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Aliases for LYPD4 Gene

Aliases for LYPD4 Gene

  • LY6/PLAUR Domain Containing 4 2 3 5
  • Ly6/PLAUR Domain-Containing Protein 4 3
  • Testicular Tissue Protein Li 159 3
  • Sperm Membrane Receptor 3
  • SMR 3

External Ids for LYPD4 Gene

Previous GeneCards Identifiers for LYPD4 Gene

  • GC19M047033
  • GC19M042341
  • GC19M038774

Summaries for LYPD4 Gene

GeneCards Summary for LYPD4 Gene

LYPD4 (LY6/PLAUR Domain Containing 4) is a Protein Coding gene. Diseases associated with LYPD4 include Erysipeloid and Mitral Valve Insufficiency. An important paralog of this gene is TEX101.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPD4 Gene

Genomics for LYPD4 Gene

Regulatory Elements for LYPD4 Gene

Enhancers for LYPD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around LYPD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LYPD4 Gene

41,833,686 bp from pter
41,844,862 bp from pter
11,177 bases
Minus strand

Genomic View for LYPD4 Gene

Genes around LYPD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPD4 Gene

Proteins for LYPD4 Gene

  • Protein details for LYPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ly6/PLAUR domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8IYW0

    Protein attributes for LYPD4 Gene

    246 amino acids
    Molecular mass:
    26763 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LYPD4 Gene


neXtProt entry for LYPD4 Gene

Post-translational modifications for LYPD4 Gene

  • Glycosylation at Asn 117
  • Modification sites at PhosphoSitePlus

Other Protein References for LYPD4 Gene

No data available for DME Specific Peptides for LYPD4 Gene

Domains & Families for LYPD4 Gene

Gene Families for LYPD4 Gene

Protein Domains for LYPD4 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 UPAR/Ly6 domain.
  • Contains 1 UPAR/Ly6 domain.
genes like me logo Genes that share domains with LYPD4: view

Function for LYPD4 Gene

genes like me logo Genes that share phenotypes with LYPD4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LYPD4

CRISPR Products

miRNA for LYPD4 Gene

miRTarBase miRNAs that target LYPD4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYPD4 Gene

Localization for LYPD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPD4 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for LYPD4 Gene COMPARTMENTS Subcellular localization image for LYPD4 gene
Compartment Confidence
extracellular 3
plasma membrane 3
chloroplast 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LYPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with LYPD4: view

Pathways & Interactions for LYPD4 Gene

SuperPathways for LYPD4 Gene

No Data Available

Interacting Proteins for LYPD4 Gene

Gene Ontology (GO) - Biological Process for LYPD4 Gene


No data available for Pathways by source and SIGNOR curated interactions for LYPD4 Gene

Drugs & Compounds for LYPD4 Gene

No Compound Related Data Available

Transcripts for LYPD4 Gene

Unigene Clusters for LYPD4 Gene

LY6/PLAUR domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPD4 Gene

No ASD Table

Relevant External Links for LYPD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LYPD4 Gene

mRNA expression in normal human tissues for LYPD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYPD4 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for LYPD4 Gene

This gene is overexpressed in Monocytes (54.6) and Testis (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LYPD4 Gene

Protein tissue co-expression partners for LYPD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYPD4 Gene:


SOURCE GeneReport for Unigene cluster for LYPD4 Gene:

genes like me logo Genes that share expression patterns with LYPD4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LYPD4 Gene

Orthologs for LYPD4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LYPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LYPD4 34
  • 79.59 (n)
  • 70.61 (a)
(Canis familiaris)
Mammalia LYPD4 34
  • 83.33 (n)
  • 76.83 (a)
(Mus musculus)
Mammalia Lypd4 34
  • 77.64 (n)
  • 69.96 (a)
Lypd4 16
(Pan troglodytes)
Mammalia LYPD4 34
  • 88.41 (n)
  • 85.98 (a)
Species where no ortholog for LYPD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYPD4 Gene

Gene Tree for LYPD4 (if available)
Gene Tree for LYPD4 (if available)

Paralogs for LYPD4 Gene

Paralogs for LYPD4 Gene

(1) SIMAP similar genes for LYPD4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LYPD4: view

Variants for LYPD4 Gene

Sequence variations from dbSNP and Humsavar for LYPD4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35476281 - 41,837,333(+) AGGTG(C/G)TATTG reference, missense
rs3922888 -- 41,839,452(+) CTCCC(G/T)CAGAC intron-variant
rs4130852 -- 41,839,081(-) CAGTT(A/C)ACGGG intron-variant
rs11395843 -- 41,841,686(+) AAAAA(-/A)GTGAA intron-variant
rs28847113 -- 41,834,480(+) AATTT(A/G)GCATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LYPD4 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV gain 19592680

Variation tolerance for LYPD4 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYPD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYPD4 Gene

Disorders for LYPD4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LYPD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • infection due to erysipelothrix rhusiopathiae
mitral valve insufficiency
  • congenital insufficiency of mitral valve
- elite association - COSMIC cancer census association via MalaCards
Search LYPD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LYPD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LYPD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LYPD4 Gene

Publications for LYPD4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn L.W. … O'Brien S.J. (J. Infect. Dis. 2010) 46 65
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3 65
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3 65

Products for LYPD4 Gene

Sources for LYPD4 Gene

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