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Aliases for MACC1 Gene

Aliases for MACC1 Gene

  • Metastasis Associated In Colon Cancer 1 2 3
  • SH3 Domain-Containing Protein 7a5 3 4
  • Metastasis-Associated In Colon Cancer Protein 1 3
  • Putative Binding Protein 7a5 3
  • SH3BP4L 3
  • 7A5 3

External Ids for MACC1 Gene

Summaries for MACC1 Gene

Entrez Gene Summary for MACC1 Gene

  • MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]

GeneCards Summary for MACC1 Gene

MACC1 (Metastasis Associated In Colon Cancer 1) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is SH3BP4.

UniProtKB/Swiss-Prot for MACC1 Gene

  • Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MACC1 Gene

Genomics for MACC1 Gene

Genomic Location for MACC1 Gene

20,134,655 bp from pter
20,217,404 bp from pter
82,750 bases
Minus strand

Genomic View for MACC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MACC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MACC1 Gene

Regulatory Elements for MACC1 Gene

Proteins for MACC1 Gene

  • Protein details for MACC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metastasis-associated in colon cancer protein 1
    Protein Accession:
    Secondary Accessions:
    • A8MUS5
    • B2RNR9
    • Q6ZQN8
    • Q7Z5A5

    Protein attributes for MACC1 Gene

    852 amino acids
    Molecular mass:
    96639 Da
    Quaternary structure:
    • Interacts with FASLG.
    • Sequence=BAC87646.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW93719.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MACC1 Gene

Proteomics data for MACC1 Gene at MOPED

Post-translational modifications for MACC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MACC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MACC1 Gene

Domains for MACC1 Gene

Protein Domains for MACC1 Gene



  • Contains 1 SH3 domain.:
    • Q6ZN28
genes like me logo Genes that share domains with MACC1: view

No data available for Gene Families for MACC1 Gene

Function for MACC1 Gene

Molecular function for MACC1 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.

Gene Ontology (GO) - Molecular Function for MACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with MACC1: view

Phenotypes for MACC1 Gene

GenomeRNAi human phenotypes for MACC1:
genes like me logo Genes that share phenotypes with MACC1: view

miRNA for MACC1 Gene

miRTarBase miRNAs that target MACC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MACC1 Gene

Localization for MACC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MACC1 Gene

Cytoplasm. Nucleus. Note=Mainly found in the cytoplasm in non-metastasizing tumors.

Subcellular locations from

Jensen Localization Image for MACC1 Gene COMPARTMENTS Subcellular localization image for MACC1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MACC1: view

Pathways for MACC1 Gene

SuperPathways for MACC1 Gene

No Data Available

Interacting Proteins for MACC1 Gene

Selected Interacting proteins: Q6ZN28-MACC1_HUMAN for MACC1 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0051781 positive regulation of cell division IEA --
genes like me logo Genes that share ontologies with MACC1: view

No data available for Pathways by source for MACC1 Gene

Transcripts for MACC1 Gene

mRNA/cDNA for MACC1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MACC1 Gene

Metastasis associated in colon cancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MACC1 Gene

No ASD Table

Relevant External Links for MACC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MACC1 Gene

mRNA expression in normal human tissues for MACC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MACC1 Gene

This gene is overexpressed in Minor Salivary Gland (6.5) and Esophagus - Mucosa (5.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MACC1 Gene

SOURCE GeneReport for Unigene cluster for MACC1 Gene Hs.598388

mRNA Expression by UniProt/SwissProt for MACC1 Gene

Tissue specificity: Preferentially expressed in metastasizing tumors.
genes like me logo Genes that share expressions with MACC1: view

Orthologs for MACC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MACC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MACC1 36
  • 99.41 (n)
  • 98.83 (a)
MACC1 37
  • 99 (a)
(Bos Taurus)
Mammalia MACC1 36
  • 87.21 (n)
  • 81.92 (a)
MACC1 37
  • 83 (a)
(Canis familiaris)
Mammalia MACC1 36
  • 87.66 (n)
  • 82.02 (a)
MACC1 37
  • 82 (a)
(Mus musculus)
Mammalia Macc1 36
  • 81.86 (n)
  • 76.85 (a)
Macc1 16
Macc1 37
  • 77 (a)
(Monodelphis domestica)
Mammalia MACC1 37
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia MACC1 37
  • 69 (a)
(Rattus norvegicus)
Mammalia Macc1 36
  • 81.25 (n)
  • 76.12 (a)
(Gallus gallus)
Aves MACC1 36
  • 68.66 (n)
  • 64.08 (a)
MACC1 37
  • 62 (a)
(Anolis carolinensis)
Reptilia MACC1 37
  • 61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32836 36
tropical clawed frog
(Silurana tropicalis)
Amphibia macc1 36
  • 64.11 (n)
  • 60.91 (a)
(Danio rerio)
Actinopterygii macc1 36
  • 56.06 (n)
  • 46.99 (a)
macc1 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1683 37
  • 28 (a)
Species with no ortholog for MACC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MACC1 Gene

Gene Tree for MACC1 (if available)
Gene Tree for MACC1 (if available)

Paralogs for MACC1 Gene

Paralogs for MACC1 Gene

Selected SIMAP similar genes for MACC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MACC1: view

Variants for MACC1 Gene

Sequence variations from dbSNP and Humsavar for MACC1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs734035 -- 20,154,077(-) ATCCA(C/T)TAACT intron-variant
rs973071 -- 20,157,830(-) GTTAG(A/G)GATCT intron-variant
rs975263 - 20,158,817(-) ACTCT(C/T)GAATC reference, missense
rs1010701 -- 20,156,403(-) TGTAT(A/T)TTTTG intron-variant
rs1468442 -- 20,177,610(-) AAGTT(G/T)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MACC1 Gene

Variant ID Type Subtype PubMed ID
nsv830919 CNV Loss 17160897
nsv887832 CNV Loss 21882294
esv2734100 CNV Deletion 23290073
nsv520265 CNV Loss 19592680
nsv5650 CNV Insertion 18451855
esv2734101 CNV Deletion 23290073
nsv887833 CNV Loss 21882294

Relevant External Links for MACC1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for MACC1 Gene

(1) University of Copenhagen DISEASES for MACC1 Gene

Relevant External Links for MACC1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with MACC1: view

No data available for UniProtKB/Swiss-Prot for MACC1 Gene

Publications for MACC1 Gene

  1. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M. … Janssen O. (BMC Immunol. 2009) 3 4
  2. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. (PMID: 19098908) Stein U. … Schlag P.M. (Nat. Med. 2009) 3 4
  3. Unexpected domain composition of MACC1 links MET signaling and apoptosis. (PMID: 19499089) KokoszyA8ska K. … Wyrwicz L.S. (Acta Biochim. Pol. 2009) 3
  4. MACC1 controls Met: what a difference an Sp1 site makes. (PMID: 19556890) Stein U. … Arlt F. (Cell Cycle 2009) 3
  5. MACC1 - more than metastasis? Facts and predictions about a novel gene. (PMID: 19787327) Stein U. … Walther W. (J. Mol. Med. 2010) 3

Products for MACC1 Gene

Sources for MACC1 Gene

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