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Aliases &
Descriptions
for MAB21L2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| | | Descriptions |
|---|
| mab-21 (C. elegans)-like 2 1 | | mab-21-like 2 (C. elegans) 2 | | mab-21-like protein 2 2 |
|
| |
Search outside databases for aliases for MAB21L2 genePrevious GC identifers: GC04P152311 GC04P151890 GC04P152080 GC04P151860 |
Summaries
for MAB21L2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for MAB21L2:
This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of
transforming growth factor-beta signaling. It is thought that this gene may be involved in neural
development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic
localization has been observed. [provided by RefSeq]
UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586Function: Required for several aspects of embryonic development including normal development of the
eye (By similarity) |
Genomic Location
for MAB21L2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the MAB21L2 gene 
Entrez Gene cytogenetic band: 4q31 Ensembl cytogenetic band: 4q31.3 HGNC cytogenetic band: 4q31MAB21L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P151722:
(about GC identifiers)
Start:
|
151,722,753 bp from pter |
End:
|
151,725,295 bp from pter |
Size:
|
2,543 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016354.18
| Proteins
for MAB21L2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586 (See
protein sequence)Recommended Name: Protein mab-21-like 2 Size: 359 amino acids; 40923 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B3KP37 Q9HBA7Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006430.1
ENSEMBL proteins: ENSP00000324701
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
Antibodies for MAB21L2:
Assays for MAB21L2: | Protein
Domains/
Families
for MAB21L2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y586
ProtoNet protein and cluster: Q9Y586 1 Blocks protein family: IPB000772 Ricin B lectin domain
UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586Similarity: Belongs to the mab-21 family | Gene Function
for MAB21L2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006439
 Applied Biosystems Silencer® siRNAs for MAB21L2
 Sigma-Aldrich siRNA for MAB21L2
Sigma-Aldrich shRNA for MAB21L2
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_006439
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006439
untagged cDNA clone in CMV expression vector: NM_006439
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_006439
UniProtKB/Swiss-Prot: MB212_HUMAN, Q9Y586Function: Required for several aspects of embryonic development including normal development of the
eye (By similarity)Genatlas biochemistry entry for MAB21L2:mab-21 (C elegans)-like 2,member of a family of genes,involved in vertebrate neural development6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mab21l2):
| Pathways & Interactions
for MAB21L2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
--5 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007399 | nervous system development |
TAS | 10556287 | | GO:0008284 | positive regulation of cell proliferation |
IEA | -- | | GO:0010172 | embryonic body morphogenesis |
IEA | -- | | GO:0043010 | camera-type eye development |
IEA | -- |
About this table
|
Drugs & Compounds
for MAB21L2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MAB21L2
|
Transcripts
for MAB21L2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006439
Sigma-Aldrich siRNA for MAB21L2
Sigma-Aldrich shRNA for MAB21L2
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_006439 REFSEQ mRNAs for MAB21L2 gene: NM_006439.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006439
OriGene GFP tagged cDNA clone in CMV expression vector: NM_006439
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006439
untagged cDNA clone in CMV expression vector: NM_006439
Additional cDNA sequence: AF262032.1 AF370007.1 AK055665.1 BC009983.2 CR620783.1 3 DOTS entries: DT.40225367 DT.100646301 DT.95350475 24/37 AceView cDNA sequences (see all 37
):BC009983 CR620783 NM_006439 AL515812 AL702293 BM728642 BF314563 BI195867 AL522676 CB857031 AF262032 BX493567 AA679158 BX283081 AL515813 AK055665 BX645470 BX348661 AF370007 BE260646 BF316056 CA395355 BI481050 BP346235
 highest scoring ESTs for MAB21L2:AA365382 AA679158 AF262032 AF370007 AK055665 AL515812 AL522675 AL523558 AL712791 AW884958 Unigene Cluster for MAB21L2: Mab-21-like 2 (C. elegans) Hs.584852 [show with all ESTs]Unigene Representative Sequence: NM_006439
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000317605
|
Expression
for MAB21L2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MAB21L2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MAB21L2
1 / 2 / 3 4 probe-sets matching MAB21L2 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AAGACGCTGC
SOURCE GeneReport for Unigene cluster: Hs.584852
|
Orthologs
for MAB21L2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MAB21L2 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for MAB21L2
ENSEMBL Gene Tree for MAB21L2 | Paralogs
for MAB21L2(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MAB21L2 gene
- C1orf1612 MAB21L12
|
SNPs/Variants
for MAB21L2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for MAB21L2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604357
|
Medical News
for MAB21L2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MAB21L2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for MAB21L2 gene: |
Search for MAB21L2
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAB21L2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MAB21L2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAB21L2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for MAB21L2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for MAB21L2:
 | |
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| | |  | Search Tocris compounds for MAB21L2 |
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