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Aliases for M1AP Gene

Aliases for M1AP Gene

  • Meiosis 1 Associated Protein 2 3
  • Spermatogenesis Associated 37 2 3
  • Meiosis 1 Arresting Protein 2 3
  • C2orf65 3 4
  • SPATA37 3 4
  • Spermatogenesis-Associated Protein 37 4
  • Chromosome 2 Open Reading Frame 65 2
  • Meiosis 1-Associated Protein 4
  • Meiosis 1-Arresting Protein 4
  • Meiosis 1 Arrest Protein 3
  • D6Mm5e 3

External Ids for M1AP Gene

Previous Symbols for M1AP Gene

  • C2orf65

Summaries for M1AP Gene

Entrez Gene Summary for M1AP Gene

  • This gene encodes a protein that is likely to function in progression of meiosis. A similar protein in mouse plays a role in gametogenesis in both sexes. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for M1AP Gene

M1AP (Meiosis 1 Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for M1AP Gene

  • Required for meiosis I progression during spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for M1AP Gene

Genomics for M1AP Gene

Genomic Location for M1AP Gene

Start:
74,557,883 bp from pter
End:
74,648,867 bp from pter
Size:
90,985 bases
Orientation:
Minus strand

Genomic View for M1AP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for M1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for M1AP Gene

No data available for Regulatory Elements for M1AP Gene

Proteins for M1AP Gene

  • Protein details for M1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC57-M1AP_HUMAN
    Recommended name:
    Meiosis 1 arrest protein
    Protein Accession:
    Q8TC57
    Secondary Accessions:
    • B7Z6E7
    • E9PGG8
    • Q6ZP30
    • Q96L07

    Protein attributes for M1AP Gene

    Size:
    530 amino acids
    Molecular mass:
    59386 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for M1AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for M1AP Gene

Proteomics data for M1AP Gene at MOPED

Post-translational modifications for M1AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for M1AP Gene

Domains for M1AP Gene

Protein Domains for M1AP Gene

ProtoNet:
genes like me logo Genes that share domains with M1AP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for M1AP Gene

Function for M1AP Gene

Molecular function for M1AP Gene

UniProtKB/Swiss-Prot Function: Required for meiosis I progression during spermatogenesis.

Gene Ontology (GO) - Molecular Function for M1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with M1AP: view
genes like me logo Genes that share phenotypes with M1AP: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for M1AP Gene

Localization for M1AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for M1AP Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for M1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0016021 integral component of membrane NAS 9927484
genes like me logo Genes that share ontologies with M1AP: view

Pathways for M1AP Gene

SuperPathways for M1AP Gene

No Data Available

Interacting Proteins for M1AP Gene

Gene Ontology (GO) - Biological Process for M1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing NAS 9927484
GO:0007283 spermatogenesis ISS --
GO:0007292 female gamete generation ISS 16881047
GO:0030154 cell differentiation IEA --
GO:0031497 chromatin assembly NAS 9927484
genes like me logo Genes that share ontologies with M1AP: view

No data available for Pathways by source for M1AP Gene

Transcripts for M1AP Gene

Unigene Clusters for M1AP Gene

Meiosis 1 associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for M1AP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - -
SP3: -
SP4: - - - - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - -

Relevant External Links for M1AP Gene

GeneLoc Exon Structure for
M1AP
ECgene alternative splicing isoforms for
M1AP

Expression for M1AP Gene

mRNA expression in normal human tissues for M1AP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for M1AP Gene

This gene is overexpressed in Testis (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for M1AP Gene

SOURCE GeneReport for Unigene cluster for M1AP Gene Hs.348645

genes like me logo Genes that share expressions with M1AP: view

Orthologs for M1AP Gene

This gene was present in the common ancestor of chordates.

Orthologs for M1AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia M1AP 36
  • 99.37 (n)
  • 98.86 (a)
M1AP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia M1AP 36
  • 85.99 (n)
  • 80.42 (a)
M1AP 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia M1AP 36
  • 87.36 (n)
  • 82.95 (a)
M1AP 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia M1ap 36
  • 78.77 (n)
  • 72.24 (a)
M1ap 16
M1ap 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia M1AP 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia M1AP 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia M1ap 36
  • 79.97 (n)
  • 73.9 (a)
chicken
(Gallus gallus)
Aves C4H2ORF65 36
  • 61.26 (n)
  • 54.31 (a)
lizard
(Anolis carolinensis)
Reptilia M1AP 37
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170614 36
  • 48.15 (n)
  • 37.78 (a)
zebrafish
(Danio rerio)
Actinopterygii m1ap 36
  • 53.18 (n)
  • 45.65 (a)
m1ap 37
  • 43 (a)
OneToOne
Species with no ortholog for M1AP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for M1AP Gene

ENSEMBL:
Gene Tree for M1AP (if available)
TreeFam:
Gene Tree for M1AP (if available)

Paralogs for M1AP Gene

No data available for Paralogs for M1AP Gene

Variants for M1AP Gene

Sequence variations from dbSNP and Humsavar for M1AP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs205651 -- 74,628,996(-) ttccc(A/G)tgcaa intron-variant
rs363674 -- 74,586,489(+) TGCAC(C/T)TCTTC intron-variant
rs363675 -- 74,587,963(+) TAAAA(A/T)TAAAG intron-variant
rs363676 -- 74,578,932(+) TAATG(A/C)CAGCA intron-variant, upstream-variant-2KB
rs363677 -- 74,578,999(+) AATTT(C/T)CCCAG intron-variant, upstream-variant-2KB

Relevant External Links for M1AP Gene

HapMap Linkage Disequilibrium report
M1AP

No data available for Structural Variations from Database of Genomic Variants (DGV) for M1AP Gene

Disorders for M1AP Gene

No disorders were found for M1AP Gene.

No data available for UniProtKB/Swiss-Prot for M1AP Gene

Publications for M1AP Gene

  1. Expression analysis and evolutionary conservation of the mouse germ cell-specific D6Mm5e gene. (PMID: 16881047) Arango N.A. … Donahoe P.K. (Dev. Dyn. 2006) 2 3
  2. Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice. (PMID: 23269666) Arango N.A. … Donahoe P.K. (Biol. Reprod. 2013) 2 3
  3. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. (PMID: 24939585) Fransen E. … Friedman R.A. (Eur. J. Hum. Genet. 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for M1AP Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate M1AP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for M1AP
    • Block miRNA regulation of M1AP using miScript Target Protectors

    Sources for M1AP Gene

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