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Aliases for M1AP Gene

Aliases for M1AP Gene

  • Meiosis 1 Associated Protein 2 3 5
  • Spermatogenesis Associated 37 2 3
  • Meiosis 1 Arresting Protein 2 3
  • C2orf65 3 4
  • SPATA37 3 4
  • Spermatogenesis-Associated Protein 37 4
  • Chromosome 2 Open Reading Frame 65 2
  • Meiosis 1-Associated Protein 4
  • Meiosis 1-Arresting Protein 4
  • Meiosis 1 Arrest Protein 3
  • D6Mm5e 3

External Ids for M1AP Gene

Previous HGNC Symbols for M1AP Gene

  • C2orf65

Previous GeneCards Identifiers for M1AP Gene

  • GC02M074786

Summaries for M1AP Gene

Entrez Gene Summary for M1AP Gene

  • This gene encodes a protein that is likely to function in progression of meiosis. A similar protein in mouse plays a role in gametogenesis in both sexes. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for M1AP Gene

M1AP (Meiosis 1 Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for M1AP Gene

  • Required for meiosis I progression during spermatogenesis.

Additional gene information for M1AP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for M1AP Gene

Genomics for M1AP Gene

Regulatory Elements for M1AP Gene

Enhancers for M1AP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H074842 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -198.8 -198752 9 FOXA2 ZFP64 ARID4B SIN3A ATF7 FOS RUNX3 DEK JUNB PPARG HK2 SEMA4F M1AP ENSG00000236209 LINC01293 LBX2 GC02M074813 GC02M074860
GH02H074872 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -225.6 -225576 4 SCRT1 CTCF ZNF654 HLF TRIM22 REST CEBPG RAD21 KLF16 CEBPA HK2 M1AP SEMA4F MTHFD2 LBX2 GC02P074877 GC02M074860
GH02H074739 1.5 FANTOM5 Ensembl ENCODE 10.7 -92.2 -92165 3 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 BRCA1 GTF3C2 FOS DEK ENSG00000273245 MOGS SEMA4F DUSP11 PCGF1 AUP1 TTC31 DGUOK-AS1 CCDC142 M1AP
GH02H074570 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.2 +76.0 76025 4 HDAC1 HDGF PKNOX1 FOXA2 ARID4B BMI1 ZBTB40 BATF RAD21 RARA DOK1 LBX2-AS1 HTRA2 AUP1 PCGF1 LBX2 TLX2 DQX1 MRPL53 MOGS
GH02H074583 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +64.9 64900 1 MAFG BACH1 JUNB DPF2 BATF JUND ZNF316 POLR2A FOS NFE2 LOXL3 DOK1 HTRA2 AUP1 TLX2 PCGF1 CCDC142 TTC31 DQX1 LBX2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around M1AP on UCSC Golden Path with GeneCards custom track

Genomic Location for M1AP Gene

Chromosome:
2
Start:
74,557,883 bp from pter
End:
74,648,852 bp from pter
Size:
90,970 bases
Orientation:
Minus strand

Genomic View for M1AP Gene

Genes around M1AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
M1AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for M1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for M1AP Gene

Proteins for M1AP Gene

  • Protein details for M1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC57-M1AP_HUMAN
    Recommended name:
    Meiosis 1 arrest protein
    Protein Accession:
    Q8TC57
    Secondary Accessions:
    • B7Z6E7
    • E9PGG8
    • Q6ZP30
    • Q96L07

    Protein attributes for M1AP Gene

    Size:
    530 amino acids
    Molecular mass:
    59386 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for M1AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for M1AP Gene

Post-translational modifications for M1AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for M1AP Gene

Domains & Families for M1AP Gene

Gene Families for M1AP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for M1AP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with M1AP: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for M1AP Gene

Function for M1AP Gene

Molecular function for M1AP Gene

UniProtKB/Swiss-Prot Function:
Required for meiosis I progression during spermatogenesis.

Phenotypes From GWAS Catalog for M1AP Gene

Gene Ontology (GO) - Molecular Function for M1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with M1AP: view
genes like me logo Genes that share phenotypes with M1AP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for M1AP Gene

Localization for M1AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for M1AP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for M1AP gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for M1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0016021 integral component of membrane NAS 9927484
genes like me logo Genes that share ontologies with M1AP: view

Pathways & Interactions for M1AP Gene

No Data Available

Gene Ontology (GO) - Biological Process for M1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing NAS 9927484
GO:0007127 meiosis I IEA --
GO:0007283 spermatogenesis ISS 16881047
GO:0007292 female gamete generation ISS 16881047
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with M1AP: view

No data available for Pathways by source and SIGNOR curated interactions for M1AP Gene

Drugs & Compounds for M1AP Gene

No Compound Related Data Available

Transcripts for M1AP Gene

Unigene Clusters for M1AP Gene

Meiosis 1 associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for M1AP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - -
SP3: -
SP4: - - - - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - -

Relevant External Links for M1AP Gene

GeneLoc Exon Structure for
M1AP
ECgene alternative splicing isoforms for
M1AP

Expression for M1AP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for M1AP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for M1AP Gene

This gene is overexpressed in Testis (x9.0).

Protein differential expression in normal tissues from HIPED for M1AP Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for M1AP Gene



Protein tissue co-expression partners for M1AP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of M1AP Gene:

M1AP

SOURCE GeneReport for Unigene cluster for M1AP Gene:

Hs.348645
genes like me logo Genes that share expression patterns with M1AP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for M1AP Gene

Orthologs for M1AP Gene

This gene was present in the common ancestor of chordates.

Orthologs for M1AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia M1AP 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia M1AP 33 34
  • 87.36 (n)
cow
(Bos Taurus)
Mammalia M1AP 33 34
  • 85.99 (n)
rat
(Rattus norvegicus)
Mammalia M1ap 33
  • 79.97 (n)
mouse
(Mus musculus)
Mammalia M1ap 33 16 34
  • 78.77 (n)
oppossum
(Monodelphis domestica)
Mammalia M1AP 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia M1AP 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves C4H2ORF65 33
  • 61.26 (n)
lizard
(Anolis carolinensis)
Reptilia M1AP 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170614 33
  • 48.15 (n)
zebrafish
(Danio rerio)
Actinopterygii m1ap 33 34
  • 53.18 (n)
Species where no ortholog for M1AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for M1AP Gene

ENSEMBL:
Gene Tree for M1AP (if available)
TreeFam:
Gene Tree for M1AP (if available)

Paralogs for M1AP Gene

No data available for Paralogs for M1AP Gene

Variants for M1AP Gene

Sequence variations from dbSNP and Humsavar for M1AP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000039060 -- 74,603,320(+) CAAGG(G/T)GCTTA intron-variant
rs1000053489 -- 74,623,927(+) TTGCC(C/T)CCCGA intron-variant
rs1000059030 -- 74,585,967(+) CCTTC(-/TTG)TTGTC intron-variant
rs1000127390 -- 74,584,666(+) AAGTA(A/G)GGAAA intron-variant
rs1000221941 -- 74,584,811(+) ATATA(A/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for M1AP Gene

Variant ID Type Subtype PubMed ID
nsv1001495 CNV gain 25217958
nsv1003960 CNV gain 25217958
nsv963623 CNV duplication 23825009

Variation tolerance for M1AP Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for M1AP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
M1AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for M1AP Gene

Disorders for M1AP Gene

Relevant External Links for M1AP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
M1AP

No disorders were found for M1AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for M1AP Gene

Publications for M1AP Gene

  1. Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice. (PMID: 23269666) Arango NA … Donahoe PK (Biology of reproduction 2013) 2 3 60
  2. Expression analysis and evolutionary conservation of the mouse germ cell-specific D6Mm5e gene. (PMID: 16881047) Arango NA … Donahoe PK (Developmental dynamics : an official publication of the American Association of Anatomists 2006) 2 3 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  5. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 60

Products for M1AP Gene

Sources for M1AP Gene

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