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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LYN Gene

protein-coding   GIFtS: 70
GCID: GC08P056792

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
 Explore 57 diseases affiliated with
LYN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LYN    

Aliases
for LYN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog1 2 3     P56Lyn1
JTK81 2 3     EC 2.7.10.23 8
Lck/Yes-Related Novel Protein Tyrosine Kinase2 3     Tyrosine-Protein Kinase Lyn2
P53Lyn1     EC 2.7.108

External Ids:    HGNC: 67351   Entrez Gene: 40672   Ensembl: ENSG000002540877   OMIM: 1651205   UniProtKB: P079483   

Export aliases for LYN gene to outside databases

Previous GC identifers: GC08P055975 GC08P056731 GC08P056515 GC08P056842 GC08P056954 GC08P052260


Summaries
for LYN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LYN:
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and
erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an
important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors
and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as
negative regulator, but can also function as activator, depending on the context. Required for the initiation of the
B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell
differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of
several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and
TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines
and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as
dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well
as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation,
survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways
by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for
phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of
kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19,
CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation
of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein.
Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an
effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid
differentiation during the switch between proliferation and maturation. Depending on the context, activates or
inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates
activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1,
MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'

Gene Wiki entry for LYN


Genomic Views
for LYN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LYN gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LYN promoter sequence
   Search SABiosciences Chromatin IP Primers for LYN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LYN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q13

LYN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYN gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P056792:  view genomic region     (about GC identifiers)

Start:
 56,792,372 bp from pter      End:
 56,923,940 bp from pter
Size:
 131,569 bases      Orientation:
 plus strand

Proteins
for LYN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LYN_HUMAN, P07948 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Lyn  
Size: 512 amino acids; 58574 Da
Subunit: Interacts with TEC (By similarity). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts
with LIME1 and with CD79A upon activation of the B-cell antigen receptor. Interacts with the B-cell receptor complex.
Interacts with phosphorylated THEMIS2. Interacts with EPOR (By similarity). Interacts with MS4A2/FCER1B. Interaction
(via the SH2 and SH3 domains) with MUC1 is stimulated by IL7 and the subsequent phosphorylation increases the binding
between MUC1 and CTNNB1/beta-catenin. Interacts with Epstein-Barr virus LMP2A. Interacts with Herpes virus saimiri
tyrosine kinase interacting protein (Tip). Interacts with ADAM15. Interacts with NDFIP2 and more weakly with NDFIP1.
Interacts with FASLG. Interacts with KIT. Interacts with HCLS1. Interacts with FCGR2B. Interacts with FCGR1A; the
interaction may be indirect. Interacts with CD19, CD22, CD79A and CD79B. Interacts (via SH3 domain) with PPP1R15A and
PDE4A. Interacts with TGFB1I1. Interacts (via SH3 domain) with PIK3R1, the regulatory subunit of phosphatidylinositol
3-kinase; this interaction enhances phosphatidylinositol 3-kinase activity. Interacts with CSF2RB, the common subunit
of the IL3, IL5 and CSF2 receptors. Interacts with PAG1; identified in a complex with PAG1 and STAT3. Interacts with
ABL1. Interacts with PTPN6/SHP-1. Interacts (via SH3 domain) with SCIMP (via proline-rich region). Interacts with LPXN
(via LD motif 3) and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via ankyrin
repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN (By similarity). Forms a
multiprotein complex with LYN and HS1 (By similarity)
Subcellular location: Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus.
Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by
inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase
domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on
plasma membrane lipid rafts
3 PDB 3D structures from and Proteopedia for LYN:
1W1F (3D)        1WA7 (3D)        3A4O (3D)    
Secondary accessions: A0AVQ5
Alternative splicing: 2 isoforms:  P07948-1   P07948-2   

Explore the universe of human proteins at neXtProt for LYN: NX_P07948

Post-translational modifications:

  • Ubiquitinated by CBL, leading to its degradation. Ubiquitination is SH3-dependent1
  • Autophosphorylated. Phosphorylated on tyrosine residues in response to KIT signaling. Phosphorylation at Tyr-397 is
    • required for optimal activity. Phosphorylation at Tyr-508 inhibits kinase activity. Phosphorylated at Tyr-508 by CSK.
    Dephosphorylated by PTPRC/CD45. Becomes rapidly phosphorylated upon activation of the B-cell receptor and the
    immunoglobulin receptor FCGR1A1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07948

    • 4/26 DME Specific Peptides for LYN (P07948) (see all 26)
     FLIRESE  LSVRDFD  DAWEIPR  DNGGYYI 

    LYN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001104567.1  NP_002341.1  

    ENSEMBL proteins: 
     ENSP00000428924   ENSP00000428424   ENSP00000428313  
    Reactome Protein details: P07948
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant LYN Protein
    R&D Systems Recombinant & Natural Proteins for LYN (Lyn B)
    Enzo Life Sciences proteins for LYN
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for LYN 
    GenScript Custom Purified and Recombinant Proteins Services for LYN
    Novus Biologicals LYN Proteins
    Novus Biologicals LYN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LYN

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005624membrane fraction ----
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005758mitochondrial intermembrane space IEA--


    LYN for ontologies           About GeneDecksing



    LYN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LYN
    R&D Systems Antibodies for LYN
    Cell Signaling Technology (CST) Antibodies for LYN 
    OriGene Antibodies (see all 4): LYN
    OriGene Custom Antibody Services for LYN 
    GenScript Superior Antibodies for LYN
    Novus Biologicals LYN Antibodies
    Abcam antibodies for LYN 
    Uscn Antibodies for LYN
    ThermoFisher Antibody for LYN

    Assay Products for LYN: 
    EMD Millipore Kits and Assays for the Analysis of LYN
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for LYN         (see all)
    GenScript LYN-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for LYN

    Protein Domains /
    Families
    for LYN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LYN for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_cat_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P07948

    ProtoNet protein and cluster: P07948

    3 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
    Domain: The protein kinase domain plays an important role in its localization in the cell membrane
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Function
    for LYN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
    Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an
    important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors
    and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as
    negative regulator, but can also function as activator, depending on the context. Required for the initiation of the
    B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell
    differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of
    several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and
    TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines
    and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as
    dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well
    as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation,
    survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways
    by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for
    phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of
    kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19,
    CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation
    of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein.
    Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an
    effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid
    differentiation during the switch between proliferation and maturation. Depending on the context, activates or
    inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates
    activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1,
    MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and the
    C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by CSK at
    Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by dephosphorylation by
    PTPRC/CD45. Inhibited by Dasatinib, PP2, and SU6656

         Genatlas biochemistry entry for LYN:
    Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog,highly expressed in the central nervous system,physically
    linked to AMPA receptor and activated following stimulation of the receptor,then activating the MAP Kinase pathway

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): LYN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LYN
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LYN (see all 16):
    hsa-miR-3163 hsa-miR-30c hsa-miR-4324 hsa-miR-3651 hsa-miR-30d hsa-miR-4282 hsa-miR-146a* hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmid: LYN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LYN (see all 7)
    OriGene shRNA RFP: LYN
    OriGene siRNA: LYN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LYN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LYN

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LYN (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LYN (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): LYN (NM_002350)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LYN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYN 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for LYN
    Search LifeMap BioReagents cell lines for LYN

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYN

    Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS--
    GO:0004716receptor signaling protein tyrosine kinase activity TAS10748115
    GO:0005102receptor binding ----


    LYN for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for LYN:
     Decreased focal adhesion (FA)   Decreased viability in HMC1.1   Decreased viability with TRAIL  Increased colony dispersion (i 
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for LYN: Lyntm1Tya Lyntm1Sor Lyntm1Ard
         9 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Lyn):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  nervous system  renal/urinary system 

    LYN for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LYN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/61 super-pathways (see all 61) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Phosphorylation of GAB2 by SFKs
    		Phosphorylation of GAB2 by SFKs1.00
    		Regulation of KIT signaling0.44
    		Phosphorylation of STATs0.47
    		PECAM1 interactions0.38
    2Immune response Fc epsilon RI pathway
    		Immune response Fc epsilon RI pathway1.00
    		Fc-epsilon receptor I signaling in mast cells0.33
    		Immune response_Fc epsilon RI pathway0.99
    3Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    4Development_EPO-induced Jak-STAT pathway
    		Development EPO-induced Jak-STAT pathway1.00
    		EPO signaling pathway0.34
    		Development_EPO-induced Jak-STAT pathway1.00
    5B cell receptor signaling pathway
    		B cell receptor signaling pathway1.00
    		PI3K Signaling in B-Lymphocyte0.35
    		BCR signaling pathway0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for LYN (see all 6)
        Immune response BCR pathway
    Immune response Role of integrins in NK cells cytotoxicity
    Development EPO-induced Jak-STAT pathway
    Development EPO-induced MAPK pathway
    Immune response NFAT in immune response

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LYN (see all 9)
        Fc-Gamma-RIIB Signaling in B-Cells
    Fc-GammaR Pathway
    PI3K Signaling in B-Lymphocyte
    NF-KappaB Family Pathway
    p70S6K Signaling

    3 Cell Signaling Technology (CST) Pathways for LYN
        MAP Kinase Signaling
    Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    5/6 GeneGo (Thomson Reuters) Pathways for LYN (see all 6)
        Development EPO-induced MAPK pathway
    Development EPO-induced Jak-STAT pathway
    Immune response Fc epsilon RI pathway
    Immune response BCR pathway
    Immune response Role of integrins in NK cells cytotoxicity

    5/24 BioSystems Pathways for LYN (see all 24) 
        IL-7 Signaling Pathway
    IL-3 Signaling Pathway
    IL-6 Signaling Pathway
    Kit Receptor Signaling Pathway
    RANKL/RANK Signaling Pathway

    5/31        Reactome Pathways for LYN (see all 31)
        Costimulation by the CD28 family
    FCGR activation
    Regulation of signaling by CBL
    CBL ubiquitinates PI3K
    GPVI stimulates PI3K beta, gamma


    5/6         Kegg Pathways  (Kegg details for LYN) (see all 6):
        Chemokine signaling pathway
    B cell receptor signaling pathway
    Fc epsilon RI signaling pathway
    Fc gamma R-mediated phagocytosis
    Long-term depression


    LYN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LYN

    5/153 Interacting proteins for LYN (P079481, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-62610 MINT-62708 MINT-62784 I2D: score=5 
    HCLS1P143172, 3MINT-61343 MINT-8026812 I2D: score=7 
    TRIP10Q156422, 3MINT-50925 MINT-50926 I2D: score=2 
    CBLP226812, 3MINT-16347 I2D: score=5 
    PAG1Q9NWQ82, 3MINT-8036542 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/85 biological process terms (GO ID links to tree view) (see all 85):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001782B cell homeostasis ISS--
    GO:0001817regulation of cytokine production ISS--
    GO:0001932regulation of protein phosphorylation TAS15489917
    GO:0001933negative regulation of protein phosphorylation ISS--
    GO:0002431Fc receptor mediated stimulatory signaling pathway ISS--


    LYN for ontologies           About GeneDecksing



    Drugs & Compounds
    for LYN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LYN for compounds           About GeneDecksing

    EMD Millipore small molecules for LYN:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for LYN

    Browse Tocris compounds for LYN

    2 HMDB Compounds for LYN    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for LYN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine-- --target--10592235

    10/54 Novoseek chemical compound relationships for LYN gene (see all 54)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 87.9 425 8666899 (5), 9573010 (4), 11053250 (4), 11443118 (4) (see all 99)
    dasatinib 79.9 10 18577747 (1), 17218385 (1), 17431118 (1), 19447874 (1) (see all 10)
    pp55 71.7 1 9195899 (1)
    herbimycin a 65.1 4 7499232 (1), 1730866 (1), 11751911 (1), 12206990 (1)
    phosphatidylinositol 62.8 25 1371009 (2), 10844001 (1), 11694268 (1), 15287886 (1) (see all 16)
    imatinib 62.3 41 18577747 (6), 18235045 (5), 19340007 (4), 15175350 (3) (see all 15)
    phosphotyrosine 61.1 3 10764829 (1), 7525568 (1), 8709147 (1)
    3-tyrosine 57.1 1 12763027 (1)
    phosphatidylinositol-3,4,5-trisphosphate 53.4 1 7650013 (1)
    phosphoinositide 45.4 5 12871380 (1), 15252124 (1), 19290925 (1), 11781242 (1)

    Search CenterWatch for drugs/clinical trials and news about LYN 

    Transcripts
    for LYN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LYN gene (2 alternative transcripts): 
    NM_001111097.2  NM_002350.3  

    Unigene Cluster for LYN:

    V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    Hs.491767  [show with all ESTs]
    Unigene Representative Sequence: NM_002350
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519728 ENST00000520220(uc003xsl.4 uc003xsk.4) ENST00000520050
    ENST00000420292

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LYN
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LYN (see all 16):
    hsa-miR-3163 hsa-miR-30c hsa-miR-4324 hsa-miR-3651 hsa-miR-30d hsa-miR-4282 hsa-miR-146a* hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmid: LYN 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LYN (see all 7)
    OriGene shRNA RFP: LYN
    OriGene siRNA: LYN
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): LYN (NM_002350)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LYN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYN 
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    Additional cDNA sequence: 

    AK130135.1 AK290494.1 AK298677.1 BC059394.1 BC068551.1 BC075001.2 BC075002.2 BC126456.1 
    BC126458.1 M16038.1 M79321.1 

    4 DOTS entries:

    DT.101982560  DT.451584  DT.100815202  DT.40218716 

    24/296 AceView cDNA sequences (see all 296):

    BQ063502 AA233811 BM972679 BU632298 M79321 BM129257 AL520258 AA875840 
    BQ013735 BC075001 CA844339 AW130010 BE674884 AI095406 CD367523 AA307109 
    AK130135 CB118101 BM792299 AW675807 CN480554 AI680175 CB990993 BE467336 

    GeneLoc Exon Structure


    Expression
    for LYN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LYN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTGTTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LYN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    HeartHeart TubeHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LYN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LYN

    SOURCE GeneReport for Unigene cluster: Hs.491767

    UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
    Tissue specificity: Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and
    kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and
    neuronal cells. Expressed in primary neuroblastoma tumors

        SABiosciences Expression via Pathway-Focused PCR Arrays including LYN: 
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              Antifungal Response in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYN

    Orthologs
    for LYN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LYN gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LYN1 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 80.15(n)
    87.2(a)    		   421127  NM_001006390.1  NP_001006390.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LYN6
    		 --
    		 86(a)
    		 1 ↔ 1
    		 GL343244.1(159422-183857)
    African clawed frog
    (Xenopus laevis)    		 Amphibia lyn-A2 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 78.94(n)    AB003358.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii lyn1 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 71.59(n)
    76.57(a)    		   447804  NM_001004543.1  NP_001004543.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Src64B3 ring canal formation protein tyrosine kinase 48(a)   64B12   --
    worm
    (Caenorhabditis elegans)    		 Secernentea src-13 Expression: vulva, anus, mu_bod, pharyngeal
    muscle, more    		 43(a)
    (best of 9)    		   I(1567610-1580076)   --


    ENSEMBL Gene Tree for LYN (if available)
    TreeFam Gene Tree for LYN (if available) 

    Paralogs
    for LYN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LYN gene
    TEC2  FRK2  LCK2  BLK2  FGR2  ITK2  TXK2  HCK2  
    YES12  PTK62  SRC2  ABL12  FYN2  BMX2  ABL22  SRMS2  
    BTK2  
    18/43 SIMAP similar genes for LYN using alignment to 3 protein entries:     LYN_HUMAN (see all proteins) (see all similar genes):
    HCK    BLK    YES1    c-fgr    FGR    FYN
    SRC    FRK    EPHA2    LCK    NCK1    NCK2
    EPHA6    BMX    BTK kinase deficient isoform 2    EPHA3    EPHA4    PTK6

    LYN for paralogs           About GeneDecksing



    Genomic Variants
    for LYN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2461 NCBI SNPs in LYN are shown (see all 2461)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs801066231,2
    		F,--52259078(+) CCTGAT/AGATGC 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs796340121,2
    		--52259388(+) GGATTC/GTTGAT 2 -- us2k11Minor allele frequency- G:0.01WA 118
    rs726514541,2
    		C,F,--52259636(+) TCAGAA/GCATTG 2 -- us2k11Minor allele frequency- G:0.17NA 120
    rs726514561,2
    		C,F,--52260103(+) TGAACA/TGCCTC 2 -- us2k11Minor allele frequency- T:0.18NA 120
    rs107124491,2
    		C,--52261158(+) GGCTC-/ACCGCG 2 -- int10--------
    rs1113531901,2
    		C,--52261174(+) TTCCCG/TGTGAG 2 -- int10--------
    rs744642091,2
    		C,--52261184(+) GGGCCC/GGAGGG 2 -- int13Minor allele frequency- G:0.09NA WA EA 240
    rs69831301,2
    		C,F,A,H,--52261429(+) GCTGCA/GGCGGA 2 -- int17Minor allele frequency- G:0.15NS EA WA NA 776
    rs781876461,2
    		F,--52262248(+) CCCTCC/GATTCT 2 -- int11Minor allele frequency- G:0.07WA 118
    rs573579721,2
    		C,F,--52262324(+) GGTGAC/GTGGGC 2 -- int13Minor allele frequency- G:0.12WA 122

    HapMap Linkage Disequilibrium report for LYN (56792372 - 56923940 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for LYN
         3 CNVs: 8604 53572 52585
    Human Gene Mutation Database (HGMD): LYN

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for LYN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LYN for disorders           About GeneDecksing

    OMIM gene information: 165120    OMIM disorders: --

    UniProtKB/Swiss-Prot: LYN_HUMAN, P07948
  • Note=Constitutively phosphorylated and activated in cells from a number of chronic myelogenous leukemia (CML)
    • and acute myeloid leukemia (AML) patients. Mediates phosphorylation of the BCR-ABL fusion protein. Abnormally elevated
    expression levels or activation of LYN signaling may play a role in survival and proliferation of some types of cancer
    cells

    20/57 diseases for LYN (see all 57):    About MalaCards
    human t-cell leukemia virus type 1    sarcoma    myeloid leukemia    lupus erythematosus
    lymphocytic leukemia    b-cell lymphomas    lymphoblastic leukemia    systemic lupus erythematosus
    leukemia    acute promyelocytic leukemia    differentiating neuroblastoma    acanthocytosis
    alexia    megakaryocytic leukemia    acute lymphoblastic leukemia    chronic lymphocytic leukemia
    acute lymphocytic leukemia    chronic myeloid leukemia    acute myeloid leukemia    burkitt's lymphoma

    2 diseases from the University of Copenhagen DISEASES database for LYN:
    Leukemia     Lymphoma

    10/26 Novoseek disease relationships for LYN gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 59.3 3 18235045 (2), 17432977 (1)
    myeloid leukemia 34.5 1 7512079 (1)
    leukemia 33.1 3 17344919 (1), 7636265 (1), 15175350 (1)
    lymphoblastic leukemia acute 29.6 9 10720701 (2), 17344919 (2), 10658677 (2)
    lymphocytic leukemia chronic b-cell 27.4 1 18768392 (1)
    myeloma 26.4 7 20079716 (4), 7831290 (1), 10201980 (1)
    lupus erythematosus systemic 23.5 4 15022330 (1), 20087361 (1), 19369946 (1), 16320343 (1)
    lymphoma 23.4 17 8264235 (2), 18070987 (2), 20043832 (2), 17640867 (1) (see all 6)
    leukemogenesis 23.1 1 15781338 (1)
    leukemia t-cell 17.3 1 1379847 (1)

    Human Genome Epidemiology (HuGE) Navigator: LYN (22 documents)
    Tumor Gene Database (TGDB): LYN

    Export disorders for LYN gene to outside databases

    Publications
    for LYN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LYN gene, integrated from 9 sources (see all 697):
    (articles sorted by number of sources associating them with LYN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. (PubMed id 3561390)1, 2, 3 Yamanashi Y.... Toyoshima K. (1987)
    2. Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity. (PubMed id 18817770)1, 2, 9 Ikeda K.... Yamaguchi N. (2008)
    3. Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells. (PubMed id 9341198)1, 2, 9 Linnekin D....Mou S. (1997)
    4. Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. (PubMed id 18577747)1, 2, 9 Wu J....Donato N.J. (2008)
    5. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. (PubMed id 18235045)1, 2, 9 Wu J....Donato N.J. (2008)
    6. Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain. (PubMed id 15173188)1, 2, 9 Kasahara K....Yamaguchi N. (2004)
    7. Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage. (PubMed id 10891478)1, 2, 9 Yoshida K....Kufe D. (2000)
    8. Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. (PubMed id 9171348)1, 2, 9 Hirao A....Yamaguchi N. (1997)
    9. Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. (PubMed id 18070987)1, 2, 9 Tauzin S....Hoessli D.C. (2008)
    10. Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage. (PubMed id 10574931)1, 2, 9 Yoshida K....Kufe D. (1999)

    External Searches for LYN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LYN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4067 HGNC: 6735 AceView: LYN Ensembl:ENSG00000254087 euGenes: HUgn4067
    ECgene: LYN Kegg: 4067 H-InvDB: LYN

    Other Databases showing LYN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LYN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LYN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LYN Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for LYN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LYN gene:
    Search GeneIP for patents involving LYN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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