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Aliases & Descriptions for M6PRBP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC11117 2 | | MGC2012 2 | | PP17 1, 2, 3 | | TIP47 1, 2, 3, 5 |
| | | Descriptions |
|---|
| 47 kDa MPR-binding protein 3 | | 47 kDa mannose 6-phosphate receptor-binding protein 3 | | Cargo selection protein TIP47 2, 3 | | MPR-BINDING PROTEIN, 47-KD 2 | | MPR-binding protein 47 kDa 2 | | Placental protein 17 2, 3 | cargo selection protein (mannose 6 phosphate receptor binding protein) 2 | | mannose 6 phosphate receptor binding protein 1 2 | | mannose-6-phosphate receptor binding protein 1 2 | | tail-interacting protein, 47 kD 2 |
|
| | Search outside databases for aliases for M6PRBP1 gene |
Summaries for M6PRBP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for M6PRBP1: Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. [provided by RefSeq] UniProtKB/Swiss-Prot: M6PBP_HUMAN, O60664Function: Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi networkGene Wiki entry for M6PRBP1 |
Genomic Location for M6PRBP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the M6PRBP1 gene 
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3M6PRBP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M004789:
(about GC identifiers)
Start:
|
4,789,346 bp from pter |
End:
|
4,818,676 bp from pter |
Size:
|
29,331 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011255.14
| Proteins for M6PRBP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: M6PBP_HUMAN, O60664 (See
protein sequence)Recommended Name: Mannose-6-phosphate receptor-binding protein 1 Size: 434 amino acids; 47047 Da
Subunit: Interacts with the cytoplasmic domains of both M6PR and IGF2R. Homo-oligomer. Isoform A also exists as a homodimer (known as PP17C)
Subcellular location: Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Lipid droplet membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Note=Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails
Secondary accessions: A8K4Y9 Q53G77 Q9BS03 Q9UBD7 Q9UP92Alternative splicing: 2 isoforms: O60664-1 O60664-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005808.2
ENSEMBL proteins: ENSP00000221957
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: M6PRBP1 
5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
): About this table
Antibodies for M6PRBP1: Assays for M6PRBP1: | Protein
Domains/ Families for M6PRBP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O60664
ProtoNet protein and cluster: O60664 1 Blocks protein family: IPB004279 Perilipin
UniProtKB/Swiss-Prot: M6PBP_HUMAN, O60664Similarity: Belongs to the perilipin family | Gene Function for M6PRBP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005817
Applied Biosystems Silencer® siRNAs for M6PRBP1
Sigma-Aldrich siRNA for M6PRBP1  Sigma-Aldrich shRNA for M6PRBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005817                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005817                                  untagged cDNA clone in CMV expression vector: NM_005817 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005817
UniProtKB/Swiss-Prot: M6PBP_HUMAN, O60664Function: Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network | Pathways & Interactions for M6PRBP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for M6PRBP1 
5/12 Interacting proteins for M6PRBP1 (ENSP000002219573 O606642) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016192 | vesicle-mediated transport |
TAS | 9590177 | About this table
|
Drugs & Compounds for M6PRBP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for M6PRBP1 4 Novoseek chemical compound relationships for M6PRBP1 gene
About this table
|
Transcripts for M6PRBP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005817
Sigma-Aldrich siRNA for M6PRBP1  Sigma-Aldrich shRNA for M6PRBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005817 REFSEQ mRNAs for M6PRBP1 gene: NM_005817.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005817               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005817                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005817                                  untagged cDNA clone in CMV expression vector: NM_005817  Additional cDNA sequence: AF051314.1 AF051315.1 AF055574.1 AF057140.1 AK122671.1 AK223054.1 AK225045.1 AK225400.1 AK226088.1 AK291104.1 AK312740.1 BC001590.2 BC005818.2 BC007566.1 BC019278.1 BT007235.1 CR607156.1 23 DOTS entries: DT.87016130 DT.91998370 DT.100814644 DT.121448014 DT.100814633 DT.100814634 DT.101985172 DT.100814628 DT.121448013 DT.100814625 DT.121448029 DT.100814642 DT.121448015 DT.95167273 DT.95261621 DT.95337660 DT.121447988 DT.40131602 DT.92471308 DT.95347206 DT.100759476 DT.100814624 DT.100814632 12 AceView cDNA sequences:NM_005817 CR607156 AF055574 BC005818 AF057140 BT007235 BC019278 AF051315 AF051314 BC007566 AK122671 BC001590
highest scoring ESTs for M6PRBP1:AF057140 AF055574 AK122671 BC001590 BC005818 BC007566 BC019278 AA194698 AA283656 AA375178 Unigene Cluster for M6PRBP1: Mannose-6-phosphate receptor binding protein 1 Hs.140452 [show with all ESTs]Unigene Representative Sequence: NM_005817
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for M6PRBP1 (see all 8
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | |
| SP1: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for M6PRBP1
1 Ensembl transcript including schematic representation: ENST00000221957
|
Expression for M6PRBP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| M6PRBP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for M6PRBP1
1 / 2 / 3 4 probe-sets matching M6PRBP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTAGCAGGTG
SOURCE GeneReport for Unigene cluster: Hs.140452
Expression variation in blood from EXPOLDB for M6PRBP1 |
Orthologs for M6PRBP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for M6PRBP1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for M6PRBP1
ENSEMBL Gene Tree for M6PRBP1 | Paralogs for M6PRBP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for M6PRBP1 gene
- LSDP52 ADFP2 PLIN2
|
SNPs/Variants for M6PRBP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for M6PRBP1 (up to first 250kb)
|
Disorders & Mutations for M6PRBP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602702
5 Novoseek disease relationships for M6PRBP1 gene
About this table
|
Medical News for M6PRBP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for M6PRBP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/60 PubMed articles for M6PRBP1 gene (see all 60
):- TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. (PubMed id 9590177)1, 2, 3, 4 Diaz E. and Pfeffer S.R. (1998)
- Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). (PubMed id 6856484)2, 3, 4 Bohn H....Winckler W. (1983)
- Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants. (PubMed id 9874244)1, 3, 4 Than N.G.... Bohn H. (1998)
- Spatial integration of TIP47 and adipophilin in macrophage lipid bodies. (PubMed id 15545278)1, 3, 4 Robenek H.... Troyer D. (2005)
- Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein. (PubMed id 10393528)1, 3, 4 Than N.G.... Bohn H. (1999)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Self-assembly is important for TIP47 function in mannose 6-phosphate receptor transport. (PubMed id 12535272)1, 3 Sincock P.M....Pfeffer S.R. (2003)
- TIP47, a lipid cargo protein involved in macrophage triglyceride metabolism. (PubMed id 19286631)1, 3 Buers I....Hofnagel O. (2009)
- Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein. (PubMed id 10908666)1, 3 Orsel J.G....Pfeffer S.R. (2000)
|
Search for M6PRBP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing M6PRBP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing M6PRBP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing M6PRBP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for M6PRBP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for M6PRBP1:

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Incremental update: 13 Oct 2009
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