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LYRM7 Gene

protein-coding   GIFtS: 45
GCID: GC05P130536

LYR Motif Containing 7

(Previous names: chromosome 5 open reading frame 31, Lyrm7 homolog (mouse))
(Previous symbol: C5orf31)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LYR Motif Containing 71 2     Chromosome 5 Open Reading Frame 311
C5orf311 2 3     Lyrm7 Homolog (Mouse)1
MZM1L2 3     Complex III Assembly Factor LYRM72
LYR Motif-Containing Protein 72 3     Lyrm7 Homolog2

External Ids:    HGNC: 280721   Entrez Gene: 906242   Ensembl: ENSG000001866877   UniProtKB: Q5U5X03   

Export aliases for LYRM7 gene to outside databases

Previous GC identifer: GC05P125697


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LYRM7 Gene:
LYRM7 (LYR motif containing 7) is a protein-coding gene. Diseases associated with LYRM7 include mitochondrial complex iii deficiency, nuclear type 6.

UniProtKB/Swiss-Prot: LYRM7_HUMAN, Q5U5X0
Function: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII)
complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it
prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner
membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the LYRM7 gene promoter:
         STAT1   Sox5   GATA-3   ATF-2   E4BP4   Evi-1   MZF-1   Nkx6-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLYRM7 promoter sequence
   Search Chromatin IP Primers for LYRM7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LYRM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.3   Ensembl cytogenetic band:  5q23.3   HGNC cytogenetic band: 5q31.1

LYRM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYRM7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P130536:  view genomic region     (about GC identifiers)

Start:
130,506,503 bp from pter      End:
130,541,119 bp from pter
Size:
34,617 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LYRM7_HUMAN, Q5U5X0 (See protein sequence)
Recommended Name: Complex III assembly factor LYRM7  
Size: 104 amino acids; 11955 Da
Subunit: Interacts with UQCRFS1
Secondary accessions: A8MPQ9 Q86Y68

Explore the universe of human proteins at neXtProt for LYRM7: NX_Q5U5X0

Explore proteomics data for LYRM7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys6, Lys82, Lys87
  • Modification sites at PhosphoSitePlus

  • See LYRM7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_859056.2  
    ENSEMBL proteins: 
     ENSP00000368688   ENSP00000423283   ENSP00000423991  

    LYRM7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for LYRM7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LYRM: LYR motif containing

    1 InterPro protein domain:
     IPR008011 Complex1_LYR

    Graphical View of Domain Structure for InterPro Entry Q5U5X0

    ProtoNet protein and cluster: Q5U5X0

    UniProtKB/Swiss-Prot: LYRM7_HUMAN, Q5U5X0
    Similarity: Belongs to the complex I LYR family


    LYRM7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYRM7_HUMAN, Q5U5X0
    Function: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII)
    complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it
    prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner
    membrane

    Phenotypes:
         1 GenomeRNAi human phenotype for LYRM7:

     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LYRM7
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    miRNA
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    miRTarBase miRNAs that target LYRM7:
    hsa-mir-30e-5p (MIRT044132), hsa-mir-21-5p (MIRT030859), hsa-mir-192-5p (MIRT026378), hsa-mir-215-5p (MIRT024706)

    Block miRNA regulation of human, mouse, rat LYRM7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LYRM7 (see all 28):
    hsa-miR-607 hsa-miR-4311 hsa-miR-539 hsa-miR-520d-5p hsa-miR-548v hsa-miR-192 hsa-miR-1257 hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYRM7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYRM7_HUMAN, Q5U5X0: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix IEA--

    LYRM7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LYRM7
    Interactions:

        Search GeneGlobe Interaction Network for LYRM7

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LYRM7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LYRM7 gene: 
    NM_181705.2  

    Unigene Cluster for LYRM7:

    LYR motif containing 7
    Hs.115467  [show with all ESTs]
    Unigene Representative Sequence: NM_181705
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379380(uc003kvg.1) ENST00000510516 ENST00000507584 ENST00000521227

    miRNA
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    Block miRNA regulation of human, mouse, rat LYRM7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LYRM7 (see all 28):
    hsa-miR-607 hsa-miR-4311 hsa-miR-539 hsa-miR-520d-5p hsa-miR-548v hsa-miR-192 hsa-miR-1257 hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LYRM7
    Predesigned siRNA for gene silencing in human, mouse, rat LYRM7
    Clone
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    OriGene clones in human, mouse for LYRM7 (see all 7)
    OriGene ORF clones in mouse, rat for LYRM7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LYRM7 (NM_181705)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LYRM7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYRM7
    Primer
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    OriGene qPCR primer pairs and template standards for LYRM7
    OriGene qSTAR qPCR primer pairs in human, mouse for LYRM7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LYRM7
      QuantiTect SYBR Green Assays in human, mouse, rat LYRM7
      QuantiFast Probe-based Assays in human, mouse, rat LYRM7

    Additional mRNA sequence: 

    AK000803.1 AK056991.1 BC022429.1 BC037930.1 BC047079.1 

    12 DOTS entries:

    DT.202732  DT.99940844  DT.105355  DT.87015741  DT.100747273  DT.411620  DT.95272690  DT.99987657 
    DT.40264062  DT.425193  DT.120841943  DT.120841981 

    Selected AceView cDNA sequences (see all 72):

    AW675551 AA416991 AA383033 BE907078 AK000803 BM804279 AI816072 AA470056 
    BU753991 BI224922 BI599224 BI603906 BU852113 BG718813 BI601105 BU615173 
    AW971567 BG220006 AW967653 BE781307 BI601025 BU945402 BG714922 BI597308 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LYRM7    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                                                              
    SP2:                                                                              
    SP3:                          -                                                   
    SP4:                                                  -                           
    SP5:                                            -     -                           


    ECgene alternative splicing isoforms for LYRM7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LYRM7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTCAGGTC
    LYRM7 Expression
    About this image

    LYRM7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LYRM7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.115467
        Custom PCR Arrays for LYRM7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYRM7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LYRM7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lyrm71 , 5 LYR motif containing 71, 5 86.22(n)1
    83.65(a)1
      11 (32.13 cM)5
    755301  NM_029327.31  NP_083603.21 
     548268665 
    chicken
    (Gallus gallus)
    Aves LYRM71 Lyrm7 homolog (mouse) 72(n)
    72(a)
      768932  XM_001231595.3  XP_001231596.1 
    lizard
    (Anolis carolinensis)
    Reptilia LYRM76
    LYR motif containing 7
    67(a)
    1 ↔ 1
    2(31309064-31315144)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW638504.12   -- 80.09(n)    AW638504.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1655971 zgc:165597 61.81(n)
    61.17(a)
      100002948  NM_001098759.1  NP_001092229.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG341506
    --
    31(a)
    1 ↔ 1
    3R(20639984-20640652)


    ENSEMBL Gene Tree for LYRM7 (if available)
    TreeFam Gene Tree for LYRM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LYRM7 (see all 702)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100432441,2
    C,F--130504709(+) TGAGAT/CGCAAA 1 -- us2k17Minor allele frequency- C:0.33NA WA CSA 246
    rs100646261,2
    C,F--130504768(+) aggggG/Tcaaag 1 -- us2k1 tfbs32Minor allele frequency- T:0.24WA 120
    rs1479260331,2
    --130504859(+) GTTGAC/GATGTT 1 -- us2k10--------
    rs1906244291,2
    --130504929(+) GTAGAA/CCCTTG 1 -- us2k10--------
    rs1822919091,2
    --130505029(+) CCATTA/GTTTGG 1 -- us2k10--------
    rs77340191,2
    C,F,A--130505083(+) aaaccA/Ttcttc 1 -- us2k16Minor allele frequency- T:0.19NA WA CSA 246
    rs754185011,2
    F--130505093(+) CAATTT/CTCCTT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1174791771,2
    C,F--130505100(+) CCTTAC/TGCTGG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1142082151,2
    C,F--130505136(+) TCTACA/GTGTTC 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs77341771,2
    C,F,A,H--130505154(+) actgcC/Tcttac 1 -- us2k117Minor allele frequency- T:0.24NS EA NA WA CSA 1866

    HapMap Linkage Disequilibrium report for LYRM7 (130506503 - 130541119 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LYRM7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882884CNV Loss21882294
    dgv6326n71CNV Loss21882294
    nsv882885CNV Gain21882294
    nsv882883CNV Gain21882294
    dgv1852e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LYRM7
    DNA2.0 Custom Variant and Variant Library Synthesis for LYRM7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for LYRM7:    
    About MalaCards
    mitochondrial complex iii deficiency, nuclear type 6


    LYRM7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LYRM7
    Human Genome Epidemiology (HuGE) Navigator: LYRM7 (2 documents)

    Export disorders for LYRM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LYRM7 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with LYRM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial Complex III assembly in human cells. (PubMed id 23168492)1, 2, 3 Sanchez E....Fernandez-Vizarra E. (Biochim. Biophys. Acta 2013)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90624 HGNC: 28072 AceView: LOC90624 Ensembl:ENSG00000186687 euGenes: HUgn90624
    ECgene: LYRM7 H-InvDB: LYRM7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LYRM7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LYRM7 gene:
    Search GeneIP for patents involving LYRM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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