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Aliases for LZTS2 Gene

Aliases for LZTS2 Gene

  • Leucine Zipper Tumor Suppressor 2 2 3 5
  • Leucine Zipper, Putative Tumor Suppressor 2 2 3
  • Protein LAPSER1 3 4
  • LAPSER1 3 4
  • Leucine Zipper Putative Tumor Suppressor 2 3
  • KIAA1813 4
  • HLZTS2 4

External Ids for LZTS2 Gene

Previous GeneCards Identifiers for LZTS2 Gene

  • GC10P102424
  • GC10P102746
  • GC10P096386
  • GC10P102756

Summaries for LZTS2 Gene

Entrez Gene Summary for LZTS2 Gene

  • The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for LZTS2 Gene

LZTS2 (Leucine Zipper Tumor Suppressor 2) is a Protein Coding gene. An important paralog of this gene is LZTS1.

UniProtKB/Swiss-Prot for LZTS2 Gene

  • Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.

Additional gene information for LZTS2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LZTS2 Gene

Genomics for LZTS2 Gene

GeneHancer (GH) Regulatory Elements for LZTS2 Gene

Promoters and enhancers for LZTS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I100995 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.7 2686 7.4 HDGF SMAD1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 LZTS2 MRPL43 SEMA4G MIR608 ENSG00000272572 KCNIP2 PDZD7
GH10I101828 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 64.1 +834.4 834365 4.4 HDGF PKNOX1 CLOCK SMAD1 ARNT SIN3A ZNF2 ZBTB7B ZNF766 ZNF302 PPRC1 LDB1 GBF1 LZTS2 MRPL43 HPS6 NOLC1 SUFU ENSG00000272572 KCNIP2-AS1
GH10I100986 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 32.3 -9.0 -8971 2.5 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B MRPL43 GC10M100989 PIR54177 PIR47631 PIR56323 PIR57005 PIR34755 TWNK PHBP9 LZTS2
GH10I100228 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.1 -767.1 -767125 1.8 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B CHUK ENSG00000227492 BLOC1S2 EBAG9P1 MRPL43 CWF19L1 SLC25A28 PHBP9 LZTS2 ENSG00000236308
GH10I101692 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10 +697.7 697729 3.1 HDGF ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 SP3 SP5 FBXW4 PPRC1 GBF1 MRPL43 LDB1 ENSG00000272572 HPS6 TWNK SUFU LZTS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LZTS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LZTS2 gene promoter:

Genomic Locations for LZTS2 Gene

Genomic Locations for LZTS2 Gene
chr10:100,996,618-101,007,836
(GRCh38/hg38)
Size:
11,219 bases
Orientation:
Plus strand
chr10:102,756,375-102,767,593
(GRCh37/hg19)

Genomic View for LZTS2 Gene

Genes around LZTS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LZTS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LZTS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LZTS2 Gene

Proteins for LZTS2 Gene

  • Protein details for LZTS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRK4-LZTS2_HUMAN
    Recommended name:
    Leucine zipper putative tumor suppressor 2
    Protein Accession:
    Q9BRK4
    Secondary Accessions:
    • B1AL14
    • D3DR72
    • Q8N3I0
    • Q96J79
    • Q96JL2

    Protein attributes for LZTS2 Gene

    Size:
    669 amino acids
    Molecular mass:
    72759 Da
    Quaternary structure:
    • Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
    SequenceCaution:
    • Sequence=BAB47442.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LZTS2 Gene

Post-translational modifications for LZTS2 Gene

No data available for DME Specific Peptides for LZTS2 Gene

Domains & Families for LZTS2 Gene

Gene Families for LZTS2 Gene

Protein Domains for LZTS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LZTS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRK4

UniProtKB/Swiss-Prot:

LZTS2_HUMAN :
  • Belongs to the LZTS2 family.
Family:
  • Belongs to the LZTS2 family.
genes like me logo Genes that share domains with LZTS2: view

Function for LZTS2 Gene

Molecular function for LZTS2 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
UniProtKB/Swiss-Prot Induction:
By inhibition of NF-kappa-B signaling.

Phenotypes From GWAS Catalog for LZTS2 Gene

Gene Ontology (GO) - Molecular Function for LZTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LZTS2: view
genes like me logo Genes that share phenotypes with LZTS2: view

Animal Models for LZTS2 Gene

MGI Knock Outs for LZTS2:

Animal Model Products

miRNA for LZTS2 Gene

miRTarBase miRNAs that target LZTS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LZTS2 Gene

Localization for LZTS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LZTS2 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LZTS2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LZTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with LZTS2: view

Pathways & Interactions for LZTS2 Gene

SuperPathways for LZTS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LZTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0007049 cell cycle IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with LZTS2: view

No data available for Pathways by source and SIGNOR curated interactions for LZTS2 Gene

Drugs & Compounds for LZTS2 Gene

No Compound Related Data Available

Transcripts for LZTS2 Gene

Unigene Clusters for LZTS2 Gene

Leucine zipper, putative tumor suppressor 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LZTS2 Gene

No ASD Table

Relevant External Links for LZTS2 Gene

GeneLoc Exon Structure for
LZTS2
ECgene alternative splicing isoforms for
LZTS2

Expression for LZTS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LZTS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LZTS2 Gene

This gene is overexpressed in Urine (48.6) and Testis (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LZTS2 Gene



NURSA nuclear receptor signaling pathways regulating expression of LZTS2 Gene:

LZTS2

SOURCE GeneReport for Unigene cluster for LZTS2 Gene:

Hs.523221

mRNA Expression by UniProt/SwissProt for LZTS2 Gene:

Q9BRK4-LZTS2_HUMAN
Tissue specificity: Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.

Evidence on tissue expression from TISSUES for LZTS2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LZTS2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LZTS2 Gene

Orthologs for LZTS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LZTS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LZTS2 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia LZTS2 33 34
  • 90.77 (n)
cow
(Bos Taurus)
Mammalia LZTS2 33 34
  • 89.27 (n)
mouse
(Mus musculus)
Mammalia Lzts2 33 16 34
  • 86.84 (n)
rat
(Rattus norvegicus)
Mammalia Lzts2 33
  • 85.8 (n)
oppossum
(Monodelphis domestica)
Mammalia LZTS2 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LZTS2 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LZTS2 33 34
  • 68.09 (n)
lizard
(Anolis carolinensis)
Reptilia LZTS2 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lzts2 33
  • 58.92 (n)
zebrafish
(Danio rerio)
Actinopterygii lzts2a 33 34
  • 58.87 (n)
lzts2b 34
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3837 34
  • 35 (a)
OneToMany
Species where no ortholog for LZTS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LZTS2 Gene

ENSEMBL:
Gene Tree for LZTS2 (if available)
TreeFam:
Gene Tree for LZTS2 (if available)

Paralogs for LZTS2 Gene

Paralogs for LZTS2 Gene

(2) SIMAP similar genes for LZTS2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with LZTS2: view

Variants for LZTS2 Gene

Sequence variations from dbSNP and Humsavar for LZTS2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs367898512 A colorectal cancer sample 101,002,900(+) G/A coding_sequence_variant, missense_variant
VAR_036365 A breast cancer sample p.Gly291Arg
rs1000158407 -- 101,001,508(+) CCCC/CCC 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000194497 -- 100,995,980(+) C/T upstream_transcript_variant
rs1000246107 -- 100,998,915(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LZTS2 Gene

Variant ID Type Subtype PubMed ID
nsv467443 CNV loss 19166990
nsv517698 CNV loss 19592680
nsv831965 CNV loss 17160897

Variation tolerance for LZTS2 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LZTS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LZTS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LZTS2 Gene

Disorders for LZTS2 Gene

Additional Disease Information for LZTS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LZTS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LZTS2 Gene

Publications for LZTS2 Gene

  1. LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. (PMID: 18490357) Sudo H … Maru Y (Human molecular genetics 2008) 2 3 4 22 58
  2. LAPSER1: a novel candidate tumor suppressor gene from 10q24.3. (PMID: 11709705) Cabeza-Arvelaiz Y … Chinault AC (Oncogene 2001) 2 3 4 22 58
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
  5. Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells. (PMID: 17950943) Hyun Hwa Cho … Jin Sup Jung (Biochimica et biophysica acta 2008) 3 4 58

Products for LZTS2 Gene

Sources for LZTS2 Gene

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