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Aliases for MAATS1 Gene

Aliases for MAATS1 Gene

  • MYCBP Associated And Testis Expressed 1 2 3
  • AMY-1-Associating Protein Expressed In Testis 1 2 3 4
  • MYCBP-Associated, Testis Expressed 1 2 3 5
  • MYCBP/AMY-1-Associated Testis-Expressed Protein 1 3 4
  • MYCBP/AMY-1-Associated, Testis Expressed 1 2 3
  • Spermatogenesis Associated 26 2 3
  • MYCBP-Binding Protein 2 3
  • C3orf15 3 4
  • AAT-1 3 4
  • AAT1 3 4
  • Chromosome 3 Open Reading Frame 15 2
  • AAT1-Alpha 3
  • AAT1alpha 3
  • CaM-IP2 3
  • SPATA26 3

External Ids for MAATS1 Gene

Previous HGNC Symbols for MAATS1 Gene

  • C3orf15

Previous GeneCards Identifiers for MAATS1 Gene

  • GC03P119422

Summaries for MAATS1 Gene

GeneCards Summary for MAATS1 Gene

MAATS1 (MYCBP Associated And Testis Expressed 1) is a Protein Coding gene. GO annotations related to this gene include adenosylmethionine decarboxylase activity.

UniProtKB/Swiss-Prot for MAATS1 Gene

  • Isoform 4 may play a role in spermatogenesis.

Gene Wiki entry for MAATS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAATS1 Gene

Genomics for MAATS1 Gene

Regulatory Elements for MAATS1 Gene

Promoters for MAATS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAATS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAATS1 Gene

Chromosome:
3
Start:
119,703,022 bp from pter
End:
119,767,102 bp from pter
Size:
64,081 bases
Orientation:
Plus strand

Genomic View for MAATS1 Gene

Genes around MAATS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAATS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAATS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAATS1 Gene

Proteins for MAATS1 Gene

  • Protein details for MAATS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4T9-MAAT1_HUMAN
    Recommended name:
    Protein MAATS1
    Protein Accession:
    Q7Z4T9
    Secondary Accessions:
    • A0AVK2
    • A8K1J9
    • B3KP23
    • B4DG52
    • B4DZ14
    • C9JUG4
    • Q68DX2
    • Q8TD41
    • Q96A45
    • Q96JE8

    Protein attributes for MAATS1 Gene

    Size:
    603 amino acids
    Molecular mass:
    70999 Da
    Quaternary structure:
    • Interacts with MYCBP and AKAP1. Isoform 4 is part of a complex containing MYCBP, AKAP1 and PRKAR2B. Isoform 3 does not interact with MYCBP.

    Alternative splice isoforms for MAATS1 Gene

neXtProt entry for MAATS1 Gene

Proteomics data for MAATS1 Gene at MOPED

Post-translational modifications for MAATS1 Gene

No data available for DME Specific Peptides for MAATS1 Gene

Domains & Families for MAATS1 Gene

Protein Domains for MAATS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAATS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAATS1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MAATS1 Gene

Function for MAATS1 Gene

Molecular function for MAATS1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 4 may play a role in spermatogenesis.
genes like me logo Genes that share phenotypes with MAATS1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAATS1 Gene

Localization for MAATS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAATS1 Gene

Cytoplasm. Mitochondrion. Note=Isoform 4 is found in the mitochondria and localized in the neck of the sperm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAATS1 Gene COMPARTMENTS Subcellular localization image for MAATS1 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAATS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MAATS1: view

Pathways & Interactions for MAATS1 Gene

SuperPathways for MAATS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAATS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAATS1 Gene

Drugs & Compounds for MAATS1 Gene

No Compound Related Data Available

Transcripts for MAATS1 Gene

Unigene Clusters for MAATS1 Gene

MYCBP-associated, testis expressed 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAATS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ·
SP1: - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6: - -
SP7:
SP8:

ExUns: 19c ^ 20 ^ 21a · 21b · 21c · 21d
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for MAATS1 Gene

GeneLoc Exon Structure for
MAATS1
ECgene alternative splicing isoforms for
MAATS1

Expression for MAATS1 Gene

mRNA expression in normal human tissues for MAATS1 Gene

mRNA differential expression in normal tissues according to GTEx for MAATS1 Gene

This gene is overexpressed in Pituitary (x8.1).

Protein differential expression in normal tissues from HIPED for MAATS1 Gene

This gene is overexpressed in Fetal Liver (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAATS1 Gene



SOURCE GeneReport for Unigene cluster for MAATS1 Gene Hs.341906

mRNA Expression by UniProt/SwissProt for MAATS1 Gene

Q7Z4T9-MAAT1_HUMAN
Tissue specificity: Isoform 1 is strongly expressed in the liver. Isoform 4 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis, as well as the spermatid and mature sperm. Isoform 4 is also expressed in Leydig cells. Isoform 3 is expressed in the testis.
genes like me logo Genes that share expression patterns with MAATS1: view

Protein tissue co-expression partners for MAATS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAATS1 Gene

Orthologs for MAATS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAATS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAATS1 35
  • 86.3 (n)
  • 83.77 (a)
MAATS1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR1I2 35
  • 87.53 (n)
  • 83.83 (a)
MAATS1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Maats1 35
  • 80.53 (n)
  • 76.74 (a)
Maats1 16
Maats1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAATS1 35
  • 99.35 (n)
  • 99.09 (a)
MAATS1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Maats1 35
  • 78.57 (n)
  • 76.02 (a)
oppossum
(Monodelphis domestica)
Mammalia MAATS1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAATS1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H3ORF15 35
  • 69.03 (n)
  • 63.5 (a)
MAATS1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAATS1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia maats1 35
  • 64.6 (n)
  • 62.25 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-265i7.2 35
  • 60 (n)
  • 56.6 (a)
MAATS1 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15143 36
  • 11 (a)
OneToMany
CG15144 36
  • 14 (a)
OneToMany
CG15145 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for MAATS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAATS1 Gene

ENSEMBL:
Gene Tree for MAATS1 (if available)
TreeFam:
Gene Tree for MAATS1 (if available)

Paralogs for MAATS1 Gene

(1) SIMAP similar genes for MAATS1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MAATS1: view

No data available for Paralogs for MAATS1 Gene

Variants for MAATS1 Gene

Sequence variations from dbSNP and Humsavar for MAATS1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6438544 - 119,715,680(+) ACTCT(C/G)CAGAA nc-transcript-variant, reference, missense
rs9817771 - 119,726,245(+) AAGCC(A/T)CTCTC nc-transcript-variant, reference, missense
rs9819218 - 119,730,318(+) GTGGT(C/G)TAAAC nc-transcript-variant, reference, missense
rs1129708 -- 119,766,739(+) AATGC(A/G)CATGA nc-transcript-variant, utr-variant-3-prime
rs1016086 -- 119,725,616(-) ccaca(C/T)ctggc intron-variant

Variation tolerance for MAATS1 Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.68; 72.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAATS1 Gene

HapMap Linkage Disequilibrium report
MAATS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAATS1 Gene

Disorders for MAATS1 Gene

Relevant External Links for MAATS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAATS1

No disorders were found for MAATS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAATS1 Gene

Publications for MAATS1 Gene

  1. AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex between AMY-1, A-kinase anchor protein 84 and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. (PMID: 12223483) Yukitake H. … Ariga H. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. A conserved CaM- and radial spoke associated complex mediates regulation of flagellar dynein activity. (PMID: 17967944) Dymek E.E. … Smith E.F. (J. Cell Biol. 2007) 2 3
  3. Structure and characterization of AAT-1 isoforms. (PMID: 15863901) Matsuda E. … Ariga H. (Biol. Pharm. Bull. 2005) 3 23
  4. Are polymorphic markers within the alpha-1-antitrypsin gene associated with risk of human immunodeficiency virus disease? (PMID: 14551891) Hayes V.M. … Gardiner-Garden M. (J. Infect. Dis. 2003) 2 3
  5. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3

Products for MAATS1 Gene

Sources for MAATS1 Gene

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