Aliases for M6PR Gene
External Ids for M6PR Gene
Previous GeneCards Identifiers for M6PR Gene
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
GeneCards Summary for M6PR Gene
M6PR (Mannose-6-Phosphate Receptor, Cation Dependent) is a Protein Coding gene. Diseases associated with M6PR include Niemann-Pick Disease and Mucopolysaccharidisis Type Iiia. Among its related pathways are Clathrin derived vesicle budding and Phagosome. GO annotations related to this gene include transmembrane signaling receptor activity and mannose transmembrane transporter activity.
UniProtKB/Swiss-Prot for M6PR Gene
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.