LYPD3 Gene
protein-coding GIFtS: 49
GCID: GC19M043964
|
|
LY6/PLAUR domain containing 3
| |
Aliases
for LYPD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| LY6/PLAUR Domain Containing 31 2 | | GPI-Anchored Metastasis-Associated Protein C4.4A Homolog2 3 | | C4.4A1 2 3 | | 2310061G07Rik2 | | Matrigel-Induced Gene C4 Protein2 3 | | GPI-Anchored Metastasis-Associated Protein Homolog2 | | MIG-C42 3 | | Ly6/PLAUR Domain-Containing Protein 32 |
Export aliases for LYPD3 gene to outside databasesPrevious GC identifers: GC19M048660 GC19M040394 |
Summaries
for LYPD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LYPD3_HUMAN, O95274Function: Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumorprogression
Gene Wiki entry for LYPD3
|
Genomic Views
for LYPD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LYPD3 gene promoter:
Sp1 AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for LYPD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LYPD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.31 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.31LYPD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M043964: view genomic region
(about GC identifiers)
Start:
|
43,964,946 bp from pter |
End:
|
43,969,831 bp from pter |
Size:
|
4,886 bases |
Orientation:
|
minus strand |
|
Proteins
for LYPD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LYPD3_HUMAN, O95274 (See
protein sequence)Recommended Name: Ly6/PLAUR domain-containing protein 3 precursor Size: 346 amino acids; 35971 Da
Subunit: Binds laminin-1 and laminin-5. Interacts with LGALS3 (By similarity). Interacts with AGR2 and AGR3
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Mass spectrometry: Mass=21442.9; Method=MALDI; Range=1-204; Source=PubMed:15012588;
Secondary accessions: Q9UJ74Explore the universe of human proteins at neXtProt for LYPD3: NX_O95274
Post-translational modifications:
N-glycosylated and O-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95274
LYPD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055215.2
ENSEMBL proteins: ENSP00000244333
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
LYPD3 for ontologies About GeneDecksing
LYPD3 Antibody Products:
Assay Products for LYPD3: |
Protein
Domains /
Families
for LYPD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LYPD3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95274ProtoNet protein and cluster: O95274 1 Blocks protein family: IPB001526 CD59 antigen
UniProtKB/Swiss-Prot: LYPD3_HUMAN, O95274Similarity: Contains 2 UPAR/Ly6 domains |
Function
for LYPD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LYPD3_HUMAN, O95274Function: Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumorprogressionInduction: Up-regulated in migrating keratinocytes during epithelisation of incisional skin wounds
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LYPD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LYPD3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LYPD3 (NM_014400) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LYPD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYPD3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYPD3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0043236 | laminin binding |
IEA | -- |
LYPD3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Lypd3tm1Lex for LYPD3
1 MGI phenotypic allele  for Lypd3 (no phenotypes)
LYPD3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for LYPD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LYPD3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for LYPD3 (O952743 ENSP000002443334) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006928 | cellular component movement |
IEA | -- | | GO:0007160 | cell-matrix adhesion |
IEA | -- |
LYPD3 for ontologies About GeneDecksing
|
Drugs & Compounds
for LYPD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LYPD3
Search CenterWatch for drugs/clinical trials and news about LYPD3
|
Transcripts
for LYPD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LYPD3 gene: NM_014400.2 Unigene Cluster for LYPD3: LY6/PLAUR domain containing 3 Hs.631594 [show with all ESTs]Unigene Representative Sequence: AL8321531 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000244333(uc002owl.1 uc002owm.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LYPD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LYPD3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LYPD3 (NM_014400) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LYPD3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYPD3 |
Additional cDNA sequence: AF082889.1 AJ223603.2 AK075464.1 AK290905.1 AK314773.1 AL832153.1 AY359006.1 BC039167.1 BC041061.1 7 DOTS entries: DT.114327 DT.121431170 DT.100022646 DT.100717886 DT.95163099 DT.95304365 DT.100814164 24/131 AceView cDNA sequences (see all 131): CR591150 CR610737 BG740590 C00511 AW450151 AI206356 BQ011687 AI202455 BE713074 N57021 BC041061 AA369339 CR620698 AI680020 AA479609 BE713165 BF842499 BU682308 BG679186 BM672653 CR622986 AY359006 BU179573 AJ223603
GeneLoc Exon Structure
|
Expression
for LYPD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LYPD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGCGCCAA
About this image
See LYPD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LYPD3
SOURCE GeneReport for Unigene cluster: Hs.631594
UniProtKB/Swiss-Prot: LYPD3_HUMAN, O95274Tissue specificity: Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds.Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary andmetastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normaltissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive andmetastatic urothelial cancers
SABiosciences Custom PCR Arrays for LYPD3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LYPD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LYPD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LYPD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LYPD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYPD3 |
Orthologs
for LYPD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for LYPD3 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
40(a) |
1 → many |
LGf(1004850-1009038) |
ENSEMBL Gene Tree for LYPD3 (if available)
TreeFam Gene Tree for LYPD3 (if available) |
Paralogs
for LYPD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LYPD3 gene
- LYPD52
1 SIMAP similar gene for LYPD3 using alignment to 2 protein entries: LYPD3_HUMAN (see all proteins):DKFZp686D0114
LYPD3 for paralogs About GeneDecksing
|
Genomic Variants
for LYPD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LYPD3 (43964946 - 43969831 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LYPD3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LYPD3 |
|
Disorders
/ Diseases
for LYPD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LYPD3 for disorders About GeneDecksing
OMIM gene information: 609484
OMIM disorders: --
8  diseases for LYPD3: About MalaCardsesophageal squamous cell carcinoma squamous cell carcinoma transitional cell carcinoma colorectal cancer
esophagitis lung cancer carcinoma breast cancer
Export disorders for LYPD3 gene to outside databases
|
Publications
for LYPD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LYPD3 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with LYPD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium. (PubMed id 11245483)1, 2, 3, 9 Smith B.A....Southgate J. (2001)
- Cloning of the human homologue of the metastasis-associated rat C4.4A. (PubMed id 11179665)1, 2, 3 Wuerfel J.... Zoeller M. (2001)
- Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor. (PubMed id 15012588)1, 2, 9 Hansen L.V.... Ploug M. (2004)
- hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PubMed id 12592373)1, 2, 9 Fletcher G.C....Terrett J.A. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Membrane-bound and exosomal metastasis-associated C4.4 A promotes migration by associating with the a(6)b(4) integrin and MT1-MMP. (PubMed id 22431918)1 Ngora H....Zoller M. (2012)
- C4.4A is associated with tumor budding and epithelial- mesenchymal transition of colorectal cancer. (PubMed id 22404718)1 Oshiro R....Mori M. (2012)
- Expression of C4.4A at the invasive front is a novel prognostic marker for disease recurrence of colorectal cancer. (PubMed id 20825414)1 Konishi K....Mori M. (2010)
|
External Searches for LYPD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LYPD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LYPD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LYPD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for LYPD3 gene:
Search GeneIP for patents involving LYPD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LYPD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LYPD3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LYPD3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LYPD3 | | | OriGene Protein Over-expression Lysate for LYPD3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LYPD3 | | OriGene 3'-UTR Clone for LYPD3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LYPD3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LYPD3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LYPD3 | | OriGene Custom Protein Services for LYPD3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LYPD3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LYPD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LYPD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LYPD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LYPD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LYPD3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for LYPD3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | LYPD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYPD3 |
|  |  |  | | | | Search ThermoFisher Antibodies for LYPD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYPD3 |
|
|
|
|
