Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAB21L1 Gene

protein-coding   GIFtS: 50
GCID: GC13M036048

mab-21-like 1 (C. elegans)

(Previous name: mab-21 (C. elegans)-like 1 )
 Explore 5 diseases affiliated with
MAB21L1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAB21L1    

Aliases
for MAB21L1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mab-21-Like 1 (C. Elegans)1 2
CAGR11 2 3
Mab-21 (C. Elegans)-Like 11
Mab-21-Like Protein 12
Protein Mab-21-Like 12

External Ids:    HGNC: 67571   Entrez Gene: 40812   Ensembl: ENSG000001806607   OMIM: 6012805   UniProtKB: Q133943   

Export aliases for MAB21L1 gene to outside databases

Previous GC identifers: GC13M034035 GC13M030034 GC13M034984 GC13M033846 GC13M034946 GC13M016860


Summaries
for MAB21L1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAB21L1:
This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and
cerebellum development, and it has been proposed that expansion of a trinucleotide repeat region in the 5' UTR may
play a role in a variety of psychiatric disorders. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: MB211_HUMAN, Q13394
Function: Required for several aspects of embryonic development including normal development of the eye (By similarity)




Genomic Views
for MAB21L1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAB21L1 gene promoter:
         NF-1/L   NF-1   MyoD   POU6F1 (c2)   CUTL1   YY1   E47   AREB6   Chx10   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAB21L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAB21L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAB21L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.3

MAB21L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAB21L1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M036048:  view genomic region     (about GC identifiers)

Start:
 36,047,926 bp from pter      End:
 36,050,832 bp from pter
Size:
 2,907 bases      Orientation:
 minus strand

Proteins
for MAB21L1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MB211_HUMAN, Q13394 (See protein sequence)
Recommended Name: Protein mab-21-like 1  
Size: 359 amino acids; 40956 Da
Subcellular location: Nucleus (By similarity)
Miscellaneous: A CAG trinucleotide repeat occurs in the 5'-UTR of this gene. This repeat has been found to be highly
polymorphic, although expanded alleles have not yet been definitely linked with any phenotypic abnormality
Secondary accessions: Q6I9T5

Explore the universe of human proteins at neXtProt for MAB21L1: NX_Q13394

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13394

    • MAB21L1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005575.1  
    ENSEMBL proteins: 
     ENSP00000369251  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MAB21L1
    OriGene Custom Protein Services for MAB21L1 
    GenScript Custom Purified and Recombinant Proteins Services for MAB21L1
    Novus Biologicals MAB21L1 Proteins
    Novus Biologicals MAB21L1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAB21L1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    MAB21L1 for ontologies           About GeneDecksing



    MAB21L1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MAB21L1 
    GenScript Custom Superior Antibodies Services for MAB21L1
    Novus Biologicals MAB21L1 Antibodies
    Search for Antibodies for MAB21L1 at Abcam  
    Uscn Antibodies for MAB21L1
    ThermoFisher Antibodies for MAB21L1

    Assay Products for MAB21L1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAB21L1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAB21L1

    Protein Domains /
    Families
    for MAB21L1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAB21L1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR024801 Mab21L1
     IPR024810 Mab-21_dom
     IPR020950 Mab-21-rel

    Graphical View of Domain Structure for InterPro Entry Q13394

    ProtoNet protein and cluster: Q13394

    UniProtKB/Swiss-Prot: MB211_HUMAN, Q13394
    Similarity: Belongs to the mab-21 family


    Function
    for MAB21L1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MB211_HUMAN, Q13394
    Function: Required for several aspects of embryonic development including normal development of the eye (By similarity)

         Genatlas biochemistry entry for MAB21L1:
    originally detected in a retina cDNA library,highly expressed in the cerebellum,homolog to the C elegans cell fate
    determining gene mab-21,with a highly polymorphic CAG repeat(from 5 to 31 triplets),transmitted unstably between
    generation,exhibiting somatic mosaicism,but not correlated to a clinical phenotype

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MAB21L1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAB21L1
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate MAB21L1 (see all 54):
    hsa-miR-21* hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-4272 hsa-miR-548k hsa-miR-624* hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: MAB21L1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAB21L1 (see all 7)
    OriGene shRNA RFP: MAB21L1
    OriGene siRNA: MAB21L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAB21L1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAB21L1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAB21L1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAB21L1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAB21L1 (NM_005584)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAB21L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAB21L1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAB21L1
    Search LifeMap BioReagents cell lines for MAB21L1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAB21L1

    Animal Models:
         Mouse knock-out Mab21l1tm1Nao for MAB21L1
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mab21l1):
     endocrine/exocrine gland  integument  pigmentation  renal/urinary system  reproductive system 
     vision/eye 

    MAB21L1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAB21L1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAB21L1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MAB21L1 (Q133943 ENSP000003692514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INSRP062133I2D: score=1 
    SIRT3ENSP000003721914STRING: ENSP00000372191
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0009653anatomical structure morphogenesis TAS8733127
    GO:0043010camera-type eye development IEA--
    GO:0048568embryonic organ development IEA--


    MAB21L1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAB21L1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAB21L1
    Search CenterWatch for drugs/clinical trials and news about MAB21L1 / MB211 

    Transcripts
    for MAB21L1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAB21L1 gene: 
    NM_005584.4  

    Unigene Cluster for MAB21L1:

    Mab-21-like 1 (C. elegans)
    Hs.584776  [show with all ESTs]
    Unigene Representative Sequence: NM_005584
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000379919

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MAB21L1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAB21L1
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate MAB21L1 (see all 54):
    hsa-miR-21* hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-4272 hsa-miR-548k hsa-miR-624* hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: MAB21L1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAB21L1 (see all 7)
    OriGene shRNA RFP: MAB21L1
    OriGene siRNA: MAB21L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAB21L1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAB21L1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAB21L1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAB21L1 (NM_005584)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAB21L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAB21L1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAB21L1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAB21L1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAB21L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAB21L1

    Additional cDNA sequence: 

    AB073388.1 AB593021.1 AB593022.1 AK313185.1 BC028170.1 CR457420.1 

    4 DOTS entries:

    DT.95271926  DT.91750943  DT.100823246  DT.100742775 

    24/41 AceView cDNA sequences (see all 41):

    BM675060 CR590874 AW872915 CR624056 CA390601 CD674336 AI277809 CR624017 
    BM679323 AW950224 BM720613 BM718567 AL528421 BC028170 CR457420 BX327709 
    AA318770 NM_005584 BM682674 AL520964 AL712144 BM723481 AA318776 H17867 

    GeneLoc Exon Structure


    Expression
    for MAB21L1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAB21L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCCTCTGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAB21L1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    BoneMandibular ProcessBone
    BoneMaxillary ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAB21L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAB21L1

    SOURCE GeneReport for Unigene cluster: Hs.584776

    UniProtKB/Swiss-Prot: MB211_HUMAN, Q13394
    Tissue specificity: Expressed in brain, cerebellum and skeletal muscle

        SABiosciences Custom PCR Arrays for MAB21L1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAB21L1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAB21L1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAB21L1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAB21L1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAB21L1

    Orthologs
    for MAB21L1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAB21L1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAB21L11 mab-21-like 1 (C. elegans) 86.44(n)
    100(a)    		   395208  NM_204533.1  NP_989864.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAB21L16
    		 --
    		 98(a)
    		 1 ↔ 1
    		 3(182369009-182370088)
    zebrafish
    (Danio rerio)    		 Actinopterygii mab21l11 mab-21-like 1 80.13(n)
    97.49(a)    		   246091  NM_152974.2  NP_694506.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BcDNA:GH114153
    mab-211    		 CG4746-PA1 72(a)3
    68.25(n)1
    75.21(a)1    		   441271  NM_143714.31  NP_651971.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea mab-211 , 3 Expression: hyp7, hypodermal, neurons,
    mu_bod, more3
    Protein MAB-211    		 44(a)3
    57.26(n)1
    57.26(a)1    		   III(4672169-4673773)3
    1756071  NM_065539.41  NP_497940.21 


    ENSEMBL Gene Tree for MAB21L1 (if available)
    TreeFam Gene Tree for MAB21L1 (if available) 

    Paralogs
    for MAB21L1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAB21L1 gene
    MAB21L22  MAB21L32  
    1 SIMAP similar gene for MAB21L1 using alignment to 2 protein entries:     MB211_HUMAN (see all proteins):
    MAB21L2

    MAB21L1 for paralogs           About GeneDecksing



    Genomic Variants
    for MAB21L1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 NCBI SNPs in MAB21L1 are shown (see all 90)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs178162401,2
    		C,F,H,--16860271(+) TGCTCC/GCACAG 1 -- int112Minor allele frequency- G:0.03NA NS EA 1102
    rs170522451,2
    		C,F,--16860479(+) GCTGCA/CAATGT 1 -- int15Minor allele frequency- C:0.03NA WA 262
    rs177598411,2
    		C,F,H,--16861397(+) AAATGT/CCTGGA 1 -- int1 ese318Minor allele frequency- C:0.03NA NS EA 1834
    rs10653161,2
    		H--16862798(-) TCATCT/CCCCCC 2 -- int1 us2k1 ese36Minor allele frequency- C:0.00MN NS EA NA 592
    rs170522461,2
    		C,F,--16864125(+) GAAACG/CTTATG 2 -- int15Minor allele frequency- C:0.02NA WA 262
    rs79977401,2
    		C,F,H,--16864180(+) ATTTGT/CTGAAT 2 -- int115Minor allele frequency- C:0.06NS EA NA WA 1888
    rs13814771,2
    		C,F,--16864666(+) GGGGGG/TTTTTT 2 -- int11Minor allele frequency- T:0.07WA 118
    rs734979431,2
    		C,--16864974(+) AACAAG/CATATT 2 -- int11Minor allele frequency- C:0.50WA 2
    rs619491641,2
    		C,F,--16865137(+) TGCGTG/TGCACC 2 -- int13Minor allele frequency- T:0.11NA 124
    rs619491651,2
    		C,--16865173(+) TCCATC/TCCCTT 2 -- int12Minor allele frequency- T:0.05NA 122

    HapMap Linkage Disequilibrium report for MAB21L1 (36047926 - 36050832 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAB21L1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAB21L1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAB21L1

    Disorders / Diseases
    for MAB21L1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAB21L1 for disorders           About GeneDecksing

    OMIM gene information: 601280    OMIM disorders: --

    5 diseases for MAB21L1:    About MalaCards
    neural tube defect    gastroesophageal reflux disease    bipolar affective disorder    neuroblastoma
    neuronitis

    Genetic Association Database (GAD): MAB21L1
    Human Genome Epidemiology (HuGE) Navigator: MAB21L1 (1 document)

    Export disorders for MAB21L1 gene to outside databases

    Publications
    for MAB21L1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAB21L1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with MAB21L1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a human homologue of the Caenorhabditis elegans cell fate-determining gene mab-21: expression, chromosomal localization and analysis of a highly polymorphic (CAG)n trinucleotide repeat. (PubMed id 8733127)1, 2, 3 Margolis R.L.... Ross C.A. (1996)
    2. Unstable expansion of the CAG trinucleotide repeat in MAB21L1: report of a second pedigree and effect on protein expression. (PubMed id 9950369)1, 2, 9 Margolis R.L.... Potter N.T. (1999)
    3. Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3. (PubMed id 11526470)1, 4 Meira-Lima I.V....Vallada H. (2001)
    4. Molecular genetic analysis of human homologs of Caenorhabditis elegans mab-21-like 1 gene in patients with neural tube defects. (PubMed id 15526290)2, 9 Merello E.... Capra V. (2004)
    5. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    6. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    7. PTH regulates myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway. (PubMed id 21465527)1 Kim B.G....Cho J.Y. (2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for MAB21L1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAB21L1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4081 HGNC: 6757 AceView: MAB21L1 Ensembl:ENSG00000180660 euGenes: HUgn4081
    ECgene: MAB21L1 H-InvDB: MAB21L1

    Other Databases showing MAB21L1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAB21L1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAB21L1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAB21L1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAB21L1 gene:
    Search GeneIP for patents involving MAB21L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MAB21L1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for MAB21L1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAB21L1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAB21L1  
     OriGene Protein Over-expression Lysate for MAB21L1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MAB21L1   OriGene 3'-UTR Clone for MAB21L1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAB21L1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAB21L1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAB21L1   OriGene Custom Protein Services for MAB21L1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAB21L1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAB21L1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAB21L1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAB21L1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAB21L1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAB21L1
     GenScript Custom Purified and Recombinant Proteins Services for MAB21L1 GenScript cDNA clones with any tag delivered in your preferred vector for MAB21L1
     GenScript Custom Assay Services for MAB21L1 GenScript Custom Superior Antibodies Services for MAB21L1
     GenScript Custom overexpressing Cell Line Services for MAB21L1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MAB21L1 promoter
     Search Chromatin IP Primers for MAB21L1
     RT2 qPCR Primer Assay in human, mouse, rat MAB21L1
     Search GNC Networks for MAB21L1
     SABiosciences Custom PCR Arrays for MAB21L1
     Search Tocris compounds for MAB21L1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MAB21L1 antibodies
     MAB21L1 proteins
     MAB21L1 lysates
     Search for Antibodies for MAB21L1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MAB21L1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MAB21L1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MAB21L1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAB21L1
     SwitchGear 3'UTR luciferase reporter plasmids for MAB21L1
     SwitchGear Promoter luciferase reporter plasmids for MAB21L1
     ThermoFisher Antibodies for MAB21L1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAB21L1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MAB21L1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4