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Aliases for LYPD4 Gene

Aliases for LYPD4 Gene

  • LY6/PLAUR Domain Containing 4 2 3
  • Ly6/PLAUR Domain-Containing Protein 4 3
  • Sperm Membrane Receptor 3
  • SMR 3

External Ids for LYPD4 Gene

Previous GeneCards Identifiers for LYPD4 Gene

  • GC19M047033
  • GC19M042341
  • GC19M038774

Summaries for LYPD4 Gene

GeneCards Summary for LYPD4 Gene

LYPD4 (LY6/PLAUR Domain Containing 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPD4 Gene

Genomics for LYPD4 Gene

Regulatory Elements for LYPD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LYPD4 Gene

41,833,686 bp from pter
41,844,766 bp from pter
11,081 bases
Minus strand

Genomic View for LYPD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LYPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPD4 Gene

Proteins for LYPD4 Gene

  • Protein details for LYPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ly6/PLAUR domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8IYW0

    Protein attributes for LYPD4 Gene

    246 amino acids
    Molecular mass:
    26763 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LYPD4 Gene


neXtProt entry for LYPD4 Gene

Proteomics data for LYPD4 Gene at MOPED

Post-translational modifications for LYPD4 Gene

  • Glycosylation at Asn117
  • Modification sites at PhosphoSitePlus

Other Protein References for LYPD4 Gene

No data available for DME Specific Peptides for LYPD4 Gene

Domains for LYPD4 Gene

Protein Domains for LYPD4 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 UPAR/Ly6 domain.
  • Contains 1 UPAR/Ly6 domain.
genes like me logo Genes that share domains with LYPD4: view

No data available for Gene Families for LYPD4 Gene

Function for LYPD4 Gene

Phenotypes for LYPD4 Gene

genes like me logo Genes that share phenotypes with LYPD4: view

Animal Model Products

miRNA for LYPD4 Gene

miRTarBase miRNAs that target LYPD4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LYPD4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for LYPD4 Gene

Localization for LYPD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPD4 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for LYPD4 Gene COMPARTMENTS Subcellular localization image for LYPD4 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for LYPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with LYPD4: view

Pathways for LYPD4 Gene

SuperPathways for LYPD4 Gene

No Data Available

Interacting Proteins for LYPD4 Gene

Gene Ontology (GO) - Biological Process for LYPD4 Gene


No data available for Pathways by source for LYPD4 Gene

Transcripts for LYPD4 Gene

Unigene Clusters for LYPD4 Gene

LY6/PLAUR domain containing 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LYPD4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPD4 Gene

No ASD Table

Relevant External Links for LYPD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LYPD4 Gene

mRNA expression in normal human tissues for LYPD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYPD4 Gene

This gene is overexpressed in Testis (52.6).

Protein differential expression in normal tissues for LYPD4 Gene

This gene is overexpressed in Monocytes (54.6) and Testis (11.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LYPD4 Gene

SOURCE GeneReport for Unigene cluster for LYPD4 Gene Hs.98660

genes like me logo Genes that share expressions with LYPD4: view

Expression partners for LYPD4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LYPD4 Gene

Orthologs for LYPD4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LYPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LYPD4 35
  • 79.59 (n)
  • 70.61 (a)
(Canis familiaris)
Mammalia LYPD4 35
  • 83.33 (n)
  • 76.83 (a)
(Mus musculus)
Mammalia Lypd4 35
  • 77.64 (n)
  • 69.96 (a)
Lypd4 16
(Pan troglodytes)
Mammalia LYPD4 35
  • 88.41 (n)
  • 85.98 (a)
Species with no ortholog for LYPD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYPD4 Gene

Gene Tree for LYPD4 (if available)
Gene Tree for LYPD4 (if available)

Paralogs for LYPD4 Gene

(1) SIMAP similar genes for LYPD4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LYPD4: view

No data available for Paralogs for LYPD4 Gene

Variants for LYPD4 Gene

Sequence variations from dbSNP and Humsavar for LYPD4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1457143 -- 41,834,878(-) ACTAC(A/T)TGCAT utr-variant-3-prime
rs1457144 -- 41,834,712(-) TGTAT(G/T)ACATC utr-variant-3-prime
rs2290695 -- 41,838,245(-) GGAGT(C/T)GTGGG reference, synonymous-codon
rs3922888 -- 41,839,452(+) CTCCC(G/T)CAGAC intron-variant
rs4060827 -- 41,838,855(+) NANGA(-/AA)NTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LYPD4 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
dgv3882n71 CNV Loss 21882294

Relevant External Links for LYPD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYPD4 Gene

Disorders for LYPD4 Gene

Relevant External Links for LYPD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for LYPD4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for LYPD4 Gene

Publications for LYPD4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn L.W. … O'Brien S.J. (J. Infect. Dis. 2010) 48

Products for LYPD4 Gene

Sources for LYPD4 Gene

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