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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LYPD4 Gene

protein-coding GIFtS: 47
GCID: GC19M042341

LY6/PLAUR domain containing 4

Explore 5 diseases affiliated with
LYPD4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
LY6/PLAUR Domain Containing 4¹ ²
MGC42718¹
SMR²
Ly6/PLAUR Domain-Containing Protein 4²
Sperm Membrane Receptor²

External Ids:	HGNC: 28659¹	Entrez Gene: 147719²	Ensembl: ENSG00000183103⁷	UniProtKB: Q6UWN0³

Export aliases for LYPD4 gene to outside databases

Previous GC identifers: GC19M047033 GC19M038774

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LYPD4 gene promoter:
PPAR-alpha GR p53 GR-beta GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LYPD4 promoter sequence

Search SABiosciences Chromatin IP Primers for LYPD4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LYPD4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

LYPD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYPD4 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M042341: view genomic region (about GC identifiers)

Start:	42,341,148 bp from pter	End:	42,348,736 bp from pter
Size:	7,589 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LYPD4_HUMAN, Q6UWN0 (See protein sequence)

Recommended Name: Ly6/PLAUR domain-containing protein 4 precursor

Size: 246 amino acids; 26763 Da

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential)

Secondary accessions: Q8IYW0

Alternative splicing: 2 isoforms: Q6UWN0-1 Q6UWN0-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LYPD4: NX_Q6UWN0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UWN0

LYPD4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775777.3

ENSEMBL proteins:

ENSP00000328737 ENSP00000339568

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0031225	anchored to membrane	IEA	--

LYPD4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LYPD4 for domains About GeneDecksing

1 InterPro domain/family:

IPR001526 LY6_UPAR

Graphical View of Domain Structure for InterPro Entry Q6UWN0

ProtoNet protein and cluster: Q6UWN0

1 Blocks protein family: IPB001526 CD59 antigen

UniProtKB/Swiss-Prot: LYPD4_HUMAN, Q6UWN0

Similarity: Contains 1 UPAR/Ly6 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
2 GenomeRNAi human phenotypes for LYPD4:

Decreased Tat-dependent transc

Decreased p24 protein expressi

1 MGI phenotypic allele

for Lypd4 (no phenotypes)

LYPD4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Lypd4^tm1Lex for LYPD4

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LYPD4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for LYPD4 (ENSP00000328737⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SHBG	ENSP00000369816⁴	STRING: ENSP00000369816

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LYPD4
Search CenterWatch for drugs/clinical trials and news about LYPD4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LYPD4 gene:

NM_173506.4

Unigene Cluster for LYPD4:

LY6/PLAUR domain containing 4

Hs.98660 [show with all ESTs]

Unigene Representative Sequence: AK292305

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000330743(uc002orp.1 uc002orq.1) ENST00000343055

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Additional cDNA sequence:

AK292305.1 AY358726.1 AY771680.1 BC034629.2

3 DOTS entries:

DT.110445 DT.97812100 DT.121491242

23 AceView cDNA sequences:

AA430173 AA813342 BC034629 AA759304 AA431328 AI688054 AA725624 BX280836

AA431616 BI831626 AY358726 NM_173506 BX283069 AI335754 AA912641 BG211938

BG722930 AI014589 BU852651 AA923430 AI656828 AW340541 BQ376364

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for LYPD4 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6
SP1:					-				-
SP2:											-

ECgene alternative splicing isoforms for LYPD4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LYPD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTGTGCTC

About this image

LYPD4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Mature Sertoli Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LYPD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LYPD4

SOURCE GeneReport for Unigene cluster: Hs.98660

SABiosciences Custom PCR Arrays for LYPD4

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for LYPD4 (if available)
TreeFam Gene Tree for LYPD4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LYPD4 gene

CD177² CD177P1² TEX101²

2 SIMAP similar genes for LYPD4 using alignment to 1 protein entry: LYPD4_HUMAN:

SMR CD177

LYPD4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12976571^1,2	C,F,A,H	--	42340769(+)	`ATTCGA/GGACCA`	1	--	ds500¹		15		NS EA NA WA CSA	792
rs8104958^1,2	C,F,A,H	--	42340805(+)	`CCCCAT/CGTCAA`	1	--	ds500¹		22		NS EA NA WA CSA	2347
rs138973275^1,2		--	42340945(+)	`GACCCG/TGATTA`	1	--	ds500¹		0	--	--	--	--
rs142105726^1,2		--	42341141(+)	`CAGGAC/TAATGC`	1	--	ds500¹		0	--	--	--	--
rs150431199^1,2		--	42341153(+)	`GAAAGA/GGAACT`	1	--	ut3¹		0	--	--	--	--
rs200694458^1,2		--	42341203(+)	`GTCGGA/GTGCAG`	1	--	ut3¹		0	--	--	--	--
rs138182532^1,2	C	--	42341205(+)	`CGGGTA/GCAGCT`	1	--	ut3¹		0	--	--	--	--
rs143131074^1,2	C	--	42341219(+)	`TGGTCA/GGTCCC`	2	R *	stop-lost		1		NA	4552
rs148256898^1,2	C	--	42341250(+)	`AAGACG/AACACC`	2	/V	syn¹		1		NA	4552
rs186047531^1,2	C	--	42341287(+)	`CTGCAC/TCAACA`	2	D G	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LYPD4 (42341148 - 42348736 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LYPD4: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LYPD4 for disorders About GeneDecksing

5 diseases for LYPD4: About MalaCards

erysipeloid gnathomiasis angiostrongyliasis paragonimiasis

erysipelas

Human Genome Epidemiology (HuGE) Navigator: LYPD4 (1 document)

Export disorders for LYPD4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LYPD4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LYPD4)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)¹ Girard A....Carmell M.A. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 147719	HGNC: 28659	AceView: MGC42718	Ensembl:ENSG00000183103	euGenes: HUgn147719
ECgene: LYPD4	H-InvDB: LYPD4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LYPD4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LYPD4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LYPD4 gene:
Search GeneIP for patents involving LYPD4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LYPD4 gene at Home site.

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LYPD4 Gene

LY6/PLAUR domain containing 4

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LYPD4 Gene

LY6/PLAUR domain containing 4

Aliasesfor LYPD4 gene

Summariesfor LYPD4 gene

Genomic Viewsfor LYPD4 gene

Proteinsfor LYPD4 gene

Protein Domains /Familiesfor LYPD4 gene

Functionfor LYPD4 gene

Pathways & Interactionsfor LYPD4 gene

Drugs & Compoundsfor LYPD4 gene

Transcriptsfor LYPD4 gene

Expression for LYPD4 gene

Orthologsfor LYPD4 gene

Paralogsfor LYPD4 gene

Genomic Variantsfor LYPD4 gene

Disorders / Diseasesfor LYPD4 gene

Publicationsfor LYPD4 gene

External Searches for LYPD4 gene

Genome Databases showing LYPD4 gene

Other Databases showing LYPD4 gene

Specialized Databases showing LYPD4 gene

Intellectual Propertyfor LYPD4 gene

Productsfor LYPD4 gene

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Aliases
for LYPD4 gene

Summaries
for LYPD4 gene

Genomic Views
for LYPD4 gene

Proteins
for LYPD4 gene

Protein Domains /
Families
for LYPD4 gene

Function
for LYPD4 gene

Pathways & Interactions
for LYPD4 gene

Drugs & Compounds
for LYPD4 gene

Transcripts
for LYPD4 gene

Expression
for LYPD4 gene

Orthologs
for LYPD4 gene

Paralogs
for LYPD4 gene

Genomic Variants
for LYPD4 gene

Disorders / Diseases
for LYPD4 gene

Publications
for LYPD4 gene

Intellectual Property
for LYPD4 gene

Products
for LYPD4 gene