MAB21L2 Gene
protein-coding GIFtS : 46
GCID: GC04 P151503
mab-21-like 2 (C. elegans) (Previous name: mab-21 (C. elegans)-like 2 )
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Aliasesfor MAB21L2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Mab-21-Like 2 (C. Elegans) 1 2 Mab-21 (C. Elegans)-Like 21 Protein Mab-21-Like 22
Export aliases for MAB21L2 gene to outside databases Previous GC identifers: GC04P152311 GC04P151890 GC04P152080 GC04P151860 GC04P151722 GC04P147228
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Summariesfor MAB21L2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MAB21L2 : This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586 Function : Required for several aspects of embryonic development including normal development of the eye (By similarity)
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Genomic Viewsfor MAB21L2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MAB21L2 gene promoter: E2F-4 E2F-3a E2F-5 Nkx2-5 CUTL1 E2F-2 FOXL1 Egr-2 E2F E2F-1 Other transcription factors Search SABiosciences Chromatin IP Primers for MAB21L2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MAB21L2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q31 Ensembl cytogenetic band: 4q31.3 HGNC cytogenetic band: 4q31 MAB21L2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P151503: view genomic region
(about GC identifiers )
Start:
151,503,077 bp from pter
End:
151,505,845 bp from pter
Size:
2,769 bases
Orientation:
plus strand
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Proteinsfor MAB21L2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586 (See
protein sequence )Recommended Name: Protein mab-21-like 2 Size : 359 amino acids; 40923 Da
Subcellular location : Nucleus (By similarity)
Secondary accessions : B3KP37 Q9HBA7Explore the universe of human proteins at neXtProt for MAB21L2: NX_Q9Y586 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9Y586 MAB21L2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_006430.1 ENSEMBL proteins: ENSP00000324701 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
MAB21L2 for ontologies About GeneDecksing MAB21L2 Antibody Products: Assay Products for MAB21L2:
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Protein
Domains / Familiesfor MAB21L2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MAB21L2 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9Y586 ProtoNet protein and cluster: Q9Y586
1 Blocks protein family : IPB000772 Ricin B lectin domain UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586 Similarity : Belongs to the mab-21 family
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Functionfor MAB21L2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586 Function : Required for several aspects of embryonic development including normal development of the eye (By similarity)
Genatlas biochemistry entry for MAB21L2 : mab-21 (C elegans)-like 2,member of a family of genes,involved in vertebrate neural development Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MAB21L2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MAB21L2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MAB21L2 (NM_006439 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAB21L2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MAB21L2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAB21L2
Animal Models: Mouse knock-out Mab21l2 tm1Nao for MAB21L2 5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mab21l2) :
MAB21L2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor MAB21L2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAB21L2 Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
MAB21L2 for ontologies About GeneDecksing
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Drugs & Compoundsfor MAB21L2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MAB21L2 Search CenterWatch for drugs/clinical trials and news about MAB21L2 / MB212
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Transcriptsfor MAB21L2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MAB21L2 gene: NM_006439.4 Unigene Cluster for MAB21L2:
Mab-21-like 2 (C. elegans) Hs.584852 [show with all ESTs ] Unigene Representative Sequence: NM_006439 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000317605 (uc003ilw.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MAB21L2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MAB21L2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MAB21L2 (NM_006439 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAB21L2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MAB21L2
Additional cDNA sequence: AF262032.1 AF370007.1 AK055665.1 BC009983.2
3 DOTS entries : DT.40225367 DT.100646301
DT.95350475 24/37 AceView cDNA sequences (see all 37 ):
BC009983 CR620783 NM_006439 BM728642 AF370007 BX283081 AL702293 BX348661 AL515813 AK055665 AL515812 AL522676 AF262032 BX493567 BI195867 CB857031 BX645470 BF314563 AA679158 AL522675 CA395355 AL562226 BP346235 BF316056 GeneLoc Exon Structure
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Expression for MAB21L2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MAB21L2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAGACGCTGC
About this image MAB21L2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MAB21L2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MAB21L2 SOURCE GeneReport for Unigene cluster: Hs.584852 SABiosciences Custom PCR Arrays for MAB21L2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MAB21L2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MAB21L2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MAB21L2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MAB21L2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAB21L2
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Orthologsfor MAB21L2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for MAB21L2 gene from 4/16 species (see all 16 ) About this table
ENSEMBL Gene Tree for MAB21L2 (if available)TreeFam Gene Tree for MAB21L2 (if available)
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Paralogsfor MAB21L2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MAB21L2 gene MAB21L3 2 MAB21L1 2 1 SIMAP similar gene for MAB21L2 using alignment to 1 protein entry: MB212_HUMAN :MAB21L1
MAB21L2 for paralogs About GeneDecksing
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Genomic Variantsfor MAB21L2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MAB21L2
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Disorders
/ Diseasesfor MAB21L2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MAB21L2 for disorders About GeneDecksing
OMIM gene information: 604357
OMIM disorders : --2 diseases for MAB21L2 : About MalaCards microphthalmia neuronitis Export disorders for MAB21L2 gene to outside databases
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Publicationsfor MAB21L2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MAB21L2 gene integrated from 9 sources : (articles sorted by number of sources associating them with MAB21L2) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development. (PubMed id 10556287) 1 , 2 Mariani M.... Consalez G.G. (1999) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Genomic cloning and chromosomal localization of the mouse Mab21l2 locus. (PubMed id 10516425) 9 Wong R.L....Chow K.L. (1999) MAB21L2, a vertebrate member of the Male-abnormal 21 family, modulates BMP signaling and interacts with SMAD1. (PubMed id 15613244) 9 Baldessari D....Consalez G.G. (2004)
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External Searches for MAB21L2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MAB21L2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MAB21L2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MAB21L2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MAB21L2 gene: Search GeneIP for patents involving MAB21L2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MAB21L2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MAB21L2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MAB21L2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MAB21L2 OriGene Protein Over-expression Lysate for MAB21L2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MAB21L2 OriGene 3'-UTR Clone for MAB21L2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MAB21L2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MAB21L2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MAB21L2 OriGene Custom Protein Services for MAB21L2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAB21L2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MAB21L2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MAB21L2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MAB21L2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MAB21L2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MAB21L2
Search Tocris compounds for MAB21L2
MAB21L2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAB21L2
Search ThermoFisher Antibodies for MAB21L2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MAB21L2
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Aliases for MAB21L2
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