Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LYPLA1 Gene

Aliases for LYPLA1 Gene

  • Lysophospholipase I 2 3 4 5
  • Acyl-Protein Thioesterase 1 2 3
  • LysoPLA I 3 4
  • APT-1 3 4
  • LPL-I 3 4
  • HAPT1 3 4
  • APT1 3 4
  • LPL1 3 4
  • Lysophospholipid-Specific Lysophospholipase 3
  • Lysophospholipase 1 4
  • EC 3.1.2.- 4
  • EC 3.1.2 61

External Ids for LYPLA1 Gene

Previous GeneCards Identifiers for LYPLA1 Gene

  • GC08M054231
  • GC08M054898
  • GC08M054682
  • GC08M055008
  • GC08M055121
  • GC08M050427

Summaries for LYPLA1 Gene

Entrez Gene Summary for LYPLA1 Gene

  • This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

GeneCards Summary for LYPLA1 Gene

LYPLA1 (Lysophospholipase I) is a Protein Coding gene. Among its related pathways are eNOS activation and regulation and Glycerophospholipid biosynthesis. GO annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is LYPLA2.

UniProtKB/Swiss-Prot for LYPLA1 Gene

  • Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.

Gene Wiki entry for LYPLA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPLA1 Gene

Genomics for LYPLA1 Gene

Regulatory Elements for LYPLA1 Gene

Enhancers for LYPLA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G054883 0.4 ENCODE 5 -780.3 -780299 0.2 CREB1 LYPLA1 LOC105375842 GC08P055061
GH08G054105 1.1 FANTOM5 ENCODE 0.7 -4.5 -4502 1.7 HDAC1 TBP PKNOX1 ELK1 FOS USF2 ZEB2 HDAC8 ZNF592 POLR2H MRPL15 TCEA1 RGS20 ATP6V1H PIR33175 LYPLA1
GH08G054100 1 ENCODE 0.7 +0.6 585 2.7 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF766 GLIS2 ELK1 TCEA1 MRPL15 LYPLA1 TDGF1P5
GH08G054098 0.4 ENCODE 0.7 +3.7 3742 0.2 ZNF3 NCOR1 MRPL15 TCEA1 LYPLA1 TDGF1P5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LYPLA1 on UCSC Golden Path with GeneCards custom track

Promoters for LYPLA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000224642 617 2001 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF766 GLIS2 ELK1

Genomic Location for LYPLA1 Gene

Chromosome:
8
Start:
54,046,367 bp from pter
End:
54,102,017 bp from pter
Size:
55,651 bases
Orientation:
Minus strand

Genomic View for LYPLA1 Gene

Genes around LYPLA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPLA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPLA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPLA1 Gene

Proteins for LYPLA1 Gene

  • Protein details for LYPLA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75608-LYPA1_HUMAN
    Recommended name:
    Acyl-protein thioesterase 1
    Protein Accession:
    O75608
    Secondary Accessions:
    • O43202
    • Q9UQF9

    Protein attributes for LYPLA1 Gene

    Size:
    230 amino acids
    Molecular mass:
    24670 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAB88180.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYPLA1 Gene

    Alternative splice isoforms for LYPLA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYPLA1 Gene

Selected DME Specific Peptides for LYPLA1 Gene

O75608:
  • GMMHSSCQQEMMD
  • HGLGDTGHGWA
  • DPLVPLMFGSLT
  • AAENIKALI
  • ALSCWLPL
  • VIFLHGL
  • KYICPHAP
  • LGGFSQGGALSLYTALT
  • FLHGLGD

Post-translational modifications for LYPLA1 Gene

  • Ubiquitination at Lys105
  • Modification sites at PhosphoSitePlus

Domains & Families for LYPLA1 Gene

Protein Domains for LYPLA1 Gene

Graphical View of Domain Structure for InterPro Entry

O75608

UniProtKB/Swiss-Prot:

LYPA1_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
genes like me logo Genes that share domains with LYPLA1: view

No data available for Gene Families for LYPLA1 Gene

Function for LYPLA1 Gene

Molecular function for LYPLA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-protein + H(2)O = palmitate + protein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by palmostatin-B, leading to impair depalmitoylating of Ras.
UniProtKB/Swiss-Prot Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.

Enzyme Numbers (IUBMB) for LYPLA1 Gene

Gene Ontology (GO) - Molecular Function for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity TAS 10064899
GO:0005515 protein binding IPI --
GO:0008474 palmitoyl-(protein) hydrolase activity TAS --
GO:0016298 lipase activity IDA 24682756
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with LYPLA1: view
genes like me logo Genes that share phenotypes with LYPLA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LYPLA1

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYPLA1 Gene

Localization for LYPLA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPLA1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYPLA1 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
peroxisome 2
nucleus 2

Gene Ontology (GO) - Cellular Components for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LYPLA1: view

Pathways & Interactions for LYPLA1 Gene

genes like me logo Genes that share pathways with LYPLA1: view

Pathways by source for LYPLA1 Gene

Gene Ontology (GO) - Biological Process for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IBA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0042997 negative regulation of Golgi to plasma membrane protein transport IEA --
GO:0050999 regulation of nitric-oxide synthase activity TAS --
genes like me logo Genes that share ontologies with LYPLA1: view

No data available for SIGNOR curated interactions for LYPLA1 Gene

Drugs & Compounds for LYPLA1 Gene

(3) Drugs for LYPLA1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Choline alfoscerate Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(34) Additional Compounds for LYPLA1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • 1-Palmitoyl-glycero-3-phosphocholine
  • 1-Palmitoyl-lysophosphatidylcholine
  • LPC(16:0)
  • LPC(16:0/0:0)
  • LyPC(16:0)
genes like me logo Genes that share compounds with LYPLA1: view

Transcripts for LYPLA1 Gene

Unigene Clusters for LYPLA1 Gene

Lysophospholipase I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPLA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9:
SP10: -

Relevant External Links for LYPLA1 Gene

GeneLoc Exon Structure for
LYPLA1
ECgene alternative splicing isoforms for
LYPLA1

Expression for LYPLA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYPLA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYPLA1 Gene

This gene is overexpressed in Bone (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LYPLA1 Gene



Protein tissue co-expression partners for LYPLA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYPLA1 Gene:

LYPLA1

SOURCE GeneReport for Unigene cluster for LYPLA1 Gene:

Hs.744046

Evidence on tissue expression from TISSUES for LYPLA1 Gene

  • Nervous system(4.6)
  • Blood(4.3)
  • Bone marrow(4.2)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with LYPLA1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYPLA1 Gene

Orthologs for LYPLA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LYPLA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYPLA1 34
  • 99.13 (n)
oppossum
(Monodelphis domestica)
Mammalia LYPLA1 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LYPLA1 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lypla1 34
  • 88.99 (n)
mouse
(Mus musculus)
Mammalia Lypla1 34 16 35
  • 88.55 (n)
cow
(Bos Taurus)
Mammalia LYPLA1 34 35
  • 87.25 (n)
-- 35
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia LYPLA1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC770321 34
  • 78.6 (n)
LYPLA1 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LYPLA1 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lypla1 34
  • 74.35 (n)
Str.355 34
zebrafish
(Danio rerio)
Actinopterygii lypla1 34 35
  • 74.02 (n)
Dr.15000 34
fruit fly
(Drosophila melanogaster)
Insecta CG18815 36 35
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea ath-1 34 35
  • 56.09 (n)
K04G2.5 36
  • 49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17908g 34
  • 48.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YLR118C 34
  • 46.76 (n)
-- 35
  • 35 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G22305 34
  • 49.16 (n)
rice
(Oryza sativa)
Liliopsida Os04g0669500 34
  • 47.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2523 35
  • 47 (a)
OneToMany
Species where no ortholog for LYPLA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYPLA1 Gene

ENSEMBL:
Gene Tree for LYPLA1 (if available)
TreeFam:
Gene Tree for LYPLA1 (if available)

Paralogs for LYPLA1 Gene

Paralogs for LYPLA1 Gene

(1) SIMAP similar genes for LYPLA1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for LYPLA1 Gene

genes like me logo Genes that share paralogs with LYPLA1: view

Variants for LYPLA1 Gene

Sequence variations from dbSNP and Humsavar for LYPLA1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000059847 -- 54,072,875(+) CTCAG(G/T)AGGCT intron-variant
rs1000111910 -- 54,073,104(+) GGCCA(A/T)CAGGA intron-variant
rs1000124359 -- 54,066,152(+) CAGGA(C/T)GGTCT intron-variant
rs1000139836 -- 54,046,336(+) CAAAT(A/G)TTAAC downstream-variant-500B, upstream-variant-2KB
rs1000177438 -- 54,066,398(+) TCACA(A/G)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LYPLA1 Gene

Variant ID Type Subtype PubMed ID
esv2349042 CNV deletion 18987734
esv2667256 CNV deletion 23128226
esv2737007 CNV deletion 23290073
esv2759617 CNV gain 17122850
esv3543508 CNV deletion 23714750
esv3576573 CNV gain 25503493
esv4675 CNV loss 18987735
esv6149 CNV loss 19470904
nsv1026869 CNV gain 25217958
nsv1077043 CNV deletion 25765185
nsv1119178 CNV deletion 24896259
nsv1137366 CNV deletion 24896259
nsv1152591 CNV deletion 26484159
nsv956051 CNV deletion 24416366
nsv967590 CNV duplication 23825009
nsv971309 CNV duplication 23825009

Variation tolerance for LYPLA1 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYPLA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYPLA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYPLA1 Gene

Disorders for LYPLA1 Gene

Relevant External Links for LYPLA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYPLA1

No disorders were found for LYPLA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYPLA1 Gene

Publications for LYPLA1 Gene

  1. Small-molecule inhibition of APT1 affects Ras localization and signaling. (PMID: 20418879) Dekker F.J. … Waldmann H. (Nat. Chem. Biol. 2010) 3 4 22 64
  2. A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization. (PMID: 10064899) Wang A. … Dennis E.A. (Biochim. Biophys. Acta 1999) 2 3 22 64
  3. Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1. (PMID: 19439193) Hirano T. … Izumi T. (Biochim. Biophys. Acta 2009) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64

Products for LYPLA1 Gene

Sources for LYPLA1 Gene

Content
Loading form....