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M6PR Gene

protein-coding GIFtS: 63

GC12M008984

mannose-6-phosphate receptor (cation dependent)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD-MPR ^², ³
FLJ32994 ^²
MPR46 ^², ³
MPRD ^³
SMPR ^²

Descriptions
46 kDa mannose 6-phosphate receptor ^³
46-kDa mannose 6-phosphate receptor ^²
CD Man-6-P receptor ^³
MPR 46 ^³
Mr 46,000 Man6PR ^²
cation-dependent mannose-6-phosphate receptor ^²
mannose-6-phosphate receptor (cation dependent) ^²

External Ids
HGNC: 6752¹
Entrez Gene: 4074²
UniProtKB: P20645³
Ensembl: ENSG00000003056⁷

Search outside databases for aliases for M6PR gene

Previous GC identifers: GC12M008801 GC12M009241 GC12M008993

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for M6PR:

The protein encoded by this gene is a receptor for mannose-6-phosphate groups on lysosomal enzymes.

The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes

and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an

integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma

membrane. [provided by RefSeq]

UniProtKB/Swiss-Prot: MPRD_HUMAN, P20645

Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface

to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to

mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is

transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the

complex

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the M6PR gene

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC chromosome: 12

M6PR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M008984: (about GC identifiers)

Start:	8,984,231 bp from pter
End:	8,993,519 bp from pter
Size:	9,289 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009714.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MPRD_HUMAN, P20645 (See protein sequence)

Recommended Name: Cation-dependent mannose-6-phosphate receptor precursor

Size: 277 amino acids; 30993 Da

Subunit: Homodimer. Binds GGA1, GGA2 and GGA3

Subcellular location: Lysosome membrane; Single-pass type I membrane protein

Miscellaneous: This receptor has optimal binding in the presence of divalent cations

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002346.1

ENSEMBL proteins:

ENSP00000000412

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Mannose 6 Phosphate Receptor (Cation dependent))
	Human Recombinant Proteins from Abnova (M6PR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005765	lysosomal membrane	IEA	--
GO:0005770	late endosome	IEA	--
GO:0005887	integral to plasma membrane	TAS	10799489
GO:0009986	cell surface	IDA	12493773
GO:0016020	membrane	IEA	--

About this table

Antibodies for M6PR:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of M6PR
	Sigma-Aldrich Antibodies for M6PR
	R&D Systems Antibodies for M6PR (CD-M6PR)
	Antibodies from Abcam (Mannose 6 Phosphate Receptor (Cation dependent)), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (M6PR)
	Novus Biologicals Antibodies for M6PR

Assays for M6PR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P20645

ProtoNet protein and cluster: P20645

1 Blocks protein family: IPB000296 Cation-dependent mannose-6-phosphate receptor signature

UniProtKB/Swiss-Prot: MPRD_HUMAN, P20645

Domain: The extracellular domain is homologous to the repeating units (of approximately 147 AA) of

the cation-independent mannose 6-phosphate receptor

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (M6PR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (M6PR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002355

Applied Biosystems Silencer® siRNAs for M6PR

Sigma-Aldrich siRNA for M6PR

Sigma-Aldrich shRNA for M6PR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for M6PR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002355
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002355
untagged cDNA clones in CMV expression vector (see all 2): NM_002355

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002355

UniProtKB/Swiss-Prot: MPRD_HUMAN, P20645

Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface

to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to

mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is

transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the

complex

Genatlas biochemistry entry for M6PR:

mannose 6-phosphate receptor,cation dependent ,expressed on the cell surface of Golgi and late

endosome membrane,targetting phosphorylated enzymes to lysosomes

10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for M6pr):

behavior/neurological	cellular	growth/size	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	renal/urinary system	reproductive system	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	TAS	10799489
GO:0005515	protein binding	IEA	--
GO:0005537	mannose binding	IEA	--
GO:0015578	mannose transmembrane transporter activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for M6PR

5/38 Interacting proteins for M6PR (ENSP00000000412³ P20645²) via UniProtKB, MINT, and/or STRING (see all 38 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GGA1	Q9UJY5²	STRING (score=.989) MINT-18661
GGA3	Q9NZ52²	STRING (score=.876) MINT-18640
M6PRBP1	ENSP00000221957³	STRING (score=.988)
KIF13A	ENSP00000259711³	STRING (score=.968)
CTSD	ENSP00000236671³	STRING (score=.958)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0006898	receptor-mediated endocytosis	TAS	10799489
GO:0008333	endosome to lysosome transport	TAS	10799489
GO:0015761	mannose transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for M6PR
10/16 Novoseek chemical compound relationships for M6PR gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose 6-phosphate	98.98	551	12535273 (7), 9152028 (5), 8163521 (5), 2170115 (4) (see all 99)
3-(2,4-dinitroanilino)-3'-amino-n-methyldipropylamine	70.58	1	9278305 (1)
mannose	66.00	14	11801606 (1), 14557264 (1), 18838694 (1), 8435067 (1) (see all 13)
ricin	50.20	10	12154075 (3), 11102518 (1), 17389686 (1), 11452006 (1)
heparan sulfate	45.97	2	16280358 (2)
monensin	30.99	1	11444150 (1)
percoll	27.94	3	16438964 (1), 10896932 (1)
wortmannin	24.22	1	8735606 (1)
asparagine	18.55	3	1847926 (2)
glycogen	15.24	4	14567965 (1), 2268275 (1), 9736785 (1), 9322088 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (M6PR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (M6PR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002355

Sigma-Aldrich siRNA for M6PR

Sigma-Aldrich shRNA for M6PR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002355

REFSEQ mRNAs for M6PR gene:

NM_002355.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002355

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002355
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002355
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002355

Additional cDNA sequence:

AK222792.1 AK291143.1 AK312689.1 BC017111.1 BC024206.1 CR457412.1 CR616312.1 M16985.1

24/31 DOTS entries (see all 31 ):

DT.92461710 DT.99952542 DT.95140600 DT.91823927 DT.121125363 DT.95140538 DT.121125259 DT.100798763

DT.121125309 DT.92461707 DT.101959691 DT.100798750 DT.40229521 DT.121125323 DT.75194392 DT.100798771

DT.99955155 DT.121125285 DT.121125337 DT.92059916 DT.92390918 DT.95140531 DT.95140574 DT.100798747

24/724 AceView cDNA sequences (see all 724 ):

F02749 BQ711958 BU623427 BQ063972 AW166940 BU956843 BU180356 CD365016

T99739 BM713289 BU528095 AU130397 AA593608 BF725875 BQ877840 CF527783

N48193 BU197162 BM559376 AW239331 BC024206 BQ214599 BI255821 BE047627

highest scoring ESTs for M6PR:

AA034480 AA176278 AA206571 AA218618 AA223457 AA223856 AA368680 AA370358 AA370482 AA370763

Unigene Cluster for M6PR:

Mannose-6-phosphate receptor (cation dependent)

Hs.134084 [show with all ESTs]

Unigene Representative Sequence: BC024206

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for M6PR (see all 9 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b
SP1:							-		-																-						-
SP2:							-		-		-														-						-
SP3:							-		-								-		-						-						-
SP4:															-		-		-		-		-		-						-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for M6PR

1 Ensembl transcript including schematic representation:

ENST00000000412

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

M6PR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for M6PR

¹ / ² / ³

5 probe-sets matching M6PR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32547_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X56253	0.20	1.00	0.72	1
200901_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002355	0.60	1.00	0.82	1
200900_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI583537	0.40	1.00	0.76	1
200901_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200900_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTCCACTGG

SOURCE GeneReport for Unigene cluster: Hs.134084

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for M6PR gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	M6PR¹	--	mannose-6-phosphate receptor (cation dependent)	93.02(n) 94.95(a)	477700 XM_534894.2 XP_534894.1
chimpanzee (Pan troglodytes)	M6PR¹	--	mannose-6-phosphate receptor (cation dependent)	99.76(n) 100(a)	736013 XM_001138077.1 XP_001138077.1
cow (Bos taurus)	M6PR¹	--	mannose-6-phosphate receptor (cation dependent)	90.13(n) 93.14(a)	281291 NM_175779.3 NP_786973.1
rat (Rattus norvegicus)	M6pr¹	--	mannose-6-phosphate receptor, cation dependent	87.24(n) 91.34(a)	312689 NM_001007700.1 NP_001007701.1
mouse (Mus musculus)	M6pr^{1, 5}	6 (54.40 cM)⁵	mannose-6-phosphate receptor, cation dependent^{1, 5}	87.97(n)¹ 92.06(a)¹	17113¹ NM_010749.6¹ NP_034879.2¹ AK133943⁵ AK145913⁵ (see all 31)

About this table Species with no ortholog for M6PR

ENSEMBL Gene Tree for M6PR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/72 NCBI SNPs in M6PR are shown (see all 72 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 63)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs987917^1,2	A,C,F,H	8993842(+)	`GGGTGA/CGAGGG`	1	--	ng3¹		14		EA NA MN EU WA	1300
	rs10842598^1,2	A,C,F,H	8994192(+)	`CTGCAA/CCCACC`	1	--	ng3¹		12		EA NA EU WA	968
	rs1805754^1,2	C,F,H,O	8994515(-)	`AGAATA/CAAAAA`	1	--	ng3¹ tfbs³		8		EU EA WA NA	628
	rs4639983^1,2	A,C,F,H	8995474(+)	`ACTTAC/TTTTTT`	1	--	ng3¹ tfbs³		12		EU EA WA NA	1048
	rs1805755^1,2	C,F,H	8993679(-)	`GCTGAT/CGGAAC`	1	--	ng3¹		9		MN EU EA WA	1018
	rs933462^1,2	A,F,H	8994932(+)	`GAAAAT/GGAAAG`	1	--	ng3¹ tfbs³		4		EU EA WA	382
--	rs12582129^1,2	C	8995154(+)	`aacatA/Ggtgag`	1	--	ng3¹		0	--	--	--	--
--	rs2377671^1,2	A	8995109(+)	`ggcagA/Gaggat`	1	--	ng3¹		0	--	--	--	--
	rs1805728^1,2	A,C,F,H,O	8988501(-)	`GGAGAG/TGACCA`	1	--	int¹		8		MN EU EA WA NA	744
	rs1805727^1,2	A,C,F,H,O	8988665(-)	`ACTTAA/CAAATA`	1	--	int¹		8		MN EU EA WA NA	744

About this table

HapMap Linkage Disequilibrium images for M6PR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 154540

10/15 Novoseek disease relationships for M6PR gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
i-cell disease	86.06	4	11451951 (1)
lysosomal storage diseases	72.25	2	18838694 (1), 8527473 (1)
pompe disease	65.86	3	19046416 (1), 2268275 (1)
niemann-pick diseases	57.81	1	10407147 (1)
mps iiia	55.96	2	15542395 (1), 9405287 (1)
fabry disease	55.38	1	16532254 (1)
enzyme deficiency	46.31	1	8764823 (1)
aids	3.15	1	8164745 (1)
tumors	1.96	2	10849765 (1), 8486360 (1)
necrosis	1.50	1	8486360 (1)

About this table

Genetic Association Database: M6PR
Human Genome Epidemiology Navigator: M6PR (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/267 PubMed articles for M6PR gene (see all 267 ):

Isolation and analysis of the human 46-kDa mannose 6-phosphate receptor gene. (PubMed id 1849818)^{1, 3, 4} Klier H.J.... Pohlmann R. (1991)
Sorting of mannose 6-phosphate receptors mediated by the GGAs. (PubMed id 11387475)^{1, 3, 4} Puertollano R....Bonifacino J.S. (2001)
Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease. (PubMed id 15167696)^{1, 3, 6} Kolsch H....Heun R. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. (PubMed id 11886874)^{3, 4} Doray B.... Kornfeld S. (2002)
Cloning of a cDNA encoding the human cation-dependent mannose 6- phosphate-specific receptor. (PubMed id 2441386)^{3, 4} Pohlmann R.... von Figura K. (1987)
The overexpressed human 46-kDa mannose 6-phosphate receptor mediates endocytosis and sorting of beta-glucuronidase. (PubMed id 2172972)^{1, 3} Watanabe H....Sly W.S. (1990)
Requirement of the Human GARP Complex for Mannose 6-phosphate-receptor-dependent Sorting of Cathepsin D to Lysosomes. (PubMed id 18367545)^{1, 3} Perez-Victoria F.J....Bonifacino J.S. (2008)
SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. (PubMed id 18088323)^{1, 3} Mari M....Geuze H.J. (2008)
Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor. (PubMed id 12697764)^{1, 3} Nair P....Rohrer J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4074	HGNC: 6752	AceView: M6PR	Ensembl:ENSG00000003056	euGenes: HUgn4074
ECgene: M6PR	H-InvDB: M6PR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for M6PR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for M6PR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for M6PR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for M6PR		Antibodies for M6PR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for M6PR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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M6PR Gene at Home site.
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M6PR Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for M6PR

Summaries
for M6PR

Genomic Location
for M6PR

Proteins
for M6PR

Protein Domains/
Families
for M6PR

Gene Function
for M6PR

Pathways & Interactions
for M6PR

Drugs & Compounds
for M6PR

Transcripts
for M6PR

Expression
for M6PR

Orthologs
for M6PR

Paralogs
for M6PR

SNPs/Variants
for M6PR

Disorders & Mutations
for M6PR

Medical News
for M6PR

Publications
for M6PR

Search for M6PR

Genome Databases showing M6PR

Other Databases showing M6PR

Specialized Databases showing M6PR

Licensable Technologies
for M6PR

Services
for M6PR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

M6PR Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor M6PR

Summariesfor M6PR

Genomic Locationfor M6PR

Proteinsfor M6PR

Protein Domains/Familiesfor M6PR

Gene Functionfor M6PR

Pathways & Interactionsfor M6PR

Drugs & Compoundsfor M6PR

Transcriptsfor M6PR

Expression for M6PR

Orthologsfor M6PR

Paralogsfor M6PR

SNPs/Variantsfor M6PR

Disorders & Mutationsfor M6PR

Medical Newsfor M6PR

Publicationsfor M6PR

Search for M6PR

Genome Databases showing M6PR

Other Databases showing M6PR

Specialized Databases showing M6PR

Licensable Technologiesfor M6PR

Servicesfor M6PR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for M6PR

Summaries
for M6PR

Genomic Location
for M6PR

Proteins
for M6PR

Protein Domains/
Families
for M6PR

Gene Function
for M6PR

Pathways & Interactions
for M6PR

Drugs & Compounds
for M6PR

Transcripts
for M6PR

Expression
for M6PR

Orthologs
for M6PR

Paralogs
for M6PR

SNPs/Variants
for M6PR

Disorders & Mutations
for M6PR

Medical News
for M6PR

Publications
for M6PR

Licensable Technologies
for M6PR

Services
for M6PR