V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

MACF1 Gene

protein-coding GIFtS: 60

GC01P039319

microtubule-actin crosslinking factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABP620 ^¹, ², ³
ACF7 ^¹, ², ³, ⁵
FLJ45612 ^¹, ²
FLJ46776 ^¹, ²
KIAA0465 ^¹, ², ³
KIAA1251 ^¹, ², ³, ⁵
MACF ^¹, ²
Macrophin-1 ^³
OFC4 ^²
OTTHUMP00000009301 ^²
OTTHUMP00000009303 ^²
Trabeculin-alpha ^³
trabeculin-alpha ^²

Descriptions
620 kDa actin binding protein ^²
620 kDa actin-binding protein ^³
Actin cross-linking family protein 7 ^², ³
actin cross-linking factor ^²
macrophin 1 ^²
microfilament and actin filament cross-linker protein ^²
microtubule-actin crosslinking factor 1 ^²

External Ids
HGNC: 13664¹
Entrez Gene: 23499²
UniProtKB: Q9UPN3³
UniProtKB: Q96PK2³
Ensembl: ENSG00000127603⁷

Search outside databases for aliases for MACF1 gene

Previous GC identifers: GC01P039467 GC01P038550 GC01P039010 GC01P038963 GC01P038960 GC01P039216

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MACF1:

The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This

protein family forms bridges between different cytoskeletal elements through specialized modular

domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal

proteins. It has functional actin and microtubule binding domains, and it appears to stabilize

actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics

to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule

network to cellular junctions. Alternatively spliced transcript variants encoding distinct

isoforms have been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: MACF4_HUMAN, Q96PK2

Function: May play a role in cross-linking cytoskeletal proteins by binding intermediate filaments

to the N-terminal plectin repeats and microtubules to the C-terminus

Gene Wiki entry for MACF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MACF1 gene

Entrez Gene cytogenetic band: 1p32-p31 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p32-p31

MACF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P039319: (about GC identifiers)

Start:	39,319,705 bp from pter
End:	39,725,376 bp from pter
Size:	405,672 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MACF1_HUMAN, Q9UPN3 (See protein sequence)

Recommended Name: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Size: 5430 amino acids; 620418 Da

Subcellular location: Cytoplasm, cytoskeleton

Secondary accessions: O75053 Q5VW20 Q8WXY2 Q9H540 Q9UKP0 Q9ULG9

Alternative splicing: 5 isoforms: Q9UPN3-2 Q9UPN3-1 Q9UPN3-3 Q96PK2-1 Q9UPN3-4

UniProtKB/Swiss-Prot: MACF4_HUMAN, Q96PK2 (See protein sequence)

Recommended Name: Microtubule-actin cross-linking factor 1, isoform 4

Size: 5938 amino acids; 670151 Da

Subcellular location: Cytoplasm, cytoskeleton (By similarity)

Secondary accessions: Q8WXY1

Alternative splicing: 5 isoforms: Q96PK2-1 Q9UPN3-1 Q9UPN3-2 Q9UPN3-3 Q9UPN3-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_036222.3 NP_149033.2

ENSEMBL proteins:

ENSP00000289893 ENSP00000362006 ENSP00000353231 ENSP00000337600 ENSP00000361991 ENSP00000313438

ENSP00000386085 ENSP00000354573 ENSP00000289890 ENSP00000362016

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Acf7)
	Human Recombinant Proteins from Abnova (MACF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--
GO:0005856	cytoskeleton	NAS	10529403

About this table

Antibodies for MACF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MACF1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Acf7), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MACF1)
	Novus Biologicals Antibodies for MACF1

Assays for MACF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UPN3

Graphical View of Domain Structure for InterPro Entry Q96PK2

ProtoNet protein and cluster: Q9UPN3

4 Blocks protein families:

IPB001589 Actin-binding

IPB001715 Calponin-like actin-binding

IPB002017 Spectrin repeat

IPB003108 Growth-arrest-specific protein 2

UniProtKB/Swiss-Prot: MACF1_HUMAN, Q9UPN3

Similarity: Belongs to the plakin or cytolinker family

Similarity: Contains 1 actin-binding domain

Similarity: Contains 2 CH (calponin-homology) domains

Similarity: Contains 2 EF-hand domains

Similarity: Contains 1 SH3 domain

Similarity: Contains 37 spectrin repeats

UniProtKB/Swiss-Prot: MACF4_HUMAN, Q96PK2

Similarity: Belongs to the plakin or cytolinker family

Similarity: Contains 2 EF-hand domains

Similarity: Contains 19 plectin repeats

Similarity: Contains 32 spectrin repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MACF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MACF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_033044

Applied Biosystems Silencer® siRNAs for MACF1

Sigma-Aldrich siRNA and siRNA Panels for MACF1

Sigma-Aldrich shRNA Panels and shRNA for MACF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_012090
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_012090
untagged cDNA clones in CMV expression vector (see all 2): NM_012090

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_033044

UniProtKB/Swiss-Prot: MACF1_HUMAN, Q9UPN3

Function: F-actin-binding protein which may play a role in cross-linking actin to other

cytoskeletal proteins. Also binds to microtubules (By similarity)

UniProtKB/Swiss-Prot: MACF4_HUMAN, Q96PK2

Function: May play a role in cross-linking cytoskeletal proteins by binding intermediate filaments

to the N-terminal plectin repeats and microtubules to the C-terminus

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Macf1):

embryogenesis

homeostasis/metabolism

lethality-prenatal/perinatal

skin/coat/nails

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	NAS	--
GO:0005515	protein binding	IPI	17043677
GO:0008017	microtubule binding	NAS	--
GO:0051015	actin filament binding	NAS	10529403 10559237

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MACF1

5/13 Interacting proteins for MACF1 (ENSP00000289893³ Q9UPN3^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DISC1	Q9NRI5¹	EBI-522925, EBI-529989
ATF7IP	Q6VMQ6²	MINT-61902
SKIL	P12757²	MINT-61643
WNT1	ENSP00000293549³	STRING (score=.926)
GSK3B	ENSP00000324806³	STRING (score=.923)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007050	cell cycle arrest	IEA	--
GO:0008150	biological_process	ND	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MACF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MACF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MACF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_033044

Sigma-Aldrich siRNA and siRNA Panels for MACF1

Sigma-Aldrich shRNA Panels and shRNA for MACF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012090 NM_033044

REFSEQ mRNAs for MACF1 gene (2 alternative transcripts):

NM_012090.3 NM_033044.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012090 NM_033044

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_012090
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_012090
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012090

Additional cDNA sequence:

AB007934.3 AB029290.1 AB033077.1 AF317696.1 AK023285.1 AK023406.1 AK023821.1 AK127519.1

AK297854.1 AK299010.1 AK304414.1 BC007330.2 BC071925.1 BC107866.1 BX647441.1 CR597314.1

24/48 DOTS entries (see all 48 ):

DT.100845848 DT.456319 DT.97862225 DT.97862226 DT.100747158 DT.121411212 DT.100845850 DT.308262

DT.95169213 DT.100645516 DT.91882401 DT.95253158 DT.100845849 DT.91743056 DT.100727278 DT.121411434

DT.91745444 DT.121411229 DT.40262169 DT.65284224 DT.75115816 DT.91836855 DT.95361130 DT.100845856

11 AceView cDNA sequences:

CD675344 BX107650 AI017174 AI290294 BX116150 AA047436 AI804425 AA333144

AA047475 BM932057 AA046765

highest scoring ESTs for MACF1:

AB007934 AA059074 AA059168 AA169568 AA195678 AA195679 AA214545 AA278170 AA278402 AA303170

Unigene Cluster for MACF1:

Microtubule-actin crosslinking factor 1

Hs.580782 [show with all ESTs]

Unigene Representative Sequence: NM_033044

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for MACF1 (see all 20 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^	20	^	21	^
SP1:									-		-		-		-								-																		-						-
SP2:
SP3:
SP4:
SP5:

ExUns:	22	^	23	^	24	^	25	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39	^	40	^	41	^	42	^	43a	·	43b	^	44	^	45	^
SP1:																																									-		-		-
SP2:																																									-		-		-
SP3:
SP4:
SP5:

ExUns:	46	^	47	^	48	^	49	^	50	^	51	^	52	^	53	^	54	^	55	^	56	^	57	^	58	^	59	^	60	^	61	^	62a	·	62b	^	63	^	64	^	65	^	66	^	67	^	68	^	69	^	70	^
SP1:																													-
SP2:																	-												-												-
SP3:
SP4:
SP5:

ExUns:	71	^	72	^	73	^	74	^	75	^	76	^	77	^	78a	·	78b	^	79	^	80a	·	80b	^	81	^	82	^	83	^	84	^	85	^	86	^	87a	·	87b	^	88	^	89a	·	89b	^	90	^	91a	·	91b	^
SP1:																																											-
SP2:																																											-
SP3:																																											-
SP4:
SP5:

ExUns:	92a	·	92b	^	93a	·	93b	^	94	^	95	^	96a	·	96b	^	97	^	98a	·	98b	·	98c	·	98d	^	99a	·	99b	·	99c	^	100	^	101a	·
SP1:	-														-		-		-												-		-
SP2:	-														-		-		-												-		-
SP3:	-						-		-		-		-		-		-		-		-		-								-
SP4:															-		-		-												-
SP5:

About this scheme

ECgene alternative splicing isoforms for MACF1

10 Ensembl transcripts including schematic representations:

ENST00000289893 ENST00000372915 ENST00000360115 ENST00000335924 ENST00000372900 ENST00000317713

ENST00000404645 ENST00000361689 ENST00000289890 ENST00000372925

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MACF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MACF1

¹ / ² / ³

20 probe-sets matching MACF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38704_at²^{, 3}	U95-A	1	1.00	1.00	0.79	1.64	AB007934	1.00	0.90	0.95	1
80665_r_at²^{, 3}	U95-E	6	1.00	0.95	0.02	0.37	AI963771	0.80	1.00	0.91	1
55840_at²^{, 3}	U95-B	1	0.94	1.00	-0.04	1.32	AA046493	0.60	1.00	0.82	1
85786_at²^{, 3}	U95-E	1	0.88	1.00	0.68	0.79	T79797	0.40	1.00	0.76	1
69219_at²^{, 3}	U95-D	1	0.38	1.00	0.47	0.93	AI703088	0.60	1.00	0.82	1
214894_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK023285	0.80	1.00	0.91	1
208633_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	W61052	0.80	1.00	0.91	1
215222_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK023406	0.60	1.00	0.82	1
241896_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI017174	0.60	1.00	0.82	1
207358_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012090	0.60	1.00	0.82	1
208634_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB029290	0.80	0.88	0.84	1
232168_x_at²^{, 3}	U133-B	63	1.00	0.77	--	--	AK023821	0.60	1.00	0.82	1
214894_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215222_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
241896_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207358_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208633_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208634_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553407_at²	U133Plus2	19	1.00	0.91	--	--	--	--	--	--	--
232168_x_at²	U133Plus2	63	1.00	0.77	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGCTGTGTG

SOURCE GeneReport for Unigene cluster: Hs.580782
Expression variation in blood from EXPOLDB for MACF1
UniProtKB/Swiss-Prot: MACF1_HUMAN, Q9UPN3
Tissue specificity: Ubiquitously expressed
UniProtKB/Swiss-Prot: MACF4_HUMAN, Q96PK2
Tissue specificity: Expressed in heart, lung, pituitary and placenta, not found in brain, kidney,
liver, pancreas or skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MACF1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	MACF1¹	--	microtubule-actin crosslinking factor 1	99.54(n) 99.46(a)	456778 XM_513340.2 XP_513340.2
mouse (Mus musculus)	Macf1^{1, 5}	4 (57.40 cM)⁵	microtubule-actin crosslinking factor 1^{1, 5}	84.3(n)¹ 82.57(a)¹	11426¹ XM_884922.3¹ XP_890015.3¹ AF150755⁵ AI551319⁵ (see all 29)
zebrafish (Danio rerio)	LOC562044¹	--	similar to Microtubule-actin cross-linking factor 1	55.94(n) 51.21(a)	562044 XM_001920059.1 XP_001920094.1
fruit fly (Drosophila melanogaster)	shot^{1, 3}	50C6--11³	microtubule-based process actin binding³ short stop¹	25(a)³ 44.05(n)¹ 32.02(a)¹	36542¹ NM_166019.1¹ NP_725339.1¹
worm (Caenorhabditis elegans)	M116.5³ vab-10¹	IV(8414779-8421194)³	Variable ABnormal morphology¹	48(a)³ 40.96(n)¹ 25.47(a)¹	173058¹ NM_001026684.1¹ NP_001021855.1¹

About this table Species with no ortholog for MACF1

ENSEMBL Gene Tree for MACF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MACF1 gene

EVPL² EVPLL² PPL² DST²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2053 NCBI SNPs in MACF1 are shown (see all 2053 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 491)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs587404^1,2	A,C,F,H,O	39681093(+)	`TGGAAG/ACCATG`	2	T/A	mis¹		13	MN EU EA WA	1440
	rs1569053^1,2	A,C,F,H,O	39725409(-)	`AACAAG/AATTAA`	2	--	ng3¹		3	EA WA	298
	rs668556^1,2	A,C,F,H	39686950(-)	`TCTGAC/GTATCT`	2	S/T	mis¹		19	MN EA NA EU WA	1836
	rs9659165^1,2	A,C,F,H	39317856(+)	`CCTAGC/TGTAAC`	1	--	ng5¹		8	EU EA WA	840
	rs710915^1,2	A,C,F,H	39725332(-)	`GAATGC/TATTTA`	2	--	ut3¹ ese³		4	EU EA WA	380
	rs2296172^1,2	C,F,H,O	39608404(+)	`CTTCTA/GTGAGT`	2	M/V	mis¹ ese³		13	EA EU WA	1992
	rs10047195^1,2	C,F,H	39572274(+)	`TAAAGC/GACCTT`	2	A/G	mis¹ int¹		8	EU EA WA	822
--	rs17570718^1,2	C,F,H	39574755(+)	`AGAAAA/CGACAG`	2	K/T	mis¹ int¹ trp³		11	NA EU EA WA	968
	rs16826072^1,2	C,F,H	39571020(+)	`TTGCAC/TTACAG`	2	T/I	mis¹ int¹ ese³		12	NA EU EA WA	1058
	rs12068423^1,2	C,F,H	39692089(+)	`CCATCA/GTCCGA`	2	I/V	mis¹ ese³		8	EU EA WA	840

About this table

HapMap Linkage Disequilibrium images for MACF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608271

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/31 PubMed articles for MACF1 gene (see all 31 ):

MACF1 gene structure: a hybrid of plectin and dystrophin. (PubMed id 11845288)^{1, 3, 4} Gong T.-W.L.... Lomax M.I. (2001)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. (PubMed id 16097034)^{3, 4} Gevaert K.... Vandekerckhove J. (2005)
Molecular cloning of macrophin, a human homologue of Drosophila kakapo with a close structural similarity to plectin and dystrophin. (PubMed id 10529403)^{2, 3} Okuda T....Hamaguchi M. (1999)
Novel actin crosslinker superfamily member identified by a two step degenerate PCR procedure. (PubMed id 7635207)^{2, 3} Byers T.J.... Kunkel L.M. (1995)
Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins. (PubMed id 11112700)^{1, 3} Sun D....Liem R.K. (2001)
Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. (PubMed id 15265687)^{1, 3} Kakinuma T....Toh B.H. (2004)
Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins. (PubMed id 10559237)^{1, 3} Sun Y.... Chen L.B. (1999)
Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex. (PubMed id 16076900)^{1, 3} Lin C.M....Liem R.K. (2005)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23499	HGNC: 13664	AceView: MACF1	Ensembl:ENSG00000127603	euGenes: HUgn23499
ECgene: MACF1	H-InvDB: MACF1

(According to HUGE)
About This Section

HUGE: KIAA1251 KIAA0465

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for MACF1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MACF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MACF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MACF1		Antibodies for MACF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MACF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MACF1)
	Antibodies (MACF1)
	Chimera RNAi (MACF1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Acf7)
	Antibodies (Acf7)

Search OriGene for MACF1

Search Tocris compounds for MACF1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MACF1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MACF1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

MACF1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for MACF1

Summaries
for MACF1

Genomic Location
for MACF1

Proteins
for MACF1

Protein Domains/
Families
for MACF1

Gene Function
for MACF1

Pathways & Interactions
for MACF1

Drugs & Compounds
for MACF1

Transcripts
for MACF1

Expression
for MACF1

Orthologs
for MACF1

Paralogs
for MACF1

SNPs/Variants
for MACF1

Disorders & Mutations
for MACF1

Medical News
for MACF1

Publications
for MACF1

Search for MACF1

Genome Databases showing MACF1

Other Databases showing MACF1

Specialized Databases showing MACF1

Licensable Technologies
for MACF1

Services
for MACF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MACF1 (Gene Symbol)
ABP620
ACF7
FLJ45612
FLJ46776
KIAA0465
KIAA1251
MACF
Macrophin-1
OFC4
OTTHUMP00000009301
OTTHUMP00000009303
Trabeculin-alpha
trabeculin-alpha
620 kDa actin binding protein
620 kDa actin-binding protein
Actin cross-linking family protein 7
actin cross-linking factor
macrophin 1
microfilament and actin filament cross-linker protein
microtubule-actin crosslinking factor 1

MACF1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor MACF1

Summariesfor MACF1

Genomic Locationfor MACF1

Proteinsfor MACF1

Protein Domains/Familiesfor MACF1

Gene Functionfor MACF1

Pathways & Interactionsfor MACF1

Drugs & Compoundsfor MACF1

Transcriptsfor MACF1

Expression for MACF1

Orthologsfor MACF1

Paralogsfor MACF1

SNPs/Variantsfor MACF1

Disorders & Mutationsfor MACF1

Medical Newsfor MACF1

Publicationsfor MACF1

Search for MACF1

Genome Databases showing MACF1

Other Databases showing MACF1

Specialized Databases showing MACF1

Licensable Technologiesfor MACF1

Servicesfor MACF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MACF1

Summaries
for MACF1

Genomic Location
for MACF1

Proteins
for MACF1

Protein Domains/
Families
for MACF1

Gene Function
for MACF1

Pathways & Interactions
for MACF1

Drugs & Compounds
for MACF1

Transcripts
for MACF1

Expression
for MACF1

Orthologs
for MACF1

Paralogs
for MACF1

SNPs/Variants
for MACF1

Disorders & Mutations
for MACF1

Medical News
for MACF1

Publications
for MACF1

Licensable Technologies
for MACF1

Services
for MACF1