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LYNX1 Gene

protein-coding   GIFtS: 49
GCID: GC08M143844

Ly6/Neurotoxin 1

  See LYNX1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ly6/Neurotoxin 11 2     SLURP22 3
Secreted Ly-6/UPAR Domain-Containing Protein 22 3     Ly-6 Neurotoxin-Like Protein 12
Secreted Ly-6/UPAR-Related Protein 22 3     Ly-6/Neurotoxin-Like Protein 12
SLURP-22 3     Secreted Ly6/UPAR Related Protein 22

External Ids:    HGNC: 296041   Entrez Gene: 660042   Ensembl: ENSG000001801557   OMIM: 6061105   UniProtKB: Q9BZG93   

Export aliases for LYNX1 gene to outside databases

Previous GC identifers: GC08M142160 GC08M144089 GC08M143650 GC08M143908 GC00U920623 GC08M139097


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LYNX1 Gene:
This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the
cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine
residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand
or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of
acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced
variants encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for LYNX1 Gene:
LYNX1 (Ly6/neurotoxin 1) is a protein-coding gene. Diseases associated with LYNX1 include psoriasis.

UniProtKB/Swiss-Prot: LYNX1_HUMAN, Q9BZG9
Function: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain,
isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration.
Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and
slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2)
nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In
keratinocytes, isoform 3 delays differentiation and prevents apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the LYNX1 gene promoter:
         E2F-5   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LYNX1 promoter sequence
   Search Chromatin IP Primers for LYNX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LYNX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

LYNX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYNX1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M143844:  view genomic region     (about GC identifiers)

Start:
143,845,752 bp from pter      End:
143,859,640 bp from pter
Size:
13,889 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LYNX1_HUMAN, Q9BZG9 (See protein sequence)
Recommended Name: Ly-6/neurotoxin-like protein 1 precursor  
Size: 131 amino acids; 14026 Da
Subunit: Isoform 2 interacts with nAChRs, including alpha(4)beta(2) (CHRNA4/CHRNB2) and alpha(7) (CHRNA7) (By
similarity). Competes with alpha-bungarotoxin for nAChR alpha(7) binding. Isoform 3 may interact with
heteropentameric nAChRs expressed by keratinocytes
Miscellaneous: Isoform 2 is considered to be an endogenous "prototoxin", that shares a N-terminal three-finger
structure with snake alpha-neurotoxins
2 PDB 3D structures from and Proteopedia for LYNX1:
1VYE (3D)        2L03 (3D)    
Secondary accessions: D3DWI7 G3XAC2 Q86SR0
Alternative splicing: 3 isoforms:  Q9BZG9-1   Q9BZG9-2   Q9BZG9-3   (Contains a potential GPI-anchor site at Gly-93. The propeptide 94-116 may be cleaved out upon GPI-anchor attachment (Potential))

Explore the universe of human proteins at neXtProt for LYNX1: NX_Q9BZG9

Explore proteomics data for LYNX1 at MOPED


See LYNX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts): 
NP_076435.1  NP_803252.1  NP_803253.1  NP_803429.1  NP_803430.1  

ENSEMBL proteins: 
 ENSP00000428713   ENSP00000319846   ENSP00000337950   ENSP00000428465   ENSP00000378618  
 ENSP00000332495   ENSP00000429261   ENSP00000428157   ENSP00000381878  

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antibodies-online proteins for LYNX1 (4 products) 

 
antibodies-online peptides for LYNX1

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antibodies-online kits for LYNX1 (9 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR001526 LY6_UPAR

Graphical View of Domain Structure for InterPro Entry Q9BZG9

ProtoNet protein and cluster: Q9BZG9

1 Blocks protein domain: IPB001526 CD59 antigen

UniProtKB/Swiss-Prot: LYNX1_HUMAN, Q9BZG9
Similarity: Contains 1 UPAR/Ly6 domain


Find genes that share domains with LYNX1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LYNX1_HUMAN, Q9BZG9
Function: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain,
isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration.
Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and
slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2)
nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In
keratinocytes, isoform 3 delays differentiation and prevents apoptosis

Phenotypes:
     2 GenomeRNAi human phenotypes for LYNX1:

 Increased G1 DNA content  Increased gamma-H2AX phosphory 

     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lynx1):
 behavior/neurological  cellular  homeostasis/metabolism  nervous system 

Find genes that share phenotypes with LYNX1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Lynx1tm1Htz for LYNX1

   genOway: Develop your customized and physiologically relevant rodent model for LYNX1

miRNA
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miRTarBase miRNAs that target LYNX1:
hsa-mir-744-5p (MIRT037680)

Block miRNA regulation of human, mouse, rat LYNX1 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate LYNX1:
hsa-miR-194* hsa-miR-1321 hsa-miR-1827
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LYNX1_HUMAN, Q9BZG9: Isoform 1: Secreted (Potential)
LYNX1_HUMAN, Q9BZG9: Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor (Potential). Cell projection, dendrite
(By similarity). Note=Detected in Purkinje cells soma and proximal dendrites (By similarity)
LYNX1_HUMAN, Q9BZG9: Isoform 3: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
plasma membrane5

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005886plasma membrane IEA--
GO:0030425dendrite IEA--
GO:0031225anchored component of membrane IEA--

Find genes that share ontologies with LYNX1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LYNX1
Interactions:

    Search GeneGlobe Interaction Network for LYNX1

1 Interacting protein for LYNX1 (Q9BZG93) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PLSCR1O151623I2D: score=1 
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LYNX1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for LYNX1 gene (5 alternative transcripts): 
NM_023946.2  NM_177457.3  NM_177458.1  NM_177476.2  NM_177477.2  

Unigene Cluster for LYNX1:

Ly6/neurotoxin 1
Hs.158665  [show with all ESTs]
Unigene Representative Sequence: NM_177457
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000523332 ENST00000317543(uc003yxa.3) ENST00000335822(uc003yxb.3)
ENST00000521396 ENST00000395192(uc003yxc.1 uc003yxe.1) ENST00000345173
ENST00000522929 ENST00000520131 ENST00000522906 ENST00000398906(uc003yxd.1)

miRNA
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3 qRT-PCR Assays for microRNAs that regulate LYNX1:
hsa-miR-194* hsa-miR-1321 hsa-miR-1827
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LYNX1
  QuantiTect SYBR Green Assays in human, mouse, rat LYNX1
  QuantiFast Probe-based Assays in human, mouse, rat LYNX1

Additional mRNA sequence: 

AB081838.1 AF321824.1 AK123335.1 AK126845.1 AL353948.1 AY358417.1 AY587277.1 BC014560.2 
BC047923.1 

10 DOTS entries:

DT.97836752  DT.75149360  DT.75193153  DT.452203  DT.435594  DT.95146038  DT.75101335  DT.120641758 
DT.120641764  DT.75124592 

Selected AceView cDNA sequences (see all 115):

BM710954 NM_177457 BM671159 F10147 BM706020 BE463468 NM_177477 BQ721166 
BU684587 BQ447772 Z41583 NM_177476 BQ446612 AI817793 BM709301 BQ182328 
BM668941 NM_177458 BI821239 AK123335 BI488424 BQ186410 BU732447 AI474372 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for LYNX1 (see all 7)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1:              -     -     -     -                       -     -     -     -               
SP2:              -     -     -     -                                                         
SP3:                                -                                                         
SP4:                                                                                          
SP5:                                                                                          


ECgene alternative splicing isoforms for LYNX1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LYNX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCCTGCTGC
LYNX1 Expression
About this image


LYNX1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Metencephalon
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Mature Choroid Plexus Cells Choroid Plexus
         Midbrain tegmentum
 
 Epithelial Cells
         Mature Choroid Plexus Cells Choroid Plexus
 
 Liver (Hepatobiliary System)
         Mature Mesothelial Cells Hepatic Mesenchyme
 
 Esophagus (Gastrointestinal Tract)
LYNX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LYNX1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.158665

UniProtKB/Swiss-Prot: LYNX1_HUMAN, Q9BZG9
Tissue specificity: Isoform 3 is expressed at highest levels in cervix and esophagus, followed by adult and fetal
skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not
detected in spleen nor bone marrow. In the epidermis, predominantly produced by keratinocytes of the suprabasal
epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located
in the lowermost epithelial layers (at protein level). Up-regulated 3-fold in psoriatic lesional skin. Detected
in serum (at protein level)

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for LYNX1 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lynx11 , 5 Ly6/neurotoxin 11, 5 80.75(n)1
81.03(a)1
  15 (34.27 cM)5
239361  NM_011838.41  NP_035968.11 
 747478565 


ENSEMBL Gene Tree for LYNX1 (if available)
TreeFam Gene Tree for LYNX1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LYNX1 gene

Find genes that share paralogs with LYNX1           About GenesLikeMe


1 Pseudogenes.org Pseudogene for LYNX1
PGOHUM00000257202


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LYNX1 (see all 449)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs78221931,2
C,F,A,H--143845269(+) GAGGTG/AGTGTT 2 -- ds500121Minor allele frequency- A:0.36NS EA NA WA CSA 2343
rs1487187681,2
--143845325(+) CTGGCC/TCAGGG 2 -- ds50010--------
rs1828809641,2
--143845344(+) GAGGGC/TGAGGG 2 -- ds50010--------
rs793277651,2
F--143845431(+) TCCTCC/TACCCC 2 -- ds50012Minor allele frequency- T:0.06CSA WA 120
rs78126231,2
C,F,A,H--143845449(+) CTCCAT/CGTCTC 2 -- ds500111Minor allele frequency- C:0.43NS EA NA WA CSA 779
rs78259801,2
C,F--143845459(+) CAGCCG/AGGGTG 2 -- ds50019Minor allele frequency- A:0.42NA WA CSA EA 370
rs781420271,2
C,F--143845499(+) TCTGGG/AGTGGA 2 -- ds50012Minor allele frequency- A:0.07CSA WA 120
rs1155992711,2
C,F--143845656(+) TGGGGT/CAGTAG 2 -- ds50011Minor allele frequency- C:0.03WA 118
rs78164801,2
C,F,A,H--143845714(+) TCTACT/CCCCAA 2 -- ds500121Minor allele frequency- C:0.36NS EA NA WA CSA 2346
rs1886327671,2
--143845767(+) CACACA/GATCCA 2 -- ut310--------

HapMap Linkage Disequilibrium report for LYNX1 (143845752 - 143859640 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for LYNX1 (see all 17):    About this table    
Variant IDTypeSubtypePubMed ID
esv2737933CNV Deletion23290073
esv2737931CNV Deletion23290073
esv2661137CNV Deletion23128226
esv2737932CNV Deletion23290073
nsv891646CNV Loss21882294
dgv7917n71CNV Loss21882294
dgv7910n71CNV Loss21882294
dgv7915n71CNV Loss21882294
nsv831485CNV Loss17160897
nsv891638CNV Loss21882294

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SeqTarget long-range PCR primers for resequencing LYNX1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606110    OMIM disorders: --

1 disease for LYNX1:    
About MalaCards
psoriasis


Find genes that share disorders with LYNX1           About GenesLikeMe

1 Novoseek inferred disease relationship for LYNX1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis 51.1 3 12573258 (2), 16575903 (1)

Genetic Association Database (GAD): LYNX1
Human Genome Epidemiology (HuGE) Navigator: LYNX1 (1 document)

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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LYNX1 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with LYNX1)
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  1. SLURP-2, a novel member of the human Ly-6 superfamily that is up- regulated in psoriasis vulgaris. (PubMed id 12573258)1, 2, 3, 9 Tsuji H.... Inoko H. (Genomics 2003)
  2. SLURP-2: a novel cholinergic signaling peptide in human mucocutaneous epithelium. (PubMed id 16575903)1, 2, 9 Arredondo J....Grando S.A. (J. Cell. Physiol. 2006)
  3. NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1. (PubMed id 21252236)1, 2 Lyukmanova E.N.... Kirpichnikov M.P. (J. Biol. Chem. 2011)
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  6. lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. (PubMed id 10402197)1, 3 Miwa J.M....Heintz N. (Neuron 1999)
  7. Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors. (PubMed id 23585571)1 Lyukmanova E.N....Tsetlin V.I. (J. Biol. Chem. 2013)
  8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
  9. Metastatic effect of LY-6K gene in breast cancer cells. (PubMed id 19639180)1 Choi S.H....Park J.H. (Int. J. Oncol. 2009)
  10. Activated cholinergic signaling provides a target in squamous cell lung carcinoma. (PubMed id 18559515)1 Song P....Spindel E.R. (Cancer Res. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 66004 HGNC: 29604 AceView: LYNX1 Ensembl:ENSG00000180155 euGenes: HUgn66004
ECgene: LYNX1 H-InvDB: LYNX1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for LYNX1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LYNX1 gene:
Search GeneIP for patents involving LYNX1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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