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LYN Gene

protein-coding GIFtS: 74

GC08P056954

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.2 ^³
FLJ26625 ^²
JTK8 ^¹, ²

Descriptions
Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ^²
Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog ^²
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog ^²

External Ids
HGNC: 6735¹
Entrez Gene: 4067²
UniProtKB: P07948³
Ensembl: ENSG00000147507⁷

Search outside databases for aliases for LYN gene

Previous GC identifers: GC08P055975 GC08P056731 GC08P056515 GC08P056842

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for LYN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LYN gene

Entrez Gene cytogenetic band: 8q13 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q13

LYN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P056954: (about GC identifiers)

Start:	56,954,926 bp from pter
End:	57,086,493 bp from pter
Size:	131,568 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LYN_HUMAN, P07948 (See protein sequence)

Recommended Name: Tyrosine-protein kinase Lyn

Size: 512 amino acids; 58574 Da

Subunit: Interacts with phosphorylated LIME1 and with CD79A upon BCR activation. Interacts with

Epstein-Barr virus LMP2A. Interacts with TGFB1I1. Interaction, via the SH2 and SH3, domains with

MUC1 is stimulated by IL7 and, the subsequent phosphorylation increases the binding between MUC1

and CTNNB1/beta-catenin. Interacts with PPP1R15A via the SH3 domain

PDB structure from and Proteopedia :

1W1F (3D)

1WA7 (3D)

Secondary accessions: A0AVQ5

Alternative splicing: 2 isoforms: P07948-1 P07948-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001104567.1 NP_002341.1

ENSEMBL proteins:

ENSP00000385606 ENSP00000276497

Human Recombinant Proteins

	Invitrogen human recombinant proteins for LYN
	Millipore Purified and/or Recombinant LYN Protein
	Sigma-Aldrich Proteins for LYN
	R&D Systems Recombinant & Natural Proteins for LYN
	Enzo Life Sciences proteins for LYN
	Recombinant Proteins from Abcam (Lyn)
	Human Recombinant Proteins from Abnova (LYN)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--
GO:0005794	Golgi apparatus	IDA	18029348
GO:0005886	plasma membrane	IDA	18029348
GO:0045121	membrane raft	IDA	11313396

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Antibodies for LYN:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of LYN
	Sigma-Aldrich Antibodies for LYN
	R&D Systems Antibodies for LYN
	Cell Signaling Technology (CST) Antibodies for LYN
	Antibodies from Abcam (Lyn), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LYN)
	Novus Biologicals Antibodies for LYN

Assays for LYN:

	Invitrogen Assays for LYN
	Millipore Kits and Assays for the Analysis of LYN
	R&D Systems ELISAs for LYN (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07948

ProtoNet protein and cluster: P07948

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: LYN_HUMAN, P07948

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LYN)
		Millipore RNAi Products for the Analysis of LYN Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (LYN)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002350

Applied Biosystems Silencer® siRNAs for LYN

Sigma-Aldrich siRNA and siRNA Panels for LYN

Sigma-Aldrich shRNA Panels and shRNA for LYN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LYN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001111097
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001111097
untagged cDNA clones in CMV expression vector (see all 5): NM_001111097

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002350

UniProtKB/Swiss-Prot: LYN_HUMAN, P07948

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for LYN:

Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog,highly expressed in the central nervous

system,physically linked to AMPA receptor and activated following stimulation of the receptor,then

activating the MAP Kinase pathway

7 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Lyn):

digestive/alimentary	hematopoietic system	immune system	life span-post-weaning/aging	liver/biliary system
nervous system	renal/urinary system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--
GO:0004716	receptor signaling protein tyrosine kinase activity	TAS	10748115
GO:0005515	protein binding	ISS	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for LYN (Your Favorite Gene powered by Ingenuity) (see all 9 )

CXCR4 Signaling
Fc&gamma
GM-CSF Signaling
B Cell Receptor Signaling
Fc Epsilon RI Signaling

GeneDecks LYN for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for LYN

5/29 Interacting proteins for LYN (P07948^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 29 )
Interactant Interaction Details
GeneCard External ID(s)
ENSG00000206300 P67870¹^,² EBI-79452, EBI-348169 MINT-62610 MINT-62708 MINT-62784
ENSG00000206406 P67870¹^,² EBI-79452, EBI-348169 MINT-62610 MINT-62708 MINT-62784
CSNK2B P67870¹^,² EBI-79452, EBI-348169 MINT-62610 MINT-62708 MINT-62784 EBI-79452, EBI-348169 MINT-62610 MINT-62708 MINT-62784
KHDRBS1 Q07666¹^,² EBI-79452, EBI-1364 MINT-17535 EBI-79452, EBI-1364 MINT-17535
CD22 P20273¹ EBI-79452, EBI-78277
About this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein amino acid phosphorylation TAS 3561390
GO:0007165 signal transduction TAS 7650013
GO:0008284 positive regulation of cell proliferation ISS --
GO:0009725 response to hormone stimulus ISS --
GO:0030218 erythrocyte differentiation ISS --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for LYN

Browse Small Molecules at Sigma-Aldrich

Compounds for LYN available from Tocris Bioscience
10/37 Novoseek chemical compound relationships for LYN gene (see all 37 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	88.01	412	8666899 (5), 9573010 (4), 11053250 (4), 11443118 (4) (see all 99)
pp55	72.35	1	9195899 (1)
phosphatidylinositol	63.75	19	1371009 (2), 10844001 (1), 11694268 (1), 15287886 (1) (see all 15)
phosphotyrosine	62.27	3	10764829 (1), 7525568 (1), 8709147 (1)
3-tyrosine	58.18	1	12763027 (1)
phosphatidylinositol-3,4,5-trisphosphate	55.06	1	7650013 (1)
piceatannol	47.02	1	9723676 (1)
threonine	46.35	4	14570903 (1), 9784629 (1), 16110156 (1), 10432313 (1)
phosphoinositide	45.54	5	12871380 (1), 15252124 (1), 19290925 (1), 11781242 (1)
wortmannin	36.61	1	8534912 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LYN)
		Millipore RNAi Products for the Analysis of LYN Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (LYN)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002350

Sigma-Aldrich siRNA and siRNA Panels for LYN

Sigma-Aldrich shRNA Panels and shRNA for LYN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001111097 NM_002350

REFSEQ mRNAs for LYN gene (2 alternative transcripts):

NM_001111097.1 NM_002350.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001111097 NM_002350

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001111097
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001111097
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001111097

Additional cDNA sequence:

AK130135.1 AK290494.1 AK298677.1 BC059394.1 BC068551.1 BC075001.2 BC075002.2 BC126456.1

BC126458.1 CR621022.1 M16038.1 M79321.1

6 DOTS entries:

DT.101982560 DT.451584 DT.100815202 DT.75166039 DT.99997760 DT.40218716

24/296 AceView cDNA sequences (see all 296 ):

AW074020 BM673476 AI073988 AI523491 BQ055093 BF974154 CR621022 BE397325

CB156199 AI868434 AI243743 BM907457 CB243846 BE676081 BM909567 AW137620

BF727023 BQ012823 AW572623 BQ711318 BX479795 CK819543 AI082800 CA748533

highest scoring ESTs for LYN:

M16038 M79321 AA019107 AA075628 AA213832 AA278894 AA287863 AA341009 AA383926 AA385906

Unigene Cluster for LYN:

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Hs.699154 [show with all ESTs]

Unigene Representative Sequence: NM_002350

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for LYN

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b
SP1:					-		-				-																-
SP2:																											-
SP3:					-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LYN

2 Ensembl transcripts including schematic representations:

ENST00000403181 ENST00000276497

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LYN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LYN

¹ / ² / ³

10 probe-sets matching LYN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1402_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.98	M16038	1.00	1.00	1.00	1
32616_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.97	M16038	1.00	1.00	1.00	1
54933_at²^{, 3}	U95-B	2	1.00	0.97	0.96	1.20	AI356461	0.80	1.00	0.91	1
2024_s_at²^{, 3}	U95-A	2	1.00	0.97	0.96	0.86	M79321	1.00	1.00	1.00	1
202625_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI356412	0.60	1.00	0.82	1
210754_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M79321	1.00	1.00	1.00	1
202626_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002350	0.60	1.00	0.82	1
202625_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210754_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202626_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LYN for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATGTGTTTCA

SOURCE GeneReport for Unigene cluster: Hs.699154
Expression variation in blood from EXPOLDB for LYN
UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
Tissue specificity: Expressed in primary neuroblastoma tumors

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LYN gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LYN¹	--	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	91.34(n) 97.07(a)	477886 XM_535078.2 XP_535078.2
chimpanzee (Pan troglodytes)	LYN¹	--	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	99.54(n) 100(a)	472771 XM_528143.2 XP_528143.2
cow (Bos taurus)	LYN¹	--	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	89.91(n) 96.87(a)	534996 XM_614963.3 XP_614963.2
rat (Rattus norvegicus)	Lyn¹	--	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	87.89(n) 96.09(a)	81515 NM_030857.1 NP_110484.1
mouse (Mus musculus)	Lyn^{1, 5}	4 (0.00 cM)⁵	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog^{1, 5}	88.32(n)¹ 95.52(a)¹	17096¹ NM_010747.1¹ NP_034877.1¹ AA407514⁵ AK028112⁵ (see all 22)

About this table Species with no ortholog for LYN

ENSEMBL Gene Tree for LYN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LYN gene

LCK² BLK² HCK²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/861 NCBI SNPs in LYN are shown (see all 861 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 257)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2271400^1,2	A,C,F,H	56953798(-)	`GGGTTA/GCCCAT`	1	--	ng5¹		2	EA	178
	rs3808391^1,2	A,C,F,H	56953203(-)	`TCCTAT/CTGATA`	1	--	ng5¹		12	EU EA WA	1256
	rs182832^1,2	A,C,F,H	56953415(+)	`GGGGAG/TCTGGT`	1	--	ng5¹		7	NA EA EU WA	670
	rs6985298^1,2	A,F,H	57085771(+)	`ATGATT/ATTTTT`	2	--	ut3¹ trp³		4	EU EA WA	418
--	rs1450741^1,2	C,F	56954713(+)	`TCCTCC/TGGAGA`	1	--	ng5¹		1	MN	184
--	rs1050855^1,2	C,F	56955140(+)	`GCTGGA/GCCGCC`	2	--	ut5¹ ese³		1	MN	184
--	rs2227980^1,2	F,O	57029006(+)	`CAGAAG/ACCATG`	2	K/K	syn¹		8	MN NA EU EA WA	624
--	rs16922474^1,2	F	57029069(+)	`CTTGGC/TGCTGG`	2	G/G	syn¹ ese³		3	NA	140
	rs1877301^1,2	A,C,F,H,O	57039144(+)	`TTAAGA/TTCTAC`	1	--	int¹		7	EU EA WA NA	558
	rs1473075^1,2	A,C,F,H,O	57016226(+)	`GTTTAG/CCTGGA`	1	--	int¹		9	EU EA WA NA	738

About this table

HapMap Linkage Disequilibrium images for LYN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165120

10/26 Novoseek disease relationships for LYN gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	57.69	3	18235045 (2), 17432977 (1)
myeloid leukemia	31.70	1	7512079 (1)
leukemia	30.18	3	17344919 (1), 7636265 (1), 15175350 (1)
lymphoblastic leukemia acute	28.78	8	10720701 (2), 17344919 (2), 10658677 (2)
leukemogenesis	25.16	1	15781338 (1)
myeloma	24.63	2	7831290 (1), 10201980 (1)
lymphoma	23.83	7	8264235 (2), 18070987 (2), 17640867 (1), 8688094 (1) (see all 5)
lymphocytic leukemia chronic b-cell	20.42	1	18768392 (1)
lupus erythematosus systemic	20.24	2	15022330 (1), 16320343 (1)
leukemia t-cell	18.98	1	1379847 (1)

About this table

Human Gene Mutation Database: LYN
Human Genome Epidemiology Navigator: LYN (16 documents)
Tumor Gene Database: LYN

(Possibly Related Articles in Doctor's Guide)
About This Section

Activation of LYN Kinase Is Associated With Imatinib Resistance in CML Patients

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/584 PubMed articles for LYN gene (see all 584 ):

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. (PubMed id 3561390)^{2, 3, 4} Yamanashi Y.... Toyoshima K. (1987)
Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. (PubMed id 7895172)^{1, 3, 4} Miller C.L.... Kieff E. (1995)
Expression of the B cell-associated tyrosine kinase gene Lyn in primary neuroblastoma tumours and its modulation during the differentiation of neuroblastoma cell lines. (PubMed id 1510669)^{1, 3, 4} Bielke W.... Miescher G.C. (1992)
Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. (PubMed id 17233630)^{1, 3, 4} Rathore V.B.... Newman D.K. (2007)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7. (PubMed id 12750561)^{3, 4} Li Y....Kufe D. (2003)
Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. (PubMed id 11517336)^{3, 4} Grishin A.V....Corey S.J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4067	HGNC: 6735	AceView: LYN	Ensembl:ENSG00000147507	euGenes: HUgn4067
ECgene: LYN	H-InvDB: LYN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LYN	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for LYN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LYN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LYN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LYN		Antibodies for LYN
	Explore super-pooled esiRNAs		Proteins for LYN
	Lentivirus-delivered shRNAs for LYN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LYN)
	Antibodies (LYN)
	Chimera RNAi (LYN)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for LYN

	Recombinant Proteins (Lyn)
	Antibodies (Lyn)

Search OriGene for LYN

Tocris compounds for LYN

	Drugs/Proteins for LYN
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LYN

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
LYN Gene at Home site.
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LYN Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for LYN

Summaries
for LYN

Genomic Location
for LYN

Proteins
for LYN

Protein Domains/
Families
for LYN

Gene Function
for LYN

Pathways & Interactions
for LYN

Drugs & Compounds
for LYN

Transcripts
for LYN

Expression
for LYN

Orthologs
for LYN

Paralogs
for LYN

SNPs/Variants
for LYN

Disorders & Mutations
for LYN

Medical News
for LYN

Publications
for LYN

Search for LYN

Genome Databases showing LYN

Other Databases showing LYN

Specialized Databases showing LYN

Licensable Technologies
for LYN

Services
for LYN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LYN Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor LYN

Summariesfor LYN

Genomic Locationfor LYN

Proteinsfor LYN

Protein Domains/Familiesfor LYN

Gene Functionfor LYN

Pathways & Interactionsfor LYN

Drugs & Compoundsfor LYN

Transcriptsfor LYN

Expression for LYN

Orthologsfor LYN

Paralogsfor LYN

SNPs/Variantsfor LYN

Disorders & Mutationsfor LYN

Medical Newsfor LYN

Publicationsfor LYN

Search for LYN

Genome Databases showing LYN

Other Databases showing LYN

Specialized Databases showing LYN

Licensable Technologiesfor LYN

Servicesfor LYN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LYN

Summaries
for LYN

Genomic Location
for LYN

Proteins
for LYN

Protein Domains/
Families
for LYN

Gene Function
for LYN

Pathways & Interactions
for LYN

Drugs & Compounds
for LYN

Transcripts
for LYN

Expression
for LYN

Orthologs
for LYN

Paralogs
for LYN

SNPs/Variants
for LYN

Disorders & Mutations
for LYN

Medical News
for LYN

Publications
for LYN

Licensable Technologies
for LYN

Services
for LYN