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Aliases for LYZL4 Gene

Aliases for LYZL4 Gene

  • Lysozyme Like 4 2 3
  • Lysozyme-Like 4 2 3 5
  • Lysozyme-4 3 4
  • LYC4 3 4
  • Lysozyme A 3
  • LYZA 3

External Ids for LYZL4 Gene

Summaries for LYZL4 Gene

Entrez Gene Summary for LYZL4 Gene

  • Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]

GeneCards Summary for LYZL4 Gene

LYZL4 (Lysozyme Like 4) is a Protein Coding gene. GO annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYZL4 Gene

Genomics for LYZL4 Gene

Regulatory Elements for LYZL4 Gene

Enhancers for LYZL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LYZL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LYZL4 Gene

Chromosome:
3
Start:
42,360,768 bp from pter
End:
42,410,652 bp from pter
Size:
49,885 bases
Orientation:
Minus strand

Genomic View for LYZL4 Gene

Genes around LYZL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYZL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYZL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZL4 Gene

Proteins for LYZL4 Gene

  • Protein details for LYZL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KX0-LYZL4_HUMAN
    Recommended name:
    Lysozyme-like protein 4
    Protein Accession:
    Q96KX0

    Protein attributes for LYZL4 Gene

    Size:
    146 amino acids
    Molecular mass:
    16433 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for LYZL4 Gene

Proteomics data for LYZL4 Gene at MOPED

Post-translational modifications for LYZL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYZL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LYZL4 Gene

Domains & Families for LYZL4 Gene

Gene Families for LYZL4 Gene

Protein Domains for LYZL4 Gene

Suggested Antigen Peptide Sequences for LYZL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KX0

UniProtKB/Swiss-Prot:

LYZL4_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZL4: view

Function for LYZL4 Gene

genes like me logo Genes that share phenotypes with LYZL4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LYZL4 Gene

Localization for LYZL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYZL4 Gene COMPARTMENTS Subcellular localization image for LYZL4 gene
Compartment Confidence
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for LYZL4 Gene

Pathways & Interactions for LYZL4 Gene

SuperPathways for LYZL4 Gene

No Data Available

Interacting Proteins for LYZL4 Gene

Gene Ontology (GO) - Biological Process for LYZL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LYZL4 Gene

Drugs & Compounds for LYZL4 Gene

No Compound Related Data Available

Transcripts for LYZL4 Gene

mRNA/cDNA for LYZL4 Gene

Unigene Clusters for LYZL4 Gene

Lysozyme-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LYZL4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for LYZL4 Gene

GeneLoc Exon Structure for
LYZL4
ECgene alternative splicing isoforms for
LYZL4

Expression for LYZL4 Gene

mRNA expression in normal human tissues for LYZL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYZL4 Gene

This gene is overexpressed in Testis (x48.6).

Protein differential expression in normal tissues from HIPED for LYZL4 Gene

This gene is overexpressed in Testis (51.0) and Ovary (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LYZL4 Gene



SOURCE GeneReport for Unigene cluster for LYZL4 Gene Hs.234895

mRNA Expression by UniProt/SwissProt for LYZL4 Gene

Q96KX0-LYZL4_HUMAN
Tissue specificity: Expressed in testis and epididymis.
genes like me logo Genes that share expression patterns with LYZL4: view

Protein tissue co-expression partners for LYZL4 Gene

- Elite partner

Primer Products

Orthologs for LYZL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LYZL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LYZL4 35
  • 82.07 (n)
  • 80.69 (a)
LYZL4 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lyzl4 35
  • 77.24 (n)
  • 71.03 (a)
Lyzl4 16
Lyzl4 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LYZL4 35
  • 99.32 (n)
  • 99.32 (a)
LYZL4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lyzl4 35
  • 78.85 (n)
  • 73.1 (a)
dog
(Canis familiaris)
Mammalia LYZL4 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYZL4 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii lyz 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11159 36
  • 28 (a)
ManyToMany
CG16756 36
  • 30 (a)
ManyToMany
CG16799 36
  • 22 (a)
ManyToMany
CG30062 36
  • 23 (a)
ManyToMany
CG7798 36
  • 31 (a)
ManyToMany
CG8492 36
  • 4 (a)
ManyToMany
LysB 36
  • 29 (a)
ManyToMany
LysC 36
  • 29 (a)
ManyToMany
LysD 36
  • 29 (a)
ManyToMany
LysE 36
  • 30 (a)
ManyToMany
LysP 36
  • 31 (a)
ManyToMany
LysS 36
  • 29 (a)
ManyToMany
LysX 36
  • 26 (a)
ManyToMany
Species with no ortholog for LYZL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LYZL4 Gene

ENSEMBL:
Gene Tree for LYZL4 (if available)
TreeFam:
Gene Tree for LYZL4 (if available)

Paralogs for LYZL4 Gene

Paralogs for LYZL4 Gene

(7) SIMAP similar genes for LYZL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LYZL4: view

Variants for LYZL4 Gene

Sequence variations from dbSNP and Humsavar for LYZL4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs13054 -- 42,397,262(+) GCAGG(A/C/G/T)GGCTA intron-variant, utr-variant-3-prime
rs26347 -- 42,395,110(+) AGCCA(C/T)ACAAA intron-variant
rs26348 -- 42,403,421(+) caccc(A/G)actta intron-variant
rs26349 -- 42,409,920(+) agtca(C/T)cttgc intron-variant
rs26350 -- 42,363,293(+) TGGGT(C/T)TAATG intron-variant

Variation tolerance for LYZL4 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for LYZL4 Gene

Disorders for LYZL4 Gene

Relevant External Links for LYZL4

Genetic Association Database (GAD)
LYZL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYZL4

No disorders were found for LYZL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYZL4 Gene

Publications for LYZL4 Gene

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PMID: 16014814) Zhang K. … Yu L. (Biol. Reprod. 2005) 2 3 4 23 67
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  3. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for LYZL4 Gene

Sources for LYZL4 Gene

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