Aliases for MACC1 Gene
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
GeneCards Summary for MACC1 Gene
MACC1 (MACC1, MET Transcriptional Regulator) is a Protein Coding gene. Diseases associated with MACC1 include Renal Pelvis Carcinoma and Klatskin's Tumor. GO annotations related to this gene include growth factor activity. An important paralog of this gene is SH3BP4.
UniProtKB/Swiss-Prot for MACC1 Gene
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.