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Aliases for LYZ Gene

Aliases for LYZ Gene

  • Lysozyme 2 3
  • 1,4-Beta-N-Acetylmuramidase C 3 4
  • EC 3.2.1.17 4 63
  • LZM 3 4
  • Lysozyme (Renal Amyloidosis) 2
  • Renal Amyloidosis 2
  • C-Type Lysozyme 3

External Ids for LYZ Gene

Previous GeneCards Identifiers for LYZ Gene

  • GC12M069521
  • GC12P069681
  • GC12P069458
  • GC12P068028
  • GC12P066791

Summaries for LYZ Gene

Entrez Gene Summary for LYZ Gene

  • This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

GeneCards Summary for LYZ Gene

LYZ (Lysozyme) is a Protein Coding gene. Diseases associated with LYZ include hereditary amyloidosis with primary renal involement and lyz-related familial visceral amyloidosis. Among its related pathways are Transport to the Golgi and subsequent modification and RNA Polymerase I Promoter Opening. GO annotations related to this gene include identical protein binding and lysozyme activity. An important paralog of this gene is SPACA5B.

UniProtKB/Swiss-Prot for LYZ Gene

  • Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents

Gene Wiki entry for LYZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYZ Gene

Genomics for LYZ Gene

Regulatory Elements for LYZ Gene

Genomic Location for LYZ Gene

Chromosome:
12
Start:
69,348,341 bp from pter
End:
69,354,234 bp from pter
Size:
5,894 bases
Orientation:
Plus strand

Genomic View for LYZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LYZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZ Gene

Proteins for LYZ Gene

  • Protein details for LYZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61626-LYSC_HUMAN
    Recommended name:
    Lysozyme C
    Protein Accession:
    P61626
    Secondary Accessions:
    • P00695
    • Q13170
    • Q9UCF8

    Protein attributes for LYZ Gene

    Size:
    148 amino acids
    Molecular mass:
    16537 Da
    Quaternary structure:
    • Monomer
    Miscellaneous:
    • Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides
    SequenceCaution:
    • Sequence=CAA32175.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYZ Gene

neXtProt entry for LYZ Gene

Proteomics data for LYZ Gene at MOPED

Post-translational modifications for LYZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYZ Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for LYZ Gene

Gene Families for LYZ Gene

Suggested Antigen Peptide Sequences for LYZ Gene

Graphical View of Domain Structure for InterPro Entry

P61626

UniProtKB/Swiss-Prot:

LYSC_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZ: view

Function for LYZ Gene

Molecular function for LYZ Gene

GENATLAS Biochemistry:
lysozyme,14.5kDa,released from azurophilic granules of neutrophils,oxygen independent phagocytosis of Gram- bacteria
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
UniProtKB/Swiss-Prot Function:
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents

Enzyme Numbers (IUBMB) for LYZ Gene

Gene Ontology (GO) - Molecular Function for LYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity TAS 2829884
GO:0042802 identical protein binding IPI 23353684
genes like me logo Genes that share ontologies with LYZ: view

Phenotypes for LYZ Gene

genes like me logo Genes that share phenotypes with LYZ: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for LYZ Gene

Localization for LYZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZ Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYZ Gene COMPARTMENTS Subcellular localization image for LYZ gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
lysosome 2
nucleus 2
plasma membrane 2
vacuole 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 2829884
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LYZ: view

Pathways & Interactions for LYZ Gene

genes like me logo Genes that share pathways with LYZ: view

Pathways by source for LYZ Gene

1 BioSystems pathway for LYZ Gene
2 Reactome pathways for LYZ Gene
1 KEGG pathway for LYZ Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat

SIGNOR curated interactions for LYZ Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0006954 inflammatory response TAS 366724
GO:0008152 metabolic process --
GO:0019835 cytolysis IEA --
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with LYZ: view

Drugs & Compounds for LYZ Gene

(15) Drugs for LYZ Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Aspartic acid Approved Nutra Target 0
N-Acetyl-D-glucosamine Approved Nutra 0
1-Proponol Experimental Pharma Target 0
3-Aminosuccinimide Experimental Pharma Target 0
4-Aminophenylarsonic Acid Experimental Pharma Target 0

(2) Additional Compounds for LYZ Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
NaCl
genes like me logo Genes that share compounds with LYZ: view

Transcripts for LYZ Gene

mRNA/cDNA for LYZ Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LYZ Gene

Lysozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LYZ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for LYZ Gene

GeneLoc Exon Structure for
LYZ
ECgene alternative splicing isoforms for
LYZ

Expression for LYZ Gene

mRNA expression in normal human tissues for LYZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYZ Gene

This gene is overexpressed in Whole Blood (x27.8) and Minor Salivary Gland (x14.6).

Protein differential expression in normal tissues from HIPED for LYZ Gene

This gene is overexpressed in Milk (31.8), Neutrophil (11.0), and Saliva (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LYZ Gene



SOURCE GeneReport for Unigene cluster for LYZ Gene Hs.524579

genes like me logo Genes that share expression patterns with LYZ: view

Protein tissue co-expression partners for LYZ Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LYZ Gene

Orthologs for LYZ Gene

This gene was present in the common ancestor of animals.

Orthologs for LYZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LYZ 35
  • 87.16 (n)
  • 81.08 (a)
-- 36
  • 73 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
LYSB 36
  • 70 (a)
OneToMany
LYZ 36
  • 81 (a)
OneToMany
LYZ1 36
  • 80 (a)
OneToMany
LYZ1 36
  • 70 (a)
OneToMany
LYZ2 36
  • 69 (a)
OneToMany
LYZ3 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LYZ 35
  • 83.78 (n)
  • 80.41 (a)
LYZ 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lyz2 35
  • 78.15 (n)
  • 76.35 (a)
9530003J23Rik 36
  • 60 (a)
OneToMany
Lyz1 36
  • 76 (a)
OneToMany
Lyz2 36
  • 76 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LYZ 35
  • 99.32 (n)
  • 100 (a)
LYZ 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lyz2 35
  • 76.35 (n)
  • 71.62 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia LYZ 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves LYZ 35
  • 60.92 (n)
  • 57.93 (a)
LYZ 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LYZ 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492798 35
  • 61.34 (n)
  • 58.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11159 36
  • 32 (a)
ManyToMany
CG16756 36
  • 35 (a)
ManyToMany
CG16799 36
  • 25 (a)
ManyToMany
CG30062 36
  • 29 (a)
ManyToMany
CG7798 36
  • 41 (a)
ManyToMany
CG8492 36
  • 4 (a)
ManyToMany
LysB 36
  • 40 (a)
ManyToMany
LysC 36
  • 39 (a)
ManyToMany
LysD 36
  • 40 (a)
ManyToMany
LysE 36
  • 41 (a)
ManyToMany
LysP 36
  • 38 (a)
ManyToMany
LysS 36
  • 39 (a)
ManyToMany
LysX 36
  • 37 (a)
ManyToMany
Species with no ortholog for LYZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYZ Gene

ENSEMBL:
Gene Tree for LYZ (if available)
TreeFam:
Gene Tree for LYZ (if available)

Paralogs for LYZ Gene

Paralogs for LYZ Gene

(8) SIMAP similar genes for LYZ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LYZ: view

Variants for LYZ Gene

Sequence variations from dbSNP and Humsavar for LYZ Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1384 -- 69,354,054(+) GATTT(C/T)TTAAA utr-variant-3-prime
rs2553 -- 69,353,418(+) TTTTT(C/T)AGTTT utr-variant-3-prime
rs8612 -- 69,353,874(+) GAAAA(G/T)GTTAT utr-variant-3-prime
rs10049 -- 69,353,970(+) AACCA(C/T)TTTTT utr-variant-3-prime
rs483142 -- 69,347,451(+) AAAGT(A/G)TTGTG upstream-variant-2KB

Variation tolerance for LYZ Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYZ Gene

HapMap Linkage Disequilibrium report
LYZ
Human Gene Mutation Database (HGMD)
LYZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LYZ Gene

Disorders for LYZ Gene

MalaCards: The human disease database

(64) MalaCards diseases for LYZ Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hereditary amyloidosis with primary renal involement
  • amyloidosis, ostertag type
lyz-related familial visceral amyloidosis
amyloidosis, familial visceral
  • amyloidosis, 3 or more types
al amyloidosis
  • amyloidosis al
cerebral sarcoidosis
- elite association
Search LYZ in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LYSC_HUMAN
  • Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. {ECO:0000269 PubMed:8464497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LYZ

Genetic Association Database (GAD)
LYZ
Human Genome Epidemiology (HuGE) Navigator
LYZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYZ
genes like me logo Genes that share disorders with LYZ: view

No data available for Genatlas for LYZ Gene

Publications for LYZ Gene

  1. Sulfonate group-modified FePtCu nanoparticles as a selective probe for LDI-MS analysis of oligopeptides from a peptide mixture and human serum proteins. (PMID: 19760403) Kawasaki H. … Arakawa R. (Anal Bioanal Chem 2009) 23 67
  2. Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis. (PMID: 18183478) Prakash J. … Kok R.J. (Pharm. Res. 2008) 23 67
  3. Resurveying the Tris buffer solution: the specific interaction between tris(hydroxymethyl)aminomethane and lysozyme. (PMID: 18448066) Quan L. … Lai L. (Anal. Biochem. 2008) 23 67
  4. Spectroscopic studies on the interaction between CdTe nanoparticles and lysozyme. (PMID: 18455471) Wu Y.L. … Zhang Y.K. (Spectrochim Acta A Mol Biomol Spectrosc 2008) 23 67
  5. Identification and characterization of human thymic cortical dendritic macrophages that may act as professional scavengers of apoptotic thymocytes. (PMID: 18926298) Wakimoto T. … Takahashi K. (Immunobiology 2008) 23 67

Products for LYZ Gene

Sources for LYZ Gene

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