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Aliases for LYZ Gene

Aliases for LYZ Gene

  • Lysozyme 2 3 5
  • 1,4-Beta-N-Acetylmuramidase C 3 4
  • EC 4 61
  • LZM 3 4
  • Lysozyme (Renal Amyloidosis) 2
  • Renal Amyloidosis 2
  • C-Type Lysozyme 3
  • Lysozyme F1 3
  • Lysozyme C 3
  • LYZF1 3

External Ids for LYZ Gene

Previous GeneCards Identifiers for LYZ Gene

  • GC12M069521
  • GC12P069681
  • GC12P069458
  • GC12P068028
  • GC12P066791

Summaries for LYZ Gene

Entrez Gene Summary for LYZ Gene

  • This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

GeneCards Summary for LYZ Gene

LYZ (Lysozyme) is a Protein Coding gene. Diseases associated with LYZ include Amyloidosis, Familial Visceral and Al Amyloidosis. Among its related pathways are Immune System and Salivary secretion. GO annotations related to this gene include identical protein binding and lysozyme activity. An important paralog of this gene is SPACA3.

UniProtKB/Swiss-Prot for LYZ Gene

  • Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Gene Wiki entry for LYZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYZ Gene

Genomics for LYZ Gene

Regulatory Elements for LYZ Gene

Enhancers for LYZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F069340 1.5 FANTOM5 Ensembl ENCODE 57.3 -5.6 -5641 5.4 ZNF133 ARID4B SIN3A ZNF2 ZNF121 GLIS2 ZNF143 KLF13 SP3 SP5 LYZ YEATS4 NUP107 ENSG00000274979
GH12F069336 1.4 FANTOM5 Ensembl ENCODE 61.3 -10.1 -10141 2.8 SOX13 ELF3 ATF1 SAP130 TAL1 ZMYM3 CEBPG ZSCAN9 RAD21 RARA LYZ YEATS4 CPM ENSG00000274979
GH12F069358 1.1 ENCODE 52.2 +11.7 11661 2.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 LYZ YEATS4 LOC105369821 RPL7P42 NUP107 RN7SL804P
GH12F069328 1.4 FANTOM5 ENCODE 40.7 -16.8 -16833 6.1 HDGF ATF1 MLX ARID4B FEZF1 YY1 ELK1 ZNF548 ZMIZ1 PAF1 LYZ NUP107 CNOT2 YEATS4 KRT8P39 CPM ENSG00000274979 GC12M069304
GH12F069238 1.4 FANTOM5 ENCODE 23.5 -108.3 -108311 3.1 HDGF ATF1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2 YY1 LYZ NUP107 CPSF6 MDM2 YEATS4 FRS2 CCT2 SLC35E3 RAB3IP GC12P069269
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LYZ on UCSC Golden Path with GeneCards custom track

Promoters for LYZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for LYZ Gene

69,348,341 bp from pter
69,354,234 bp from pter
5,894 bases
Plus strand

Genomic View for LYZ Gene

Genes around LYZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZ Gene

Proteins for LYZ Gene

  • Protein details for LYZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysozyme C
    Protein Accession:
    Secondary Accessions:
    • P00695
    • Q13170
    • Q9UCF8

    Protein attributes for LYZ Gene

    148 amino acids
    Molecular mass:
    16537 Da
    Quaternary structure:
    • Monomer.
    • Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
    • Sequence=CAA32175.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYZ Gene

neXtProt entry for LYZ Gene

Selected DME Specific Peptides for LYZ Gene


Post-translational modifications for LYZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYZ Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LYZ Gene

Gene Families for LYZ Gene

Suggested Antigen Peptide Sequences for LYZ Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 22 family.
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZ: view

Function for LYZ Gene

Molecular function for LYZ Gene

GENATLAS Biochemistry:
lysozyme,14.5kDa,released from azurophilic granules of neutrophils,oxygen independent phagocytosis of Gram- bacteria
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
UniProtKB/Swiss-Prot Function:
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Enzyme Numbers (IUBMB) for LYZ Gene

Gene Ontology (GO) - Molecular Function for LYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IEA,TAS 2829884
GO:0003824 catalytic activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0042802 identical protein binding IPI 23353684
genes like me logo Genes that share ontologies with LYZ: view
genes like me logo Genes that share phenotypes with LYZ: view

Human Phenotype Ontology for LYZ Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LYZ Gene

MGI Knock Outs for LYZ:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for LYZ Gene

Localization for LYZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZ Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYZ gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for LYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 2829884
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LYZ: view

Pathways & Interactions for LYZ Gene

genes like me logo Genes that share pathways with LYZ: view

Pathways by source for LYZ Gene

1 KEGG pathway for LYZ Gene

SIGNOR curated interactions for LYZ Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0006954 inflammatory response TAS 366724
GO:0008152 metabolic process IEA --
GO:0016998 cell wall macromolecule catabolic process IBA --
GO:0019835 cytolysis IEA --
genes like me logo Genes that share ontologies with LYZ: view

Drugs & Compounds for LYZ Gene

(17) Drugs for LYZ Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Aspartic acid Approved Nutra Target 0
N-Acetyl-D-glucosamine Approved Nutra 0
(R)-Propylene glycol Experimental Pharma Target 0
1-Proponol Experimental Pharma Target 0
3-Aminosuccinimide Experimental Pharma Target 0

(3) Additional Compounds for LYZ Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
Propyl alcohol
  • 1-Hydroxypropane
  • 1-Propanol
  • 1-Propyl alcohol
  • Ethylcarbinol
  • Hydroxypropane

(1) ApexBio Compounds for LYZ Gene

Compound Action Cas Number
egg white lysozyme (19-36) [Gallus gallus] Dissolution of cell wall
genes like me logo Genes that share compounds with LYZ: view

Transcripts for LYZ Gene

mRNA/cDNA for LYZ Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LYZ Gene

Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYZ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: - -

Relevant External Links for LYZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LYZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYZ Gene

This gene is overexpressed in Whole Blood (x27.8) and Minor Salivary Gland (x14.6).

Protein differential expression in normal tissues from HIPED for LYZ Gene

This gene is overexpressed in Milk (31.8), Neutrophil (11.0), and Saliva (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LYZ Gene

Protein tissue co-expression partners for LYZ Gene

NURSA nuclear receptor signaling pathways regulating expression of LYZ Gene:


SOURCE GeneReport for Unigene cluster for LYZ Gene:

genes like me logo Genes that share expression patterns with LYZ: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LYZ Gene

Orthologs for LYZ Gene

This gene was present in the common ancestor of animals.

Orthologs for LYZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LYZ 34 35
  • 99.32 (n)
(Bos Taurus)
Mammalia LYZ 34 35
  • 87.16 (n)
LYZ1 35 35
  • 80 (a)
-- 35
  • 75 (a)
-- 35
  • 73 (a)
-- 35
  • 71 (a)
-- 35
  • 70 (a)
  • 70 (a)
LYZ3 35
  • 70 (a)
LYZ2 35
  • 69 (a)
-- 35
  • 65 (a)
(Canis familiaris)
Mammalia LYZ 34 35
  • 83.78 (n)
(Mus musculus)
Mammalia Lyz2 34 16 35
  • 78.15 (n)
Lyz1 35
  • 76 (a)
9530003J23Rik 35
  • 60 (a)
(Rattus norvegicus)
Mammalia Lyz2 34
  • 76.35 (n)
(Ornithorhynchus anatinus)
Mammalia LYZ 35
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
-- 35
  • 69 (a)
-- 35
  • 66 (a)
-- 35
  • 56 (a)
(Gallus gallus)
Aves LYZ 34 35
  • 60.92 (n)
(Anolis carolinensis)
Reptilia LYZ 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492798 34
  • 61.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7798 35
  • 41 (a)
LysE 35
  • 41 (a)
LysB 35
  • 40 (a)
LysD 35
  • 40 (a)
LysC 35
  • 39 (a)
LysS 35
  • 39 (a)
LysP 35
  • 38 (a)
LysX 35
  • 37 (a)
CG16756 35
  • 35 (a)
CG11159 35
  • 32 (a)
CG30062 35
  • 29 (a)
CG16799 35
  • 25 (a)
CG8492 35
  • 4 (a)
Species where no ortholog for LYZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYZ Gene

Gene Tree for LYZ (if available)
Gene Tree for LYZ (if available)

Paralogs for LYZ Gene

Paralogs for LYZ Gene

(8) SIMAP similar genes for LYZ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LYZ: view

Variants for LYZ Gene

Sequence variations from dbSNP and Humsavar for LYZ Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs121913547 Amyloidosis 8 (AMYL8) [MIM:105200], Pathogenic 69,350,192(+) TGGGA(C/T)ATTTC reference, missense
rs121913548 Amyloidosis 8 (AMYL8) [MIM:105200] 69,350,224(+) GTAAT(C/G)ATGGC reference, missense
rs121913549 Pathogenic 69,350,194(+) GGATA(A/T)TTCAG reference, missense
rs387906535 Pathogenic 69,350,170(+) CTGGA(C/G)ACAGA reference, missense
rs387906536 Pathogenic 69,350,215(+) GCTAC(A/C/T)GGTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LYZ Gene

Variant ID Type Subtype PubMed ID
nsv952201 CNV duplication 24416366

Variation tolerance for LYZ Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYZ Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYZ Gene

Disorders for LYZ Gene

MalaCards: The human disease database

(58) MalaCards diseases for LYZ Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amyloidosis, familial visceral
  • amyloidosis, 3 or more types
al amyloidosis
  • amyloidosis al
lyz-related familial visceral amyloidosis
  • amyloid disease
reticulohistiocytic granuloma
  • reticulohistiocytoma
- elite association - COSMIC cancer census association via MalaCards
Search LYZ in MalaCards View complete list of genes associated with diseases


  • Amyloidosis 8 (AMYL8) [MIM:105200]: A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system. {ECO:0000269 PubMed:8464497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LYZ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LYZ: view

No data available for Genatlas for LYZ Gene

Publications for LYZ Gene

  1. Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. (PMID: 18591461) Turner S.T. … Boerwinkle E. (Hypertension 2008) 3 22 46 64
  2. Human lysozyme gene mutations cause hereditary systemic amyloidosis. (PMID: 8464497) Pepy M.B. … Hsuan J.J. (Nature 1993) 2 3 4 64
  3. The human lysozyme gene. Sequence organization and chromosomal localization. (PMID: 2546758) Peters C.W.B. … Sippel A.E. (Eur. J. Biochem. 1989) 2 3 4 64
  4. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64
  5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64

Products for LYZ Gene

Sources for LYZ Gene

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