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Aliases for LYVE1 Gene

Aliases for LYVE1 Gene

  • Lymphatic Vessel Endothelial Hyaluronan Receptor 1 2 3 5
  • Cell Surface Retention Sequence-Binding Protein 1 3 4
  • Extracellular Link Domain-Containing Protein 1 3 4
  • Extracellular Link Domain Containing 1 2 3
  • Hyaluronic Acid Receptor 3 4
  • CRSBP-1 3 4
  • LYVE-1 3 4
  • XLKD1 3 4
  • HAR 3 4
  • Cell Surface Retention Sequence Binding Protein-1 3
  • Extracellular Link Domain-Containing 1 3
  • CRSBP1 4

External Ids for LYVE1 Gene

Previous HGNC Symbols for LYVE1 Gene

  • XLKD1

Previous GeneCards Identifiers for LYVE1 Gene

  • GC11M010536
  • GC11M010251

Summaries for LYVE1 Gene

Entrez Gene Summary for LYVE1 Gene

  • This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for LYVE1 Gene

LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1) is a Protein Coding gene. Diseases associated with LYVE1 include complete androgen insensitivity syndrome and capillary lymphangioma. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include receptor activity and hyaluronic acid binding. An important paralog of this gene is CD44.

UniProtKB/Swiss-Prot for LYVE1 Gene

  • Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Gene Wiki entry for LYVE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYVE1 Gene

Genomics for LYVE1 Gene

Regulatory Elements for LYVE1 Gene

Genomic Location for LYVE1 Gene

Chromosome:
11
Start:
10,556,966 bp from pter
End:
10,611,689 bp from pter
Size:
54,724 bases
Orientation:
Minus strand

Genomic View for LYVE1 Gene

Genes around LYVE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYVE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYVE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYVE1 Gene

Proteins for LYVE1 Gene

  • Protein details for LYVE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y7-LYVE1_HUMAN
    Recommended name:
    Lymphatic vessel endothelial hyaluronic acid receptor 1
    Protein Accession:
    Q9Y5Y7
    Secondary Accessions:
    • Q8TC18
    • Q9UNF4

    Protein attributes for LYVE1 Gene

    Size:
    322 amino acids
    Molecular mass:
    35213 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN (By similarity).

neXtProt entry for LYVE1 Gene

Proteomics data for LYVE1 Gene at MOPED

Post-translational modifications for LYVE1 Gene

Other Protein References for LYVE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LYVE1 Gene

Domains & Families for LYVE1 Gene

Protein Domains for LYVE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y7

UniProtKB/Swiss-Prot:

LYVE1_HUMAN :
  • Contains 1 Link domain.
Domain:
  • Contains 1 Link domain.
genes like me logo Genes that share domains with LYVE1: view

No data available for Gene Families for LYVE1 Gene

Function for LYVE1 Gene

Molecular function for LYVE1 Gene

UniProtKB/Swiss-Prot Function:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Gene Ontology (GO) - Molecular Function for LYVE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10037799
genes like me logo Genes that share ontologies with LYVE1: view
genes like me logo Genes that share phenotypes with LYVE1: view

Animal Models for LYVE1 Gene

MGI Knock Outs for LYVE1:

Animal Model Products

  • Taconic Biosciences Mouse Models for LYVE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LYVE1 Gene

Localization for LYVE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYVE1 Gene

Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYVE1 Gene COMPARTMENTS Subcellular localization image for LYVE1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LYVE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 10037799
genes like me logo Genes that share ontologies with LYVE1: view

Pathways & Interactions for LYVE1 Gene

genes like me logo Genes that share pathways with LYVE1: view

Pathways by source for LYVE1 Gene

Gene Ontology (GO) - Biological Process for LYVE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion TAS 10037799
GO:0009611 response to wounding TAS 10037799
GO:0030212 hyaluronan metabolic process TAS --
genes like me logo Genes that share ontologies with LYVE1: view

No data available for SIGNOR curated interactions for LYVE1 Gene

Drugs & Compounds for LYVE1 Gene

(17) Drugs for LYVE1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma 362

(17) Additional Compounds for LYVE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LYVE1: view

Transcripts for LYVE1 Gene

Unigene Clusters for LYVE1 Gene

Lymphatic vessel endothelial hyaluronan receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LYVE1 Gene

No ASD Table

Relevant External Links for LYVE1 Gene

GeneLoc Exon Structure for
LYVE1
ECgene alternative splicing isoforms for
LYVE1

Expression for LYVE1 Gene

mRNA expression in normal human tissues for LYVE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYVE1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.4) and Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for LYVE1 Gene

This gene is overexpressed in Urine (15.0), Serum (12.8), Plasma (11.2), and Synovial fluid (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LYVE1 Gene



SOURCE GeneReport for Unigene cluster for LYVE1 Gene Hs.655332

mRNA Expression by UniProt/SwissProt for LYVE1 Gene

Q9Y5Y7-LYVE1_HUMAN
Tissue specificity: Mainly expressed in endothelial cells lining lymphatic vessels.
genes like me logo Genes that share expression patterns with LYVE1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for LYVE1 Gene

Orthologs for LYVE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LYVE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYVE1 35
  • 98.86 (n)
  • 98.45 (a)
LYVE1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LYVE1 36
  • 68 (a)
OneToOne
LYVE1 35
  • 80.33 (n)
  • 71.43 (a)
dog
(Canis familiaris)
Mammalia LYVE1 35
  • 85.27 (n)
  • 77.12 (a)
LYVE1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lyve1 16
Lyve1 35
  • 76.94 (n)
  • 68.55 (a)
Lyve1 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LYVE1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Lyve1 35
  • 76.54 (n)
  • 67.52 (a)
chicken
(Gallus gallus)
Aves LYVE1 35
  • 52.68 (n)
  • 41.31 (a)
LYVE1 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LYVE1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lyve1 35
  • 49.24 (n)
  • 41.88 (a)
zebrafish
(Danio rerio)
Actinopterygii LYVE1 (2 of 2) 36
  • 20 (a)
OneToMany
lyve1b 36
  • 21 (a)
OneToMany
LOC560618 35
  • 44.49 (n)
  • 29.78 (a)
Species with no ortholog for LYVE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LYVE1 Gene

ENSEMBL:
Gene Tree for LYVE1 (if available)
TreeFam:
Gene Tree for LYVE1 (if available)

Paralogs for LYVE1 Gene

Paralogs for LYVE1 Gene

(1) SIMAP similar genes for LYVE1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LYVE1: view

Variants for LYVE1 Gene

Sequence variations from dbSNP and Humsavar for LYVE1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_027763 -
VAR_027764 -
VAR_027765 -

Structural Variations from Database of Genomic Variants (DGV) for LYVE1 Gene

Variant ID Type Subtype PubMed ID
nsv7675 CNV Insertion 18451855
nsv819020 CNV Loss 19587683

Variation tolerance for LYVE1 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYVE1 Gene

HapMap Linkage Disequilibrium report
LYVE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYVE1 Gene

Disorders for LYVE1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for LYVE1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
complete androgen insensitivity syndrome
  • androgen insensitivity syndrome, complete
capillary lymphangioma
  • cutaneous lymphangioma
kaposi sarcoma
  • human herpesvirus 8
androgen insensitivity, partial, with or without breast cancer
  • partial androgen insensitivity syndrome
intestinal lymphangiectasia
  • lymphangiectasis, intestinal
- elite association - COSMIC cancer census association via MalaCards
Search LYVE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LYVE1

Genetic Association Database (GAD)
LYVE1
Human Genome Epidemiology (HuGE) Navigator
LYVE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYVE1
genes like me logo Genes that share disorders with LYVE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LYVE1 Gene

Publications for LYVE1 Gene

  1. LYVE-1, a new homologue of the CD44 glycoprotein is a lymph-specific receptor for hyaluronan. (PMID: 10037799) Banerji S. … Jackson D.G. (J. Cell Biol. 1999) 2 3 4 23 67
  2. Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human livers. (PMID: 19908110) Arimoto J. … Ueda M. (J. Gastroenterol. 2010) 3 23
  3. [Expression of lymphatic vessel endothelial hyaluronan receptor-1 in human colorectal cancer and its clinical significance]. (PMID: 19742347) Li Z.X. … Fan Y.Z. (Zhonghua Wei Chang Wai Ke Za Zhi 2009) 3 23
  4. Histopathologic determinants of regional lymph node metastasis in early colorectal cancer. (PMID: 18181096) Ishikawa Y. … Ishii T. (Cancer 2008) 3 23
  5. Distribution of lymphatic vessel network in normal urinary bladder. (PMID: 18342921) Matsumoto K. … Baba S. (Urology 2008) 3 23

Products for LYVE1 Gene

Sources for LYVE1 Gene

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