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Aliases for LYPLA2 Gene

Aliases for LYPLA2 Gene

  • Lysophospholipase II 2 3 4 5
  • LysoPLA II 3 4
  • LPL-II 3 4
  • APT-2 3 4
  • APT2 3 4
  • Testicular Tissue Protein Li 3 3
  • Acyl-Protein Thioesterase 2 3
  • EC 3.1.2.- 4
  • DJ886K2.4 3
  • EC 3.1.2 58

External Ids for LYPLA2 Gene

Previous GeneCards Identifiers for LYPLA2 Gene

  • GC01P023675
  • GC01P023188
  • GC01P023587
  • GC01P023862
  • GC01P023990
  • GC01P024117
  • GC01P022369

Summaries for LYPLA2 Gene

Entrez Gene Summary for LYPLA2 Gene

  • Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for LYPLA2 Gene

LYPLA2 (Lysophospholipase II) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Developmental Biology. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is LYPLA1.

UniProtKB/Swiss-Prot for LYPLA2 Gene

  • May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.

Additional gene information for LYPLA2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPLA2 Gene

Genomics for LYPLA2 Gene

Regulatory Elements for LYPLA2 Gene

Enhancers for LYPLA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H023824 1.1 ENCODE 11.9 +34.4 34351 2.3 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 FUCA1 LYPLA2 KDM1A GC01P023838 PIR41142
GH01H023930 1 Ensembl ENCODE dbSUPER 11.4 +140.5 140476 1.5 ZNF362 ZBTB33 ZNF18 PNRC2 FUCA1 SRSF10 LYPLA2 GC01P023930 ENSG00000230228
GH01H023751 0.7 ENCODE 11.6 -39.3 -39310 0.2 ELF3 HDGF CTCF ARID4B ZNF2 RAD21 CC2D1A SCRT2 SMC3 ZNF143 PITHD1 ELOA-AS1 LYPLA2 GC01P023754 ELOA
GH01H023750 0.2 ENCODE 11.6 -39.9 -39860 0.2 PITHD1 ELOA-AS1 LYPLA2 GC01P023754 ELOA
GH01H023789 1.4 ENCODE dbSUPER 0.7 +1.1 1084 5.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 LINC01355 SRSF10 FUCA1 SRRM1 LOC105376860 LYPLA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LYPLA2 on UCSC Golden Path with GeneCards custom track

Promoters for LYPLA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003090 715 1401 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF143 ZNF207 SP3 ZHX2 MXD4

Transcription factor binding sites by QIAGEN in the LYPLA2 gene promoter:

Genomic Locations for LYPLA2 Gene

Genomic Locations for LYPLA2 Gene
chr1:23,790,785-23,795,539
(GRCh38/hg38)
Size:
4,755 bases
Orientation:
Plus strand
chr1:24,117,460-24,122,029
(GRCh37/hg19)

Genomic View for LYPLA2 Gene

Genes around LYPLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPLA2 Gene

Proteins for LYPLA2 Gene

  • Protein details for LYPLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95372-LYPA2_HUMAN
    Recommended name:
    Acyl-protein thioesterase 2
    Protein Accession:
    O95372
    Secondary Accessions:
    • Q7Z4Z2

    Protein attributes for LYPLA2 Gene

    Size:
    231 amino acids
    Molecular mass:
    24737 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97210.1; Type=Frameshift; Positions=5, 164, 179; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYPLA2 Gene

neXtProt entry for LYPLA2 Gene

Selected DME Specific Peptides for LYPLA2 Gene

O95372:
  • IVLGGFS
  • AAENIKALI
  • ALSCWLPL
  • VIFLHGL
  • KYICPHAP
  • LGGFSQGGALSLYTALT
  • FLHGLGD

Post-translational modifications for LYPLA2 Gene

  • Ubiquitination at Lys108 and Lys190
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for LYPLA2
  • Cloud-Clone Corp. Antibodies for LYPLA2

Domains & Families for LYPLA2 Gene

Gene Families for LYPLA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LYPLA2 Gene

Suggested Antigen Peptide Sequences for LYPLA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95372

UniProtKB/Swiss-Prot:

LYPA2_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
genes like me logo Genes that share domains with LYPLA2: view

Function for LYPLA2 Gene

Molecular function for LYPLA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-protein + H(2)O = palmitate + protein.
UniProtKB/Swiss-Prot Function:
May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.

Enzyme Numbers (IUBMB) for LYPLA2 Gene

Gene Ontology (GO) - Molecular Function for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008474 palmitoyl-(protein) hydrolase activity IBA,TAS --
GO:0016787 hydrolase activity IEA --
GO:0045296 cadherin binding IDA 25468996
GO:0052689 carboxylic ester hydrolase activity IBA --
genes like me logo Genes that share ontologies with LYPLA2: view
genes like me logo Genes that share phenotypes with LYPLA2: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYPLA2 Gene

Localization for LYPLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPLA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYPLA2 gene
Compartment Confidence
extracellular 5
cytosol 5
peroxisome 2
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 25468996
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LYPLA2: view

Pathways & Interactions for LYPLA2 Gene

genes like me logo Genes that share pathways with LYPLA2: view

Pathways by source for LYPLA2 Gene

3 Reactome pathways for LYPLA2 Gene
1 KEGG pathway for LYPLA2 Gene

Gene Ontology (GO) - Biological Process for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IBA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with LYPLA2: view

No data available for SIGNOR curated interactions for LYPLA2 Gene

Drugs & Compounds for LYPLA2 Gene

(3) Drugs for LYPLA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Choline alfoscerate Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(33) Additional Compounds for LYPLA2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • 1-Palmitoyl-glycero-3-phosphocholine
  • 1-Palmitoyl-lysophosphatidylcholine
  • LPC(16:0)
  • LPC(16:0/0:0)
  • LyPC(16:0)
genes like me logo Genes that share compounds with LYPLA2: view

Transcripts for LYPLA2 Gene

Unigene Clusters for LYPLA2 Gene

Lysophospholipase II:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPLA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for LYPLA2 Gene

GeneLoc Exon Structure for
LYPLA2
ECgene alternative splicing isoforms for
LYPLA2

Expression for LYPLA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYPLA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYPLA2 Gene

This gene is overexpressed in Bone (14.6) and Urine (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LYPLA2 Gene



Protein tissue co-expression partners for LYPLA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYPLA2 Gene:

LYPLA2

SOURCE GeneReport for Unigene cluster for LYPLA2 Gene:

Hs.533479

Evidence on tissue expression from TISSUES for LYPLA2 Gene

  • Intestine(4.2)
  • Nervous system(3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with LYPLA2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYPLA2 Gene

Orthologs for LYPLA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LYPLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYPLA2 33 34
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia LYPLA2 33 34
  • 96.25 (n)
cow
(Bos Taurus)
Mammalia LYPLA2 33 34
  • 94.52 (n)
mouse
(Mus musculus)
Mammalia Lypla2 33 16 34
  • 93.36 (n)
rat
(Rattus norvegicus)
Mammalia Lypla2 33
  • 92.78 (n)
oppossum
(Monodelphis domestica)
Mammalia LYPLA2 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYPLA2 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LYPLA2 33 34
  • 81.24 (n)
lizard
(Anolis carolinensis)
Reptilia LYPLA2 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lypla2 33
  • 72.01 (n)
MGC75683 33
African clawed frog
(Xenopus laevis)
Amphibia MGC52664 33
zebrafish
(Danio rerio)
Actinopterygii lypla2 34 33
  • 73.3 (n)
OneToOne
zgc73210 33
fruit fly
(Drosophila melanogaster)
Insecta CG18815 35 33 34
  • 59.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012126 33
  • 55.61 (n)
worm
(Caenorhabditis elegans)
Secernentea K04G2.5 35
  • 45 (a)
ath-1 34
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 32 (a)
OneToMany
-- 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G20060 33
  • 46.5 (n)
rice
(Oryza sativa)
Liliopsida Os01g0175000 33
  • 47.67 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02027 33
  • 56.25 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8E11.04c 33
  • 47.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2523 34
  • 47 (a)
OneToMany
Species where no ortholog for LYPLA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYPLA2 Gene

ENSEMBL:
Gene Tree for LYPLA2 (if available)
TreeFam:
Gene Tree for LYPLA2 (if available)

Paralogs for LYPLA2 Gene

Paralogs for LYPLA2 Gene

(1) SIMAP similar genes for LYPLA2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LYPLA2: view

Variants for LYPLA2 Gene

Sequence variations from dbSNP and Humsavar for LYPLA2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs535702110 Uncertain significance 23,795,622(+) GTTTT(A/T)ATTTT downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs557214506 Uncertain significance 23,795,620(+) TGTTT(-/TTA)TTATT downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs576468712 Uncertain significance 23,795,757(+) AGATA(A/G)GAGTT downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000219306 -- 23,793,275(+) GTCCT(C/G)TCATC intron-variant
rs1000550545 -- 23,794,865(+) CCTCT(C/G)GGGGC upstream-variant-2KB, utr-variant-3-prime

Variation tolerance for LYPLA2 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYPLA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYPLA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LYPLA2 Gene

Disorders for LYPLA2 Gene

Relevant External Links for LYPLA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYPLA2

No disorders were found for LYPLA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYPLA2 Gene

Publications for LYPLA2 Gene

  1. Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. (PMID: 21152083) Tomatis VM … Daniotti JL (PloS one 2010) 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Enzymatic protein depalmitoylation by acyl protein thioesterases. (PMID: 25849916) Lin DT … Conibear E (Biochemical Society transactions 2015) 3 60

Products for LYPLA2 Gene

Sources for LYPLA2 Gene

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