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Aliases for M6PR Gene

Aliases for M6PR Gene

  • Mannose-6-Phosphate Receptor (Cation Dependent) 2 3
  • CD Man-6-P Receptor 3 4
  • MPR 46 3 4
  • CD-MPR 3 4
  • MPR46 3 4
  • Cation-Dependent Mannose-6-Phosphate Receptor 3
  • 46-KDa Mannose 6-Phosphate Receptor 3
  • 46 KDa Mannose 6-Phosphate Receptor 4
  • Small Mannose 6-Phosphate Receptor 3
  • Mr 46,000 Man6PR 3
  • MPR-46 3
  • SMPR 3
  • MPRD 4

External Ids for M6PR Gene

Previous GeneCards Identifiers for M6PR Gene

  • GC12M008801
  • GC12M009241
  • GC12M008993
  • GC12M009092

Summaries for M6PR Gene

Entrez Gene Summary for M6PR Gene

  • This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]

GeneCards Summary for M6PR Gene

M6PR (Mannose-6-Phosphate Receptor (Cation Dependent)) is a Protein Coding gene. Diseases associated with M6PR include mucopolysaccharidosis vii. Among its related pathways are Lysosome and Clathrin derived vesicle budding. GO annotations related to this gene include transmembrane signaling receptor activity and mannose transmembrane transporter activity.

UniProtKB/Swiss-Prot for M6PR Gene

  • Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex

Gene Wiki entry for M6PR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for M6PR Gene

Genomics for M6PR Gene

Regulatory Elements for M6PR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for M6PR Gene

Start:
8,940,361 bp from pter
End:
8,949,955 bp from pter
Size:
9,595 bases
Orientation:
Minus strand

Genomic View for M6PR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for M6PR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for M6PR Gene

Proteins for M6PR Gene

  • Protein details for M6PR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20645-MPRD_HUMAN
    Recommended name:
    Cation-dependent mannose-6-phosphate receptor
    Protein Accession:
    P20645
    Secondary Accessions:
    • A8K528
    • D3DUV5

    Protein attributes for M6PR Gene

    Size:
    277 amino acids
    Molecular mass:
    30993 Da
    Quaternary structure:
    • Homodimer. Binds GGA1, GGA2 and GGA3
    Miscellaneous:
    • This receptor has optimal binding in the presence of divalent cations

    Three dimensional structures from OCA and Proteopedia for M6PR Gene

neXtProt entry for M6PR Gene

Proteomics data for M6PR Gene at MOPED

Post-translational modifications for M6PR Gene

  • Glycosylation at Asn57, Asn83, Asn94, Asn107, and Asn113
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for M6PR Gene

Domains for M6PR Gene

Suggested Antigen Peptide Sequences for M6PR Gene

Graphical View of Domain Structure for InterPro Entry

P20645

UniProtKB/Swiss-Prot:

MPRD_HUMAN :
  • P20645
Domain:
  • The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor
genes like me logo Genes that share domains with M6PR: view

No data available for Gene Families for M6PR Gene

Function for M6PR Gene

Molecular function for M6PR Gene

GENATLAS Biochemistry: mannose 6-phosphate receptor,cation dependent ,expressed on the cell surface of Golgi and late endosome membrane,targetting phosphorylated enzymes to lysosomes
UniProtKB/Swiss-Prot Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex

Gene Ontology (GO) - Molecular Function for M6PR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10799489
GO:0005537 mannose binding IEA --
GO:0015578 mannose transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with M6PR: view
genes like me logo Genes that share phenotypes with M6PR: view

Animal Models for M6PR Gene

MGI Knock Outs for M6PR:

Animal Model Products

CRISPR Products

miRNA for M6PR Gene

miRTarBase miRNAs that target M6PR

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for M6PR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for M6PR Gene

Localization for M6PR Gene

Subcellular locations from UniProtKB/Swiss-Prot for M6PR Gene

Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for M6PR Gene COMPARTMENTS Subcellular localization image for M6PR gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 4
extracellular 3
golgi apparatus 3
endoplasmic reticulum 2
cytosol 1

Gene Ontology (GO) - Cellular Components for M6PR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000323 lytic vacuole --
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IDA 15078902
GO:0005770 late endosome IEA --
genes like me logo Genes that share ontologies with M6PR: view

Pathways for M6PR Gene

genes like me logo Genes that share pathways with M6PR: view

Pathways by source for M6PR Gene

Gene Ontology (GO) - Biological Process for M6PR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS 10799489
GO:0007165 signal transduction TAS 10799489
GO:0008333 endosome to lysosome transport TAS 10799489
GO:0015761 mannose transport IEA --
genes like me logo Genes that share ontologies with M6PR: view

Compounds for M6PR Gene

(1) HMDB Compounds for M6PR Gene

Compound Synonyms Cas Number PubMed IDs
Mannose 6-phosphate
  • D-Mannose 6-phosphate
3672-15-9

(3) Drugbank Compounds for M6PR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-3 Sugar Ring of Pentamannosyl 6-Phosphate
target
Alglucosidase alfa
420784-05-0 target binder
Alpha-D-Mannose-6-Phosphate
target

(24) Novoseek inferred chemical compound relationships for M6PR Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 99 214
mannose 70.4 15
3-(2,4-dinitroanilino)-3-amino-n-methyldipropylamine 70.3 1
nh4cl 64 6
ricin 49.2 6
genes like me logo Genes that share compounds with M6PR: view

Transcripts for M6PR Gene

Unigene Clusters for M6PR Gene

Mannose-6-phosphate receptor (cation dependent):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for M6PR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for M6PR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - - - - - -
SP7: - -
SP8: -
SP9: - -

Relevant External Links for M6PR Gene

GeneLoc Exon Structure for
M6PR
ECgene alternative splicing isoforms for
M6PR

Expression for M6PR Gene

mRNA expression in normal human tissues for M6PR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for M6PR Gene

SOURCE GeneReport for Unigene cluster for M6PR Gene Hs.134084

genes like me logo Genes that share expressions with M6PR: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for M6PR Gene

Orthologs for M6PR Gene

This gene was present in the common ancestor of chordates.

Orthologs for M6PR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia M6PR 35
  • 99.76 (n)
  • 100 (a)
M6PR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia M6PR 35
  • 90.01 (n)
  • 92.78 (a)
M6PR 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia M6PR 35
  • 92.9 (n)
  • 94.58 (a)
M6PR 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia M6pr 35
  • 87.97 (n)
  • 92.06 (a)
M6pr 16
M6pr 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia M6PR 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia M6PR 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia M6pr 35
  • 87.24 (n)
  • 91.34 (a)
chicken
(Gallus gallus)
Aves M6PR 35
  • 70.15 (n)
  • 70.28 (a)
M6PR 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia M6PR 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia m6pr-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia m6pr 35
  • 62.2 (n)
  • 61.79 (a)
Str.4991 35
zebrafish
(Danio rerio)
Actinopterygii m6pr 35
  • 58.26 (n)
  • 52.94 (a)
m6pr 36
  • 49 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
Species with no ortholog for M6PR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for M6PR Gene

ENSEMBL:
Gene Tree for M6PR (if available)
TreeFam:
Gene Tree for M6PR (if available)

Paralogs for M6PR Gene

Pseudogenes.org Pseudogenes for M6PR Gene

genes like me logo Genes that share paralogs with M6PR: view

No data available for Paralogs for M6PR Gene

Variants for M6PR Gene

Sequence variations from dbSNP and Humsavar for M6PR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs933462 -- 8,951,069(+) GAAAA(G/T)GAAAG upstream-variant-2KB
rs987917 -- 8,949,979(+) GGGTG(A/C)GAGGG upstream-variant-2KB
rs1805248 -- 8,948,541(+) GGCCC(A/G)GTAGC intron-variant
rs1805725 -- 8,945,337(-) TGGCC(G/T)TTTCT intron-variant
rs1805726 -- 8,945,199(-) ACTTA(C/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for M6PR Gene

Variant ID Type Subtype PubMed ID
nsv832327 CNV Loss 17160897

Relevant External Links for M6PR Gene

HapMap Linkage Disequilibrium report
M6PR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for M6PR Gene

Disorders for M6PR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for M6PR Gene including...

Search for M6PR Gene in MalaCards »

(1) University of Copenhagen DISEASES for M6PR Gene

(15) Novoseek inferred disease relationships for M6PR Gene

Disease -log(P) Hits PubMed IDs
i-cell disease 85.6 1
lysosomal storage diseases 73.4 3
pompe disease 64.3 2
niemann-pick diseases 56.9 1
mps iiia 54 2

Relevant External Links for M6PR

Genetic Association Database (GAD)
M6PR
Human Genome Epidemiology (HuGE) Navigator
M6PR
genes like me logo Genes that share disorders with M6PR: view

No data available for UniProtKB/Swiss-Prot for M6PR Gene

Publications for M6PR Gene

  1. Isolation and analysis of the human 46-kDa mannose 6-phosphate receptor gene. (PMID: 1849818) Klier H.J. … Pohlmann R. (Eur. J. Biochem. 1991) 3 4 23
  2. Sorting of mannose 6-phosphate receptors mediated by the GGAs. (PMID: 11387475) Puertollano R. … Bonifacino J.S. (Science 2001) 3 4 23
  3. Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease. (PMID: 15167696) KAPlsch H. … Heun R. (Psychiatr. Genet. 2004) 3 23 48
  4. Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor. (PMID: 12697764) Nair P. … Rohrer J. (J. Biol. Chem. 2003) 3 23
  5. P-type lectins. (PMID: 12223278) Dahms N. … Hancock M.K. (Biochim. Biophys. Acta 2002) 3 23

Products for M6PR Gene

  • Addgene plasmids for M6PR

Sources for M6PR Gene

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