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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LYZ Gene

protein-coding   GIFtS: 67
GCID: GC12P069681

Lysozyme

(Previous name: lysozyme (renal amyloidosis))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
lysozyme1 2     Lysozyme (Renal Amyloidosis)1
1,4-Beta-N-Acetylmuramidase C2 3     Renal Amyloidosis1
LZM2 3     Lysozyme C2
EC 3.2.1.173 8     

External Ids:    HGNC: 67401   Entrez Gene: 40692   Ensembl: ENSG000000903827   OMIM: 1534505   UniProtKB: P616263   

Export aliases for LYZ gene to outside databases

Previous GC identifers: GC12M069521 GC12P069458 GC12P068028 GC12P066791


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LYZ Gene:
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the
beta(1-4)glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the
anti-microbial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells,
plasma, saliva, and tears. Missense mutations in LYZ have been identified in heritable renal amyloidosis.
(provided by RefSeq, Jul 2008)

GeneCards Summary for LYZ Gene: 
LYZ (lysozyme) is a protein-coding gene. Diseases associated with LYZ include microscopic colitis, and lyz-related familial visceral amyloidosis, and among its related super-pathways are Packaging Of Telomere Ends and Gastric acid secretion. GO annotations related to this gene include lysozyme activity. An important paralog of this gene is LYZL6.

UniProtKB/Swiss-Prot: LYSC_HUMAN, P61626
Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with
the monocyte-macrophage system and enhance the activity of immunoagents

Gene Wiki entry for LYZ (Lysozyme) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LYZ gene promoter:
         C/EBPbeta   Sp1   p53   CUTL1   Evi-1   AREB6   STAT3   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLYZ promoter sequence
   Search SABiosciences Chromatin IP Primers for LYZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LYZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

LYZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYZ gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P069681:  view genomic region     (about GC identifiers)

Start:
69,742,121 bp from pter      End:
69,748,014 bp from pter
Size:
5,894 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LYSC_HUMAN, P61626 (See protein sequence)
Recommended Name: Lysozyme C precursor  
Size: 148 amino acids; 16537 Da
Subunit: Monomer
Subcellular location: Secreted
Miscellaneous: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase
activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin
oligosaccharides
Sequence caution: Sequence=CAA32175.1; Type=Erroneous initiation;
6/203 PDB 3D structures from and Proteopedia for LYZ (see all 203):
133L (3D)        134L (3D)        1B5U (3D)        1B5V (3D)        1B5W (3D)        1B5X (3D)    
Secondary accessions: P00695 Q13170 Q9UCF8

Explore the universe of human proteins at neXtProt for LYZ: NX_P61626

Explore proteomics data for LYZ at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61626

  • 4/17 DME Specific Peptides for LYZ (P61626) (see all 17)
     CLAKWES  CELARTL  YNTRATN  WCNDGKT 

    LYZ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LYZ Protein Expression
    REFSEQ proteins: NP_000230.1  
    ENSEMBL proteins: 
     ENSP00000261267   ENSP00000449898   ENSP00000449969  
    Reactome Protein details: P61626
    Human Recombinant Protein Products for LYZ: 
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    Novus Biologicals LYZ Proteins
    Novus Biologicals LYZ Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for LYZ
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS2829884

    LYZ for ontologies           About GeneDecksing



    LYZ Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR023346 Lysozyme-like_dom
     IPR001916 Glyco_hydro_22
     IPR000974 Glyco_hydro_22_lys
     IPR019799 Glyco_hydro_22_CS

    Graphical View of Domain Structure for InterPro Entry P61626

    ProtoNet protein and cluster: P61626

    1 Blocks protein domain: IPB000974 Lysozyme signature

    UniProtKB/Swiss-Prot: LYSC_HUMAN, P61626
    Similarity: Belongs to the glycosyl hydrolase 22 family


    LYZ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYSC_HUMAN, P61626
    Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with
    the monocyte-macrophage system and enhance the activity of immunoagents
    Catalytic activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine
    residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

         Genatlas biochemistry entry for LYZ:
    lysozyme,14.5kDa,released from azurophilic granules of neutrophils,oxygen independent phagocytosis of Gram-
    bacteria

         Enzyme Number (IUBMB): EC 3.2.1.171 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003796lysozyme activity TAS2829884
    GO:0042802identical protein binding IPI--
         
    LYZ for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LYZ:
     Decreased melanin production  Increased cell death in HCC-19 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LYZ 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LYZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LYZ 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LYZ 

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    hsa-miR-3607-3p hsa-miR-4287 hsa-miR-3160-3p hsa-miR-1270 hsa-miR-3168 hsa-miR-620 hsa-miR-518a-5p hsa-miR-556-5p
    SwitchGear 3'UTR luciferase reporter plasmidLYZ 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYZ


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LYZ About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Amyloids0.41
    2Gastric acid secretion
    Salivary secretion0.34
    3C-MYB transcription factor network
    C-MYB transcription factor network
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for LYZ
        C-MYB transcription factor network


    2        Reactome Pathways for LYZ
        Amyloids
    Disease


    1         Kegg Pathway  (Kegg details for LYZ):
        Salivary secretion


    LYZ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LYZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for LYZ (P616262, 3 ENSP000002612674) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198382, 3, ENSP000002265744MINT-48658 I2D: score=1 STRING: ENSP00000226574
    IKBKBO149202, 3, ENSP000003391514MINT-48076 I2D: score=2 STRING: ENSP00000339151
    LYZP616262MINT-8407128 MINT-8407111 MINT-8407143
    LRRK1Q38SD23, ENSP000003736004I2D: score=2 STRING: ENSP00000373600
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS366724
    GO:0016998cell wall macromolecule catabolic process IEA--
    GO:0019835cytolysis IEA--
    GO:0042742defense response to bacterium IEA--

    LYZ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LYZ for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LYZ (LYSC)

    1 HMDB Compound for LYZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    N-Acetyl-D-glucosamine2-(acetylamino)-2-deoxyhexose (see all 9)7512-17-6--

    10/15 DrugBank Compounds for LYZ (see all 15)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Proponol-- 71-23-8target--17139284 17016423 10592235
    3-Aminosuccinimide-- --target--17139284 17016423 10592235
    4-Aminophenylarsonic Acid-- --target--17139284 17016423 10592235
    4-Methylumbelliferyl Chitobiose-- --target--17139284 17016423 10592235
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    Chitotriose-- --target--17139284 17016423 10592235
    Cu-Bicyclam-- --target--17139284 17016423 10592235
    Cu-Cyclam-- --target--17139284 17016423 10592235
    Di(N-Acetyl-D-Glucosamine)-- --target--17139284 17016423 10592235
    Methylumbelliferyl Chitotriose-- --target--17139284 17016423 10592235

    1 Novoseek inferred chemical compound relationship for LYZ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nacl 6.42 1 17126536 (1)

    Search CenterWatch for drugs/clinical trials and news about LYZ / LYSC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LYZ gene: 
    NM_000239.2  

    Unigene Cluster for LYZ:

    Lysozyme
    Hs.524579  [show with all ESTs]
    Unigene Representative Sequence: AK130149
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261267(uc001suw.2) ENST00000549690 ENST00000548839
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LYZ (see all 9):
    hsa-miR-3607-3p hsa-miR-4287 hsa-miR-3160-3p hsa-miR-1270 hsa-miR-3168 hsa-miR-620 hsa-miR-518a-5p hsa-miR-556-5p
    SwitchGear 3'UTR luciferase reporter plasmidLYZ 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LYZ

    Additional mRNA sequence: 

    AK130127.1 AK130149.1 AK310930.1 AK311779.1 BC004147.2 FJ795023.1 J03801.1 M19045.1 
    M21119.1 U25677.1 

    24/26 DOTS entries (see all 26):

    DT.97760262  DT.92466956  DT.95306318  DT.95326891  DT.95100802  DT.100876164  DT.92407741  DT.100876171 
    DT.121150025  DT.91663489  DT.121150074  DT.95370206  DT.97865549  DT.100876170  DT.121150069  DT.97760264 
    DT.100763650  DT.121150034  DT.121150042  DT.121150068  DT.121150073  DT.97760263  DT.100876160  DT.100876162 

    10 AceView cDNA sequences:

    BC004147 CR615077 NM_000239 J03801 CR607267 AK130149 AK130127 M19045 
    M21119 U25677 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LYZ    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                    -                     
    SP2:                    -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for LYZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LYZ expression in normal human tissues (normalized intensities)      LYZ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTAAAAAA
    LYZ Expression
    About this image


    LYZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 16 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells
             Fetal Liver CD36+ Cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Cord Blood Pan-T Cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             Thymus   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
             small intestine   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
             Trachea   

    See LYZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LYZ

    SOURCE GeneReport for Unigene cluster: Hs.524579
        SABiosciences Expression via Pathway-Focused PCR Arrays including LYZ: 
              Innate & Adaptive Immune Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LYZ gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LYZ1 lysozyme (renal amyloidosis) 60.92(n)
    57.93(a)
      396218  NM_205281.1  NP_990612.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    LYZ6
    (see all 3)
    Uncharacterized protein
    (see all 3)
    48(a)
    46(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    GL343326.1(688767-698644)
    GL343252.1(87196-91595)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77986
    LysB6
    (see all 9)
    Lysozyme B
    (see all 9)
    41(a)
    40(a)
    (see all 9)
    possible ortholog
    possible ortholog
    (see all 9)
    2R(12109617-12110132)
    3L(1207371-1207856)
            Species with no ortholog for LYZ

    ENSEMBL Gene Tree for LYZ (if available)
    TreeFam Gene Tree for LYZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LYZ gene
    LYZL62  LYZL42  SPACA32  LALBA2  SPACA5B2  LYZL22  SPACA52  LYZL12  
    8 SIMAP similar genes for LYZ using alignment to 3 protein entries:     LYSC_HUMAN (see all proteins):
    SPACA5    SPACA5B    SPACA3    LYZL1    LYZL2    LALBA
    LYZL6    LYZL4

    LYZ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/197 SNPs in LYZ are shown (see all 197)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0042814
    Amyloidosis 8 (AMYL8)4--see VAR_0042812 D H mis40--------
    VAR_0042804
    Amyloidosis 8 (AMYL8)4--see VAR_0042802 I T mis40--------
    rs1853564021,2
    --69577358(+) CTGGAA/CATACA 1 -- us2k10--------
    rs567923751,2
    F--69577448(+) TATTTA/TTTATT 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1901196141,2
    --69577494(+) ACTCTC/TTTTCC 1 -- us2k10--------
    rs1814010961,2
    --69577542(+) AACCTC/TCGCCT 1 -- us2k10--------
    rs1871378391,2
    C--69577681(+) TCGAAC/TTCCTG 1 -- us2k10--------
    rs1385727251,2
    C--69577758(+) GGCCA-/TTTTTTT 1 -- us2k10--------
    rs1919624881,2
    C--69577807(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1512959561,2
    --69577920(+) ATAGGC/TGCACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LYZ (69742121 - 69748014 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LYZ: --

    Human Gene Mutation Database (HGMD): LYZ
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LYZ
    DNA2.0 Custom Variant and Variant Library Synthesis for LYZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153450   
    OMIM disorders: 105200  
    UniProtKB/Swiss-Prot: LYSC_HUMAN, P61626
  • Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of
    apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement
    of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial
    hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/49 diseases for LYZ (see all 49):    About MalaCards
    microscopic colitis    lyz-related familial visceral amyloidosis    multicentric reticulohistiocytosis    amyloidosis, renal
    cutaneous fibrous histiocytoma    tuberculous meningitis    gastrointestinal system disease    amyloidosis
    hereditary amyloidosis    reticulosarcoma    blepharitis    keratoconjunctivitis sicca
    bacterial meningitis    dry eye syndrome    brucellosis    meningitis
    pulmonary emphysema    dental caries    mastitis    keratoconjunctivitis

    20/21 diseases from the University of Copenhagen DISEASES database for LYZ (see all 21):
    Amyloidosis     Histiocytosis     Kidney disease     Sarcoidosis
    Myeloid sarcoma     Leukemia     Malignant fibroxanthoma     Hypersensitivity reaction type II disease
    Arthritis     Lymphoma     Tuberculosis     Lung disease
    Reticulosarcoma     Crohn's disease     Sarcoma     Carcinoma
    Ulcerative colitis     Eye disease     Skin disease     Mastitis

    LYZ for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for LYZ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    meningitis 19.7 2 8403061 (1), 1560489 (1)
    necrosis 0 3 8132323 (2), 9589588 (1)
    tumors 0 3 8132323 (2), 11189425 (1)

    Genetic Association Database (GAD): LYZ
    Human Genome Epidemiology (HuGE) Navigator: LYZ (3 documents)

    Export disorders for LYZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LYZ gene, integrated from 9 sources (see all 116):
    (articles sorted by number of sources associating them with LYZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human lysozyme gene mutations cause hereditary systemic amyloidosis. (PubMed id 8464497)1, 2, 3 Pepy M.B.... Hsuan J.J. (1993)
    2. The human lysozyme gene. Sequence organization and chromosomal localization. (PubMed id 2546758)1, 2, 3 Peters C.W....Sippel A.E. (1989)
    3. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    4. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Structures of monoclinic lysozyme iodide at 1.6 A and of triclinic lysozyme nitrate at 1.1 A. (PubMed id 9757091)1, 2 Steinrauf L.K. (1998)
    8. Indication of possible post-translational formation of disulphide bonds in the beta-sheet domain of human lysozyme. (PubMed id 8503881)1, 2 Kanaya E.... Kikuchi M. (1993)
    9. The crystal structure of a mutant human lysozyme C77/95A with increased secretion efficiency in yeast. (PubMed id 2061330)1, 2 Inaka K.... Matsushima M. (1991)
    10. 1H and 15N NMR study of human lysozyme. (PubMed id 1794972)1, 2 Ohkubo T.... Kikuchi M. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4069 HGNC: 6740 AceView: LYZ Ensembl:ENSG00000090382 euGenes: HUgn4069
    ECgene: LYZ Kegg: 4069 H-InvDB: LYZ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LYZ Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LYZ
    Wikipedia http://en.wikipedia.org/wiki/Lysozyme

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LYZ gene:
    Search GeneIP for patents involving LYZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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