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LYRM4 Gene

protein-coding   GIFtS: 53
GCID: GC06M005103

LYR Motif Containing 4

(Previous name: chromosome 6 open reading frame 149)
(Previous symbol: C6orf149)
  See LYRM4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LYR Motif Containing 41 2     CGI-2032
C6orf1491 2 3 5     Homolog Of Yeast Isd112
ISD112 3 5     LYR Motif-Containing Protein 42
COXPD192 5     Mitochondrial Matrix Nfs1 Interacting Protein2
Chromosome 6 Open Reading Frame 1491     

External Ids:    HGNC: 213651   Entrez Gene: 571282   Ensembl: ENSG000002141137   OMIM: 6133115   UniProtKB: Q9HD343   

Export aliases for LYRM4 gene to outside databases

Previous GC identifers: GC06M005049 GC06M004983


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LYRM4 Gene:
LYRM4 (LYR motif containing 4) is a protein-coding gene. Diseases associated with LYRM4 include combined oxidative phosphorylation deficiency 19.

UniProtKB/Swiss-Prot: LYRM4_HUMAN, Q9HD34
Function: Required for nuclear and mitochondrial iron-sulfur protein biosynthesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LYRM4 gene promoter:
         HFH-3   HOXA3   Nkx2-2   YY1   FOXI1   Cart-1   FOXO1a   Pax-4a   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLYRM4 promoter sequence
   Search Chromatin IP Primers for LYRM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LYRM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.1   Ensembl cytogenetic band:  6p25.1   HGNC cytogenetic band: 6p25.1

LYRM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYRM4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M005103:  view genomic region     (about GC identifiers)

Start:
5,102,827 bp from pter      End:
5,261,172 bp from pter
Size:
158,346 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LYRM4_HUMAN, Q9HD34 (See protein sequence)
Recommended Name: LYR motif-containing protein 4  
Size: 91 amino acids; 10758 Da
Subunit: Interacts with FXN. Interaction is increased by nickel. Interaction is inhibited by calcium, magnesium,
manganese, copper, cobalt, zinc, and iron. Forms a complex with the cytosolic/nuclear form of NFS1. The complex
increased the stability of NFS1
Miscellaneous: Reduction of LYRM4 levels by siRNA increases the total iron content, and reduces cytosolic and
mitochondrial aconitase activities and NFS1 protein levels
Secondary accessions: A8K543 Q5XKP1

Explore the universe of human proteins at neXtProt for LYRM4: NX_Q9HD34

Explore proteomics data for LYRM4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys58
  • Modification sites at PhosphoSitePlus

  • See LYRM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001158312.1  NP_001158313.1  NP_065141.3  

    ENSEMBL proteins: 
     ENSP00000418787   ENSP00000418321   ENSP00000420026   ENSP00000417885   ENSP00000419928  
     ENSP00000443900  
    Reactome Protein details: Q9HD34

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LYRM: LYR motif containing

    1 InterPro protein domain:
     IPR008011 Complex1_LYR

    Graphical View of Domain Structure for InterPro Entry Q9HD34

    ProtoNet protein and cluster: Q9HD34

    1 Blocks protein domain: IPB008011 Complex 1 LYR protein

    UniProtKB/Swiss-Prot: LYRM4_HUMAN, Q9HD34
    Similarity: Belongs to the complex I LYR family


    Find genes that share domains with LYRM4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYRM4_HUMAN, Q9HD34
    Function: Required for nuclear and mitochondrial iron-sulfur protein biosynthesis

    Phenotypes:
         1 GenomeRNAi human phenotype for LYRM4:

     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LYRM4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LYRM4
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    hsa-miR-374a* hsa-miR-323-5p hsa-miR-766 hsa-miR-636 hsa-miR-1284 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidLYRM4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYRM4_HUMAN, Q9HD34: Mitochondrion. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--

    Find genes that share ontologies with LYRM4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LYRM4 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    2Mitochondrial Iron-Sulfur Cluster Biogenesis
    Mitochondrial Iron-Sulfur Cluster Biogenesis


    Find genes that share SuperPaths with LYRM4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for LYRM4
        Mitochondrial iron-sulfur cluster biogenesis


    UniProtKB/Swiss-Prot: LYRM4_HUMAN, Q9HD34
    Pathway: Cofactor biosynthesis; iron-sulfur cluster biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LYRM4
    Interactions:

        GeneGlobe Interaction Network for LYRM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for LYRM4 (ENSP000004200264) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFS1ENSP000003632054STRING: ENSP00000363205
    FXNENSP000003664824STRING: ENSP00000366482
    NDUFAB1ENSP000000075164STRING: ENSP00000007516
    SCLYENSP000002546634STRING: ENSP00000254663
    DNAJC17ENSP000002204964STRING: ENSP00000220496
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with LYRM4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LYRM4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LYRM4 gene (3 alternative transcripts): 
    NM_001164840.2  NM_001164841.2  NM_020408.5  

    Unigene Cluster for LYRM4:

    LYR motif containing 4
    Hs.387755  [show with all ESTs]
    Unigene Representative Sequence: NM_001164841
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330636(uc010jnu.3 uc003mwp.3 uc003mwq.3) ENST00000606472
    ENST00000468929 ENST00000464010 ENST00000463032 ENST00000458438 ENST00000480566
    ENST00000455814 ENST00000500576(uc021ykw.1)
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate LYRM4:
    hsa-miR-374a* hsa-miR-323-5p hsa-miR-766 hsa-miR-636 hsa-miR-1284 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidLYRM4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat LYRM4
      QuantiFast Probe-based Assays in human, mouse, rat LYRM4

    Additional mRNA sequence: 

    AF088060.1 AF170070.1 AF258559.1 AF285118.1 AK291158.1 AK309458.1 AK309661.1 BC009552.2 
    BC067762.1 BC105601.1 

    7 DOTS entries:

    DT.456023  DT.95102408  DT.97844689  DT.91754311  DT.100785854  DT.401335  DT.95183970 

    Selected AceView cDNA sequences (see all 190):

    BF223668 CK819965 AA460551 BE674395 CR620170 BE551136 BM273251 AA806250 
    AA973406 Z44785 BQ011543 AI264112 AW135277 BE327186 CK819966 CR605553 
    BQ773920 Z40588 AF088060 W77957 BM549348 BM462091 AA676766 AW207098 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LYRM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LYRM4 Expression
    About this image


    LYRM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    LYRM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LYRM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.387755

    UniProtKB/Swiss-Prot: LYRM4_HUMAN, Q9HD34
    Tissue specificity: Reduced mRNA levels in Friedreich ataxia patients

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for LYRM4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lyrm41 , 5 LYR motif containing 41, 5 89.38(n)1
    89.01(a)1
      13 (14.44 cM)5
    3808401  NM_201358.21  NP_958746.11 
     359787975 
    chicken
    (Gallus gallus)
    Aves LYRM41 LYR motif containing 4 75.29(n)
    72.94(a)
      420874  NM_001198888.1  NP_001185817.1 
    lizard
    (Anolis carolinensis)
    Reptilia LYRM46
    LYR motif containing 4
    65(a)
    1 ↔ 1
    GL343421.1(86657-94983)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lyrm41 LYR motif containing 4 69.35(n)
    68.97(a)
      100379678  NM_001198893.1  NP_001185822.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lyrm41 LYR motif containing 4 60.32(n)
    54.76(a)
      100302660  NM_001164241.1  NP_001157713.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bcn926
    bcn92
    36(a)
    1 ↔ 1
    X(2042496-2043680)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ISD116
    Cysteine desulfurase (Nfs1p) activator; essential ...
    33(a)
    1 ↔ 1
    V(250718-251002) YER048W-A


    ENSEMBL Gene Tree for LYRM4 (if available)
    TreeFam Gene Tree for LYRM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LYRM4 gene
    Selected SIMAP similar genes for LYRM4 using alignment to 6 protein entries:     LYRM4_HUMAN (see all proteins) (see all similar genes):
    ZNF585B    ASB11    EDRF1    CHID1    UBIAD1    WARS
    CRCP    DCTN5    FAM3A    RNF217    ZNF564    BTBD2
    FAM210A    NF2    SNX31    TMEM14B    TNFRSF17    ZNF212

    Find genes that share paralogs with LYRM4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LYRM4
    PGOHUM00000244814


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LYRM4 (see all 3333)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340301361,2
    C--5086643(+) CCACG-/T/TT  
            
    TTTTT
    2 -- int10--------
    rs1845582951,2
    --5108187(+) GTGAGA/CCAAGA 2 -- int10--------
    rs1466356131,2
    C--5108204(+) CGCTGC/TACTCC 2 -- int10--------
    rs1895386831,2
    --5108313(+) TTTGAA/GCGCAT 2 -- int10--------
    rs783584501,2
    C,F--5108358(+) GGAAGA/GCATGA 2 -- int11Minor allele frequency- G:0.09WA 118
    rs6675431,2
    C,F,A,H--5108391(+) AACACA/GGGCTC 2 -- int112Minor allele frequency- G:0.23NS EA WA NA CSA 783
    rs1413343391,2
    --5108405(+) CAGTGC/TGTACT 2 -- int10--------
    rs4259301,2
    C,F,A,H--5108419(+) TCCCAT/CGACCG 2 -- int110Minor allele frequency- C:0.20NS EA NA WA CSA 666
    rs737176521,2
    C,F--5108437(+) TAAAAT/CGAGGG 2 -- int16Minor allele frequency- C:0.12WA NA CSA EA 364
    rs1807357351,2
    --5108453(+) CAGTGC/TTGCAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for LYRM4 (5102827 - 5261172 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LYRM4 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2469123CNV Deletion19546169
    esv2731513CNV Deletion23290073
    esv1673345CNV Deletion17803354
    esv2660224CNV Deletion23128226
    esv2666766CNV Deletion23128226
    esv2731512CNV Deletion23290073
    esv2665378CNV Deletion23128226
    esv1953097CNV Deletion18987734
    esv29679CNV Loss19812545
    nsv5179CNV Loss18451855

    Human Gene Mutation Database (HGMD): LYRM4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LYRM4
    DNA2.0 Custom Variant and Variant Library Synthesis for LYRM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613311   
    OMIM disorders: 615595  
    1 disease for LYRM4:    
    About MalaCards
    combined oxidative phosphorylation deficiency 19


    Find genes that share disorders with LYRM4           About GenesLikeMe

    Genetic Association Database (GAD): LYRM4
    Human Genome Epidemiology (HuGE) Navigator: LYRM4 (11 documents)

    Export disorders for LYRM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LYRM4 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with LYRM4)
        Utopia: connect your pdf to the dynamic
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    1. Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones. (PubMed id 17331979)1, 2, 9 Shan Y.... Cortopassi G. (Hum. Mol. Genet. 2007)
    2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (PLoS Genet. 2011)
    3. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (Inflamm. Bowel Dis. 2010)
    4. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PubMed id 20886065)1, 4 Cleynen I....Vermeire S. (PLoS ONE 2010)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Genetic risk profiling and prediction of disease course in Crohn's disease patients. (PubMed id 19422935)1, 4 Henckaerts L....Vermeire S. (Clin. Gastroenterol. Hepatol. 2009)
    8. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1, 4 Weersma R.K.... Vermeire S. (Am. J. Gastroenterol. 2009)
    9. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. (PubMed id 19068216)1, 4 Anderson C.A....Parkes M. (Gastroenterology 2009)
    10. Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis. (PubMed id 19454487)1, 2 Shi Y.... Rouault T.A. (Hum. Mol. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57128 HGNC: 21365 AceView: C6orf149 Ensembl:ENSG00000214113 euGenes: HUgn57128
    ECgene: LYRM4 H-InvDB: LYRM4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LYRM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LYRM4 gene:
    Search GeneIP for patents involving LYRM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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