Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAB21L2 Gene

protein-coding   GIFtS: 45
GCID: GC04P151503

Mab-21-Like 2 (C. Elegans)

(Previous name: mab-21 (C. elegans)-like 2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mab-21-Like 2 (C. Elegans)1 2
Mab-21 (C. Elegans)-Like 21
Protein Mab-21-Like 22

External Ids:    HGNC: 67581   Entrez Gene: 105862   Ensembl: ENSG000001815417   OMIM: 6043575   UniProtKB: Q9Y5863   

Export aliases for MAB21L2 gene to outside databases

Previous GC identifers: GC04P152311 GC04P151890 GC04P152080 GC04P151860 GC04P151722 GC04P147228


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAB21L2 Gene:
This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming
growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein
encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MAB21L2 Gene: 
MAB21L2 (mab-21-like 2 (C. elegans)) is a protein-coding gene. Diseases associated with MAB21L2 include microphthalmia. An important paralog of this gene is MAB21L3.

UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586
Function: Required for several aspects of embryonic development including normal development of the eye (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAB21L2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Nkx2-5   CUTL1   E2F-2   FOXL1   Egr-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAB21L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAB21L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAB21L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31

MAB21L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAB21L2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P151503:  view genomic region     (about GC identifiers)

Start:
151,503,077 bp from pter      End:
151,505,845 bp from pter
Size:
2,769 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586 (See protein sequence)
Recommended Name: Protein mab-21-like 2  
Size: 359 amino acids; 40923 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B3KP37 Q9HBA7

Explore the universe of human proteins at neXtProt for MAB21L2: NX_Q9Y586

Explore proteomics data for MAB21L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y586

  • MAB21L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAB21L2 Protein Expression
    REFSEQ proteins: NP_006430.1  
    ENSEMBL proteins: 
     ENSP00000324701  

    Human Recombinant Protein Products for MAB21L2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MAB21L2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MAB21L2
    GenScript Custom Purified and Recombinant Proteins Services for MAB21L2
    Novus Biologicals MAB21L2 Protein
    Novus Biologicals MAB21L2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAB21L2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MAB21L2 for ontologies           About GeneDecksing



    MAB21L2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MAB21L2
    GenScript Custom Superior Antibodies Services for MAB21L2
    Search for Antibodies for MAB21L2 at Abcam
    Cloud-Clone Corp. Antibodies for MAB21L2 
    Search ThermoFisher Antibodies for MAB21L2
    Search LSBio for Antibodies for MAB21L2 

    Assay Products for MAB21L2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAB21L2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAB21L2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAB21L2 
    Cloud-Clone Corp. CLIAs for MAB21L2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000772 Ricin_B_lectin
     IPR024801 Mab21L1
     IPR024810 Mab-21_dom
     IPR020950 Mab-21-rel

    Graphical View of Domain Structure for InterPro Entry Q9Y586

    ProtoNet protein and cluster: Q9Y586

    1 Blocks protein domain: IPB000772 Ricin B lectin domain

    UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586
    Similarity: Belongs to the mab-21 family


    MAB21L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MB212_HUMAN, Q9Y586
    Function: Required for several aspects of embryonic development including normal development of the eye (By
    similarity)

         Genatlas biochemistry entry for MAB21L2:
    mab-21 (C elegans)-like 2,member of a family of genes,involved in vertebrate neural development

    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mab21l2):
     cardiovascular system  growth/size  mortality/aging  pigmentation  vision/eye 

    MAB21L2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mab21l2tm1Nao for MAB21L2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAB21L2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAB21L2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAB21L2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAB21L2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAB21L2
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate MAB21L2 (see all 28):
    hsa-miR-548j hsa-miR-4311 hsa-miR-548i hsa-miR-181c hsa-miR-1271 hsa-miR-3200-3p hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAB21L2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAB21L2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAB21L2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAB21L2
    Sirion Biotech Customized adenovirus for overexpression of MAB21L2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAB21L2 (see all 7)
    OriGene ORF clones in mouse, rat for MAB21L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAB21L2 (NM_006439)
    Sino Biological Human cDNA Clone for MAB21L2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAB21L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAB21L2
    Sirion Biotech Customized lentivirus for stable overexpression of MAB21L2 
                         Customized lentivirus expression plasmids for stable overexpression of MAB21L2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAB21L2
    Search LifeMap BioReagents cell lines for MAB21L2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAB21L2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAB21L2

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development TAS10556287
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0010172embryonic body morphogenesis IEA--
    GO:0043010camera-type eye development IEA--
    GO:0048568embryonic organ development IEA--

    MAB21L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAB21L2 (MB212)

    Search CenterWatch for drugs/clinical trials and news about MAB21L2 / MB212

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAB21L2 gene: 
    NM_006439.4  

    Unigene Cluster for MAB21L2:

    Mab-21-like 2 (C. elegans)
    Hs.584852  [show with all ESTs]
    Unigene Representative Sequence: NM_006439
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000317605(uc003ilw.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAB21L2
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate MAB21L2 (see all 28):
    hsa-miR-548j hsa-miR-4311 hsa-miR-548i hsa-miR-181c hsa-miR-1271 hsa-miR-3200-3p hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAB21L2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAB21L2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAB21L2
    Clone
    Products:
         
    OriGene clones in human, mouse for MAB21L2 (see all 7)
    OriGene ORF clones in mouse, rat for MAB21L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAB21L2 (NM_006439)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAB21L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAB21L2
    Sirion Biotech Customized lentivirus for stable overexpression of MAB21L2 
                         Customized lentivirus expression plasmids for stable overexpression of MAB21L2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAB21L2
    OriGene qSTAR qPCR primer pairs in human, mouse for MAB21L2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAB21L2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAB21L2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAB21L2

    Additional mRNA sequence: 

    AF262032.1 AF370007.1 AK055665.1 BC009983.2 

    3 DOTS entries:

    DT.40225367  DT.100646301  DT.95350475 

    24/37 AceView cDNA sequences (see all 37):

    NM_006439 BC009983 CR620783 AL522676 BX348661 AL515812 BM728642 AF262032 
    AL702293 AL515813 BI195867 CB857031 BF314563 AA679158 AK055665 BX645470 
    BX283081 AF370007 BX493567 AL523558 BI481050 AL522675 BP346235 CA395355 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAB21L2 expression in normal human tissues (normalized intensities)      MAB21L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGACGCTGC
    MAB21L2 Expression
    About this image


    MAB21L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
             Maxillary Process
             Human Calvarial Osteoblasts (HCO)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Normal Human Articular chondrocytes (NHAC)   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Early Retinal Progenitor Cells Retinal Neuroblastic Layer
             Human Non-Pigment Ciliary Epithelial Cells (HNPCEpiC)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Rhombencephalon

    See MAB21L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAB21L2

    SOURCE GeneReport for Unigene cluster: Hs.584852
        SABiosciences Custom PCR Arrays for MAB21L2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAB21L2
    OriGene qSTAR qPCR primer pairs in human, mouse for MAB21L2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAB21L2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAB21L2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAB21L2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAB21L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAB21L2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mab21l21 , 5 mab-21-like 2 (C. elegans)1, 5 92.39(n)1
    99.72(a)1
      3 (37.86 cM)5
    239371  NM_011839.31  NP_035969.21 
     865455815 
    chicken
    (Gallus gallus)
    Aves MAB21L26
    mab-21-like 2
    100(a)
    1 ↔ 1
    4(32453927-32455006)
    zebrafish
    (Danio rerio)
    Actinopterygii mab21l21 mab-21-like 2 82.27(n)
    96.94(a)
      117234  NM_152975.2  NP_694507.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH114153
    CG47661
    CG47661 73(a)3
    68.9(n)1
    74.37(a)1
      315331  NM_132059.21  NP_572287.11 


    ENSEMBL Gene Tree for MAB21L2 (if available)
    TreeFam Gene Tree for MAB21L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAB21L2 gene
    MAB21L32  MAB21L12  
    1 SIMAP similar gene for MAB21L2 using alignment to 1 protein entry:     MB212_HUMAN:
    MAB21L1

    MAB21L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MAB21L2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4547CNV Loss18451855
    nsv880256CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAB21L2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAB21L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604357    OMIM disorders: --

    2 diseases for MAB21L2:    About MalaCards
    microphthalmia    


    MAB21L2 for disorders           About GeneDecksing


    Export disorders for MAB21L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAB21L2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MAB21L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development. (PubMed id 10556287)1, 2 Mariani M.... Consalez G.G. (1999)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Genomic cloning and chromosomal localization of the mouse Mab21l2 locus. (PubMed id 10516425)9 Wong R.L....Chow K.L. (1999)
    8. MAB21L2, a vertebrate member of the Male-abnormal 21 family, modulates BMP signaling and interacts with SMAD1. (PubMed id 15613244)9 Baldessari D....Consalez G.G. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10586 HGNC: 6758 AceView: MAB21L2 Ensembl:ENSG00000181541 euGenes: HUgn10586
    ECgene: MAB21L2 H-InvDB: MAB21L2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAB21L2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAB21L2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAB21L2 gene:
    Search GeneIP for patents involving MAB21L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MAB21L2  
     OriGene qPCR primer pairs and template standards for MAB21L2   OriGene Protein Over-expression Lysate for MAB21L2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MAB21L2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAB21L2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MAB21L2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAB21L2   OriGene Custom Protein Services for MAB21L2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAB21L2
     QIAGEN SeqTarget long-range PCR primers for resequencing MAB21L2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAB21L2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAB21L2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAB21L2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAB21L2
     GenScript Custom Purified and Recombinant Proteins Services for MAB21L2 GenScript cDNA clones with any tag delivered in your preferred vector for MAB21L2
     GenScript Custom Assay Services for MAB21L2 GenScript Custom Superior Antibodies Services for MAB21L2
     GenScript Custom overexpressing Cell Line Services for MAB21L2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MAB21L2 promoter
     Search Chromatin IP Primers for MAB21L2
     RT2 qPCR Primer Assay in human, mouse, rat MAB21L2
     Search GNC Networks for MAB21L2
     SABiosciences Custom PCR Arrays for MAB21L2
     Search Tocris compounds for MAB21L2 (MB212)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for MAB21L2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MAB21L2 proteins
     MAB21L2 lysates
     Search for Antibodies for MAB21L2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MAB21L2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MAB21L2
     Antibodies for MAB21L2
     ELISAs for MAB21L2
     CLIAs for MAB21L2
     Search LifeMap BioReagents cell lines for MAB21L2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAB21L2
     SwitchGear 3'UTR luciferase reporter plasmids for MAB21L2
     SwitchGear Promoter luciferase reporter plasmids for MAB21L2
     Search ThermoFisher Antibodies for MAB21L2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAB21L2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MAB21L2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAB21L2
    Customized:
     lentivirus for stable overexpression of MAB21L2
     lentivirus expression plasmids for stable overexpression of MAB21L2
     adenovirus for overexpression of MAB21L2
     Search LSBio for Antibodies for MAB21L2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAB21L2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4