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Aliases for LYZL4 Gene

Aliases for LYZL4 Gene

  • Lysozyme Like 4 2 3 5
  • Lysozyme-4 3 4
  • LYC4 3 4
  • Lysozyme-Like Protein 4 3
  • Lysozyme-Like 4 2
  • Lysozyme A 3
  • LYZA 3

External Ids for LYZL4 Gene

Summaries for LYZL4 Gene

Entrez Gene Summary for LYZL4 Gene

  • Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]

GeneCards Summary for LYZL4 Gene

LYZL4 (Lysozyme Like 4) is a Protein Coding gene. GO annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYZL4 Gene

Genomics for LYZL4 Gene

Regulatory Elements for LYZL4 Gene

Enhancers for LYZL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F042368 1.1 FANTOM5 Ensembl ENCODE 11.3 +41.4 41363 1.6 PKNOX1 RFX1 SMARCA4 MTA2 PBX2 BMI1 ZNF24 CCK LYZL4 HHATL TRAK1 EIF4BP4
GH03F042682 1.2 FANTOM5 ENCODE 6.9 -274.5 -274487 5.0 ATF1 ARNT INSM2 FOS CREM SMARCA5 ZNF362 CEBPB ZNF623 ZFP69B SEC22C HHATL LYZL4 NKTR CCDC13 CCK KRBOX1 KLHL40 RN7SL567P
GH03F042525 0.7 Ensembl 10.6 -117.4 -117350 4.4 CTCF PKNOX1 ETV1 YBX1 ZFHX2 GATA3 EGR1 SCRT2 EGR2 SCRT1 VIPR1 LYZL4 SS18L2 SEC22C NKTR VIPR1-AS1
GH03F042345 0.6 ENCODE 10.9 +64.5 64503 0.9 ARID1B TAL1 MAX NFE2 REST GABPA LYZL4 EIF4BP4
GH03F042524 0.6 FANTOM5 Ensembl 10.6 -114.2 -114154 0.8 VIPR1 NKTR SS18L2 SEC22C LYZL4 CCDC13 VIPR1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LYZL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LYZL4 Gene

Chromosome:
3
Start:
42,360,768 bp from pter
End:
42,410,652 bp from pter
Size:
49,885 bases
Orientation:
Minus strand

Genomic View for LYZL4 Gene

Genes around LYZL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYZL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYZL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZL4 Gene

Proteins for LYZL4 Gene

  • Protein details for LYZL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KX0-LYZL4_HUMAN
    Recommended name:
    Lysozyme-like protein 4
    Protein Accession:
    Q96KX0

    Protein attributes for LYZL4 Gene

    Size:
    146 amino acids
    Molecular mass:
    16433 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for LYZL4 Gene

Post-translational modifications for LYZL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYZL4 Gene

No data available for DME Specific Peptides for LYZL4 Gene

Domains & Families for LYZL4 Gene

Gene Families for LYZL4 Gene

Suggested Antigen Peptide Sequences for LYZL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KX0

UniProtKB/Swiss-Prot:

LYZL4_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZL4: view

Function for LYZL4 Gene

Gene Ontology (GO) - Molecular Function for LYZL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
genes like me logo Genes that share ontologies with LYZL4: view
genes like me logo Genes that share phenotypes with LYZL4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LYZL4 Gene

Localization for LYZL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYZL4 gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for LYZL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with LYZL4: view

Pathways & Interactions for LYZL4 Gene

SuperPathways for LYZL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LYZL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016998 cell wall macromolecule catabolic process IBA --
GO:0050829 defense response to Gram-negative bacterium IBA --
GO:0050830 defense response to Gram-positive bacterium IBA --
genes like me logo Genes that share ontologies with LYZL4: view

No data available for Pathways by source and SIGNOR curated interactions for LYZL4 Gene

Transcripts for LYZL4 Gene

Unigene Clusters for LYZL4 Gene

Lysozyme-like 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYZL4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for LYZL4 Gene

GeneLoc Exon Structure for
LYZL4
ECgene alternative splicing isoforms for
LYZL4

Expression for LYZL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYZL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYZL4 Gene

This gene is overexpressed in Testis (x48.6).

Protein differential expression in normal tissues from HIPED for LYZL4 Gene

This gene is overexpressed in Testis (51.0) and Ovary (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LYZL4 Gene



Protein tissue co-expression partners for LYZL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYZL4 Gene:

LYZL4

SOURCE GeneReport for Unigene cluster for LYZL4 Gene:

Hs.234895

mRNA Expression by UniProt/SwissProt for LYZL4 Gene:

Q96KX0-LYZL4_HUMAN
Tissue specificity: Expressed in testis and epididymis.
genes like me logo Genes that share expression patterns with LYZL4: view

Orthologs for LYZL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LYZL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYZL4 34 35
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia LYZL4 34 35
  • 82.07 (n)
rat
(Rattus norvegicus)
Mammalia Lyzl4 34
  • 78.85 (n)
mouse
(Mus musculus)
Mammalia Lyzl4 34 16 35
  • 77.24 (n)
dog
(Canis familiaris)
Mammalia LYZL4 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYZL4 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 34 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii lyz 35
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7798 35
  • 31 (a)
ManyToMany
LysP 35
  • 31 (a)
ManyToMany
CG16756 35
  • 30 (a)
ManyToMany
LysE 35
  • 30 (a)
ManyToMany
LysB 35
  • 29 (a)
ManyToMany
LysC 35
  • 29 (a)
ManyToMany
LysD 35
  • 29 (a)
ManyToMany
LysS 35
  • 29 (a)
ManyToMany
CG11159 35
  • 28 (a)
ManyToMany
LysX 35
  • 26 (a)
ManyToMany
CG30062 35
  • 23 (a)
ManyToMany
CG16799 35
  • 22 (a)
ManyToMany
CG8492 35
  • 4 (a)
ManyToMany
Species where no ortholog for LYZL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LYZL4 Gene

ENSEMBL:
Gene Tree for LYZL4 (if available)
TreeFam:
Gene Tree for LYZL4 (if available)

Paralogs for LYZL4 Gene

Paralogs for LYZL4 Gene

(7) SIMAP similar genes for LYZL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LYZL4: view

Variants for LYZL4 Gene

Sequence variations from dbSNP and Humsavar for LYZL4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10049242 -- 42,378,192(+) ATCAG(C/G)ATTCC intron-variant
rs10490788 -- 42,381,546(+) GCCAG(C/T)GTTGA intron-variant
rs111248635 -- 42,405,173(+) CCTCC(C/G)GAGTA intron-variant
rs111256745 -- 42,402,361(+) ATAGA(A/T)AGGTA intron-variant
rs111293759 -- 42,408,682(+) CCATC(A/G)TTATA intron-variant

Variation tolerance for LYZL4 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYZL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYZL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LYZL4 Gene

Disorders for LYZL4 Gene

Relevant External Links for LYZL4

Genetic Association Database (GAD)
LYZL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYZL4

No disorders were found for LYZL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYZL4 Gene

Publications for LYZL4 Gene

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PMID: 16014814) Zhang K. … Yu L. (Biol. Reprod. 2005) 2 3 4 22 64
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3 64
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3 64

Products for LYZL4 Gene

Sources for LYZL4 Gene

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