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Aliases for LYZL6 Gene

Aliases for LYZL6 Gene

  • Lysozyme-Like 6 2 3
  • LYC1 3 4
  • Lysozyme Homolog 3
  • EC 3.2.1.17 4
  • PRO1485 3
  • TKAL754 3
  • UNQ754 3

External Ids for LYZL6 Gene

Previous GeneCards Identifiers for LYZL6 Gene

  • GC17M031285
  • GC17M034261
  • GC17M030446

Summaries for LYZL6 Gene

Entrez Gene Summary for LYZL6 Gene

  • This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for LYZL6 Gene

LYZL6 (Lysozyme-Like 6) is a Protein Coding gene. GO annotations related to this gene include lysozyme activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYZL6 Gene

Genomics for LYZL6 Gene

Regulatory Elements for LYZL6 Gene

Genomic Location for LYZL6 Gene

Chromosome:
17
Start:
35,934,518 bp from pter
End:
35,943,710 bp from pter
Size:
9,193 bases
Orientation:
Minus strand

Genomic View for LYZL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LYZL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZL6 Gene

Proteins for LYZL6 Gene

  • Protein details for LYZL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75951-LYZL6_HUMAN
    Recommended name:
    Lysozyme-like protein 6
    Protein Accession:
    O75951
    Secondary Accessions:
    • Q6UW30

    Protein attributes for LYZL6 Gene

    Size:
    148 amino acids
    Molecular mass:
    16956 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for LYZL6 Gene

Proteomics data for LYZL6 Gene at MOPED

Post-translational modifications for LYZL6 Gene

No Post-translational modifications

Other Protein References for LYZL6 Gene

Antibody Products

No data available for DME Specific Peptides for LYZL6 Gene

Domains & Families for LYZL6 Gene

Gene Families for LYZL6 Gene

Protein Domains for LYZL6 Gene

Suggested Antigen Peptide Sequences for LYZL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75951

UniProtKB/Swiss-Prot:

LYZL6_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZL6: view

Function for LYZL6 Gene

Molecular function for LYZL6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Enzyme Numbers (IUBMB) for LYZL6 Gene

Gene Ontology (GO) - Molecular Function for LYZL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IEA --
genes like me logo Genes that share ontologies with LYZL6: view

Phenotypes for LYZL6 Gene

GenomeRNAi human phenotypes for LYZL6:
genes like me logo Genes that share phenotypes with LYZL6: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LYZL6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LYZL6 Gene

Localization for LYZL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYZL6 Gene COMPARTMENTS Subcellular localization image for LYZL6 gene
Compartment Confidence
extracellular 3
chloroplast 1

Gene Ontology (GO) - Cellular Components for LYZL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LYZL6: view

Pathways & Interactions for LYZL6 Gene

SuperPathways for LYZL6 Gene

No Data Available

Interacting Proteins for LYZL6 Gene

Gene Ontology (GO) - Biological Process for LYZL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with LYZL6: view

No data available for Pathways by source and SIGNOR curated interactions for LYZL6 Gene

Drugs & Compounds for LYZL6 Gene

(1) Drugs for LYZL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra 0
genes like me logo Genes that share compounds with LYZL6: view

Transcripts for LYZL6 Gene

mRNA/cDNA for LYZL6 Gene

Unigene Clusters for LYZL6 Gene

Lysozyme-like 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LYZL6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYZL6 Gene

No ASD Table

Relevant External Links for LYZL6 Gene

GeneLoc Exon Structure for
LYZL6
ECgene alternative splicing isoforms for
LYZL6

Expression for LYZL6 Gene

mRNA expression in normal human tissues for LYZL6 Gene

mRNA differential expression in normal tissues according to GTEx for LYZL6 Gene

This gene is overexpressed in Testis (x52.8).

SOURCE GeneReport for Unigene cluster for LYZL6 Gene Hs.97477

mRNA Expression by UniProt/SwissProt for LYZL6 Gene

O75951-LYZL6_HUMAN
Tissue specificity: Expressed in testis and epididymis.
genes like me logo Genes that share expression patterns with LYZL6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LYZL6 Gene

Orthologs for LYZL6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LYZL6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LYZL6 35
  • 84.35 (n)
  • 76.19 (a)
dog
(Canis familiaris)
Mammalia LOC480492 35
  • 85.06 (n)
  • 77.24 (a)
mouse
(Mus musculus)
Mammalia Lyzl6 35
  • 79.82 (n)
  • 71.43 (a)
Lyzl6 16
chimpanzee
(Pan troglodytes)
Mammalia LYZL6 35
  • 99.55 (n)
  • 98.65 (a)
rat
(Rattus norvegicus)
Mammalia Lyzl6 35
  • 80.95 (n)
  • 70.75 (a)
Species with no ortholog for LYZL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYZL6 Gene

ENSEMBL:
Gene Tree for LYZL6 (if available)
TreeFam:
Gene Tree for LYZL6 (if available)

Paralogs for LYZL6 Gene

(8) SIMAP similar genes for LYZL6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LYZL6: view

No data available for Paralogs for LYZL6 Gene

Variants for LYZL6 Gene

Sequence variations from dbSNP and Humsavar for LYZL6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9604 -- 35,936,787(-) AAAAG(G/T)ATTGT reference, missense
rs2526329 -- 35,935,451(+) ttctc(A/T)gtcac intron-variant
rs2526330 -- 35,940,862(+) ctatg(A/G)ttgaa intron-variant, upstream-variant-2KB
rs2702951 -- 35,943,401(+) TTCAG(A/C)CAAAC intron-variant
rs2735472 -- 35,941,550(-) tggtt(C/T)cttag intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LYZL6 Gene

Variant ID Type Subtype PubMed ID
nsv833424 CNV Gain 17160897

Variation tolerance for LYZL6 Gene

Residual Variation Intolerance Score: 63.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.75; 78.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYZL6 Gene

HapMap Linkage Disequilibrium report
LYZL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYZL6 Gene

Disorders for LYZL6 Gene

Relevant External Links for LYZL6

Genetic Association Database (GAD)
LYZL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYZL6
genes like me logo Genes that share disorders with LYZL6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYZL6 Gene

Publications for LYZL6 Gene

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PMID: 16014814) Zhang K. … Yu L. (Biol. Reprod. 2005) 23 67
  2. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PMID: 10213461) Nomiyama H. … Yoshie O. (J. Interferon Cytokine Res. 1999) 2 67
  3. Production of LYZL6, a novel human c-type lysozyme, in recombinant Pichia pastoris employing high cell density fed-batch fermentation. (PMID: 24745549) Zhou X. … Yu L. (J. Biosci. Bioeng. 2014) 67
  4. Characterisation of Lyzls in mice and antibacterial properties of human LYZL6. (PMID: 24013621) Wei J. … Li J.Y. (Asian J. Androl. 2013) 67
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67

Products for LYZL6 Gene

Sources for LYZL6 Gene

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