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Aliases for M1AP Gene

Aliases for M1AP Gene

  • Meiosis 1 Associated Protein 2 3 5
  • Spermatogenesis Associated 37 2 3
  • Meiosis 1 Arresting Protein 2 3
  • C2orf65 3 4
  • SPATA37 3 4
  • Spermatogenesis-Associated Protein 37 4
  • Chromosome 2 Open Reading Frame 65 2
  • Meiosis 1-Associated Protein 4
  • Meiosis 1-Arresting Protein 4
  • D6Mm5e 3

External Ids for M1AP Gene

Previous HGNC Symbols for M1AP Gene

  • C2orf65

Previous GeneCards Identifiers for M1AP Gene

  • GC02M074786

Summaries for M1AP Gene

Entrez Gene Summary for M1AP Gene

  • This gene encodes a protein that is likely to function in progression of meiosis. A similar protein in mouse plays a role in gametogenesis in both sexes. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for M1AP Gene

M1AP (Meiosis 1 Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for M1AP Gene

  • Required for meiosis I progression during spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for M1AP Gene

Genomics for M1AP Gene

Regulatory Elements for M1AP Gene

Enhancers for M1AP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around M1AP on UCSC Golden Path with GeneCards custom track

Genomic Location for M1AP Gene

74,557,883 bp from pter
74,648,852 bp from pter
90,970 bases
Minus strand

Genomic View for M1AP Gene

Genes around M1AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
M1AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for M1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for M1AP Gene

Proteins for M1AP Gene

  • Protein details for M1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meiosis 1 arrest protein
    Protein Accession:
    Secondary Accessions:
    • B7Z6E7
    • E9PGG8
    • Q6ZP30
    • Q96L07

    Protein attributes for M1AP Gene

    530 amino acids
    Molecular mass:
    59386 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for M1AP Gene


neXtProt entry for M1AP Gene

Proteomics data for M1AP Gene at MOPED

Post-translational modifications for M1AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for M1AP Gene

Domains & Families for M1AP Gene

Protein Domains for M1AP Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with M1AP: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for M1AP Gene

Function for M1AP Gene

Molecular function for M1AP Gene

UniProtKB/Swiss-Prot Function:
Required for meiosis I progression during spermatogenesis.
genes like me logo Genes that share phenotypes with M1AP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for M1AP Gene

Localization for M1AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for M1AP Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for M1AP Gene

Pathways & Interactions for M1AP Gene

SuperPathways for M1AP Gene

No Data Available

Interacting Proteins for M1AP Gene

Gene Ontology (GO) - Biological Process for M1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing NAS 9927484
GO:0051308 male meiosis chromosome separation ISS --
genes like me logo Genes that share ontologies with M1AP: view

No data available for Pathways by source and SIGNOR curated interactions for M1AP Gene

Drugs & Compounds for M1AP Gene

No Compound Related Data Available

Transcripts for M1AP Gene

Unigene Clusters for M1AP Gene

Meiosis 1 associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for M1AP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - -
SP3: -
SP4: - - - - - -
SP5: - - - -
SP7: - -
SP8: - - -

Relevant External Links for M1AP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for M1AP Gene

mRNA expression in normal human tissues for M1AP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for M1AP Gene

This gene is overexpressed in Testis (x9.0).

Protein differential expression in normal tissues from HIPED for M1AP Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for M1AP Gene

SOURCE GeneReport for Unigene cluster for M1AP Gene Hs.348645

genes like me logo Genes that share expression patterns with M1AP: view

Protein tissue co-expression partners for M1AP Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for M1AP Gene

Orthologs for M1AP Gene

This gene was present in the common ancestor of chordates.

Orthologs for M1AP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia M1AP 35
  • 85.99 (n)
  • 80.42 (a)
M1AP 36
  • 79 (a)
(Canis familiaris)
Mammalia M1AP 35
  • 87.36 (n)
  • 82.95 (a)
M1AP 36
  • 83 (a)
(Mus musculus)
Mammalia M1ap 35
  • 78.77 (n)
  • 72.24 (a)
M1ap 16
M1ap 36
  • 72 (a)
(Pan troglodytes)
Mammalia M1AP 35
  • 99.37 (n)
  • 98.86 (a)
M1AP 36
  • 99 (a)
(Rattus norvegicus)
Mammalia M1ap 35
  • 79.97 (n)
  • 73.9 (a)
(Monodelphis domestica)
Mammalia M1AP 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia M1AP 36
  • 46 (a)
(Gallus gallus)
Aves C4H2ORF65 35
  • 61.26 (n)
  • 54.31 (a)
(Anolis carolinensis)
Reptilia M1AP 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170614 35
  • 48.15 (n)
  • 37.78 (a)
(Danio rerio)
Actinopterygii m1ap 35
  • 53.18 (n)
  • 45.65 (a)
m1ap 36
  • 43 (a)
Species with no ortholog for M1AP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for M1AP Gene

Gene Tree for M1AP (if available)
Gene Tree for M1AP (if available)

Paralogs for M1AP Gene

No data available for Paralogs for M1AP Gene

Variants for M1AP Gene

Sequence variations from dbSNP and Humsavar for M1AP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3025980 - 74,640,262(+) TAGTT(C/T)GCCCA reference, missense
rs7602159 - 74,607,067(+) GCTGG(G/T)ATCCT reference, missense
rs363674 -- 74,586,489(+) TGCAC(C/T)TCTTC intron-variant
rs363675 -- 74,587,963(+) TAAAA(A/T)TAAAG intron-variant
rs363676 -- 74,578,932(+) TAATG(A/C)CAGCA intron-variant, upstream-variant-2KB

Variation tolerance for M1AP Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for M1AP Gene

Disorders for M1AP Gene

Relevant External Links for M1AP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for M1AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for M1AP Gene

Publications for M1AP Gene

  1. Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice. (PMID: 23269666) Arango N.A. … Donahoe P.K. (Biol. Reprod. 2013) 2 3 67
  2. Expression analysis and evolutionary conservation of the mouse germ cell-specific D6Mm5e gene. (PMID: 16881047) Arango N.A. … Donahoe P.K. (Dev. Dyn. 2006) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T. … Zhu X. (Hum. Genet. 2010) 3

Products for M1AP Gene

Sources for M1AP Gene