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LYN Gene

protein-coding   GIFtS: 74
GCID: GC08P056792

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog

  See LYN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog1 2 3     p56Lyn2 3
Lck/Yes-Related Novel Protein Tyrosine Kinase2 3     EC 2.7.10.23 8
JTK82 3     Tyrosine-Protein Kinase Lyn2
p53Lyn2 3     EC 2.7.108

External Ids:    HGNC: 67351   Entrez Gene: 40672   Ensembl: ENSG000002540877   OMIM: 1651205   UniProtKB: P079483   

Export aliases for LYN gene to outside databases

Previous GC identifers: GC08P055975 GC08P056731 GC08P056515 GC08P056842 GC08P056954 GC08P052260


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LYN Gene:
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation,
and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for LYN Gene:
LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a protein-coding gene. Diseases associated with LYN include chorea-acanthocytosis, and sarcoma. GO annotations related to this gene include SH3 domain binding and enzyme binding. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an
important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth
factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions
primarily as negative regulator, but can also function as activator, depending on the context. Required for the
initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in
the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune
self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5,
CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial
lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors,
platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts
downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays
an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration,
adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of
immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such
as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their
substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A,
CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of
SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein.
Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as
an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid
differentiation during the switch between proliferation and maturation. Depending on the context, activates or
inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation.
Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2,
MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on
'Tyr-72'

summary for LYN Gene:
Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that
interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of
the Src kinase family have a very similar domain structure with a high degree of homology in the SH1
(catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association)
domains. The activity of the Src kinase family can also be regulated by phosphatases (e.g. SHP1), by binding
to adaptor proteins (e.g. Cbp) and by proteasomal degradation. Src kinases are key upstream mediators of
both the PI 3-K and MAPK signaling pathways, and have been shown to have important roles in cell
proliferation, migration and survival.

Gene Wiki entry for LYN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LYN gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LYN promoter sequence
   Search Chromatin IP Primers for LYN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LYN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q13

LYN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYN gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P056792:  view genomic region     (about GC identifiers)

Start:
56,792,372 bp from pter      End:
56,923,940 bp from pter
Size:
131,569 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LYN_HUMAN, P07948 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Lyn  
Size: 512 amino acids; 58574 Da
Subunit: Interacts with TEC. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with LIME1
and with CD79A upon activation of the B-cell antigen receptor. Interacts with the B-cell receptor complex.
Interacts with phosphorylated THEMIS2. Interacts with EPOR. Interacts with MS4A2/FCER1B. Interaction (via the SH2
and SH3 domains) with MUC1 is stimulated by IL7 and the subsequent phosphorylation increases the binding between
MUC1 and CTNNB1/beta-catenin. Interacts with ADAM15. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts
with FASLG. Interacts with KIT. Interacts with HCLS1. Interacts with FCGR2B. Interacts with FCGR1A; the
interaction may be indirect. Interacts with CD19, CD22, CD79A and CD79B. Interacts (via SH3 domain) with CBLC,
PPP1R15A and PDE4A. Interacts with TGFB1I1. Interacts (via SH3 domain) with PIK3R1, the regulatory subunit of
phosphatidylinositol 3-kinase; this interaction enhances phosphatidylinositol 3-kinase activity. Interacts with
CSF2RB, the common subunit of the IL3, IL5 and CSF2 receptors. Interacts with PAG1; identified in a complex with
PAG1 and STAT3. Interacts with ABL1. Interacts with PTPN6/SHP-1. Interacts (via SH3 domain) with SCIMP (via
proline-rich region). Interacts with LPXN (via LD motif 3) and the interaction is induced upon B-cell antigen
receptor (BCR) activation. Interacts (via SH3-domain) with ANKRD54 (via ankyrin repeat region) in an
activation-independent status of LYN. Forms a multiprotein complex with ANKRD54 and HCLS1. Interacts with
Epstein-Barr virus LMP2A. Interacts with Herpes virus saimiri tyrosine kinase interacting protein (Tip)
3 PDB 3D structures from and Proteopedia for LYN:
1W1F (3D)        1WA7 (3D)        3A4O (3D)    
Secondary accessions: A0AVQ5
Alternative splicing: 2 isoforms:  P07948-1   P07948-2   

Explore the universe of human proteins at neXtProt for LYN: NX_P07948

Explore proteomics data for LYN at MOPED

Post-translational modifications: 

  • Ubiquitinated by CBL, leading to its degradation. Ubiquitination is SH3-dependent1
  • Autophosphorylated. Phosphorylated on tyrosine residues in response to KIT signaling. Phosphorylation at Tyr-397
    is required for optimal activity. Phosphorylation at Tyr-508 inhibits kinase activity. Phosphorylated at Tyr-508
    by CSK. Dephosphorylated by PTPRC/CD45. Becomes rapidly phosphorylated upon activation of the B-cell receptor and
    the immunoglobulin receptor FCGR1A1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LYN (P07948) (see all 26)
     FLIRESE  LSVRDFD  DAWEIPR  DNGGYYI 


    See LYN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001104567.1  NP_002341.1  

    ENSEMBL proteins: 
     ENSP00000428924   ENSP00000428424   ENSP00000428313  
    Reactome Protein details: P07948

    LYN Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant LYN Protein
    R&D Systems Recombinant & Natural Proteins for LYN (Lyn B)
    Enzo Life Sciences proteins for LYN
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LYN
    GenScript Custom Purified and Recombinant Proteins Services for LYN
    Novus Biologicals LYN Proteins
    Novus Biologicals LYN Lysates
    Sino Biological Recombinant Protein for LYN
    Sino Biological Cell Lysate for LYN
    ProSpec Recombinant Protein for LYN
    Cloud-Clone Corp. Proteins for LYN

     
    Search eBioscience for Proteins for LYN 

    LYN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LYN
    R&D Systems Antibodies for LYN
    Cell Signaling Technology (CST) Antibodies for LYN 
    OriGene Antibodies for LYN
    OriGene Custom Antibody Services for LYN
    Novus Biologicals LYN Antibodies
    Search for Antibodies for LYN at Abcam
    Cloud-Clone Corp. Antibodies for LYN
    ThermoFisher Antibody for LYN
    LSBio Antibodies in human, mouse, rat for LYN

    LYN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LYN
    R&D Systems ELISAs for LYN         (see all)
    GenScript LYN-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LYN
    Cloud-Clone Corp. CLIAs for LYN
    Search eBioscience for ELISAs for LYN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    Src family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P07948

    ProtoNet protein and cluster: P07948

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
    Domain: The protein kinase domain plays an important role in its localization in the cell membrane
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with LYN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYN_HUMAN, P07948
    Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an
    important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth
    factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions
    primarily as negative regulator, but can also function as activator, depending on the context. Required for the
    initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in
    the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune
    self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5,
    CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial
    lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors,
    platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts
    downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays
    an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration,
    adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of
    immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such
    as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their
    substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A,
    CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of
    SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein.
    Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as
    an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid
    differentiation during the switch between proliferation and maturation. Depending on the context, activates or
    inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation.
    Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2,
    MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on
    'Tyr-72'
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and
    the C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by
    CSK at Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by
    dephosphorylation by PTPRC/CD45. Inhibited by Dasatinib, PP2, and SU6656

         Genatlas biochemistry entry for LYN:
    Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog,highly expressed in the central nervous
    system,physically linked to AMPA receptor and activated following stimulation of the receptor,then activating the
    MAP Kinase pathway

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS--
    GO:0004716receptor signaling protein tyrosine kinase activity TAS10748115
    GO:0005102receptor binding ----
         
    Find genes that share ontologies with LYN           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for LYN:
     Decreased focal adhesion (FA)   Decreased viability in HMC1.1   Decreased viability with TRAIL  Increased colony dispersion (i 
     Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Lyn):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  nervous system  renal/urinary system  respiratory system 

    Find genes that share phenotypes with LYN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LYN: Lyntm1Tya Lyntm1Sor Lyntm1Ard

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LYN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LYN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LYN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LYN

    miRNA
    Products:
        
    miRTarBase miRNAs that target LYN:
    hsa-mir-222-3p (MIRT046575)

    Block miRNA regulation of human, mouse, rat LYN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LYN (see all 16):
    hsa-miR-3163 hsa-miR-30c hsa-miR-4324 hsa-miR-3651 hsa-miR-30d hsa-miR-4282 hsa-miR-146a* hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidLYN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LYN
    Predesigned siRNA for gene silencing in human, mouse, rat LYN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LYN

    Clone
    Products:
         
    OriGene clones in human, mouse for LYN (see all 16)
    OriGene ORF clones in mouse, rat for LYN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LYN (NM_002350)
    Sino Biological Human cDNA Clone for LYN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LYN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYN
    Addgene plasmids for LYN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LYN
    Browse ESI BIO Cell Lines and PureStem Progenitors for LYN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYN_HUMAN, P07948: Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus.
    Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased
    by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a
    kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport.
    Detected on plasma membrane lipid rafts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    plasma membrane5
    cytosol4
    cytoskeleton2
    extracellular2
    mitochondrion2
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005794Golgi apparatus IDA15173188
    GO:0005829cytosol TAS--

    Find genes that share ontologies with LYN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LYN About   (see all 57)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc epsilon RI signaling pathway0.41
    Immune response BCR pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    2B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    3Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42
    EPO signaling pathway0.34
    4Kit Receptor Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37
    Kit Receptor Signaling Pathway0.37
    5PI-3K cascade
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Fc epsilon receptor (FCERI) signaling0.64
    Signaling by SCF-KIT0.72
    Regulation of KIT signaling0.00


    Find genes that share SuperPaths with LYN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LYN (see all 9)
        Fc-Gamma-RIIB Signaling in B-Cells
    Fc-GammaR Pathway
    PI3K Signaling in B-Lymphocyte
    NF-KappaB Family Pathway
    p70S6K Signaling

    3 Cell Signaling Technology (CST) Pathways for LYN
        MAP Kinase Signaling
    Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    Selected GeneGo (Thomson Reuters) Pathways for LYN (see all 6)
        Development EPO-induced MAPK pathway
    Development EPO-induced Jak-STAT pathway
    Immune response Fc epsilon RI pathway
    Immune response BCR pathway
    Immune response Role of integrins in NK cells cytotoxicity

    Selected BioSystems Pathways for LYN (see all 23)
        IL-5 Signaling Pathway
    Kit Receptor Signaling Pathway
    IL-7 Signaling Pathway
    IL-6 Signaling Pathway
    B Cell Receptor Signaling Pathway


    Selected Reactome Pathways for LYN (see all 17)
        FCERI mediated MAPK activation
    FCERI mediated NF-kB activation
    FCGR activation
    Regulation of signaling by CBL
    Regulation of KIT signaling


    Selected Kegg Pathways  (Kegg details for LYN) (see all 9):
        Chemokine signaling pathway
    NF-kappa B signaling pathway
    B cell receptor signaling pathway
    Fc epsilon RI signaling pathway
    Fc gamma R-mediated phagocytosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LYN: 
              Antigen Presenting Cells in human mouse rat
              Antifungal Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LYN

    Selected Interacting proteins for LYN (P079481, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-62610 MINT-62708 MINT-62784 I2D: score=5 
    ENSG00000206406P678702, 3MINT-62610 MINT-62708 MINT-62784 I2D: score=5 
    ENSG00000224398P678702, 3MINT-62610 MINT-62708 MINT-62784 I2D: score=5 
    ENSG00000224774P678702, 3MINT-62610 MINT-62708 MINT-62784 I2D: score=5 
    ENSG00000228875P678702, 3MINT-62610 MINT-62708 MINT-62784 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 87):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001782B cell homeostasis ISS--
    GO:0001817regulation of cytokine production ISS--
    GO:0001932regulation of protein phosphorylation TAS15489917
    GO:0001933negative regulation of protein phosphorylation ISS--
    GO:0002431Fc receptor mediated stimulatory signaling pathway ISS--

    Find genes that share ontologies with LYN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for LYN
      Browse compounds at ApexBio 

    Compounds for LYN available from Tocris Bioscience    About this table
    CompoundAction CAS #
    1-Naphthyl PP1Src family kinase inhibitor; also inhibits c-Abl[221243-82-9]
    PP 2 Potent, selective Src family kinase inhibitor [172889-27-9]
    PP 3Negative control for PP 2 (Cat. No. 1407)[5334-30-5]
    BosutinibDual Src-Abl inhibitor; antiproliferative[380843-75-4]
    PP 1 Potent, selective Src family kinase inhibitor [172889-26-8]

    2 HMDB Compounds for LYN    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for LYN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine-- --target--10592235
    Ponatinib -- 943319-70-8targetinhibitor19878872
    BosutinibBosulif® (see all 3)380843-75-4target----

    Selected Novoseek inferred chemical compound relationships for LYN gene (see all 54)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 87.9 425 8666899 (5), 9573010 (4), 11053250 (4), 11443118 (4) (see all 99)
    dasatinib 79.9 10 18577747 (1), 17218385 (1), 17431118 (1), 19447874 (1) (see all 10)
    pp55 71.7 1 9195899 (1)
    herbimycin a 65.1 4 7499232 (1), 1730866 (1), 11751911 (1), 12206990 (1)
    phosphatidylinositol 62.8 25 1371009 (2), 10844001 (1), 11694268 (1), 15287886 (1) (see all 16)
    imatinib 62.3 41 18577747 (6), 18235045 (5), 19340007 (4), 15175350 (3) (see all 15)
    phosphotyrosine 61.1 3 10764829 (1), 7525568 (1), 8709147 (1)
    3-tyrosine 57.1 1 12763027 (1)
    phosphatidylinositol-3,4,5-trisphosphate 53.4 1 7650013 (1)
    phosphoinositide 45.4 5 12871380 (1), 15252124 (1), 19290925 (1), 11781242 (1)



    Find genes that share compounds with LYN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LYN gene (2 alternative transcripts): 
    NM_001111097.2  NM_002350.3  

    Unigene Cluster for LYN:

    V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    Hs.491767  [show with all ESTs]
    Unigene Representative Sequence: NM_002350
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519728 ENST00000520220(uc003xsl.4 uc003xsk.4) ENST00000520050
    ENST00000420292
    miRNA
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    hsa-miR-3163 hsa-miR-30c hsa-miR-4324 hsa-miR-3651 hsa-miR-30d hsa-miR-4282 hsa-miR-146a* hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidLYN 3' UTR sequence
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    Additional mRNA sequence: 

    AK130135.1 AK290494.1 AK298677.1 BC059394.1 BC068551.1 BC075001.2 BC075002.2 BC126456.1 
    BC126458.1 M16038.1 M79321.1 

    4 DOTS entries:

    DT.101982560  DT.451584  DT.100815202  DT.40218716 

    Selected AceView cDNA sequences (see all 296):

    BC059394 AI523491 BM909567 AW673490 AI687379 AI868434 AA307109 BF447480 
    BM907457 AI082800 BE467336 AW074020 BX479795 CK819543 AA243765 AI718267 
    BU678971 BF974154 AA626112 AI073988 CB156199 AI253585 CA844339 BM833327 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LYN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGTTTCA
    LYN Expression
    About this image


    LYN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Heart (Cardiovascular System)
             Heart Tube
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
    LYN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LYN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491767

    UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
    Tissue specificity: Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung,
    liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid,
    hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LYN: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LYN gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lyn1 , 5 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog1, 5 88.93(n)1
    96.09(a)1
      4 (2.05 cM)5
    170961  NM_001111096.11  NP_001104566.11 
     36781155 
    chicken
    (Gallus gallus)
    Aves LYN1 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 80.35(n)
    87.6(a)
      421127  NM_001006390.1  NP_001006390.1 
    lizard
    (Anolis carolinensis)
    Reptilia LYN6
    v-yes-1 Yamaguchi sarcoma viral related oncogene h...
    86(a)
    1 ↔ 1
    GL343244.1(159422-209233)
    African clawed frog
    (Xenopus laevis)
    Amphibia lyn-A2 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 78.94(n)    AB003358.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lyn1 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 71.81(n)
    77.47(a)
      447804  NM_001004543.1  NP_001004543.1 


    ENSEMBL Gene Tree for LYN (if available)
    TreeFam Gene Tree for LYN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LYN gene
    FRK2  LCK2  BLK2  FGR2  PTK62  YES12  HCK2  ABL12  
    SRC2  FYN2  ABL22  SRMS2  
    Selected SIMAP similar genes for LYN using alignment to 3 protein entries:     LYN_HUMAN (see all proteins) (see all similar genes):
    HCK    BLK    YES1    c-fgr    FYN    FGR
    SRC    FRK    EPHA2    LCK    NCK1    NCK2
    EPHA6    BMX    BTK kinase deficient isoform 2    EPHA3    EPHA4    PTK6

    Find genes that share paralogs with LYN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LYN (see all 2886)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0417374
    A breast pleomorphic lobular carcinoma sample4--see VAR_0417372 D Y mis40--------
    rs105667071,2
    C--52286193(+) aaaaa-/AGAAA/
    AGAAAGAAA
    gaaag
    4 -- int1 cds11NA 2
    rs1445798241,2
    C--52289773(+) TATAT-/ATATATATATATACA
    CACACACACACACACAC
    ACACA
    2 -- int10--------
    rs1460067391,2
    C--52289773(+) TATAT-/ATATATATATATA
    CACACACACACACAC
    ACACA
    2 -- int10--------
    rs3692566691,2
    C--52289785(+) TATAT-/ACACACACACACA
    CACACACACACACAC
    ACACA
    2 -- int10--------
    rs1482895841,2
    C--52335614(+) CCTCA-/AAA   
       TAAAT
    AAATA
    2 -- int10--------
    rs1996557581,2
    C--52335614(+) CCTCA-/AAAT  
            
    AAATA
    2 -- int10--------
    rs1930824421,2
    C--52335639(+) AAATAA/GATAAA 2 -- int10--------
    rs1420872371,2
    C--52337960(+) AATCT-/TATCAGT 2 -- int10--------
    rs792659281,2
    C--52337961(+) ATCTT-/AT/TA 
            
    CAGTT
    2 -- int10--------

    HapMap Linkage Disequilibrium report for LYN (56792372 - 56923940 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LYN (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1459437CNV Deletion17803354
    esv1236863CNV Insertion17803354
    nsv507467CNV Insertion20534489
    esv270207CNV Insertion20981092
    nsv524526CNV Loss19592680
    nsv527033CNV Loss19592680
    nsv522326CNV Gain19592680
    nsv527341CNV Gain19592680
    dgv459n21CNV Gain19592680
    esv2752257CNV Gain17911159

    Human Gene Mutation Database (HGMD): LYN
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing LYN
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165120    OMIM disorders: --

    UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
  • Note=Constitutively phosphorylated and activated in cells from a number of chronic myelogenous leukemia
    (CML) and acute myeloid leukemia (AML) patients. Mediates phosphorylation of the BCR-ABL fusion protein.
    Abnormally elevated expression levels or activation of LYN signaling may play a role in survival and
    proliferation of some types of cancer cells

  • 2 diseases for LYN:    
    About MalaCards
    chorea-acanthocytosis    sarcoma

    2 diseases from the University of Copenhagen DISEASES database for LYN:
    Leukemia     Lymphoma

    Find genes that share disorders with LYN           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LYN gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 59.3 3 18235045 (2), 17432977 (1)
    myeloid leukemia 34.5 1 7512079 (1)
    leukemia 33.1 3 17344919 (1), 7636265 (1), 15175350 (1)
    lymphoblastic leukemia acute 29.6 9 10720701 (2), 17344919 (2), 10658677 (2)
    lymphocytic leukemia chronic b-cell 27.4 1 18768392 (1)
    myeloma 26.4 7 20079716 (4), 7831290 (1), 10201980 (1)
    lupus erythematosus systemic 23.5 4 15022330 (1), 20087361 (1), 19369946 (1), 16320343 (1)
    lymphoma 23.4 17 8264235 (2), 18070987 (2), 20043832 (2), 17640867 (1) (see all 6)
    leukemogenesis 23.1 1 15781338 (1)
    leukemia t-cell 17.3 1 1379847 (1)

    Genetic Association Database (GAD): LYN
    Human Genome Epidemiology (HuGE) Navigator: LYN (22 documents)
    Tumor Gene Database (TGDB): LYN

    Export disorders for LYN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LYN gene, integrated from 10 sources (see all 718):
    (articles sorted by number of sources associating them with LYN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. (PubMed id 3561390)1, 2, 3 Yamanashi Y.... Toyoshima K. (Mol. Cell. Biol. 1987)
    2. Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity. (PubMed id 18817770)1, 2, 9 Ikeda K.... Yamaguchi N. (Exp. Cell Res. 2008)
    3. Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells. (PubMed id 9341198)1, 2, 9 Linnekin D.... Mou S. (J. Biol. Chem. 1997)
    4. Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. (PubMed id 18577747)1, 2, 9 Wu J.... Donato N.J. (J. Natl. Cancer Inst. 2008)
    5. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. (PubMed id 18235045)1, 2, 9 Wu J....Donato N.J. (Blood 2008)
    6. Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain. (PubMed id 15173188)1, 2, 9 Kasahara K.... Yamaguchi N. (J. Cell Biol. 2004)
    7. Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage. (PubMed id 10891478)1, 2, 9 Yoshida K.... Kufe D. (Mol. Cell. Biol. 2000)
    8. Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. (PubMed id 9171348)1, 2, 9 Hirao A.... Yamaguchi N. (EMBO J. 1997)
    9. Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. (PubMed id 18070987)1, 2, 9 Tauzin S.... Hoessli D.C. (Blood 2008)
    10. Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage. (PubMed id 10574931)1, 2, 9 Yoshida K.... Kufe D. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4067 HGNC: 6735 AceView: LYN Ensembl:ENSG00000254087 euGenes: HUgn4067
    ECgene: LYN Kegg: 4067 H-InvDB: LYN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LYN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LYN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LYN gene:
    Search GeneIP for patents involving LYN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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