NBR1 Gene
protein-coding GIFtS : 54
GC17P038578
neighbor of BRCA1 gene 1 (Previous names: membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: M17S2 )
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Aliases & Descriptions for NBR1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 1A1-3B 1 , 2 , 3 1A13B 3 CA125 1 FLJ55359 2 FLJ98272 2 KIAA0049 1 , 2 , 3 M17S2 2 , 3 , 5 MIG19 2
Descriptions Membrane component, chromosome 17, surface marker 2 3 Neighbor of BRCA1 gene 1 protein 3 membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) 1 , 2 migration-inducing protein 19 2 neighbor of BRCA1 gene 1 2
Search outside databases for aliases for NBR1 genePrevious GC identifer: GC17P9L0001
Summaries for NBR1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for NBR1 : The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored inovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in manygenes with transformation potential, but the function of this protein is unknown. This gene islocated on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor geneBRCA1. Three alternatively spliced variants encoding the same protein have been identified forthis gene. [provided by RefSeq] Gene Wiki entry for NBR1
Genomic Location for NBR1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the NBR1 gene Entrez Gene cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31 NBR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P038578:
(about GC identifiers )
Start:
38,576,024 bp from pter
End:
38,600,582 bp from pter
Size:
24,559 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000017.9 NT_010755.15 Proteins for NBR1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596 (See
protein sequence )Recommended Name: Next to BRCA1 gene 1 protein Size : 966 amino acids; 107432 Da
Subunit : Homooligomer and heterooligomer. Interacts with SQSTM1, titin/TTN and RNF29
Caution : Was originally (PubMed:8069304) thought to be the ovarian carcinoma antigen CA125
PDB structures from and Proteopedia : 1WJ6 (3D)
 2BKF (3D)
 2CP8 (3D)
 2G4S (3D)
 
Secondary accessions : Q13173 Q15026 Q96GB6 Q9NRF7Alternative splicing : 2 isoforms : Q14596-1 Q14596-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_005890.2 NP_114064.1 NP_114068.1 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for NBR1: Assays for NBR1:
Protein
Domains/ Families for NBR1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q14596 ProtoNet protein and cluster: Q14596
3 Blocks protein families : IPB000270 Octicosapeptide/Phox/Bem1p IPB000433 Zn-finger IPB000449 Ubiquitin-associated domain UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596 Domain : The OPR domain mediates interaction with SQSTM1Similarity : Contains 1 OPR domainSimilarity : Contains 1 UBA domainSimilarity : Contains 1 ZZ-type zinc finger
Gene Function for NBR1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_005899 Applied Biosystems Silencer ® siRNAs for NBR1 Sigma-Aldrich siRNA and siRNA Panels for NBR1 Sigma-Aldrich shRNA Panels and shRNA for NBR1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_005899                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_005899                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC009808  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005899 2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008270 zinc ion binding
IEA -- GO:0046872 metal ion binding
IEA --
About this table
Pathways & Interactions for NBR1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for NBR1 5/15 Interacting proteins for NBR1 (Q14596 2 ) via UniProtKB, MINT, and/or STRING (see all 15
)About this table
Drugs & Compounds for NBR1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for NBR1
Transcripts for NBR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_005899 Sigma-Aldrich siRNA and siRNA Panels for NBR1 Sigma-Aldrich shRNA Panels and shRNA for NBR1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005899 NM_031858 NM_031862
REFSEQ mRNAs for NBR1 gene (3 alternative transcripts): NM_005899.3 NM_031858.2 NM_031862.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005899 NM_031858 NM_031862
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_005899                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_005899                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC009808  
Additional cDNA sequence: AK308324.1 AY450308.1 D30756.1 X76952.1 XM_001124828.2
24/30 DOTS entries (see all 30
): DT.102839957 DT.100822404 DT.100822409 DT.101978440 DT.100022668 DT.100822401 DT.444984 DT.120910716 DT.97858444 DT.120910787 DT.75190497 DT.40108675 DT.100816331 DT.70103187 DT.75119216 DT.87015353 DT.91855250 DT.91924762 DT.87008244 DT.95263448 DT.437274 DT.92464067 DT.95305503 DT.100728131
24/77 AceView cDNA sequences (see all 77
):AU140463 AL044169 CB989852 CB988916 BF724610 AF227189 BM459691 CF138277 AW025470 CF135984 AL042510 AW236032 AL039232 BQ924406 M79023 CB160484 AU140448 BU161042 BM827388 BM925429 BX452264 BU152844 BU173368 BX462113
highest scoring ESTs for NBR1 :D30756 AA028089 AA028090 AA046065 AA046348 AA069906 AA083814 AA126012 AA126134 AA126858
Unigene Clusters for NBR1: Neighbor of BRCA1 gene 1 Hs.373818 [show with all ESTs ] , Hs.546264 [show with all ESTs ] Unigene Representative Sequences: AK290005 , NM_031858 GeneLoc Exon Structure
Expression for NBR1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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NBR1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for NBR1 1 / 2 / 3
5 probe-sets matching NBR1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene clusters: Hs.373818 Hs.546264 Expression variation in blood from EXPOLDB for NBR1
Orthologs for NBR1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for NBR1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for NBR1 Paralogs for NBR1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for NBR1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for NBR1 (up to first 250kb)
Disorders & Mutations for NBR1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 166945
Medical News for NBR1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for NBR1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/18 PubMed articles for NBR1 gene (see all 18
): A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. (PubMed id 8069304) 2, 3, 4 Campbell I.G....Black D.M. (1994) The kinase domain of titin controls muscle gene expression and protein turnover. (PubMed id 15802564) 3, 4 Lange S.... Gautel M. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. (PubMed id 12813044) 3, 4 Lamark T.... Johansen T. (2003) Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. (PubMed id 11179671) 3, 4 Dimitrov S.... Forejt J. (2001) Comparison of the positional cloning methods used to isolate the BRCA1 gene. (PubMed id 7581362) 3, 4 Harshman K.... Kamb A. (1995) Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044) 3, 4 Nomura N....Tabata S. (1994) Crystal structure of the PB1 domain of NBR1. (PubMed id 16376336) 4 Muller S....Wilmanns M. (2006) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 3 Rual J.F....Vidal M. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004)
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Genome Databases showing NBR1
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing NBR1
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Specialized Databases showing NBR1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for NBR1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for NBR1:
Recombinant Proteins (NBR1 ) Antibodies (NBR1 )
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