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Aliases for LYN Gene

Aliases for LYN Gene

  • LYN Proto-Oncogene, Src Family Tyrosine Kinase 2 3
  • V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog 2 3 4
  • Lck/Yes-Related Novel Protein Tyrosine Kinase 3 4
  • EC 2.7.10.2 4 63
  • P53Lyn 3 4
  • P56Lyn 3 4
  • JTK8 3 4
  • EC 2.7.10 63

External Ids for LYN Gene

Previous GeneCards Identifiers for LYN Gene

  • GC08P055975
  • GC08P056731
  • GC08P056515
  • GC08P056842
  • GC08P056954
  • GC08P056792
  • GC08P052260

Summaries for LYN Gene

Entrez Gene Summary for LYN Gene

  • This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for LYN Gene

LYN (LYN Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with LYN include hantavirus pulmonary syndrome and leukemia, chronic myeloid, somatic. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for LYN Gene

  • Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on Tyr-72. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.

Tocris Summary for LYN Gene

  • Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.

Gene Wiki entry for LYN Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYN Gene

Genomics for LYN Gene

Regulatory Elements for LYN Gene

Transcription factor binding sites by QIAGEN in the LYN gene promoter:

Genomic Location for LYN Gene

Chromosome:
8
Start:
55,878,463 bp from pter
End:
56,014,168 bp from pter
Size:
135,706 bases
Orientation:
Plus strand

Genomic View for LYN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for LYN Gene

Proteins for LYN Gene

  • Protein details for LYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07948-LYN_HUMAN
    Recommended name:
    Tyrosine-protein kinase Lyn
    Protein Accession:
    P07948
    Secondary Accessions:
    • A0AVQ5

    Protein attributes for LYN Gene

    Size:
    512 amino acids
    Molecular mass:
    58574 Da
    Quaternary structure:
    • Interacts with TEC. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with LIME1 and with CD79A upon activation of the B-cell antigen receptor. Interacts with the B-cell receptor complex. Interacts with phosphorylated THEMIS2. Interacts with EPOR. Interacts with MS4A2/FCER1B. Interaction (via the SH2 and SH3 domains) with MUC1 is stimulated by IL7 and the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with ADAM15. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with FASLG. Interacts with KIT. Interacts with HCLS1. Interacts with FCGR2B. Interacts with FCGR1A; the interaction may be indirect. Interacts with CD19, CD22, CD79A and CD79B. Interacts (via SH3 domain) with CBLC, PPP1R15A and PDE4A. Interacts with TGFB1I1. Interacts (via SH3 domain) with PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase; this interaction enhances phosphatidylinositol 3-kinase activity. Interacts with CSF2RB, the common subunit of the IL3, IL5 and CSF2 receptors. Interacts with PAG1; identified in a complex with PAG1 and STAT3. Interacts with ABL1. Interacts with PTPN6/SHP-1. Interacts (via SH3 domain) with SCIMP (via proline-rich region). Interacts with LPXN (via LD motif 3) and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via SH3-domain) with ANKRD54 (via ankyrin repeat region) in an activation-independent status of LYN. Forms a multiprotein complex with ANKRD54 and HCLS1. Interacts with Epstein-Barr virus LMP2A. Interacts with Herpes virus saimiri tyrosine kinase interacting protein (Tip). Interacts (via SH2 and SH3 domains) with UNC119; leading to LYN activation. Interacts with CD36.

    Three dimensional structures from OCA and Proteopedia for LYN Gene

    Alternative splice isoforms for LYN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYN Gene

Proteomics data for LYN Gene at MOPED

Post-translational modifications for LYN Gene

  • Autophosphorylated. Phosphorylated on tyrosine residues in response to KIT signaling. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylation at Tyr-508 inhibits kinase activity. Phosphorylated at Tyr-508 by CSK. Dephosphorylated by PTPRC/CD45. Becomes rapidly phosphorylated upon activation of the B-cell receptor and the immunoglobulin receptor FCGR1A.
  • Ubiquitinated by CBL, leading to its degradation. Ubiquitination is SH3-dependent.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYN Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LYN (Lyn)

Protein Products

Domains & Families for LYN Gene

Suggested Antigen Peptide Sequences for LYN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07948

UniProtKB/Swiss-Prot:

LYN_HUMAN :
  • The protein kinase domain plays an important role in its localization in the cell membrane.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • The protein kinase domain plays an important role in its localization in the cell membrane.
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with LYN: view

Function for LYN Gene

Molecular function for LYN Gene

GENATLAS Biochemistry:
Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog,highly expressed in the central nervous system,physically linked to AMPA receptor and activated following stimulation of the receptor,then activating the MAP Kinase pathway
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and the C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by CSK at Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by dephosphorylation by PTPRC/CD45. Inhibited by Dasatinib, PP2, and SU6656.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on Tyr-72. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.

Enzyme Numbers (IUBMB) for LYN Gene

Gene Ontology (GO) - Molecular Function for LYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS --
GO:0004716 receptor signaling protein tyrosine kinase activity TAS 10748115
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with LYN: view
genes like me logo Genes that share phenotypes with LYN: view

Animal Models for LYN Gene

MGI Knock Outs for LYN:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for LYN Gene

Localization for LYN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYN Gene

Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYN Gene COMPARTMENTS Subcellular localization image for LYN gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 4
cytoskeleton 2
lysosome 2
mitochondrion 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for LYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005794 Golgi apparatus IDA 15173188
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LYN: view

Pathways & Interactions for LYN Gene

genes like me logo Genes that share pathways with LYN: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for LYN Gene

Activates:
Inactivates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for LYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis ISS --
GO:0001817 regulation of cytokine production ISS --
GO:0001932 regulation of protein phosphorylation TAS 15489917
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with LYN: view

Drugs & Compounds for LYN Gene

(37) Drugs for LYN Gene - From: NovoSeek, HMDB, DGIdb, DrugBank, Tocris, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
bosutinib Approved Pharma inhibitor, Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors, Dual Src-Abl inhibitor; antiproliferative 0
Nintedanib Approved Pharma Target, Inhibitor VEGFR, FGFR, PDGFR, and FLT3 inhibitor, Kinase Inhibitors 94
ponatinib Approved Pharma Target, inhibitor Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors 26
Bosulif Approved September 2012 Pharma 0
Iclusig Approved December 2012 Pharma 0

(33) Additional Compounds for LYN Gene - From: NovoSeek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
1-Naphthyl PP1
221243-82-9
MLR 1023
41964-07-2
PP 3
5334-30-5
12-O-Tetradecanoylphorbol 13-acetate
genes like me logo Genes that share compounds with LYN: view

Transcripts for LYN Gene

Unigene Clusters for LYN Gene

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LYN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYN Gene

No ASD Table

Relevant External Links for LYN Gene

GeneLoc Exon Structure for
LYN
ECgene alternative splicing isoforms for
LYN

Expression for LYN Gene

mRNA expression in normal human tissues for LYN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYN Gene

This gene is overexpressed in Whole Blood (x23.5).

Protein differential expression in normal tissues from HIPED for LYN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.0), Platelet (10.7), and Lymph node (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LYN Gene



SOURCE GeneReport for Unigene cluster for LYN Gene Hs.491767

mRNA Expression by UniProt/SwissProt for LYN Gene

P07948-LYN_HUMAN
Tissue specificity: Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors.
genes like me logo Genes that share expression patterns with LYN: view

Protein tissue co-expression partners for LYN Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for LYN Gene

This gene was present in the common ancestor of animals.

Orthologs for LYN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LYN 35
  • 89.97 (n)
  • 96.87 (a)
LYN 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LYN 35
  • 91.41 (n)
  • 97.07 (a)
LYN 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lyn 35
  • 88.93 (n)
  • 96.09 (a)
Lyn 16
Lyn 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LYN 35
  • 99.61 (n)
  • 100 (a)
LYN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lyn 35
  • 87.89 (n)
  • 96.09 (a)
oppossum
(Monodelphis domestica)
Mammalia LYN 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYN 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves LYN 35
  • 80.35 (n)
  • 87.6 (a)
LYN 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LYN 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lyn 35
  • 76.5 (n)
  • 85.45 (a)
Str.11837 35
African clawed frog
(Xenopus laevis)
Amphibia lyn-A 35
zebrafish
(Danio rerio)
Actinopterygii lyn 35
  • 71.81 (n)
  • 77.47 (a)
lyn 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Src64B 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea F26E4.5 37
  • 34 (a)
K09B11.5 37
  • 35 (a)
kin-26 37
  • 32 (a)
src-1 37
  • 43 (a)
T25B9.5 37
  • 34 (a)
W01B6.5 37
  • 29 (a)
W02A2.4 37
  • 35 (a)
Y52D5A.2 37
  • 32 (a)
Y69E1A.3 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
Species with no ortholog for LYN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYN Gene

ENSEMBL:
Gene Tree for LYN (if available)
TreeFam:
Gene Tree for LYN (if available)

Paralogs for LYN Gene

Paralogs for LYN Gene

genes like me logo Genes that share paralogs with LYN: view

Variants for LYN Gene

Sequence variations from dbSNP and Humsavar for LYN Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs13636 -- 55,880,028(-) GGGCG(G/T)CCCAG utr-variant-5-prime, synonymous-codon, reference, nc-transcript-variant
rs167999 -- 55,880,126(+) GCCCA(A/G)GGGTG intron-variant
rs170783 -- 55,911,223(-) atata(C/T)acaca intron-variant
rs179692 -- 55,911,157(-) atgta(C/T)atata intron-variant
rs182832 -- 55,878,302(+) GGGGA(G/T)CTGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LYN Gene

Variant ID Type Subtype PubMed ID
dgv459n21 CNV Gain 19592680
nsv527341 CNV Gain 19592680
dgv889n27 CNV Gain 19166990
esv2752257 CNV Gain 17911159
nsv522326 CNV Gain 19592680
esv1459437 CNV Deletion 17803354
esv1236863 CNV Insertion 17803354
nsv527033 CNV Loss 19592680
nsv831319 CNV Gain 17160897
esv270207 CNV Insertion 20981092
nsv507467 CNV Insertion 20534489
nsv524526 CNV Loss 19592680

Variation tolerance for LYN Gene

Residual Variation Intolerance Score: 10.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYN Gene

HapMap Linkage Disequilibrium report
LYN
Human Gene Mutation Database (HGMD)
LYN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYN Gene

Disorders for LYN Gene

MalaCards: The human disease database

(5) MalaCards diseases for LYN Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hantavirus pulmonary syndrome
  • hps
leukemia, chronic myeloid, somatic
  • chronic myeloid leukemia
sarcoma
  • tumor of soft tissue and skeleton
chronic lymphocytic leukemia
  • lymphoplasmacytic leukemia
neuroblastoma
  • neuroblastoma 1
- elite association
Search LYN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LYN_HUMAN
  • Note=Constitutively phosphorylated and activated in cells from a number of chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) patients. Mediates phosphorylation of the BCR-ABL fusion protein. Abnormally elevated expression levels or activation of LYN signaling may play a role in survival and proliferation of some types of cancer cells.

Relevant External Links for LYN

Genetic Association Database (GAD)
LYN
Human Genome Epidemiology (HuGE) Navigator
LYN
Tumor Gene Database (TGDB):
LYN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYN
genes like me logo Genes that share disorders with LYN: view

No data available for Genatlas for LYN Gene

Publications for LYN Gene

  1. A novel signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of myeloma cells. (PMID: 20079716) Iqbal M.S. … Ishikawa H. (Biochem. Biophys. Res. Commun. 2010) 23 67
  2. Rituximab inhibits B-cell receptor signaling. (PMID: 19965664) Kheirallah S. … Bezombes C. (Blood 2010) 23 67
  3. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. (PMID: 20209107) Humbert M. … Dubreuil P. (PLoS ONE 2010) 23 67
  4. Role of very long fatty acid-containing glycosphingolipids in membrane organization and cell signaling: the model of lactosylceramide in neutrophils. (PMID: 19015977) Sonnino S. … Iwabuchi K. (Glycoconj. J. 2009) 23 67
  5. Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells. (PMID: 19340007) Gamas P. … Auberger P. (Leukemia 2009) 23 67

Products for LYN Gene

Sources for LYN Gene

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