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LYZ Gene

protein-coding   GIFtS: 67
GCID: GC12P069681

Lysozyme

(Previous name: lysozyme (renal amyloidosis))
  See LYZ-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
lysozyme1 2     Lysozyme (Renal Amyloidosis)1
1,4-Beta-N-Acetylmuramidase C2 3     Renal Amyloidosis1
LZM2 3     Lysozyme C2
EC 3.2.1.173 8     

External Ids:    HGNC: 67401   Entrez Gene: 40692   Ensembl: ENSG000000903827   OMIM: 1534505   UniProtKB: P616263   

Export aliases for LYZ gene to outside databases

Previous GC identifers: GC12M069521 GC12P069458 GC12P068028 GC12P066791


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LYZ Gene:
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the
beta(1-4)glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the
anti-microbial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells,
plasma, saliva, and tears. Missense mutations in LYZ have been identified in heritable renal amyloidosis.
(provided by RefSeq, Jul 2008)

GeneCards Summary for LYZ Gene:
LYZ (lysozyme) is a protein-coding gene. Diseases associated with LYZ include amyloidosis, renal, and microscopic colitis. GO annotations related to this gene include lysozyme activity and identical protein binding. An important paralog of this gene is LYZL6.

UniProtKB/Swiss-Prot: LYSC_HUMAN, P61626
Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with
the monocyte-macrophage system and enhance the activity of immunoagents

Gene Wiki entry for LYZ (Lysozyme) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the LYZ gene promoter:
         C/EBPbeta   Sp1   p53   CUTL1   Evi-1   AREB6   STAT3   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLYZ promoter sequence
   Search Chromatin IP Primers for LYZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LYZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

LYZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYZ gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P069681:  view genomic region     (about GC identifiers)

Start:
69,742,121 bp from pter      End:
69,748,014 bp from pter
Size:
5,894 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LYSC_HUMAN, P61626 (See protein sequence)
Recommended Name: Lysozyme C precursor  
Size: 148 amino acids; 16537 Da
Subunit: Monomer
Miscellaneous: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase
activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin
oligosaccharides
Sequence caution: Sequence=CAA32175.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for LYZ (see all 204):
133L (3D)        134L (3D)        1B5U (3D)        1B5V (3D)        1B5W (3D)        1B5X (3D)    
Secondary accessions: P00695 Q13170 Q9UCF8

Explore the universe of human proteins at neXtProt for LYZ: NX_P61626

Explore proteomics data for LYZ at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LYZ (P61626) (see all 17)
     CLAKWES  CELARTL  WCNDGKT  YNTRATN 


    See LYZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000230.1  
    ENSEMBL proteins: 
     ENSP00000261267   ENSP00000449898   ENSP00000449969  
    Reactome Protein details: P61626

    LYZ Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for LYZ
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    Novus Biologicals LYZ Proteins
    Novus Biologicals LYZ Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for LYZ
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LYZ 

    LYZ Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LYZ
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    Abcam antibodies for LYZ
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for LYZ
    LSBio Antibodies in human, mouse, rat for LYZ

    LYZ Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LYZ
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for LYZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR023346 Lysozyme-like_dom
     IPR001916 Glyco_hydro_22
     IPR000974 Glyco_hydro_22_lys
     IPR019799 Glyco_hydro_22_CS

    Graphical View of Domain Structure for InterPro Entry P61626

    ProtoNet protein and cluster: P61626

    1 Blocks protein domain: IPB000974 Lysozyme signature

    UniProtKB/Swiss-Prot: LYSC_HUMAN, P61626
    Similarity: Belongs to the glycosyl hydrolase 22 family


    Find genes that share domains with LYZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYSC_HUMAN, P61626
    Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with
    the monocyte-macrophage system and enhance the activity of immunoagents
    Catalytic activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine
    residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

         Genatlas biochemistry entry for LYZ:
    lysozyme,14.5kDa,released from azurophilic granules of neutrophils,oxygen independent phagocytosis of Gram-
    bacteria

         Enzyme Number (IUBMB): EC 3.2.1.171 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003796lysozyme activity TAS2829884
    GO:0042802identical protein binding IPI--
         
    Find genes that share ontologies with LYZ           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for LYZ:
     Decreased melanin production  Increased cell death in HCC-19 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LYZ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LYZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LYZ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LYZ

    miRNA
    Products:
        
    miRTarBase miRNAs that target LYZ:
    hsa-mir-26b-5p (MIRT030049)

    Block miRNA regulation of human, mouse, rat LYZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LYZ (see all 9):
    hsa-miR-3607-3p hsa-miR-4287 hsa-miR-3160-3p hsa-miR-1270 hsa-miR-3168 hsa-miR-620 hsa-miR-518a-5p hsa-miR-556-5p
    SwitchGear 3'UTR luciferase reporter plasmidLYZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LYZ
    Predesigned siRNA for gene silencing in human, mouse, rat LYZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LYZ

    Clone
    Products:
         
    OriGene clones in human, mouse for LYZ (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LYZ (NM_000239)
    Sino Biological Human cDNA Clone for LYZ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LYZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYZ

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LYZ 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYSC_HUMAN, P61626: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton3
    lysosome3
    plasma membrane3
    vacuole3
    cytosol2
    endoplasmic reticulum2
    endosome2
    golgi apparatus2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS2829884
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with LYZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LYZ About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    Amyloids0.68
    2Salivary secretion
    Salivary secretion0.34
    3Disease
    Disease
    4C-MYB transcription factor network
    C-MYB transcription factor network


    Find genes that share SuperPaths with LYZ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for LYZ
        C-MYB transcription factor network


    1 Reactome Pathway for LYZ
        Amyloids


    1 Kegg Pathway  (Kegg details for LYZ):
        Salivary secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LYZ: 
              Innate & Adaptive Immune Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LYZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LYZ (P616261, 2, 3 ENSP000002612674) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LYZP616261, 2EBI-355360,EBI-355360 MINT-8407128 MINT-8407111 MINT-8407143
    NFKB1P198382, 3, ENSP000002265744MINT-48658 I2D: score=1 STRING: ENSP00000226574
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    IKBKBO149202, 3, ENSP000003391514MINT-48076 I2D: score=2 STRING: ENSP00000339151
    LRRK1Q38SD23, ENSP000003736004I2D: score=2 STRING: ENSP00000373600
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001895retina homeostasis IEP--
    GO:0006954inflammatory response TAS366724
    GO:0016998cell wall macromolecule catabolic process IEA--
    GO:0019835cytolysis IEA--
    GO:0042742defense response to bacterium IEA--

    Find genes that share ontologies with LYZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LYZ (LYSC)

    1 HMDB Compound for LYZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    N-Acetyl-D-glucosamine2-(acetylamino)-2-deoxyhexose (see all 9)7512-17-6--

    Selected DrugBank Compounds for LYZ (see all 15)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Proponol-- 71-23-8target--17139284 17016423 10592235
    3-Aminosuccinimide-- --target--17139284 17016423 10592235
    4-Aminophenylarsonic Acid-- --target--17139284 17016423 10592235
    4-Methylumbelliferyl Chitobiose-- --target--17139284 17016423 10592235
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    Chitotriose-- --target--17139284 17016423 10592235
    Cu-Bicyclam-- --target--17139284 17016423 10592235
    Cu-Cyclam-- --target--17139284 17016423 10592235
    Di(N-Acetyl-D-Glucosamine)-- --target--17139284 17016423 10592235
    Methylumbelliferyl Chitotriose-- --target--17139284 17016423 10592235

    1 Novoseek inferred chemical compound relationship for LYZ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nacl 6.42 1 17126536 (1)



    Find genes that share compounds with LYZ           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LYZ gene: 
    NM_000239.2  

    Unigene Cluster for LYZ:

    Lysozyme
    Hs.524579  [show with all ESTs]
    Unigene Representative Sequence: AK130149
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261267(uc001suw.2) ENST00000549690 ENST00000548839
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LYZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LYZ (see all 9):
    hsa-miR-3607-3p hsa-miR-4287 hsa-miR-3160-3p hsa-miR-1270 hsa-miR-3168 hsa-miR-620 hsa-miR-518a-5p hsa-miR-556-5p
    SwitchGear 3'UTR luciferase reporter plasmidLYZ 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LYZ (NM_000239)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LYZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYZ
    Primer
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    OriGene qPCR primer pairs and template standards for LYZ
    OriGene qSTAR qPCR primer pairs in human, mouse for LYZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LYZ
      QuantiTect SYBR Green Assays in human, mouse, rat LYZ
      QuantiFast Probe-based Assays in human, mouse, rat LYZ

    Additional mRNA sequence: 

    AK130127.1 AK130149.1 AK310930.1 AK311779.1 BC004147.2 FJ795023.1 J03801.1 M19045.1 
    M21119.1 U25677.1 

    Selected DOTS entries (see all 26):

    DT.97760262  DT.92466956  DT.95306318  DT.95326891  DT.95100802  DT.100876164  DT.92407741  DT.100876171 
    DT.121150025  DT.91663489  DT.121150074  DT.95370206  DT.97865549  DT.100876170  DT.121150069  DT.97760264 
    DT.100763650  DT.121150034  DT.121150042  DT.121150068  DT.121150073  DT.97760263  DT.100876160  DT.100876162 

    10 AceView cDNA sequences:

    NM_000239 BC004147 CR615077 J03801 CR607267 AK130127 M19045 AK130149 
    M21119 U25677 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LYZ    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                    -                     
    SP2:                    -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for LYZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LYZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTAAAAAA
    LYZ Expression
    About this image


    LYZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             Monocytes Peripheral Blood
             Bone marrow-derived hematopoietic stem cells (family)
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Endothelium (Cardiovascular System)
             Peripheral blood-derived early endothelial progenitor cells
    LYZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LYZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524579
        Pathway & Disease-focused RT2 Profiler PCR Arrays including LYZ: 
              Innate & Adaptive Immune Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LYZ
    OriGene qSTAR qPCR primer pairs in human, mouse for LYZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LYZ
    QuantiTect SYBR Green Assays in human, mouse, rat LYZ
    QuantiFast Probe-based Assays in human, mouse, rat LYZ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LYZ gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lyz21 lysozyme 2 78.15(n)
    76.35(a)
      17105  NM_017372.3  NP_059068.1 
    chicken
    (Gallus gallus)
    Aves LYZ1 lysozyme (renal amyloidosis) 60.92(n)
    57.93(a)
      396218  NM_205281.1  NP_990612.1 
    lizard
    (Anolis carolinensis)
    Reptilia LYZ6
    lysozyme
    49(a)
    1 ↔ 1
    GL343252.1(87196-91595)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004927981 lysozyme C, milk isozyme-like 61.34(n)
    58.33(a)
      100492798  XM_002938507.1  XP_002938553.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LysE6
    CG77986
    (see all 13)
    --
    41(a)
    41(a)
    (see all 13)
    many ↔ many
    many ↔ many
    (see all 13)
    3L(1212827-1213406)
    2R(12109617-12110132)


    ENSEMBL Gene Tree for LYZ (if available)
    TreeFam Gene Tree for LYZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LYZ gene
    LYZL62  LYZL42  SPACA32  LALBA2  SPACA5B2  LYZL22  SPACA52  LYZL12  
    8 SIMAP similar genes for LYZ using alignment to 3 protein entries:     LYSC_HUMAN (see all proteins):
    SPACA5    SPACA5B    SPACA3    LYZL1    LYZL2    LYZL6
    LALBA    LYZL4

    Find genes that share paralogs with LYZ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LYZ (see all 197)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0042814
    Amyloidosis 8 (AMYL8)4--see VAR_0042812 D H mis40--------
    VAR_0042804
    Amyloidosis 8 (AMYL8)4--see VAR_0042802 I T mis40--------
    rs1853564021,2
    --69577358(+) CTGGAA/CATACA 1 -- us2k10--------
    rs567923751,2
    F--69577448(+) TATTTA/TTTATT 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1901196141,2
    --69577494(+) ACTCTC/TTTTCC 1 -- us2k10--------
    rs1814010961,2
    --69577542(+) AACCTC/TCGCCT 1 -- us2k10--------
    rs1871378391,2
    C--69577681(+) TCGAAC/TTCCTG 1 -- us2k10--------
    rs1385727251,2
    C--69577758(+) GGCCA-/TTTTTTT 1 -- us2k10--------
    rs1919624881,2
    C--69577807(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1512959561,2
    --69577920(+) ATAGGC/TGCACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LYZ (69742121 - 69748014 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LYZ: --
    Human Gene Mutation Database (HGMD): LYZ
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LYZ
    DNA2.0 Custom Variant and Variant Library Synthesis for LYZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153450   
    OMIM disorders: 105200  
    UniProtKB/Swiss-Prot: LYSC_HUMAN, P61626
  • Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of
    apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement
    of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial
    hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 16 diseases for LYZ:    
    About MalaCards
    amyloidosis, renal    microscopic colitis    lyz-related familial visceral amyloidosis    familial renal amyloidosis due to lysozyme variant
    reticulosarcoma    amyloidosis    tuberculous meningitis    malignant fibroxanthoma
    amyloidosis, hereditary renal    hereditary amyloidosis    myeloid sarcoma    amyloidosis, 3 or more types
    hypersensitivity reaction type ii disease    mastitis    bacterial meningitis    meningitis

    Selected diseases from the University of Copenhagen DISEASES database for LYZ (see all 21):
    Amyloidosis     Histiocytosis     Kidney disease     Sarcoidosis
    Myeloid sarcoma     Leukemia     Malignant fibroxanthoma     Hypersensitivity reaction type II disease
    Arthritis     Lymphoma     Tuberculosis     Lung disease
    Reticulosarcoma     Crohn's disease     Sarcoma     Carcinoma
    Ulcerative colitis     Eye disease     Skin disease     Mastitis

    Find genes that share disorders with LYZ           About GenesLikeMe

    3 Novoseek inferred disease relationships for LYZ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    meningitis 19.7 2 8403061 (1), 1560489 (1)
    necrosis 0 3 8132323 (2), 9589588 (1)
    tumors 0 3 8132323 (2), 11189425 (1)

    Genetic Association Database (GAD): LYZ
    Human Genome Epidemiology (HuGE) Navigator: LYZ (3 documents)

    Export disorders for LYZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LYZ gene, integrated from 10 sources (see all 119):
    (articles sorted by number of sources associating them with LYZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human lysozyme gene mutations cause hereditary systemic amyloidosis. (PubMed id 8464497)1, 2, 3 Pepy M.B.... Hsuan J.J. (Nature 1993)
    2. The human lysozyme gene. Sequence organization and chromosomal localization. (PubMed id 2546758)1, 2, 3 Peters C.W.B.... Sippel A.E. (Eur. J. Biochem. 1989)
    3. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    4. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Structures of monoclinic lysozyme iodide at 1.6 A and of triclinic lysozyme nitrate at 1.1 A. (PubMed id 9757091)1, 2 Steinrauf L.K. (Acta Crystallogr. D 1998)
    8. Indication of possible post-translational formation of disulphide bonds in the beta-sheet domain of human lysozyme. (PubMed id 8503881)1, 2 Kanaya E.... Kikuchi M. (Biochem. J. 1993)
    9. The crystal structure of a mutant human lysozyme C77/95A with increased secretion efficiency in yeast. (PubMed id 2061330)1, 2 Inaka K.... Matsushima M. (J. Biol. Chem. 1991)
    10. 1H and 15N NMR study of human lysozyme. (PubMed id 1794972)1, 2 Ohkubo T.... Kikuchi M. (J. Biochem. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4069 HGNC: 6740 AceView: LYZ Ensembl:ENSG00000090382 euGenes: HUgn4069
    ECgene: LYZ Kegg: 4069 H-InvDB: LYZ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LYZ Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=LYZ[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Lysozyme

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LYZ gene:
    Search GeneIP for patents involving LYZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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