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Aliases for LZTS1 Gene

Aliases for LZTS1 Gene

  • Leucine Zipper Tumor Suppressor 1 2 3 5
  • F37/Esophageal Cancer-Related Gene-Coding Leucine-Zipper Motif 2 3 4
  • Leucine Zipper, Putative Tumor Suppressor 1 2 3
  • FEZ1 3 4
  • Leucine Zipper Putative Tumor Suppressor 1 3
  • F37 3

External Ids for LZTS1 Gene

Previous GeneCards Identifiers for LZTS1 Gene

  • GC08M019978
  • GC08M020165
  • GC08M020113
  • GC08M020147
  • GC08M018643

Summaries for LZTS1 Gene

Entrez Gene Summary for LZTS1 Gene

  • This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]

GeneCards Summary for LZTS1 Gene

LZTS1 (Leucine Zipper Tumor Suppressor 1) is a Protein Coding gene. Diseases associated with LZTS1 include Esophageal Cancer and Collecting Duct Carcinoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is LZTS2.

UniProtKB/Swiss-Prot for LZTS1 Gene

  • Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.

Gene Wiki entry for LZTS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LZTS1 Gene

Genomics for LZTS1 Gene

Regulatory Elements for LZTS1 Gene

Enhancers for LZTS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F020274 0.7 ENCODE 27 +29.1 29057 0.2 LZTS1 RNU6-892P LZTS1-AS1
GH08F020273 1 Ensembl ENCODE 27 +30.1 30081 1.8 SMARCA4 POLR2A SPI1 GABPA LZTS1 RNU6-892P LZTS1-AS1
GH08F020271 0.5 Ensembl 25.6 +32.1 32081 1.0 CTBP1 GATA3 ZNF580 ZMYM3 DPF2 ZIC2 LZTS1 RNU6-892P LZTS1-AS1
GH08F020267 0.9 Ensembl ENCODE 25.2 +35.4 35399 2.8 ETV1 JUN ZIC2 ZFHX2 GLIS2 POLR2A ZNF366 FOS ZNF600 MAFK LZTS1 RNU6-892P LZTS1-AS1
GH08F020264 0.9 Ensembl ENCODE 24.5 +38.7 38681 2.2 CTCF ZNF654 ZNF146 REST RAD21 NR2F2 ZNF121 SMC3 ZNF24 FOS LZTS1 RNU6-892P LZTS1-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LZTS1 on UCSC Golden Path with GeneCards custom track

Promoters for LZTS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001439403 781 2401 TFAP4 PKNOX1 SUZ12 POLR2A SCRT2 NFYB E2F6 TCF7L2 EGR2 EZH2

Genomic Location for LZTS1 Gene

Chromosome:
8
Start:
20,246,165 bp from pter
End:
20,303,981 bp from pter
Size:
57,817 bases
Orientation:
Minus strand

Genomic View for LZTS1 Gene

Genes around LZTS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LZTS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LZTS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LZTS1 Gene

Proteins for LZTS1 Gene

  • Protein details for LZTS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y250-LZTS1_HUMAN
    Recommended name:
    Leucine zipper putative tumor suppressor 1
    Protein Accession:
    Q9Y250
    Secondary Accessions:
    • D3DSQ6
    • Q9Y5V7
    • Q9Y5V8
    • Q9Y5V9
    • Q9Y5W0
    • Q9Y5W1
    • Q9Y5W2

    Protein attributes for LZTS1 Gene

    Size:
    596 amino acids
    Molecular mass:
    66613 Da
    Quaternary structure:
    • Binds EEF1G, TLK2 and CDK1.
    Miscellaneous:
    • Defects in LZTS1 are found in many types of tumors.

    Alternative splice isoforms for LZTS1 Gene

neXtProt entry for LZTS1 Gene

Post-translational modifications for LZTS1 Gene

  • Phorphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LZTS1 Gene

Domains & Families for LZTS1 Gene

Gene Families for LZTS1 Gene

Protein Domains for LZTS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LZTS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y250

UniProtKB/Swiss-Prot:

LZTS1_HUMAN :
  • Belongs to the LZTS family.
Family:
  • Belongs to the LZTS family.
genes like me logo Genes that share domains with LZTS1: view

Function for LZTS1 Gene

Molecular function for LZTS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.

Gene Ontology (GO) - Molecular Function for LZTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10097140
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10097140
GO:0005515 protein binding IPI 17349584
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with LZTS1: view
genes like me logo Genes that share phenotypes with LZTS1: view

Human Phenotype Ontology for LZTS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LZTS1 Gene

MGI Knock Outs for LZTS1:

Animal Model Products

miRNA for LZTS1 Gene

miRTarBase miRNAs that target LZTS1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LZTS1 Gene

Localization for LZTS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LZTS1 Gene

Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LZTS1 Gene COMPARTMENTS Subcellular localization image for LZTS1 gene
Compartment Confidence
plasma membrane 4
nucleus 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for LZTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with LZTS1: view

Pathways & Interactions for LZTS1 Gene

SuperPathways for LZTS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LZTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated NAS 10097140
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0016242 negative regulation of macroautophagy IMP 22354037
GO:0044772 mitotic cell cycle phase transition IEA --
genes like me logo Genes that share ontologies with LZTS1: view

No data available for Pathways by source and SIGNOR curated interactions for LZTS1 Gene

Drugs & Compounds for LZTS1 Gene

(1) Drugs for LZTS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with LZTS1: view

Transcripts for LZTS1 Gene

Unigene Clusters for LZTS1 Gene

Leucine zipper, putative tumor suppressor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LZTS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for LZTS1 Gene

GeneLoc Exon Structure for
LZTS1
ECgene alternative splicing isoforms for
LZTS1

Expression for LZTS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LZTS1 Gene

mRNA differential expression in normal tissues according to GTEx for LZTS1 Gene

This gene is overexpressed in Brain - Cortex (x5.2), Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Amygdala (x4.3), Brain - Frontal Cortex (BA9) (x4.2), Brain - Caudate (basal ganglia) (x4.1), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for LZTS1 Gene

This gene is overexpressed in Lung (57.5) and Plasma (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LZTS1 Gene



Protein tissue co-expression partners for LZTS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LZTS1 Gene:

LZTS1

SOURCE GeneReport for Unigene cluster for LZTS1 Gene:

Hs.521432

mRNA Expression by UniProt/SwissProt for LZTS1 Gene:

Q9Y250-LZTS1_HUMAN
Tissue specificity: Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.
genes like me logo Genes that share expression patterns with LZTS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LZTS1 Gene

Orthologs for LZTS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LZTS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LZTS1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LZTS1 34 35
  • 89.24 (n)
cow
(Bos Taurus)
Mammalia LZTS1 34 35
  • 89.1 (n)
mouse
(Mus musculus)
Mammalia Lzts1 34 16 35
  • 85.58 (n)
rat
(Rattus norvegicus)
Mammalia Lzts1 34
  • 85.58 (n)
oppossum
(Monodelphis domestica)
Mammalia LZTS1 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LZTS1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LZTS1 34 35
  • 78.98 (n)
lizard
(Anolis carolinensis)
Reptilia LZTS1 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lzts1 34 35
  • 56.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3837 35
  • 25 (a)
OneToMany
Species where no ortholog for LZTS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LZTS1 Gene

ENSEMBL:
Gene Tree for LZTS1 (if available)
TreeFam:
Gene Tree for LZTS1 (if available)

Paralogs for LZTS1 Gene

Paralogs for LZTS1 Gene

(2) SIMAP similar genes for LZTS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LZTS1: view

Variants for LZTS1 Gene

Sequence variations from dbSNP and Humsavar for LZTS1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs119473032 Pathogenic 20,253,576(-) CCGAG(A/G)AGGGT reference, missense
rs28937897 Pathogenic 20,255,097(-) AGTCC(C/T)CCCAC reference, missense
rs10086667 -- 20,299,054(+) CTAAT(C/T)TGCAC intron-variant
rs10091552 -- 20,255,518(+) CTACT(C/T)TAAAC intron-variant, upstream-variant-2KB
rs10093476 -- 20,245,787(+) GGCAA(C/T)TGTAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LZTS1 Gene

Variant ID Type Subtype PubMed ID
nsv1033511 CNV gain 25217958
nsv520882 CNV loss 19592680
nsv522185 CNV gain 19592680
nsv819988 CNV gain 19587683

Variation tolerance for LZTS1 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LZTS1 Gene

Human Gene Mutation Database (HGMD)
LZTS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LZTS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LZTS1 Gene

Disorders for LZTS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LZTS1 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
collecting duct carcinoma
  • carcinoma of renal collecting duct
uveal melanoma
  • melanoma of uvea
- elite association - COSMIC cancer census association via MalaCards
Search LZTS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LZTS1_HUMAN
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:10097140}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for LZTS1

Genetic Association Database (GAD)
LZTS1
Human Genome Epidemiology (HuGE) Navigator
LZTS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LZTS1
genes like me logo Genes that share disorders with LZTS1: view

No data available for Genatlas for LZTS1 Gene

Publications for LZTS1 Gene

  1. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. (PMID: 10097140) Ishii H. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 22 64
  2. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. (PMID: 17349584) Vecchione A. … Croce C.M. (Cancer Cell 2007) 2 3 22 64
  3. Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22. (PMID: 11464283) Cabeza-Arvelaiz Y. … Chinault A.C. (Oncogene 2001) 3 4 22 64
  4. Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. (PMID: 20038947) Shyn S.I. … Hamilton S.P. (Mol. Psychiatry 2011) 3 46 64
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64

Products for LZTS1 Gene

Sources for LZTS1 Gene

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