    35505 Da
    Quaternary structure:
    • Interacts with ESR1; Interacts in a manner that is estrogen independent but is enhanced by estrogen. Interacts (via macro domain) with AR.
    Miscellaneous:
    • Overexpression may promote MCF-7 cells proliferation. There is an approximate one-third increase of the invasive capacity of MACROD1-overexpressing cells. The expression of CDH1 is repressed by MACROD1. Further analyzes demonstrats that MACROD1 inhibits CDH1 transactivation in a dose dependent manner. Inhibition is abolished by estrogen deprivation, indicating that the down-regulation of CDH1 transcription by MACROD1 requires ESR1 mediation. Binding of ESR1 to the CDH1 promoter is antagonized by MACROD1, suggesting that MACROD1 could interfere with ESR1-mediated transcription. Knockdown of MACROD1 leads to impaired AR function and greatly attenuates the coactivation of AR by other AR coactivators such as UXT and NCOA1. This interference also markedly inhibits the androgen-stimulated proliferation of androgen-sensitive LNCaP prostate cancer cells. MACROD1 knockdown does not significantly affect the growth rate of AR-negative PC-3 prostate cancer cells.
    SequenceCaution:
    • Sequence=AAH03188.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH03188.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MACROD1 Gene

neXtProt entry for MACROD1 Gene

Proteomics data for MACROD1 Gene at MOPED

Post-translational modifications for MACROD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MACROD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MACROD1 Gene

Domains & Families for MACROD1 Gene

Protein Domains for MACROD1 Gene

Suggested Antigen Peptide Sequences for MACROD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ69

UniProtKB/Swiss-Prot:

MACD1_HUMAN :
  • Contains 1 Macro domain.
Domain:
  • Contains 1 Macro domain.
genes like me logo Genes that share domains with MACROD1: view

No data available for Gene Families for MACROD1 Gene

Function for MACROD1 Gene

Molecular function for MACROD1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=373 uM for O-acetyl-ADP-ribose {ECO:0000269 PubMed:21257746};
UniProtKB/Swiss-Prot EnzymeRegulation:
Subject to competitive inhibition by the product ADP-ribose.
UniProtKB/Swiss-Prot Function:
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
UniProtKB/Swiss-Prot Induction:
Overexpressed by estrogens in breast cancer MCF-7 cells, probably via an activation of nuclear receptors for steroids (ESR1 but not ESR2). Significantly increased by estrogens in ESR1-positive Ishikawa endometrial cancer cells. Up-regulated in 17-beta-estradiol-responsive BG-1 ovarian cancer cells but down-regulated in estrogen-resistant SKOV3 ovarian cancer cells. Induced by androgen.

Enzyme Numbers (IUBMB) for MACROD1 Gene

Animal Model Products

CRISPR Products

miRNA for MACROD1 Gene

miRTarBase miRNAs that target MACROD1

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MACROD1 Gene

Localization for MACROD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MACROD1 Gene

Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MACROD1 Gene COMPARTMENTS Subcellular localization image for MACROD1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
peroxisome 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for MACROD1 Gene

Pathways & Interactions for MACROD1 Gene

SuperPathways for MACROD1 Gene

No Data Available

Interacting Proteins for MACROD1 Gene

Gene Ontology (GO) - Biological Process for MACROD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MACROD1 Gene

Drugs & Compounds for MACROD1 Gene

No Compound Related Data Available

Transcripts for MACROD1 Gene

Unigene Clusters for MACROD1 Gene

MACRO domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MACROD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: -

Relevant External Links for MACROD1 Gene

GeneLoc Exon Structure for
MACROD1
ECgene alternative splicing isoforms for
MACROD1

Expression for MACROD1 Gene

mRNA expression in normal human tissues for MACROD1 Gene

mRNA differential expression in normal tissues according to GTEx for MACROD1 Gene

This gene is overexpressed in Muscle - Skeletal (x10.0) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for MACROD1 Gene

This gene is overexpressed in Skin (10.9), Heart (7.6), and Tonsil (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MACROD1 Gene



SOURCE GeneReport for Unigene cluster for MACROD1 Gene Hs.602898

genes like me logo Genes that share expression patterns with MACROD1: view

Protein tissue co-expression partners for MACROD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MACROD1 Gene

Orthologs for MACROD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MACROD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MACROD1 35
  • 89.54 (n)
  • 89.23 (a)
MACROD1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MACROD1 35
  • 89.54 (n)
  • 88.62 (a)
MACROD1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Macrod1 35
  • 86.17 (n)
  • 86.07 (a)
Macrod1 16
Macrod1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MACROD1 35
  • 99.59 (n)
  • 99.69 (a)
MACROD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Macrod1 35
  • 86.15 (n)
  • 89.71 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MACROD1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MACROD1 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68697 35
zebrafish
(Danio rerio)
Actinopterygii macrod1 35
  • 55.79 (n)
  • 48.96 (a)
zgc65960 35
macrod1 36
  • 49 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8510 35
worm
(Caenorhabditis elegans)
Secernentea B0035.3 36
  • 43 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8148 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for MACROD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MACROD1 Gene

ENSEMBL:
Gene Tree for MACROD1 (if available)
TreeFam:
Gene Tree for MACROD1 (if available)

Paralogs for MACROD1 Gene

Paralogs for MACROD1 Gene

(1) SIMAP similar genes for MACROD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MACROD1: view

Variants for MACROD1 Gene

Sequence variations from dbSNP and Humsavar for MACROD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs167658 -- 64,016,623(+) CTGAC(A/G)GCTCT intron-variant
rs186479 -- 64,015,316(-) CCCTT(C/T)CCCAC intron-variant
rs320130 -- 64,019,988(-) GGGAG(A/G)CTGGC intron-variant
rs320131 -- 64,019,731(-) gctac(C/G)cctcc intron-variant
rs320132 -- 64,017,922(-) GGACT(A/G)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MACROD1 Gene

Variant ID Type Subtype PubMed ID
dgv1155n71 CNV Loss 21882294
dgv1156n71 CNV Loss 21882294
nsv897639 CNV Loss 21882294
esv29993 CNV Loss 17803354
dgv1159n71 CNV Loss 21882294
nsv897642 CNV Loss 21882294
dgv1160n71 CNV Loss 21882294
nsv897648 CNV Loss 21882294
esv2666053 CNV Deletion 23128226
dgv1161n71 CNV Loss 21882294
esv2669519 CNV Deletion 23128226
dgv15n68 CNV Loss 17160897
nsv897657 CNV Loss 21882294
dgv1162n71 CNV Gain 21882294
nsv354 CNV Insertion 18451855
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
nsv356 CNV Loss 18451855
esv2744613 CNV Deletion 23290073
nsv897663 CNV Loss 21882294
esv996910 CNV Loss 20482838
dgv1164n71 CNV Loss 21882294

Variation tolerance for MACROD1 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MACROD1 Gene

HapMap Linkage Disequilibrium report
MACROD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MACROD1 Gene

Disorders for MACROD1 Gene

UniProtKB/Swiss-Prot

MACD1_HUMAN
  • Note=A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein. {ECO:0000269 PubMed:17532767}.

Relevant External Links for MACROD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MACROD1

No disorders were found for MACROD1 Gene.

No data available for MalaCards and Genatlas for MACROD1 Gene

Publications for MACROD1 Gene

  1. A family of macrodomain proteins reverses cellular mono-ADP- ribosylation. (PMID: 23474712) Jankevicius G. … Ladurner A.G. (Nat. Struct. Mol. Biol. 2013) 3 4 67
  2. Mechanism of transcriptional regulation of LRP16 gene expression by 17-beta estradiol in MCF-7 human breast cancer cells. (PMID: 15691879) Zhao Y.L. … Pan C.Y. (J. Mol. Endocrinol. 2005) 2 3
  3. An LRP16-containing preassembly complex contributes to NF-I_B activation induced by DNA double-strand breaks. (PMID: 25735744) Wu Z. … Han W. (Nucleic Acids Res. 2015) 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  5. Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. (PMID: 21257746) Chen D. … Ahel I. (J. Biol. Chem. 2011) 3

Products for MACROD1 Gene

Sources for MACROD1 Gene

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