LYRM7 Gene
protein-coding GIFtS: 41
GCID: GC05P130536
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LYR motif containing 7(Previous names: chromosome 5 open reading frame 31, Lyrm7 homolog (mouse)...)
(Previous symbol: C5orf31)
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Aliases
for LYRM7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| LYR Motif Containing 71 2 | | Lyrm7 Homolog (Mouse)1 | | C5orf311 2 3 | | LYR Motif-Containing Protein 72 | | FLJ207961 | | Lyrm7 Homolog2 | | Chromosome 5 Open Reading Frame 311 | | |
Export aliases for LYRM7 gene to outside databasesPrevious GC identifer: GC05P125697 |
Summaries
for LYRM7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LYRM7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LYRM7 gene promoter:
STAT1 Sox5 GATA-3 ATF-2 E4BP4 Evi-1 MZF-1 Nkx6-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for LYRM7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LYRM7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q23.3 Ensembl cytogenetic band: 5q23.3 HGNC cytogenetic band: 5q31.1LYRM7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P130536: view genomic region
(about GC identifiers)
Start:
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130,506,503 bp from pter |
End:
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130,541,119 bp from pter |
Size:
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34,617 bases |
Orientation:
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plus strand |
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Proteins
for LYRM7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LYRM7_HUMAN, Q5U5X0 (See
protein sequence)Recommended Name: LYR motif-containing protein 7 Size: 104 amino acids; 11955 Da
Secondary accessions: A8MPQ9 Q86Y68Explore the universe of human proteins at neXtProt for LYRM7: NX_Q5U5X0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5U5X0
LYRM7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_859056.2
ENSEMBL proteins: ENSP00000368688 ENSP00000423283 ENSP00000423991
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
LYRM7 for ontologies About GeneDecksing
LYRM7 Antibody Products:
Assay Products for LYRM7: |
Protein
Domains /
Families
for LYRM7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LYRM7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5U5X0ProtoNet protein and cluster: Q5U5X0 UniProtKB/Swiss-Prot: LYRM7_HUMAN, Q5U5X0Similarity: Belongs to the complex I LYR family |
Function
for LYRM7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LYRM7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LYRM7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LYRM7 (NM_181705) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LYRM7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYRM7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYRM7 |
1 GenomeRNAi human phenotype for LYRM7:
|
Pathways & Interactions
for LYRM7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LYRM7
|
Drugs & Compounds
for LYRM7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LYRM7
Search CenterWatch for drugs/clinical trials and news about LYRM7
|
Transcripts
for LYRM7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LYRM7 gene: NM_181705.2 Unigene Cluster for LYRM7: LYR motif containing 7 Hs.115467 [show with all ESTs]Unigene Representative Sequence: NM_1817054 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379380(uc003kvg.1) ENST00000510516 ENST00000507584 ENST00000521227
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LYRM7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LYRM7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LYRM7 (NM_181705) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LYRM7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYRM7 |
Additional cDNA sequence: AK000803.1 AK056991.1 BC022429.1 BC037930.1 BC047079.1 12 DOTS entries: DT.202732 DT.99940844 DT.105355 DT.87015741 DT.100747273 DT.411620 DT.95272690 DT.99987657 DT.40264062 DT.425193 DT.120841943 DT.120841981 24/72 AceView cDNA sequences (see all 72): BE907078 AA416991 AK000803 AI816072 AA470056 BM804279 AW675551 BU753991 AA383033 BC047079 BM873904 BI224922 BU852113 BG714922 BI601025 BE781307 BI601105 BG714193 BU615173 BI858024 AW971567 BG220006 BC037930 BG530233
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for LYRM7 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for LYRM7
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Expression
for LYRM7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LYRM7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTCAGGTC
About this image
See LYRM7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LYRM7
SOURCE GeneReport for Unigene cluster: Hs.115467
SABiosciences Custom PCR Arrays for LYRM7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LYRM7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LYRM7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LYRM7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LYRM7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYRM7 |
Orthologs
for LYRM7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LYRM7 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for LYRM7 (if available)
TreeFam Gene Tree for LYRM7 (if available) |
Paralogs
for LYRM7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for LYRM7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LYRM7 (130506503 - 130541119 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LYRM7
1 CNV: 3576 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LYRM7 |
|
Disorders
/ Diseases
for LYRM7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 LYRM7 for disorders About MalaCards
LYRM7 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: LYRM7 (2 documents)
Export disorders for LYRM7 gene to outside databases
|
Publications
for LYRM7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LYRM7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LYRM7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
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External Searches for LYRM7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing LYRM7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LYRM7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LYRM7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LYRM7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for LYRM7 gene:
Search GeneIP for patents involving LYRM7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LYRM7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LYRM7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LYRM7 | | | OriGene Protein Over-expression Lysate for LYRM7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for LYRM7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LYRM7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LYRM7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LYRM7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LYRM7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LYRM7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LYRM7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LYRM7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LYRM7 |
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 |  |  |  | |
| | | | Search Tocris compounds for LYRM7 |
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 | | | LYRM7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYRM7 |
|  |  |  | | | | Search ThermoFisher Antibodies for LYRM7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYRM7 |
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