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Aliases for LYPLA2 Gene

Aliases for LYPLA2 Gene

  • Lysophospholipase II 2 3 4 5
  • LysoPLA II 3 4
  • LPL-II 3 4
  • APT-2 3 4
  • APT2 3 4
  • Testicular Tissue Protein Li 3 3
  • Acyl-Protein Thioesterase 2 3
  • EC 3.1.2.- 4
  • DJ886K2.4 3
  • EC 3.1.2 61

External Ids for LYPLA2 Gene

Previous GeneCards Identifiers for LYPLA2 Gene

  • GC01P023675
  • GC01P023188
  • GC01P023587
  • GC01P023862
  • GC01P023990
  • GC01P024117
  • GC01P022369

Summaries for LYPLA2 Gene

Entrez Gene Summary for LYPLA2 Gene

  • Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for LYPLA2 Gene

LYPLA2 (Lysophospholipase II) is a Protein Coding gene. Among its related pathways are Developmental Biology and L1CAM interactions. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is LYPLA1.

UniProtKB/Swiss-Prot for LYPLA2 Gene

  • May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPLA2 Gene

Genomics for LYPLA2 Gene

Regulatory Elements for LYPLA2 Gene

Enhancers for LYPLA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F023824 1 ENCODE 11.9 +34.4 34351 2.3 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 ZNF263 SP3 FUCA1 LYPLA2 ELOA GC01P023838 PIR41142
GH01F023750 0.2 ENCODE 11.6 -39.9 -39860 0.2 PITHD1 ELOA-AS1 LYPLA2 GC01P023754 ELOA
GH01F023751 0.2 ENCODE 11.6 -39.3 -39310 0.3 SCRT1 ELF3 CTCF ZNF654 WRNIP1 ARID4B TRIM22 REST ZNF2 RAD21 PITHD1 ELOA-AS1 LYPLA2 GC01P023754 ELOA
GH01F023930 1.3 Ensembl ENCODE 11.4 +140.5 140516 2.2 ZNF664 ZNF362 ZMYM3 CEBPB ZBTB33 FOS ZNF18 PNRC2 FUCA1 SRSF10 LYPLA2 GC01P023930 ENSG00000230228
GH01F023789 0.5 ENCODE 0.8 +1.1 1084 5.4 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 RPL11 ID3 FUCA1 TCEA3 LYPLA2 LOC105376860
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LYPLA2 on UCSC Golden Path with GeneCards custom track

Promoters for LYPLA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001518332 815 1601 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A YY1 ZNF143 ZNF207

Genomic Location for LYPLA2 Gene

Chromosome:
1
Start:
23,790,785 bp from pter
End:
23,795,539 bp from pter
Size:
4,755 bases
Orientation:
Plus strand

Genomic View for LYPLA2 Gene

Genes around LYPLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPLA2 Gene

Proteins for LYPLA2 Gene

  • Protein details for LYPLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95372-LYPA2_HUMAN
    Recommended name:
    Acyl-protein thioesterase 2
    Protein Accession:
    O95372
    Secondary Accessions:
    • Q7Z4Z2

    Protein attributes for LYPLA2 Gene

    Size:
    231 amino acids
    Molecular mass:
    24737 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97210.1; Type=Frameshift; Positions=5, 164, 179; Evidence={ECO:0000305};

neXtProt entry for LYPLA2 Gene

Selected DME Specific Peptides for LYPLA2 Gene

O95372:
  • IVLGGFS
  • AAENIKALI
  • ALSCWLPL
  • VIFLHGL
  • KYICPHAP
  • LGGFSQGGALSLYTALT
  • FLHGLGD

Post-translational modifications for LYPLA2 Gene

  • Ubiquitination at Lys 108 and Lys 190
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for LYPLA2
  • Cloud-Clone Corp. Antibodies for LYPLA2

Domains & Families for LYPLA2 Gene

Protein Domains for LYPLA2 Gene

Suggested Antigen Peptide Sequences for LYPLA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95372

UniProtKB/Swiss-Prot:

LYPA2_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
genes like me logo Genes that share domains with LYPLA2: view

No data available for Gene Families for LYPLA2 Gene

Function for LYPLA2 Gene

Molecular function for LYPLA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-protein + H(2)O = palmitate + protein.
UniProtKB/Swiss-Prot Function:
May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.

Enzyme Numbers (IUBMB) for LYPLA2 Gene

Gene Ontology (GO) - Molecular Function for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008474 palmitoyl-(protein) hydrolase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IBA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with LYPLA2: view
genes like me logo Genes that share phenotypes with LYPLA2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYPLA2 Gene

Localization for LYPLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPLA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYPLA2 Gene COMPARTMENTS Subcellular localization image for LYPLA2 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
peroxisome 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IBA 25468996
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LYPLA2: view

Pathways & Interactions for LYPLA2 Gene

genes like me logo Genes that share pathways with LYPLA2: view

Pathways by source for LYPLA2 Gene

3 Reactome pathways for LYPLA2 Gene
1 KEGG pathway for LYPLA2 Gene

Interacting Proteins for LYPLA2 Gene

Gene Ontology (GO) - Biological Process for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IBA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with LYPLA2: view

No data available for SIGNOR curated interactions for LYPLA2 Gene

Drugs & Compounds for LYPLA2 Gene

(3) Drugs for LYPLA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Choline alfoscerate Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(33) Additional Compounds for LYPLA2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • 1-Palmitoyl-glycero-3-phosphocholine
  • 1-Palmitoyl-lysophosphatidylcholine
  • LPC(16:0)
  • LPC(16:0/0:0)
  • LyPC(16:0)
genes like me logo Genes that share compounds with LYPLA2: view

Transcripts for LYPLA2 Gene

Unigene Clusters for LYPLA2 Gene

Lysophospholipase II:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPLA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for LYPLA2 Gene

GeneLoc Exon Structure for
LYPLA2
ECgene alternative splicing isoforms for
LYPLA2

Expression for LYPLA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYPLA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYPLA2 Gene

This gene is overexpressed in Bone (14.6) and Urine (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LYPLA2 Gene



Protein tissue co-expression partners for LYPLA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYPLA2 Gene:

LYPLA2

SOURCE GeneReport for Unigene cluster for LYPLA2 Gene:

Hs.533479
genes like me logo Genes that share expression patterns with LYPLA2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LYPLA2 Gene

Orthologs for LYPLA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LYPLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYPLA2 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia LYPLA2 34 35
  • 96.25 (n)
cow
(Bos Taurus)
Mammalia LYPLA2 34 35
  • 94.52 (n)
mouse
(Mus musculus)
Mammalia Lypla2 34 16 35
  • 93.36 (n)
rat
(Rattus norvegicus)
Mammalia Lypla2 34
  • 92.78 (n)
oppossum
(Monodelphis domestica)
Mammalia LYPLA2 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYPLA2 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LYPLA2 34 35
  • 81.24 (n)
lizard
(Anolis carolinensis)
Reptilia LYPLA2 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lypla2 34
  • 72.01 (n)
MGC75683 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52664 34
zebrafish
(Danio rerio)
Actinopterygii lypla2 34 35
  • 73.3 (n)
zgc73210 34
fruit fly
(Drosophila melanogaster)
Insecta CG18815 36 34 35
  • 59.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012126 34
  • 55.61 (n)
worm
(Caenorhabditis elegans)
Secernentea K04G2.5 36
  • 45 (a)
ath-1 35
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 32 (a)
OneToMany
-- 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G20060 34
  • 46.5 (n)
rice
(Oryza sativa)
Liliopsida Os01g0175000 34
  • 47.67 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02027 34
  • 56.25 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8E11.04c 34
  • 47.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2523 35
  • 47 (a)
OneToMany
Species where no ortholog for LYPLA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYPLA2 Gene

ENSEMBL:
Gene Tree for LYPLA2 (if available)
TreeFam:
Gene Tree for LYPLA2 (if available)

Paralogs for LYPLA2 Gene

Paralogs for LYPLA2 Gene

(1) SIMAP similar genes for LYPLA2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LYPLA2: view

Variants for LYPLA2 Gene

Sequence variations from dbSNP and Humsavar for LYPLA2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1049988 -- 23,795,695(-) AGGCT(C/T)TGGCA downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1063433 -- 23,795,111(+) GGCCC(C/T)CCCAG downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs112266814 -- 23,792,974(+) GGAAG(A/C)CTTCC intron-variant
rs115000504 -- 23,794,349(+) CCCCC(A/C/T)GCCCT intron-variant, upstream-variant-2KB
rs115182190 -- 23,789,342(+) ACCTT(C/G)TTGGC upstream-variant-2KB

Variation tolerance for LYPLA2 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYPLA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYPLA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LYPLA2 Gene

Disorders for LYPLA2 Gene

Relevant External Links for LYPLA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYPLA2

No disorders were found for LYPLA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYPLA2 Gene

Publications for LYPLA2 Gene

  1. Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. (PMID: 21152083) Tomatis V.M. … Daniotti J.L. (PLoS ONE 2010) 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Enzymatic protein depalmitoylation by acyl protein thioesterases. (PMID: 25849916) Lin D.T. … Conibear E. (Biochem. Soc. Trans. 2015) 3 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for LYPLA2 Gene

Sources for LYPLA2 Gene

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