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Aliases for LYZL6 Gene

Aliases for LYZL6 Gene

  • Lysozyme Like 6 2 3 5
  • LYC1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 6a 3
  • Lysozyme-Like Protein 6 3
  • Lysozyme Homolog 3
  • Lysozyme-Like 6 2
  • EC 4
  • Lysozyme B 3
  • HEL-S-6a 3
  • PRO1485 3
  • TKAL754 3
  • UNQ754 3
  • LYZB 3

External Ids for LYZL6 Gene

Previous GeneCards Identifiers for LYZL6 Gene

  • GC17M031285
  • GC17M034261
  • GC17M030446

Summaries for LYZL6 Gene

Entrez Gene Summary for LYZL6 Gene

  • This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for LYZL6 Gene

LYZL6 (Lysozyme Like 6) is a Protein Coding gene. GO annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYZL6 Gene

Genomics for LYZL6 Gene

Regulatory Elements for LYZL6 Gene

Enhancers for LYZL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F036072 1.1 FANTOM5 ENCODE 8.2 -129.1 -129104 0.4 HDGF CTCF TBL1XR1 ZMYM3 RAD21 RELA ZFHX2 EGR1 EED ZNF143 HEATR9 LYZL6 C17orf50 CCL5 MYO19 RDM1 ENSG00000277089 CCL18
GH17F035888 1.4 FANTOM5 Ensembl ENCODE 2.2 +52.5 52462 5.5 PKNOX1 SIN3A PTRF BMI1 ETV6 ZNF263 ZNF362 CEBPB JUNB ELF1 CCL3 CCL4 CCL3L3 TAF15 GAS2L2 C17orf50 HEATR9 CCL5 SLFN12L LYZL6
GH17F036148 0.5 FANTOM5 2.2 -205.0 -204988 0.0 ZNF362 MLLT1 CCL3L3 CCL3 CCL4 LYZL6 LOC101927369 GC17P036146
GH17F035947 1.1 Ensembl ENCODE 0.8 -3.7 -3733 0.7 CTCF TEAD4 ZNF384 RAD21 TEAD3 ZFHX2 ZBTB48 ZNF143 SMC3 PRDM10 CCL5 GAS2L2 C17orf50 LYZL6 ENSG00000273736
GH17F035941 0.8 ENCODE 0.8 +0.9 921 1.8 PKNOX1 TAL1 FEZF1 GATA2 NCOR1 PRDM10 TRIM24 NR2F6 ZNF600 MAFK CCL5 CCL18 RDM1 C17orf50 RASL10B MMP28 GC17M036027 LYZL6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LYZL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for LYZL6 Gene

35,934,518 bp from pter
35,943,710 bp from pter
9,193 bases
Minus strand

Genomic View for LYZL6 Gene

Genes around LYZL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYZL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYZL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZL6 Gene

Proteins for LYZL6 Gene

  • Protein details for LYZL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysozyme-like protein 6
    Protein Accession:
    Secondary Accessions:
    • Q6UW30

    Protein attributes for LYZL6 Gene

    148 amino acids
    Molecular mass:
    16956 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for LYZL6 Gene

Post-translational modifications for LYZL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYZL6 Gene

No data available for DME Specific Peptides for LYZL6 Gene

Domains & Families for LYZL6 Gene

Gene Families for LYZL6 Gene

Suggested Antigen Peptide Sequences for LYZL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 22 family.
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZL6: view

Function for LYZL6 Gene

Molecular function for LYZL6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Enzyme Numbers (IUBMB) for LYZL6 Gene

Gene Ontology (GO) - Molecular Function for LYZL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with LYZL6: view

Phenotypes for LYZL6 Gene

GenomeRNAi human phenotypes for LYZL6:
genes like me logo Genes that share phenotypes with LYZL6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LYZL6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LYZL6 Gene

Localization for LYZL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZL6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYZL6 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for LYZL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with LYZL6: view

Pathways & Interactions for LYZL6 Gene

SuperPathways for LYZL6 Gene

No Data Available

Interacting Proteins for LYZL6 Gene

Selected Interacting proteins: O75951-LYZL6_HUMAN for LYZL6 Gene via IID

Gene Ontology (GO) - Biological Process for LYZL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016998 cell wall macromolecule catabolic process IBA --
GO:0050829 defense response to Gram-negative bacterium IBA --
GO:0050830 defense response to Gram-positive bacterium IBA --
genes like me logo Genes that share ontologies with LYZL6: view

No data available for Pathways by source and SIGNOR curated interactions for LYZL6 Gene

Drugs & Compounds for LYZL6 Gene

(1) Drugs for LYZL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra 0
genes like me logo Genes that share compounds with LYZL6: view

Transcripts for LYZL6 Gene

mRNA/cDNA for LYZL6 Gene

Unigene Clusters for LYZL6 Gene

Lysozyme-like 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYZL6 Gene

No ASD Table

Relevant External Links for LYZL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LYZL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYZL6 Gene

mRNA differential expression in normal tissues according to GTEx for LYZL6 Gene

This gene is overexpressed in Testis (x52.8).

NURSA nuclear receptor signaling pathways regulating expression of LYZL6 Gene:


SOURCE GeneReport for Unigene cluster for LYZL6 Gene:


mRNA Expression by UniProt/SwissProt for LYZL6 Gene:

Tissue specificity: Expressed in testis and epididymis.
genes like me logo Genes that share expression patterns with LYZL6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LYZL6 Gene

Orthologs for LYZL6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LYZL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LYZL6 34
  • 99.55 (n)
(Canis familiaris)
Mammalia LOC480492 34
  • 85.06 (n)
(Bos Taurus)
Mammalia LYZL6 34
  • 84.35 (n)
(Rattus norvegicus)
Mammalia Lyzl6 34
  • 80.95 (n)
(Mus musculus)
Mammalia Lyzl6 34 16
  • 79.82 (n)
Species where no ortholog for LYZL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYZL6 Gene

Gene Tree for LYZL6 (if available)
Gene Tree for LYZL6 (if available)

Paralogs for LYZL6 Gene

Paralogs for LYZL6 Gene

(8) SIMAP similar genes for LYZL6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LYZL6: view

Variants for LYZL6 Gene

Sequence variations from dbSNP and Humsavar for LYZL6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10083883 -- 35,934,218(+) CACTA(A/C)TTTCT intron-variant, downstream-variant-500B
rs1052266 -- 35,937,858(-) AATGC(A/G)GATGG intron-variant, reference, synonymous-codon
rs10562162 -- 35,934,978(+) TCATT(-/GCTA)GCTAG intron-variant
rs10590560 -- 35,934,984(+) CTAGC(-/TAGC)CCTCT intron-variant
rs10643082 -- 35,943,403(+) AGCCA(-/AAC)AACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LYZL6 Gene

Variant ID Type Subtype PubMed ID
esv3554361 CNV deletion 23714750
nsv1059795 CNV gain 25217958
nsv1079030 OTHER inversion 25765185
nsv833424 CNV gain 17160897

Variation tolerance for LYZL6 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.75; 78.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYZL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYZL6 Gene

Disorders for LYZL6 Gene

Relevant External Links for LYZL6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LYZL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYZL6 Gene

Publications for LYZL6 Gene

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PMID: 16014814) Zhang K. … Yu L. (Biol. Reprod. 2005) 3 4 22 64
  2. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PMID: 10213461) Nomiyama H. … Yoshie O. (J. Interferon Cytokine Res. 1999) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Production of LYZL6, a novel human c-type lysozyme, in recombinant Pichia pastoris employing high cell density fed-batch fermentation. (PMID: 24745549) Zhou X. … Yu L. (J. Biosci. Bioeng. 2014) 3 64

Products for LYZL6 Gene

Sources for LYZL6 Gene

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