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Aliases for LYPLA1 Gene

Aliases for LYPLA1 Gene

  • Lysophospholipase I 2 3 4 5
  • LysoPLA I 3 4
  • APT-1 3 4
  • LPL-I 3 4
  • HAPT1 3 4
  • APT1 3 4
  • LPL1 3 4
  • Lysophospholipid-Specific Lysophospholipase 3
  • Lysophospholipase 1 4
  • EC 3.1.2.- 4
  • EC 3.1.2 63

External Ids for LYPLA1 Gene

Previous GeneCards Identifiers for LYPLA1 Gene

  • GC08M054231
  • GC08M054898
  • GC08M054682
  • GC08M055008
  • GC08M055121
  • GC08M050427

Summaries for LYPLA1 Gene

Entrez Gene Summary for LYPLA1 Gene

  • This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

GeneCards Summary for LYPLA1 Gene

LYPLA1 (Lysophospholipase I) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is LYPLA2.

UniProtKB/Swiss-Prot for LYPLA1 Gene

  • Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.

Gene Wiki entry for LYPLA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPLA1 Gene

Genomics for LYPLA1 Gene

Regulatory Elements for LYPLA1 Gene

Promoters for LYPLA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LYPLA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LYPLA1 Gene

Chromosome:
8
Start:
54,046,367 bp from pter
End:
54,102,017 bp from pter
Size:
55,651 bases
Orientation:
Minus strand

Genomic View for LYPLA1 Gene

Genes around LYPLA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPLA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPLA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPLA1 Gene

Proteins for LYPLA1 Gene

  • Protein details for LYPLA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75608-LYPA1_HUMAN
    Recommended name:
    Acyl-protein thioesterase 1
    Protein Accession:
    O75608
    Secondary Accessions:
    • O43202
    • Q9UQF9

    Protein attributes for LYPLA1 Gene

    Size:
    230 amino acids
    Molecular mass:
    24670 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAB88180.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYPLA1 Gene

    Alternative splice isoforms for LYPLA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYPLA1 Gene

Proteomics data for LYPLA1 Gene at MOPED

Post-translational modifications for LYPLA1 Gene

  • Ubiquitination at Lys 105
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for LYPLA1 Gene

Protein Domains for LYPLA1 Gene

Graphical View of Domain Structure for InterPro Entry

O75608

UniProtKB/Swiss-Prot:

LYPA1_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
genes like me logo Genes that share domains with LYPLA1: view

No data available for Gene Families for LYPLA1 Gene

Function for LYPLA1 Gene

Molecular function for LYPLA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-protein + H(2)O = palmitate + protein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by palmostatin-B, leading to impair depalmitoylating of Ras.
UniProtKB/Swiss-Prot Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.

Enzyme Numbers (IUBMB) for LYPLA1 Gene

Gene Ontology (GO) - Molecular Function for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity TAS 10064899
genes like me logo Genes that share ontologies with LYPLA1: view
genes like me logo Genes that share phenotypes with LYPLA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LYPLA1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYPLA1 Gene

Localization for LYPLA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPLA1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYPLA1 Gene COMPARTMENTS Subcellular localization image for LYPLA1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LYPLA1: view

Pathways & Interactions for LYPLA1 Gene

genes like me logo Genes that share pathways with LYPLA1: view

Pathways by source for LYPLA1 Gene

Interacting Proteins for LYPLA1 Gene

Gene Ontology (GO) - Biological Process for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IBA --
GO:0006631 fatty acid metabolic process IEA --
GO:0008152 metabolic process IEA --
GO:0046209 nitric oxide metabolic process TAS --
genes like me logo Genes that share ontologies with LYPLA1: view

No data available for SIGNOR curated interactions for LYPLA1 Gene

Drugs & Compounds for LYPLA1 Gene

(1) Drugs for LYPLA1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Experimental Pharma Full agonist, Agonist 20

(36) Additional Compounds for LYPLA1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glycerophosphocholine
  • 2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt
  • a-Glycerophosphorylcholine
  • a-Glycerylphosphorylcholine
  • alpha-Glycerophosphorylcholine
  • alpha-Glycerylphosphorylcholine
28319-77-9
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
genes like me logo Genes that share compounds with LYPLA1: view

Transcripts for LYPLA1 Gene

Unigene Clusters for LYPLA1 Gene

Lysophospholipase I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LYPLA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9:
SP10: -

Relevant External Links for LYPLA1 Gene

GeneLoc Exon Structure for
LYPLA1
ECgene alternative splicing isoforms for
LYPLA1

Expression for LYPLA1 Gene

mRNA expression in normal human tissues for LYPLA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYPLA1 Gene

This gene is overexpressed in Bone (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LYPLA1 Gene



SOURCE GeneReport for Unigene cluster for LYPLA1 Gene Hs.744046

genes like me logo Genes that share expression patterns with LYPLA1: view

Protein tissue co-expression partners for LYPLA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LYPLA1 Gene

Orthologs for LYPLA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LYPLA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYPLA1 35
  • 99.13 (n)
  • 99.13 (a)
cow
(Bos Taurus)
Mammalia LYPLA1 35
  • 87.25 (n)
  • 93.91 (a)
-- 36
  • 86 (a)
OneToMany
LYPLA1 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LYPLA1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lypla1 36
  • 92 (a)
OneToOne
Lypla1 16
Lypla1 35
  • 88.55 (n)
  • 91.74 (a)
oppossum
(Monodelphis domestica)
Mammalia LYPLA1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYPLA1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lypla1 35
  • 88.99 (n)
  • 92.17 (a)
chicken
(Gallus gallus)
Aves LYPLA1 36
  • 76 (a)
OneToOne
LOC770321 35
  • 78.6 (n)
  • 85.59 (a)
lizard
(Anolis carolinensis)
Reptilia LYPLA1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lypla1 35
  • 74.35 (n)
  • 80.87 (a)
Str.355 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15000 35
lypla1 35
  • 74.02 (n)
  • 77.95 (a)
lypla1 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18815 36
  • 50 (a)
OneToMany
CG18815 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea K04G2.5 37
  • 49 (a)
ath-1 36
  • 48 (a)
OneToMany
ath-1 35
  • 56.09 (n)
  • 50.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YLR118C 35
  • 46.76 (n)
  • 38.35 (a)
-- 36
  • 35 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17908g 35
  • 48.78 (n)
  • 36.24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G22305 35
  • 49.16 (n)
  • 36.87 (a)
rice
(Oryza sativa)
Liliopsida Os04g0669500 35
  • 47.55 (n)
  • 38.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2523 36
  • 47 (a)
OneToMany
Species with no ortholog for LYPLA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYPLA1 Gene

ENSEMBL:
Gene Tree for LYPLA1 (if available)
TreeFam:
Gene Tree for LYPLA1 (if available)

Paralogs for LYPLA1 Gene

Paralogs for LYPLA1 Gene

(1) SIMAP similar genes for LYPLA1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for LYPLA1 Gene

genes like me logo Genes that share paralogs with LYPLA1: view

Variants for LYPLA1 Gene

Sequence variations from dbSNP and Humsavar for LYPLA1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs11549448 - 54,052,660(-) CCTTT(C/T)CACAG intron-variant, reference, missense
rs1828835 -- 54,102,904(-) GGAGT(A/G)TTACA upstream-variant-2KB
rs4014133 -- 54,065,459(-) tattt(-/A/ATTT/ATTTATTT)NNNNN intron-variant
rs4427146 -- 54,087,972(+) tcaca(A/T)tctgt intron-variant
rs4506187 -- 54,049,767(+) TTCCT(C/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LYPLA1 Gene

Variant ID Type Subtype PubMed ID
essv22151 CNV CNV 17122850
esv2349042 CNV Deletion 18987734
esv4675 CNV Deletion 18987735
esv2737007 CNV Deletion 23290073
esv2667256 CNV Deletion 23128226
esv6149 CNV Loss 19470904
dgv7798n71 CNV Loss 21882294
nsv890922 CNV Loss 21882294

Variation tolerance for LYPLA1 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYPLA1 Gene

HapMap Linkage Disequilibrium report
LYPLA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYPLA1 Gene

Disorders for LYPLA1 Gene

Relevant External Links for LYPLA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYPLA1

No disorders were found for LYPLA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYPLA1 Gene

Publications for LYPLA1 Gene

  1. Small-molecule inhibition of APT1 affects Ras localization and signaling. (PMID: 20418879) Dekker F.J. … Waldmann H. (Nat. Chem. Biol. 2010) 3 4 23 67
  2. A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization. (PMID: 10064899) Wang A. … Dennis E.A. (Biochim. Biophys. Acta 1999) 2 3 23
  3. Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1. (PMID: 19439193) Hirano T. … Izumi T. (Biochim. Biophys. Acta 2009) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for LYPLA1 Gene

Sources for LYPLA1 Gene

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