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Aliases for LZTR1 Gene

Aliases for LZTR1 Gene

  • Leucine-Zipper-Like Transcription Regulator 1 2 3
  • Leucine-Zipper-Like Transcriptional Regulator 1 2 3
  • SWNTS2 3 6
  • LZTR-1 3 4
  • BTBD29 3
  • TCFL2 4

External Ids for LZTR1 Gene

Previous GeneCards Identifiers for LZTR1 Gene

  • GC22P018035
  • GC22P019660
  • GC22P019661
  • GC22P021339
  • GC22P004604
  • GC22P021450

Summaries for LZTR1 Gene

Entrez Gene Summary for LZTR1 Gene

  • This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for LZTR1 Gene

LZTR1 (Leucine-Zipper-Like Transcription Regulator 1) is a Protein Coding gene. Diseases associated with LZTR1 include schwannomatosis-2 and schwannomatosis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLHDC1.

UniProtKB/Swiss-Prot for LZTR1 Gene

  • Probable transcriptional regulator that may play a crucial role in embryogenesis

Gene Wiki entry for LZTR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LZTR1 Gene

Genomics for LZTR1 Gene

Regulatory Elements for LZTR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LZTR1 Gene

20,979,462 bp from pter
20,999,038 bp from pter
19,577 bases
Plus strand

Genomic View for LZTR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LZTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LZTR1 Gene

Proteins for LZTR1 Gene

  • Protein details for LZTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-zipper-like transcriptional regulator 1
    Protein Accession:
    Secondary Accessions:
    • Q14776
    • Q20WK0

    Protein attributes for LZTR1 Gene

    840 amino acids
    Molecular mass:
    94719 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA07508.1; Type=Frameshift; Positions=16, 69, 222; Evidence={ECO:0000305};

neXtProt entry for LZTR1 Gene

Proteomics data for LZTR1 Gene at MOPED

Post-translational modifications for LZTR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for LZTR1 Gene

Domains for LZTR1 Gene

Gene Families for LZTR1 Gene

Protein Domains for LZTR1 Gene

Suggested Antigen Peptide Sequences for LZTR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 BTB (POZ) domains.
  • Contains 6 Kelch repeats.
  • Contains 2 BTB (POZ) domains.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with LZTR1: view

Function for LZTR1 Gene

Molecular function for LZTR1 Gene

GENATLAS Biochemistry:
leucine zipper-like transcriptional regulator 1,deleted in DiGeorge syndrome
UniProtKB/Swiss-Prot Function:
Probable transcriptional regulator that may play a crucial role in embryogenesis

Gene Ontology (GO) - Molecular Function for LZTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 7633402
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LZTR1: view

Phenotypes for LZTR1 Gene

genes like me logo Genes that share phenotypes with LZTR1: view

Animal Model Products

miRNA for LZTR1 Gene

miRTarBase miRNAs that target LZTR1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LZTR1 Gene

Localization for LZTR1 Gene

Subcellular locations from

Jensen Localization Image for LZTR1 Gene COMPARTMENTS Subcellular localization image for LZTR1 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LZTR1 Gene

Pathways for LZTR1 Gene

SuperPathways for LZTR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LZTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 7633402
GO:0009653 anatomical structure morphogenesis TAS 7633402
genes like me logo Genes that share ontologies with LZTR1: view

No data available for Pathways by source for LZTR1 Gene

Transcripts for LZTR1 Gene

Unigene Clusters for LZTR1 Gene

Leucine-zipper-like transcription regulator 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LZTR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LZTR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ·
SP1: - - - -
SP2: - -
SP4: -
SP5: - - -
SP6: - -
SP8: -

ExUns: 17d · 17e ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1: - - -
SP3: - - - -
SP9: - - -
SP10: -
SP14: - - - - -

Relevant External Links for LZTR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LZTR1 Gene

mRNA expression in normal human tissues for LZTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for LZTR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (56.1) and CD8 Tcells (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LZTR1 Gene

SOURCE GeneReport for Unigene cluster for LZTR1 Gene Hs.78788

genes like me logo Genes that share expressions with LZTR1: view

Expression partners for LZTR1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LZTR1 Gene

Orthologs for LZTR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LZTR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LZTR1 35
  • 90.08 (n)
  • 95.49 (a)
LZTR1 36
  • 94 (a)
(Canis familiaris)
Mammalia LZTR1 35
  • 91.24 (n)
  • 96.23 (a)
LZTR1 36
  • 96 (a)
(Mus musculus)
Mammalia Lztr1 35
  • 87.76 (n)
  • 96.1 (a)
Lztr1 16
Lztr1 36
  • 95 (a)
(Pan troglodytes)
Mammalia LZTR1 35
  • 99.29 (n)
  • 99.88 (a)
LZTR1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Lztr1 35
  • 87.95 (n)
  • 96.09 (a)
(Monodelphis domestica)
Mammalia LZTR1 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
-- 36
  • 75 (a)
-- 36
  • 68 (a)
(Gallus gallus)
Aves LZTR1 35
  • 80.04 (n)
  • 89.48 (a)
-- 36
  • 21 (a)
(Anolis carolinensis)
Reptilia LZTR1 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lztr1 35
  • 75.39 (n)
  • 88.02 (a)
(Danio rerio)
Actinopterygii Dr.19626 35
lztr1 35
  • 76.91 (n)
  • 88.76 (a)
lztr1 36
  • 87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5275 35
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR7A4.19 37
  • 44 (a)
CG3711 35
  • 60.46 (n)
  • 56.66 (a)
CG3711 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004292 35
  • 61.15 (n)
  • 60.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEL1 36
  • 11 (a)
KEL2 36
  • 14 (a)
Species with no ortholog for LZTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LZTR1 Gene

Gene Tree for LZTR1 (if available)
Gene Tree for LZTR1 (if available)

Paralogs for LZTR1 Gene

Paralogs for LZTR1 Gene

(1) SIMAP similar genes for LZTR1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LZTR1: view

Variants for LZTR1 Gene

Sequence variations from dbSNP and Humsavar for LZTR1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs200224901 -- 20,998,795(+) AGCCA(G/T)GTGGG utr-variant-3-prime
rs200248773 -- 20,995,788(+) GGGAG(C/T)GGGCG reference, missense
rs200296313 -- 20,993,924(+) TGCAG(A/G)AGGAG reference, missense
rs200195452 -- 20,997,254(+) CCTGC(A/G)GTCGC missense, reference
rs200191746 -- 20,994,299(+) GGGTT(A/G)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LZTR1 Gene

Variant ID Type Subtype PubMed ID
nsv436864 CNV Insertion 17901297
nsv914390 CNV Gain 21882294
nsv523162 CNV Loss 19592680
esv2678175 CNV Deletion 23128226
nsv914419 CNV Gain 21882294
nsv834141 CNV Loss 17160897
dgv4872n71 CNV Loss 21882294
nsv914423 CNV Gain 21882294
nsv828960 CNV Loss 20364138
nsv914424 CNV Loss 21882294
nsv914425 CNV Loss 21882294
dgv4873n71 CNV Loss 21882294
nsv520145 CNV Loss 19592680
nsv471185 CNV Loss 18288195
nsv834142 CNV Gain 17160897
nsv828961 CNV Gain 20364138
nsv914428 CNV Loss 21882294
esv2724010 CNV Deletion 23290073

Relevant External Links for LZTR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LZTR1 Gene

Disorders for LZTR1 Gene

(1) OMIM Diseases for LZTR1 Gene (600574)


  • Schwannomatosis 2 (SWNTS2) [MIM:615670]: A cancer predisposition syndrome in which patients develop multiple non-vestibular schwannomas, benign neoplasms that arise from Schwann cells of the cranial, peripheral, and autonomic nerves. {ECO:0000269 PubMed:24362817}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for LZTR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LZTR1: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for LZTR1 Gene

Publications for LZTR1 Gene

  1. The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis. (PMID: 16356934) Nacak T.G. … Kroll J. (J. Biol. Chem. 2006) 2 3 23
  2. Isolation and characterization of a novel gene deleted in DiGeorge syndrome. (PMID: 7633402) Kurahashi H. … Nishisho I. (Hum. Mol. Genet. 1995) 2 3 4
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for LZTR1 Gene

Sources for LZTR1 Gene

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