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LYST Gene

protein-coding GIFtS: 51

GC01M233890

lysosomal trafficking regulator
(Previous name: Chediak-Higashi syndrome 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CHS1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CHS ^¹, ², ³
CHS1 ^², ³, ⁵
OTTHUMP00000059294 ^²

Descriptions
Beige homolog ^³
Chediak-Higashi syndrome 1 ^¹, ²
beige protein ^²
lysosomal trafficking regulator ^²

External Ids
HGNC: 1968¹
Entrez Gene: 1130²
UniProtKB: Q99698³
Ensembl: ENSG00000143669⁷

Search outside databases for aliases for LYST gene

Previous GC identifer: GC01M232151

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LYST:

This gene is thought to encode a protein that regulates intracellular protein trafficking to and

from the lysosome. Mutations in this gene are associated with Chediak-Higashi syndrome, a rare

lysosomal storage disorder. Alternatively spliced transcript variants have been described but

their full-length nature has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: LYST_HUMAN, Q99698

Function: May be required for sorting endosomal resident proteins into late multivesicular

endosomes by a mechanism involving microtubules

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LYST gene

Entrez Gene cytogenetic band: 1q42.1-q42.2 Ensembl cytogenetic band: 1q42.3 HGNC cytogenetic band: 1q42.1-q42.2

LYST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M233890: (about GC identifiers)

Start:	233,890,964 bp from pter
End:	234,096,843 bp from pter
Size:	205,880 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004836.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LYST_HUMAN, Q99698 (See protein sequence)

Recommended Name: Lysosomal-trafficking regulator

Size: 3801 amino acids; 429139 Da

Subunit: Interacts with CENPJ, LIP8 and ZNF521

Subcellular location: Cytoplasm (Potential)

Secondary accessions: O43274 Q5T2U9 Q96TD7 Q96TD8 Q99709 Q9H133

Alternative splicing: 3 isoforms: Q99698-1 Q99698-2 Q99698-3 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000072.2

ENSEMBL proteins:

ENSP00000374443 ENSP00000374444

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (LYST)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0015630	microtubule cytoskeleton	IDA	9606205

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Antibodies for LYST:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
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Assays for LYST:

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	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99698

ProtoNet protein and cluster: Q99698

1 Blocks protein family: IPB000409 Beige/BEACH domain

UniProtKB/Swiss-Prot: LYST_HUMAN, Q99698

Similarity: Contains 1 BEACH domain

Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LYST)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001005736

Applied Biosystems Silencer® siRNAs for LYST

Sigma-Aldrich siRNA for LYST

Sigma-Aldrich shRNA Panels and shRNA for LYST

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000081
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000081
untagged cDNA clones in CMV expression vector (see all 2): NM_000081

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000081

UniProtKB/Swiss-Prot: LYST_HUMAN, Q99698

Function: May be required for sorting endosomal resident proteins into late multivesicular

endosomes by a mechanism involving microtubules

Genatlas biochemistry entry for LYST:

putative lysosomal associated membrane protein,intracellular trafficking regulator,with two

alternatively spliced isoforms,homologous to mouse beige and yeast VPS15

14 MGI mutant phenotypes (inferred from 15 alleles) (MGI details for Lyst):

cellular	craniofacial	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	limbs/digits/tail	nervous system	no phenotypic analysis	pigmentation
renal/urinary system	skin/coat/nails	tumorigenesis	vision/eye

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11984006

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015031	protein transport	IEA	--
GO:0030595	leukocyte chemotaxis	ISS	--
GO:0032438	melanosome organization	ISS	--
GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway	IMP	9606205
GO:0033364	mast cell secretory granule organization	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LYST
6 Novoseek chemical compound relationships for LYST gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
chalcone	78.16	9	9223265 (1), 17028970 (1), 9002621 (1), 9774634 (1) (see all 6)
chitin	69.96	17	17302816 (4), 12429521 (2), 17971081 (2), 10826699 (1) (see all 8)
anthocyanin	47.46	1	17028970 (1)
flavonoid	32.87	1	17028970 (1)
histidine	12.84	1	10690356 (1)
cholesterol	0.00	2	14657904 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LYST)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001005736

Sigma-Aldrich siRNA for LYST

Sigma-Aldrich shRNA Panels and shRNA for LYST

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000081

REFSEQ mRNAs for LYST gene:

NM_000081.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000081

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000081
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000081
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000081

Additional cDNA sequence:

AK307457.1 AK310790.1 AK311664.1 AL833100.1 BC020793.1 BC033098.1 BC144702.1 BX649113.1

L77889.1 U67615.1 U70064.1 U72192.1 U84744.1

18 DOTS entries:

DT.95364459 DT.95173157 DT.100777965 DT.216563 DT.216564 DT.91843611 DT.95173154 DT.100777966

DT.100777967 DT.91752927 DT.40128160 DT.92427793 DT.95332360 DT.97771673 DT.97808809 DT.101974170

DT.95257026 DT.95354749

24/149 AceView cDNA sequences (see all 149 ):

BQ011080 BM055408 BM055110 U70064 CK904950 BU738114 BM700528 BQ214459

BX649113 AW236542 BX100814 BM700370 AI683851 AI869371 BC033098 AA424769

BU740347 BX492438 AA486745 BU738023 AI698283 AI275101 AA360606 NM_000081

highest scoring ESTs for LYST:

U70064 AI041860 N24226 BC033098 BG764384 BX646232 H99579 L77889 N25938 U67615

Unigene Cluster for LYST:

Lysosomal trafficking regulator

Hs.532411 [show with all ESTs]

Unigene Representative Sequence: NM_000081

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000389793 ENST00000389794

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LYST expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LYST

¹ / ² / ³

9 probe-sets matching LYST gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35695_at²^{, 3}	U95-A	1	1.00	1.00	0.89	1.52	U67615	0.80	0.88	0.84	1
35696_s_at²^{, 3}	U95-A	1	1.00	1.00	0.75	0.50	U70064	1.00	0.90	0.95	1
49515_at²^{, 3}	U95-C	1	0.31	1.00	0.96	1.02	AI041860	0.80	1.00	0.91	1
215415_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U70064	1.00	0.90	0.95	1
210943_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U84744	0.80	0.88	0.84	1
203518_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000081	0.60	1.00	0.82	1
215415_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210943_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203518_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LYST for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.532411
Expression variation in blood from EXPOLDB for LYST
UniProtKB/Swiss-Prot: LYST_HUMAN, Q99698
Tissue specificity: Abundantly expressed in adult and fetal thymus, peripheral blood leukocytes,
bone marrow and several regions of the adult brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LYST gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LYST¹	--	lysosomal trafficking regulator	90.61(n) 90.84(a)	479195 XM_536337.2 XP_536337.2
chimpanzee (Pan troglodytes)	LYST¹	--	lysosomal trafficking regulator	99.43(n) 99.11(a)	457838 XM_514288.2 XP_514288.2
cow (Bos taurus)	LYST¹	--	lysosomal trafficking regulator	90.03(n) 90.54(a)	281072 NM_174020.2 NP_776445.1
rat (Rattus norvegicus)	Lyst¹	--	lysosomal trafficking regulator	85.32(n) 85.51(a)	85419 NM_053518.1 NP_445970.1
mouse (Mus musculus)	Lyst^{1, 5}	13 (7.00 cM)⁵	lysosomal trafficking regulator^{1, 5}	85.2(n)¹ 85.64(a)¹	17101¹ NM_010748.2¹ NP_034878.2¹ AK042198⁵ AK089635⁵ (see all 12)

About this table Species with no ortholog for LYST

ENSEMBL Gene Tree for LYST

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LYST gene

NSMAF² WDFY4² WDFY3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/962 NCBI SNPs in LYST are shown (see all 962 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 300)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7524261^1,2	A,C,F,H	234040167(+)	`TGTTAA/CAAAAT`	1	L/V	mis¹		12		NA EU EA WA	1052
	rs7548449^1,2	A,C,F,H	234097264(+)	`GTGTAG/TGTCTA`	1	--	ng3¹		4		EU EA WA	412
	rs10465613^1,2	A,C,F,H	234036009(+)	`TTACAC/TTTGTA`	1	S/N	mis¹ ese³		9		EU EA WA NA	916
	rs3768067^1,2	C,F,H	234040373(+)	`CTAAAT/CGTAAT`	1	R/H	mis¹		9		EA EU WA	2294
	rs7541041^1,2	A,C,H	233989429(+)	`ATTGCG/ATTAGT`	1	M/T	mis¹		4		EU EA WA	418
	rs6665568^1,2	C,F,H	234000158(+)	`ATCTGC/GTGGTG`	1	Q/H	mis¹ ese³		9		EU EA WA NA	902
	rs34642241^1,2	C,F	233976438(+)	`GGGGAA/TATTTT`	1	F/Y	mis¹		5		NA EU EA WA	498
	rs12728185^1,2	A,H	233891901(+)	`TCTGCC/GTCCTG`	1	--	ut3¹		4		EU EA WA	418
--	rs4660117^1,2	A,C	234098156(+)	`gtggcC/Gggata`	1	--	ng3¹		0	--	--	--	--
	rs35333195^1,2	C,F	233964530(+)	`ATTCAC/TCTTGG`	1	G/D	mis¹		5		NA EU EA WA	494

About this table

HapMap Linkage Disequilibrium images for LYST (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 606897 disorders: 214500

UniProtKB/Swiss-Prot: LYST_HUMAN, Q99698

Defects in LYST are the cause of Chediak-Higashi syndrome (CHS) [MIM:214500]. CHS is a

rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic

deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and

from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an

early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT)

2 Novoseek disease relationships for LYST gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
chediak-higashi syndrome	95.55	13	10594238 (2), 17512928 (2), 16518687 (1), 9070932 (1) (see all 9)
tumors	4.55	1	11504836 (1)

About this table

GeneTests: LYST

Chediak-Higashi Syndrome

Human Gene Mutation Database: LYST

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/66 PubMed articles for LYST gene (see all 66 ):

Identification of the homologous beige and Chediak-Higashi syndrome genes. (PubMed id 8717042)^{1, 2, 3, 4} Barbosa M.D.F.S.... Kingsmore S.F. (1996)
Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. (PubMed id 8896560)^{2, 3, 4} Nagle D.L....Moore K.J. (1996)
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PubMed id 11984006)^{1, 3, 4} Tchernev V.T....Kingsmore S.F. (2002)
Apparent genotype-phenotype correlation in childhood, adolescent, and adult Chediak-Higashi syndrome. (PubMed id 11857544)^{1, 3, 4} Karim M.A.... Spritz R.A. (2002)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse. (PubMed id 9215680)^{3, 4} Barbosa M.D.F.S.... Kingsmore S.F. (1997)
Two novel CHS1 (LYST) mutations: clinical correlations in an infant with Chediak-Higashi syndrome. (PubMed id 15896657)^{1, 3} Zarzour W....Gahl W.A. (2005)
Chediak-Higashi syndrome associated with maternal uniparental isodisomy of chromosome 1. (PubMed id 10482950)^{1, 3} Dufourcq-Lagelouse R....de Saint Basile G. (1999)
Protein truncation test of LYST reveals heterogenous mutations in patients with Chediak-Higashi syndrome. (PubMed id 10648412)^{1, 3} Certain S....de Saint Basile G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1130	HGNC: 1968	AceView: CHS1	Ensembl:ENSG00000143669	euGenes: HUgn1130
ECgene: LYST	H-InvDB: LYST

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
LYSTbase	http://bioinf.uta.fi/LYSTbase/
Mutations of the LYST gene	http://www.retina-international.com/sci-news/chsmut.htm
Albinism database (ADB)	http://albinismdb.med.umn.edu/chs1mut.html

Licensable Technologies for LYST
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for LYST:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LYST-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LYST		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LYST		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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LYST Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for LYST

Summaries
for LYST

Genomic Location
for LYST

Proteins
for LYST

Protein Domains/
Families
for LYST

Gene Function
for LYST

Pathways & Interactions
for LYST

Drugs & Compounds
for LYST

Transcripts
for LYST

Expression
for LYST

Orthologs
for LYST

Paralogs
for LYST

SNPs/Variants
for LYST

Disorders & Mutations
for LYST

Medical News
for LYST

Publications
for LYST

Search for LYST

Genome Databases showing LYST

Other Databases showing LYST

Specialized Databases showing LYST

Licensable Technologies
for LYST

Services
for LYST

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LYST Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor LYST

Summariesfor LYST

Genomic Locationfor LYST

Proteinsfor LYST

Protein Domains/Familiesfor LYST

Gene Functionfor LYST

Pathways & Interactionsfor LYST

Drugs & Compoundsfor LYST

Transcriptsfor LYST

Expression for LYST

Orthologsfor LYST

Paralogsfor LYST

SNPs/Variantsfor LYST

Disorders & Mutationsfor LYST

Medical Newsfor LYST

Publicationsfor LYST

Search for LYST

Genome Databases showing LYST

Other Databases showing LYST

Specialized Databases showing LYST

Licensable Technologiesfor LYST

Servicesfor LYST

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LYST

Summaries
for LYST

Genomic Location
for LYST

Proteins
for LYST

Protein Domains/
Families
for LYST

Gene Function
for LYST

Pathways & Interactions
for LYST

Drugs & Compounds
for LYST

Transcripts
for LYST

Expression
for LYST

Orthologs
for LYST

Paralogs
for LYST

SNPs/Variants
for LYST

Disorders & Mutations
for LYST

Medical News
for LYST

Publications
for LYST

Licensable Technologies
for LYST

Services
for LYST