Aliases for MAATS1 Gene
Aliases for MAATS1 Gene
- MYCBP Associated And Testis Expressed 1 2 3
- AMY-1-Associating Protein Expressed In Testis 1 2 3 4
- MYCBP-Associated, Testis Expressed 1 2 3 5
- MYCBP/AMY-1-Associated Testis-Expressed Protein 1 3 4
- MYCBP/AMY-1-Associated, Testis Expressed 1 2 3
- Spermatogenesis Associated 26 2 3
- MYCBP-Binding Protein 2 3
- C3orf15 3 4
External Ids for MAATS1 Gene
- HGNC: 24010
- Entrez Gene: 89876
- Ensembl: ENSG00000183833
- OMIM: 609910
- UniProtKB: Q7Z4T9
Previous HGNC Symbols for MAATS1 Gene
- C3orf15
Previous GeneCards Identifiers for MAATS1 Gene
- GC03P119422
Summaries for MAATS1 Gene
GeneCards Summary for MAATS1 Gene
MAATS1 (MYCBP Associated And Testis Expressed 1) is a Protein Coding gene. GO annotations related to this gene include adenosylmethionine decarboxylase activity.
UniProtKB/Swiss-Prot for MAATS1 Gene
-
Isoform 4 may play a role in spermatogenesis.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAATS1 Gene
Genomics for MAATS1 Gene
Regulatory Elements for MAATS1 Gene
Enhancers for MAATS1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around MAATS1 on UCSC Golden Path with GeneCards custom track
Promoters for MAATS1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around MAATS1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MAATS1 Gene
- Chromosome:
- 3
- Start:
- 119,703,022 bp from pter
- End:
- 119,767,102 bp from pter
- Size:
- 64,081 bases
- Orientation:
- Plus strand
Genomic View for MAATS1 Gene
Genes around MAATS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q13.33 by Ensembl
- 3q13.33 by Entrez Gene
- 3q13.33 by HGNC
MAATS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAATS1 Gene
Proteins for MAATS1 Gene
-
Protein details for MAATS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z4T9-MAAT1_HUMAN
- Recommended name:
- Protein MAATS1
- Protein Accession:
- Q7Z4T9
- A0AVK2
- A8K1J9
- B3KP23
- B4DG52
- B4DZ14
- C9JUG4
- Q68DX2
- Q8TD41
- Q96A45
- Q96JE8
Protein attributes for MAATS1 Gene
- Size:
- 603 amino acids
- Molecular mass:
- 70999 Da
- Quaternary structure:
-
- Interacts with MYCBP and AKAP1. Isoform 4 is part of a complex containing MYCBP, AKAP1 and PRKAR2B. Isoform 3 does not interact with MYCBP.
Protein Expression for MAATS1 Gene
Post-translational modifications for MAATS1 Gene
- Isoform 4 is phosphorylated by PKA.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MAATS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MAATS1
- Abcam antibodies for C3orf15
-
Cloud-Clone Corp. Antibodies for MAATS1
- antibodies-online Antibodies for MAATS1: See all 12
- Search GeneTex for Antibodies for MAATS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAATS1
Protein Products
-
OriGene Purified Proteins for MAATS1
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-
Cloud-Clone Corp. Proteins for MAATS1
- antibodies-online Proteins for MAATS1: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MAATS1
- Abcam proteins for C3orf15
Assay Products
No data available for DME Specific Peptides for MAATS1 Gene
Domains & Families for MAATS1 Gene
Protein Domains for MAATS1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAATS1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for MAATS1 Gene
Function for MAATS1 Gene
Molecular function for MAATS1 Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 4 may play a role in spermatogenesis.
Phenotypes for MAATS1 Gene
- GenomeRNAi human phenotypes for MAATS1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for MAATS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAATS1 gene
- Search ViGene Biosciences for MAATS1
CRISPR Products
-
OriGene CRISPR knockouts for MAATS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAATS1
- GenScript: Design CRISPR guide RNA sequences for MAATS1
miRNA for MAATS1 Gene
- miRTarBase miRNAs that target MAATS1
miRNA Products
- Search ViGene Biosciences for MAATS1
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for MAATS1
- Browse OriGene Inhibitory RNA Products For MAATS1
-
ViGene Biosciences ready-to-package AAV shRNAs for MAATS1 gene
Clone Products
- OriGene clones in human for MAATS1
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MAATS1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MAATS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAATS1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAATS1 Gene
Localization for MAATS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAATS1 Gene
- Cytoplasm. Mitochondrion. Note=Isoform 4 is found in the mitochondria and localized in the neck of the sperm.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 3 |
| cytosol | 2 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for MAATS1 Gene
More details on SuperPathways for MAATS1
No Data Available
Interacting Proteins for MAATS1 Gene
Selected Interacting proteins:
ENSP00000273390
Q7Z4T9-MAAT1_HUMAN
for MAATS1 Gene via
STRING
UniProtKB
I2D
No data available for Pathways by source and SIGNOR curated interactions for MAATS1 Gene
Transcripts for MAATS1 Gene
mRNA/cDNA for MAATS1 Gene
- (8) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (54) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MAATS1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MAATS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAATS1
- GenScript: Design CRISPR guide RNA sequences for MAATS1
miRNA Products
- Search ViGene Biosciences for MAATS1
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for MAATS1
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-
ViGene Biosciences ready-to-package AAV shRNAs for MAATS1 gene
Clone Products
- OriGene clones in human for MAATS1
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 19c | ^ | 20 | ^ | 21a | · | 21b | · | 21c | · | 21d |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: | - | ||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | - | ||||||||||
| SP7: | - | ||||||||||
| SP8: |
Expression for MAATS1 Gene
mRNA differential expression in normal tissues according to GTEx for MAATS1 Gene
This gene is overexpressed in Pituitary (x8.1).
This gene is overexpressed in Fetal Liver (68.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAATS1 Gene
SOURCE GeneReport for Unigene cluster for MAATS1 Gene Hs.341906
mRNA Expression by UniProt/SwissProt for MAATS1 Gene
Q7Z4T9-MAAT1_HUMAN
Tissue specificity:
Isoform 1 is strongly expressed in the liver. Isoform 4 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis, as well as the spermatid and mature sperm. Isoform 4 is also expressed in Leydig cells. Isoform 3 is expressed in the testis.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for MAATS1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAATS1 Gene
Orthologs for MAATS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MAATS1 35 |
|
||
| MAATS1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | NR1I2 35 |
|
||
| MAATS1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Maats1 35 |
|
||
| Maats1 16 |
|
||||
| Maats1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | MAATS1 35 |
|
||
| MAATS1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Maats1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MAATS1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAATS1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C1H3ORF15 35 |
|
||
| MAATS1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | MAATS1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | maats1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-265i7.2 35 |
|
||
| MAATS1 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG15143 36 |
|
OneToMany | |
| CG15144 36 |
|
OneToMany | |||
| CG15145 36 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for MAATS1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MAATS1 Gene
(1) SIMAP similar genes for MAATS1 Gene using alignment to 5 proteins:
No data available for Paralogs for MAATS1 Gene
Variants for MAATS1 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs6438544 | - | 119,715,680(+) | ACTCT(C/G)CAGAA | nc-transcript-variant, reference, missense | |
| rs9817771 | - | 119,726,245(+) | AAGCC(A/T)CTCTC | nc-transcript-variant, reference, missense | |
| rs9819218 | - | 119,730,318(+) | GTGGT(C/G)TAAAC | nc-transcript-variant, reference, missense | |
| rs1129708 | -- | 119,766,739(+) | AATGC(A/G)CATGA | nc-transcript-variant, utr-variant-3-prime | |
| rs2293214 | -- | 119,752,361(-) | ATCTC(A/T)ACCCT | intron-variant, nc-transcript-variant |
Residual Variation Intolerance Score:
92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.68;
72.94% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MAATS1 Gene
Disorders for MAATS1 Gene
Relevant External Links for MAATS1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MAATS1
No disorders were found for MAATS1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAATS1 Gene
Publications for MAATS1 Gene
- AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex between AMY-1, A-kinase anchor protein 84 and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. (PMID: 12223483) Yukitake H. … Ariga H. (J. Biol. Chem. 2002) 2 3 4 23 67
- A conserved CaM- and radial spoke associated complex mediates regulation of flagellar dynein activity. (PMID: 17967944) Dymek E.E. … Smith E.F. (J. Cell Biol. 2007) 2 3
- Structure and characterization of AAT-1 isoforms. (PMID: 15863901) Matsuda E. … Ariga H. (Biol. Pharm. Bull. 2005) 3 23
- Are polymorphic markers within the alpha-1-antitrypsin gene associated with risk of human immunodeficiency virus disease? (PMID: 14551891) Hayes V.M. … Gardiner-Garden M. (J. Infect. Dis. 2003) 2 3
- Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3
Products for MAATS1 Gene
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- OriGene Purified Proteins for MAATS1
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- OriGene qPCR primer pairs for MAATS1
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- GenScript: Design CRISPR guide RNA sequences for MAATS1
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for MAATS1
- Novus Biologicals proteins and lysates for MAATS1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for C3orf15
- Abcam proteins for C3orf15
- Search for Assays for MAATS1 at Abcam
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- Cloud-Clone Corp. Antibodies for MAATS1
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- antibodies-online Antibodies for MAATS1: See all 12
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- antibodies-online Proteins for MAATS1: See all 4
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- ViGene Biosciences adenoviral particle packaged cDNA for MAATS1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for MAATS1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MAATS1 gene
- Search ViGene Biosciences for MAATS1
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- Santa Cruz Biotechnology (SCBT) Antibodies for MAATS1
- Search Santa Cruz Biotechnology (SCBT) for MAATS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAATS1
Sources for MAATS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon