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Aliases for LYPD8 Gene

Aliases for LYPD8 Gene

  • LY6/PLAUR Domain Containing 8 2 3 5

External Ids for LYPD8 Gene

Previous GeneCards Identifiers for LYPD8 Gene

  • GC01M248882
  • GC01M248902

Summaries for LYPD8 Gene

GeneCards Summary for LYPD8 Gene

LYPD8 (LY6/PLAUR Domain Containing 8) is a Protein Coding gene. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Metabolism of proteins.

UniProtKB/Swiss-Prot for LYPD8 Gene

  • Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPD8 Gene

Genomics for LYPD8 Gene

Regulatory Elements for LYPD8 Gene

Enhancers for LYPD8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G248731 0.7 ENCODE 0.3 +24.6 24638 0.2 ATF1 E2F1 POLR2A KDM5B NR2F6 PHF8 ZBTB2 L3MBTL2 NRF1 ZNF592 OR14I1 LOC101928226 AHCYP8 LYPD8
GH01G248752 0.2 Ensembl 0.7 +3.5 3492 0.2 LYPD8 AHCYP8
GH01G248740 0.2 Ensembl 0.4 +15.7 15692 0.2 LYPD8 AHCYP8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LYPD8 on UCSC Golden Path with GeneCards custom track

Genomic Location for LYPD8 Gene

Chromosome:
1
Start:
248,718,649 bp from pter
End:
248,755,792 bp from pter
Size:
37,144 bases
Orientation:
Minus strand

Genomic View for LYPD8 Gene

Genes around LYPD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPD8 Gene

Proteins for LYPD8 Gene

  • Protein details for LYPD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX82-LYPD8_HUMAN
    Recommended name:
    Ly6/PLAUR domain-containing protein 8
    Protein Accession:
    Q6UX82
    Secondary Accessions:
    • A0A075B722
    • K7ELG6

    Protein attributes for LYPD8 Gene

    Size:
    237 amino acids
    Molecular mass:
    25265 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LYPD8 Gene

Post-translational modifications for LYPD8 Gene

  • GPI-anchored. The GPI-anchor is cleaved, leading to secretion into the colonic lumen.
  • Highly N-glycosylated. Not O-glycosylated.
  • Glycosylation at Asn45, Asn73, posLast=107107, posLast=118118, Asn132, posLast=172172, posLast=175175, and posLast=185185
  • Modification sites at PhosphoSitePlus

Other Protein References for LYPD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LYPD8 Gene

Domains & Families for LYPD8 Gene

Gene Families for LYPD8 Gene

Protein Domains for LYPD8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6UX82

UniProtKB/Swiss-Prot:

LYPD8_HUMAN :
  • Belongs to the CNF-like-inhibitor family.
Family:
  • Belongs to the CNF-like-inhibitor family.
genes like me logo Genes that share domains with LYPD8: view

No data available for Suggested Antigen Peptide Sequences for LYPD8 Gene

Function for LYPD8 Gene

Molecular function for LYPD8 Gene

UniProtKB/Swiss-Prot Function:
Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.

Phenotypes for LYPD8 Gene

MGI mutant phenotypes for LYPD8:
inferred from 1 alleles
GenomeRNAi human phenotypes for LYPD8:
genes like me logo Genes that share phenotypes with LYPD8: view

Animal Models for LYPD8 Gene

MGI Knock Outs for LYPD8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LYPD8 Gene

Localization for LYPD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPD8 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted into the lumen of the colon following cleavage of the GPI-anchor. {ECO:0000250 UniProtKB:Q9D7S0}.

Gene Ontology (GO) - Cellular Components for LYPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,ISS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with LYPD8: view

No data available for Subcellular locations from COMPARTMENTS for LYPD8 Gene

Pathways & Interactions for LYPD8 Gene

genes like me logo Genes that share pathways with LYPD8: view

Interacting Proteins for LYPD8 Gene

Gene Ontology (GO) - Biological Process for LYPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0050829 defense response to Gram-negative bacterium IEA,ISS --
genes like me logo Genes that share ontologies with LYPD8: view

No data available for SIGNOR curated interactions for LYPD8 Gene

Drugs & Compounds for LYPD8 Gene

No Compound Related Data Available

Transcripts for LYPD8 Gene

mRNA/cDNA for LYPD8 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LYPD8 Gene

LY6/PLAUR domain containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPD8 Gene

No ASD Table

Relevant External Links for LYPD8 Gene

GeneLoc Exon Structure for
LYPD8
ECgene alternative splicing isoforms for
LYPD8

Expression for LYPD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYPD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYPD8 Gene

This gene is overexpressed in Colon - Transverse (x43.6) and Small Intestine - Terminal Ileum (x5.4).

Protein differential expression in normal tissues from HIPED for LYPD8 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LYPD8 Gene



Protein tissue co-expression partners for LYPD8 Gene

NURSA nuclear receptor signaling pathways regulating expression of LYPD8 Gene:

LYPD8

SOURCE GeneReport for Unigene cluster for LYPD8 Gene:

Hs.146268

mRNA Expression by UniProt/SwissProt for LYPD8 Gene:

Q6UX82-LYPD8_HUMAN
Tissue specificity: Expressed in the large intestine. Preferentially expressed on the epithelial layer exposed to the lumen (at protein level).
genes like me logo Genes that share expression patterns with LYPD8: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYPD8 Gene

Orthologs for LYPD8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LYPD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYPD8 34
  • 98.87 (n)
dog
(Canis familiaris)
Mammalia LYPD8 34
  • 72.66 (n)
cow
(Bos Taurus)
Mammalia LYPD8 34
  • 69.57 (n)
rat
(Rattus norvegicus)
Mammalia Lypd8 34
  • 60.89 (n)
mouse
(Mus musculus)
Mammalia Lypd8 34 16
  • 58.46 (n)
Species where no ortholog for LYPD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYPD8 Gene

ENSEMBL:
Gene Tree for LYPD8 (if available)
TreeFam:
Gene Tree for LYPD8 (if available)

Paralogs for LYPD8 Gene

No data available for Paralogs for LYPD8 Gene

Variants for LYPD8 Gene

Sequence variations from dbSNP and Humsavar for LYPD8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000141378 -- 248,749,399(+) TATGT(C/G)TCTTA intron-variant
rs1000316916 -- 248,755,987(+) CTTTG(A/G)CAAAA upstream-variant-2KB
rs1000323397 -- 248,741,591(+) AAAAA(G/T)AAACA intron-variant
rs1000862557 -- 248,746,145(+) TTATT(G/T)TGGCA intron-variant
rs1000920816 -- 248,754,534(+) CACAT(C/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LYPD8 Gene

Variant ID Type Subtype PubMed ID
dgv631n100 CNV gain 25217958
esv2259520 CNV deletion 18987734
esv2656577 CNV deletion 23128226
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv3426049 CNV duplication 20981092
esv3589566 CNV loss 21293372
esv3589570 CNV loss 21293372
esv3589571 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1013273 CNV gain 25217958

Relevant External Links for LYPD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYPD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for LYPD8 Gene

Disorders for LYPD8 Gene

Relevant External Links for LYPD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYPD8

No disorders were found for LYPD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYPD8 Gene

Publications for LYPD8 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  2. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. (PMID: 27027293) Okumura R. … Takeda K. (Nature 2016) 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64

Products for LYPD8 Gene

Sources for LYPD8 Gene

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