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Aliases for LZTS2 Gene

Aliases for LZTS2 Gene

  • Leucine Zipper, Putative Tumor Suppressor 2 2 3
  • Protein LAPSER1 3 4
  • LAPSER1 3 4
  • HLZTS2 3 4
  • KIAA1813 4

External Ids for LZTS2 Gene

Previous GeneCards Identifiers for LZTS2 Gene

  • GC10P102424
  • GC10P102746
  • GC10P096386
  • GC10P102756

Summaries for LZTS2 Gene

GeneCards Summary for LZTS2 Gene

LZTS2 (Leucine Zipper, Putative Tumor Suppressor 2) is a Protein Coding gene. An important paralog of this gene is N4BP3.

UniProtKB/Swiss-Prot for LZTS2 Gene

  • Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LZTS2 Gene

Genomics for LZTS2 Gene

Regulatory Elements for LZTS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LZTS2 Gene

Chromosome:
10
Start:
100,996,618 bp from pter
End:
101,007,836 bp from pter
Size:
11,219 bases
Orientation:
Plus strand

Genomic View for LZTS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LZTS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LZTS2 Gene

Proteins for LZTS2 Gene

  • Protein details for LZTS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRK4-LZTS2_HUMAN
    Recommended name:
    Leucine zipper putative tumor suppressor 2
    Protein Accession:
    Q9BRK4
    Secondary Accessions:
    • B1AL14
    • D3DR72
    • Q8N3I0
    • Q96J79
    • Q96JL2

    Protein attributes for LZTS2 Gene

    Size:
    669 amino acids
    Molecular mass:
    72759 Da
    Quaternary structure:
    • Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
    SequenceCaution:
    • Sequence=BAB47442.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LZTS2 Gene

Proteomics data for LZTS2 Gene at MOPED

Post-translational modifications for LZTS2 Gene

  • Ubiquitination at Lys 615
  • Modification sites at PhosphoSitePlus

Other Protein References for LZTS2 Gene

No data available for DME Specific Peptides for LZTS2 Gene

Domains & Families for LZTS2 Gene

Protein Domains for LZTS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LZTS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRK4

UniProtKB/Swiss-Prot:

LZTS2_HUMAN :
  • Belongs to the LZTS2 family.
Family:
  • Belongs to the LZTS2 family.
genes like me logo Genes that share domains with LZTS2: view

No data available for Gene Families for LZTS2 Gene

Function for LZTS2 Gene

Molecular function for LZTS2 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
UniProtKB/Swiss-Prot Induction:
By inhibition of NF-kappa-B signaling.

Gene Ontology (GO) - Molecular Function for LZTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LZTS2: view
genes like me logo Genes that share phenotypes with LZTS2: view

Animal Models for LZTS2 Gene

MGI Knock Outs for LZTS2:

Animal Model Products

miRNA for LZTS2 Gene

miRTarBase miRNAs that target LZTS2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LZTS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LZTS2 Gene

Localization for LZTS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LZTS2 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LZTS2 Gene COMPARTMENTS Subcellular localization image for LZTS2 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for LZTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005874 microtubule IEA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with LZTS2: view

Pathways & Interactions for LZTS2 Gene

SuperPathways for LZTS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LZTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IEA --
GO:0001822 kidney development IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010942 positive regulation of cell death IEA --
genes like me logo Genes that share ontologies with LZTS2: view

No data available for Pathways by source and SIGNOR curated interactions for LZTS2 Gene

Drugs & Compounds for LZTS2 Gene

No Compound Related Data Available

Transcripts for LZTS2 Gene

Unigene Clusters for LZTS2 Gene

Leucine zipper, putative tumor suppressor 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LZTS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LZTS2 Gene

No ASD Table

Relevant External Links for LZTS2 Gene

GeneLoc Exon Structure for
LZTS2
ECgene alternative splicing isoforms for
LZTS2

Expression for LZTS2 Gene

mRNA expression in normal human tissues for LZTS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LZTS2 Gene

This gene is overexpressed in Urine (48.6) and Testis (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LZTS2 Gene



SOURCE GeneReport for Unigene cluster for LZTS2 Gene Hs.523221

mRNA Expression by UniProt/SwissProt for LZTS2 Gene

Q9BRK4-LZTS2_HUMAN
Tissue specificity: Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
genes like me logo Genes that share expression patterns with LZTS2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for LZTS2 Gene

Orthologs for LZTS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LZTS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LZTS2 35
  • 89.27 (n)
  • 93.98 (a)
LZTS2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LZTS2 35
  • 90.77 (n)
  • 95.06 (a)
LZTS2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lzts2 35
  • 86.84 (n)
  • 91.74 (a)
Lzts2 16
Lzts2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LZTS2 35
  • 99.5 (n)
  • 99.7 (a)
LZTS2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lzts2 35
  • 85.8 (n)
  • 90.28 (a)
oppossum
(Monodelphis domestica)
Mammalia LZTS2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LZTS2 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LZTS2 35
  • 68.09 (n)
  • 62.17 (a)
LZTS2 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LZTS2 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lzts2 35
  • 58.92 (n)
  • 56.99 (a)
zebrafish
(Danio rerio)
Actinopterygii lzts2a 35
  • 58.87 (n)
  • 54.98 (a)
lzts2a 36
  • 47 (a)
OneToMany
lzts2b 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3837 36
  • 35 (a)
OneToMany
Species with no ortholog for LZTS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LZTS2 Gene

ENSEMBL:
Gene Tree for LZTS2 (if available)
TreeFam:
Gene Tree for LZTS2 (if available)

Paralogs for LZTS2 Gene

Paralogs for LZTS2 Gene

(2) SIMAP similar genes for LZTS2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with LZTS2: view

Variants for LZTS2 Gene

Sequence variations from dbSNP and Humsavar for LZTS2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs701834 -- 101,002,044(-) ATTAG(A/G)GAACA intron-variant
rs701835 -- 101,002,370(-) TCAAG(C/T)GCTGG intron-variant
rs750866 -- 101,001,701(+) AAGGC(A/G)GGGCA intron-variant
rs752974 -- 101,002,499(-) CAGGC(A/G)ACCTG utr-variant-5-prime
rs807024 -- 101,006,817(+) CTGGC(A/G)GAGAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for LZTS2 Gene

Variant ID Type Subtype PubMed ID
nsv831965 CNV Loss 17160897
nsv467443 CNV Loss 19166990
nsv517698 CNV Loss 19592680
nsv895961 CNV Loss 21882294
dgv813n71 CNV Loss 21882294
nsv895963 CNV Loss 21882294
nsv895964 CNV Loss 21882294

Variation tolerance for LZTS2 Gene

Residual Variation Intolerance Score: 80.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LZTS2 Gene

HapMap Linkage Disequilibrium report
LZTS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LZTS2 Gene

Disorders for LZTS2 Gene

Relevant External Links for LZTS2

Genetic Association Database (GAD)
LZTS2
Human Genome Epidemiology (HuGE) Navigator
LZTS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LZTS2
genes like me logo Genes that share disorders with LZTS2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LZTS2 Gene

Publications for LZTS2 Gene

  1. LAPSER1: a novel candidate tumor suppressor gene from 10q24.3. (PMID: 11709705) Cabeza-Arvelaiz Y. … Chinault A.C. (Oncogene 2001) 2 23 67
  2. LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. (PMID: 18490357) Sudo H. … Maru Y. (Hum. Mol. Genet. 2008) 23 67
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for LZTS2 Gene

Sources for LZTS2 Gene

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