Aliases for LYST Gene
Aliases for LYST Gene
External Ids for LYST Gene
- HGNC: 1968
- Entrez Gene: 1130
- Ensembl: ENSG00000143669
- OMIM: 606897
- UniProtKB: Q99698
Previous HGNC Symbols for LYST Gene
- CHS1
Previous GeneCards Identifiers for LYST Gene
- GC01M232151
- GC01M233890
- GC01M235824
- GC01M206276
Summaries for LYST Gene
-
This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]
GeneCards Summary for LYST Gene
LYST (Lysosomal Trafficking Regulator) is a Protein Coding gene. Diseases associated with LYST include Chediak-Higashi Syndrome and Attenuated Chédiak-Higashi Syndrome. Gene Ontology (GO) annotations related to this gene include binding and phospholipid binding. An important paralog of this gene is WDFY3.
UniProtKB/Swiss-Prot for LYST Gene
-
May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
Additional gene information for LYST Gene
- Monarch Initiative
- Search for LYST at DataMed
- Search for LYST at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYST Gene
Genomics for LYST Gene
GeneHancer (GH) Regulatory Elements for LYST Gene
- Top Transcription factor binding sites by QIAGEN in the LYST gene promoter:
Regulatory Element Products
Genomic Locations for LYST Gene
- chr1:235,661,031-235,883,708
- (GRCh38/hg38)
- Size:
- 222,678 bases
- Orientation:
- Minus strand
- chr1:235,824,341-236,046,940
- (GRCh37/hg19)
Genomic View for LYST Gene
- Cytogenetic band:
-
- 1q42.3 by Ensembl
- 1q42.3 by Entrez Gene
- 1q42.3 by HGNC


RefSeq DNA sequence for LYST Gene
Proteins for LYST Gene
-
Protein details for LYST Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99698-LYST_HUMAN
- Recommended name:
- Lysosomal-trafficking regulator
- Protein Accession:
- Q99698
- O43274
- Q5T2U9
- Q96TD7
- Q96TD8
- Q99709
- Q9H133
Protein attributes for LYST Gene
- Size:
- 3801 amino acids
- Molecular mass:
- 429139 Da
- Quaternary structure:
-
- Interacts with CENPJ, LIP8 and ZNF521.
Protein Expression for LYST Gene
Post-translational modifications for LYST Gene
- Ubiquitination at posLast=13051305 and posLast=31913191
Other Protein References for LYST Gene
Antibody Products
- Novus Biologicals Antibodies for LYST
- Invitrogen Antibodies for LYST
- antibodies-online: Search results for 6 available LYST Antibodies ranked by validation data
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Protein Products
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- Novus Biologicals proteins for LYST
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Assay Products
- antibodies-online: Search results for 4 available LYST Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for LYST Gene
Domains & Families for LYST Gene
Gene Families for LYST Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for LYST Gene
Suggested Antigen Peptide Sequences for LYST Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for LYST Gene
Function for LYST Gene
Molecular function for LYST Gene
- GENATLAS Biochemistry:
- putative lysosomal associated membrane protein,intracellular trafficking regulator,with two alternatively spliced isoforms,homologous to mouse beige and yeast VPS15
- UniProtKB/Swiss-Prot Function:
- May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
Phenotypes From GWAS Catalog for LYST Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11984006 |
Phenotypes for LYST Gene
- MGI mutant phenotypes for LYST:
-
inferred from 22 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- hematopoietic system phenotype
- pigmentation phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for LYST:
Animal Models for LYST Gene
- MGI Knock Outs for LYST:
-
- Lyst tm1b(EUCOMM)Wtsi
Animal Model Products
-
Taconic Biosciences Mouse Models for LYST
- Cyagen custom Knockout/knockin (KOKI) mouse models for LYST
-
-
ViGene Biosciences lentiviral particle packaged cDNA for LYST gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LYST gene
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CRISPR Products
-
OriGene CRISPR knockouts for LYST
- genomics-online: gRNA clones - Search results for 64 available LYST gene related products
- Overview of 64 available LYST gene related products
- Applied Biological Materials CRISPR for LYST
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LYST
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miRNA for LYST Gene
- miRTarBase miRNAs that target LYST
miRNA Products
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Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LYST
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- Overview of 64 available LYST gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LYST gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for LYST
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LYST
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LYST
-
ViGene Biosciences adenoviral particle packaged cDNA for LYST gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LYST gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LYST gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LYST Gene
Localization for LYST Gene
Subcellular locations from UniProtKB/Swiss-Prot for LYST Gene
- Cytoplasm.
- Microtubule organizing center (2)
- Nucleoplasm (2)
- Plasma membrane (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0015630 | microtubule cytoskeleton | IDA | 9606205 |
Pathways & Interactions for LYST Gene
Interacting Proteins for LYST Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | IEA | -- |
GO:0007040 | lysosome organization | IEA | -- |
GO:0015031 | protein transport | IEA | -- |
GO:0030595 | leukocyte chemotaxis | ISS | -- |
GO:0032438 | melanosome organization | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for LYST Gene
Transcripts for LYST Gene
mRNA/cDNA for LYST Gene
- (14) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (149) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for LYST Gene
CRISPR Products
-
OriGene CRISPR knockouts for LYST
- genomics-online: gRNA clones - Search results for 64 available LYST gene related products
- Overview of 64 available LYST gene related products
- Applied Biological Materials CRISPR for LYST
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LYST
- GenScript: Design CRISPR guide RNA sequences for LYST
miRNA Products
- Search ViGene Biosciences for LYST
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LYST
- Browse OriGene Inhibitory RNA Products For LYST
- genomics-online: shRNA clones - Search results for 64 available LYST gene related products
- Overview of 64 available LYST gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LYST gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for LYST
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LYST
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LYST
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LYST Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Double Positive Thymocytes Thymus
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for LYST Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LYST Gene
NURSA nuclear receptor signaling pathways regulating expression of LYST Gene:
LYSTSOURCE GeneReport for Unigene cluster for LYST Gene:
Hs.532411mRNA Expression by UniProt/SwissProt for LYST Gene:
Q99698-LYST_HUMANEvidence on tissue expression from TISSUES for LYST Gene
- Liver(4.2)
- Blood(2.7)
- Bone marrow(2.3)
- Skin(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LYST Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- respiratory
- skeletal muscle
- skeleton
- brain
- cranial nerve
- eye
- face
- head
- jaw
- mandible
- maxilla
- mouth
- nose
- skull
- tooth
- liver
- spleen
- lower limb
- shin
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- lymph node
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal cord
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for LYST
No data available for Protein tissue co-expression partners for LYST Gene
Orthologs for LYST Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LYST 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | LYST 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | LYST 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Lyst 33 |
|
||
mouse (Mus musculus) |
Mammalia | Lyst 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | LYST 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | LYST 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | LYST 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | LYST 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | lyst 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | lyst 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG42863 34 |
|
OneToOne | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for LYST was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for LYST Gene
Variants for LYST Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1013780006 | uncertain-significance, Ch\u00e9diak-Higashi syndrome | 235,866,876(-) | C/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant | |
rs10465613 | benign, conflicting-interpretations-of-pathogenicity, not specified, Ch\u00e9diak-Higashi syndrome | 235,806,086(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
rs1046600348 | uncertain-significance, Ch\u00e9diak-Higashi syndrome | 235,662,116(-) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs1056514391 | uncertain-significance, Ch\u00e9diak-Higashi syndrome | 235,833,676(-) | A/C | genic_upstream_transcript_variant, intron_variant | |
rs1063128 | benign, not specified, Ch\u00e9diak-Higashi syndrome | 235,809,567(-) | T/C | coding_sequence_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant, upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv588n100 | CNV | gain | 25217958 |
dgv589n100 | CNV | gain | 25217958 |
esv2661819 | CNV | deletion | 23128226 |
esv3589199 | CNV | loss | 21293372 |
nsv1011288 | CNV | gain | 25217958 |
nsv1012436 | CNV | loss | 25217958 |
nsv472320 | CNV | novel sequence insertion | 20440878 |
nsv508701 | CNV | deletion | 20534489 |
nsv549394 | CNV | gain | 21841781 |
nsv832936 | CNV | gain | 17160897 |
nsv832947 | CNV | gain | 17160897 |
nsv945383 | CNV | duplication | 23825009 |
Additional Variant Information for LYST Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYST Gene
Disorders for LYST Gene

(10) MalaCards diseases for LYST Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
chediak-higashi syndrome |
|
|
attenuated chédiak-higashi syndrome |
|
|
exfoliation syndrome |
|
|
hemophagocytic lymphohistiocytosis |
|
|
ichthyosis, congenital, autosomal recessive 11 |
|
|
UniProtKB/Swiss-Prot
LYST_HUMAN- Chediak-Higashi syndrome (CHS) [MIM:214500]: A rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT). {ECO:0000269 PubMed:11857544, ECO:0000269 PubMed:24521565}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LYST
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for LYST Gene
Publications for LYST Gene
- Identification of the homologous beige and Chediak-Higashi syndrome genes. (PMID: 8717042) Barbosa MD … Kingsmore SF (Nature 1996) 2 3 4 22 58
- Apparent genotype-phenotype correlation in childhood, adolescent, and adult Chediak-Higashi syndrome. (PMID: 11857544) Karim MA … Spritz RA (American journal of medical genetics 2002) 3 4 22 58
- The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev VT … Kingsmore SF (Molecular medicine (Cambridge, Mass.) 2002) 3 4 22 58
- Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. (PMID: 8896560) Nagle DL … Moore KJ (Nature genetics 1996) 2 3 4 58
- Autosomal-recessive complicated spastic paraplegia with a novel lysosomal trafficking regulator gene mutation. (PMID: 24521565) Shimazaki H … Takiyama Y (Journal of neurology, neurosurgery, and psychiatry 2014) 3 4 58
Products for LYST Gene
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- Taconic Biosciences Mouse Models for LYST
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- Humanized Mice
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- VectorBuilder custom plasmid, inducible vectors for LYST
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LYST
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 6 available LYST Antibodies ranked by validation data
- Compare Top LYST Antibodies
- Quality Products:
- antibodies-online: Search results for 4 available LYST Elisa Kits ranked by validation data
- Compare Top LYST Elisa Kits
- Quality Products:
- antibodies-online: Search results for available LYST related products ranked by validation data
- Search GeneTex for Antibodies for LYST
- Search GeneTex for Proteins for LYST
- ViGene Biosciences adenoviral particle packaged cDNA for LYST gene
- ViGene Biosciences lentiviral particle packaged cDNA for LYST gene
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- Overview of 64 available LYST gene related products
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- Overview of 64 available LYST gene related products
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- Overview of 64 available LYST gene related products
Sources for LYST Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
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