M6PR Gene
protein-coding GIFtS: 65
GCID: GC12M008993
|
|
mannose-6-phosphate receptor (cation dependent)
| |
Aliases
for M6PR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mannose-6-Phosphate Receptor (Cation Dependent)1 2 | | SMPR2 | | CD-MPR2 3 | | Cation-Dependent Mannose-6-Phosphate Receptor2 | | MPR462 3 | | Mr 46,000 Man6PR2 | | CD Man-6-P Receptor2 3 | | Small Mannose 6-Phosphate Receptor2 | | MPR 462 3 | | 46 KDa Mannose 6-Phosphate Receptor3 | | 46-KDa Mannose 6-Phosphate Receptor2 | | MPRD3 | | MPR-462 | | |
Export aliases for M6PR gene to outside databasesPrevious GC identifers: GC12M008801 GC12M009241 GC12M008984 |
Summaries
for M6PR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for M6PR:
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome functionthrough the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes.The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively splicedtranscript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is locatedon the long arm of chromosome X. (provided by RefSeq, May 2011)
UniProtKB/Swiss-Prot: MPRD_HUMAN, P20645Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgiapparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the lowpH mediates the dissociation of the complex
Gene Wiki entry for M6PR (Cation-dependent mannose-6-phosphate receptor)
|
Genomic Views
for M6PR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the M6PR gene promoter:
AhR USF1 SREBP-1c C/EBPalpha SREBP-1b IRF-2 SREBP-1a USF-1 HFH-1 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for M6PR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat M6PR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC chromosome: 12M6PR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M008993: view genomic region
(about GC identifiers)
Start:
|
9,092,959 bp from pter |
End:
|
9,102,551 bp from pter |
Size:
|
9,593 bases |
Orientation:
|
minus strand |
|
Proteins
for M6PR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MPRD_HUMAN, P20645 (See
protein sequence)Recommended Name: Cation-dependent mannose-6-phosphate receptor precursor Size: 277 amino acids; 30993 Da
Subunit: Homodimer. Binds GGA1, GGA2 and GGA3
Subcellular location: Lysosome membrane; Single-pass type I membrane protein
Miscellaneous: This receptor has optimal binding in the presence of divalent cations
Secondary accessions: A8K528 D3DUV5Explore the universe of human proteins at neXtProt for M6PR: NX_P20645
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P20645
M6PR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001193953.1 NP_002346.1
ENSEMBL proteins: ENSP00000439070 ENSP00000442100 ENSP00000000412 ENSP00000441040 ENSP00000437595 ENSP00000444684 ENSP00000442983 ENSP00000439968 ENSP00000440962 ENSP00000441030 Reactome Protein details: P20645
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
M6PR for ontologies About GeneDecksing
M6PR Antibody Products:
Assay Products for M6PR: |
Protein
Domains /
Families
for M6PR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
M6PR for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P20645ProtoNet protein and cluster: P20645 1 Blocks protein family: IPB000296 Cation-dependent mannose-6-phosphate receptor signature
UniProtKB/Swiss-Prot: MPRD_HUMAN, P20645Domain: The extracellular domain is homologous to the repeating units (of approximately 147 AA) of thecation-independent mannose 6-phosphate receptor |
Function
for M6PR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MPRD_HUMAN, P20645Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgiapparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the lowpH mediates the dissociation of the complex Genatlas biochemistry entry for M6PR:mannose 6-phosphate receptor,cation dependent ,expressed on the cell surface of Golgi and late endosomemembrane,targetting phosphorylated enzymes to lysosomes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for M6PR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for M6PR (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: M6PR (NM_002355) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for M6PR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat M6PR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for M6PR |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004888 | transmembrane signaling receptor activity |
TAS | 10799489 | | GO:0005537 | mannose binding |
IEA | -- | | GO:0015578 | mannose transmembrane transporter activity |
IEA | -- |
M6PR for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for M6PR:
Animal Models:
Mouse knock-outs for M6PR: M6prtm1Psa M6prtm1Hlk
8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for M6pr):
M6PR for phenotypes About GeneDecksing
|
Pathways & Interactions
for M6PR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin derived vesicle budding | | | 2 | Membrane Trafficking | | | 3 | Phagosome | | | 4 | Lysosome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for M6PR
2 
Kegg Pathways (Kegg details for M6PR):
M6PR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for M6PR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/8 Interacting proteins for M6PR (P206452, 3 ENSP000000004124) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
M6PR for ontologies About GeneDecksing
|
Drugs & Compounds
for M6PR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
M6PR for compounds About GeneDecksing
 Browse Tocris compounds for M6PR
1 HMDB Compound for M6PR About this table
3 DrugBank Compounds for M6PR About this table
10/24 Novoseek chemical compound relationships for M6PR gene (see all 24) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mannose 6-phosphate |
99 |
577 |
12535273 (7), 9152028 (5), 8163521 (5), 2170115 (4) (see all 99) |
| mannose |
70.4 |
17 |
11801606 (1), 14557264 (1), 18838694 (1), 8435067 (1) (see all 15) |
| 3-(2,4-dinitroanilino)-3'-amino-n-methyldipropylamine |
70.3 |
1 |
9278305 (1) |
| nh4cl |
64 |
6 |
7957663 (1), 9571245 (1), 8424762 (1), 1377692 (1) (see all 6) |
| ricin |
49.2 |
10 |
12154075 (3), 11102518 (1), 17389686 (1), 11452006 (1) |
| heparan sulfate |
44.8 |
2 |
16280358 (2) |
| phosphoric acid |
42.6 |
3 |
1847138 (1), 8950040 (1) |
| tunicamycin |
38.8 |
3 |
1847926 (1), 8647129 (1), 8621689 (1) |
| bafilomycin a1 |
34.4 |
1 |
8647129 (1) |
| monensin |
30.2 |
1 |
11444150 (1) |
Search CenterWatch for drugs/clinical trials and news about M6PR / MPRD
|
Transcripts
for M6PR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for M6PR gene (2 alternative transcripts): NM_001207024.1 NM_002355.3 Unigene Cluster for M6PR: Mannose-6-phosphate receptor (cation dependent) Hs.134084 [show with all ESTs]Unigene Representative Sequence: NM_00235512 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000539143 ENST00000541507 ENST00000000412(uc001qvf.3 uc021quk.1)
ENST00000544193 ENST00000543704 ENST00000537621 ENST00000543258 ENST00000543834
ENST00000544245 ENST00000540837 ENST00000543845 ENST00000543159
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for M6PR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for M6PR (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: M6PR (NM_002355) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for M6PR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat M6PR |
Additional cDNA sequence: AK222792.1 AK291143.1 AK312689.1 BC017111.1 BC024206.1 CR457412.1 M16985.1 24/30 DOTS entries (see all 30): DT.92461710 DT.99952542 DT.95140600 DT.91823927 DT.121125363 DT.95140538 DT.121125259 DT.121125309 DT.100798763 DT.92461707 DT.101959691 DT.100798750 DT.121125323 DT.75194392 DT.100798771 DT.40229521 DT.99955155 DT.121125285 DT.92059916 DT.95140574 DT.100798747 DT.100798761 DT.121125337 DT.121125379 24/724 AceView cDNA sequences (see all 724): AU130397 BU609171 BF115885 N36931 N92217 BU538667 BQ877840 AU131778 CD743020 CN479911 BU180356 AA223218 AU130591 AU135536 AI953305 BQ688805 AL527699 BI255821 AW851219 BU529105 AU130413 CB156588 BU194527 BU542014
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for M6PR (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for M6PR
|
Expression
for M6PR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| M6PR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTCCACTGG
About this image
See M6PR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for M6PR
SOURCE GeneReport for Unigene cluster: Hs.134084
SABiosciences Custom PCR Arrays for M6PR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for M6PR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat M6PR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat M6PR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat M6PR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for M6PR |
Orthologs
for M6PR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for M6PR gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
M6pr1 , 5 |
mannose-6-phosphate receptor, cation dependent1, 5 |
87.97(n)1
92.06(a)1 |
|
6 (57.52 cM)5
171131 NM_010749.61 NP_034879.21
1223087205 |
chicken
(Gallus gallus) |
Aves |
M6PR1 |
mannose-6-phosphate receptor (cation dependent) |
67.77(n)
66.05(a) |
|
396044 XM_416477.3 XP_416477.3 |
lizard
(Anolis carolinensis) |
Reptilia |
M6PR6 |
-- |
64(a) |
1 ↔ 1 |
2(81594900-81599046) |
African clawed frog
(Xenopus laevis) |
Amphibia |
m6pr-prov2 |
mannose-6-phosphate receptor (cation dependent) |
77.89(n) |
|
BC055993.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
m6pr1 |
mannose-6-phosphate receptor (cation dependent) |
57.35(n)
51.18(a) |
|
406486 NM_213205.1 NP_998370.1 |
ENSEMBL Gene Tree for M6PR (if available)
TreeFam Gene Tree for M6PR (if available) |
Paralogs
for M6PR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for M6PR gene
M6PR for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for M6PR
PGOHUM00000258678 PGOHUM00000241947
|
Genomic Variants
for M6PR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for M6PR (9092959 - 9102551 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for M6PR
1 CNV: 4768 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for M6PR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
M6PR for disorders About GeneDecksing
OMIM gene information: 154540
OMIM disorders: --
20  diseases for M6PR: About MalaCardsniemann-pick disease ceroid lipofuscinosis neuronal ceroid-lipofuscinosis acid sphingomyelinase deficiency
lysosomal storage disease mucopolysaccharidosis vii pick's disease fabry disease
mucopolysaccharidosis alzheimer's disease epididymitis breast cancer
cervical carcinoma colon carcinoma cervicitis myopathy
hypertension carcinoma cholesterol neuronitis
1 disease from the University of Copenhagen DISEASES database for M6PR:Lysosomal storage disease 10/15 Novoseek disease relationships for M6PR gene (see all 15) About this table
Genetic Association Database (GAD): M6PR
Human Genome Epidemiology (HuGE) Navigator: M6PR (4 documents)
Export disorders for M6PR gene to outside databases
|
Publications
for M6PR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for M6PR gene, integrated from 9 sources (see all 295):
(articles sorted by number of sources associating them with M6PR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and analysis of the human 46-kDa mannose 6-phosphate receptor gene. (PubMed id 1849818)1, 2, 9 Klier H.J.... Pohlmann R. (1991)
- Sorting of mannose 6-phosphate receptors mediated by the GGAs. (PubMed id 11387475)1, 2, 9 Puertollano R....Bonifacino J.S. (2001)
- Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease. (PubMed id 15167696)1, 4, 9 Kolsch H....Heun R. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. (PubMed id 11886874)1, 2 Doray B.... Kornfeld S. (2002)
- Cloning of a cDNA encoding the human cation-dependent mannose 6- phosphate-specific receptor. (PubMed id 2441386)1, 2 Pohlmann R.... von Figura K. (1987)
- The overexpressed human 46-kDa mannose 6-phosphate receptor mediates endocytosis and sorting of beta-glucuronidase. (PubMed id 2172972)1, 9 Watanabe H....Sly W.S. (1990)
- Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. (PubMed id 19928875)1, 9 Olson L.J....Kim J.J. (2010)
- Carbohydrate recognition by the mannose-6-phosphate r eceptors. (PubMed id 19801188)1, 9 Kim J.J....Dahms N.M. (2009)
|
External Searches for M6PR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing M6PR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing M6PR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing M6PR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for M6PR | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for M6PR gene:
Search GeneIP for patents involving M6PR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for M6PR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for M6PR | | OriGene shRNA RFP for M6PR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for M6PR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for M6PR | | | OriGene Protein Over-expression Lysate for M6PR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for M6PR | | OriGene 3'-UTR Clone for M6PR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for M6PR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for M6PR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for M6PR | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for M6PR | | OriGene Custom Protein Services for M6PR | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat M6PR | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing M6PR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat M6PR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat M6PR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat M6PR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat M6PR |
| |
 |  |  |  | |
| | | | Search Tocris compounds for M6PR |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | M6PR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for M6PR |
|  |  |  | | | | ThermoFisher Antibody for M6PR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat M6PR |
|
|
|
|
