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LYL1 Gene

protein-coding   GIFtS: 56
GCID: GC19M013209

Lymphoblastic Leukemia Associated Hematopoiesis Regulator...

(Previous name: lymphoblastic leukemia derived sequence 1)
  See LYL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lymphoblastic Leukemia Associated Hematopoiesis Regulator 11 2     Protein Lyl-12
Lymphoblastic Leukemia Derived Sequence 11 2     BHLHA183
Class A Basic Helix-Loop-Helix Protein 182 3     Lymphoblastic Leukemia-Derived Sequence 13
bHLHa182 3     

External Ids:    HGNC: 67341   Entrez Gene: 40662   Ensembl: ENSG000001049037   OMIM: 1514405   UniProtKB: P129803   

Export aliases for LYL1 gene to outside databases

Previous GC identifers: GC19M013542 GC19M013055 GC19M013070 GC19M012782


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LYL1 Gene:
This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood
vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus
(GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. (provided by RefSeq, Sep
2010)

GeneCards Summary for LYL1 Gene:
LYL1 (lymphoblastic leukemia associated hematopoiesis regulator 1) is a protein-coding gene. Diseases associated with LYL1 include leukemia, t-cell acute lymphoblastoid, and lymphoblastic leukemia. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is NHLH1.

Gene Wiki entry for LYL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LYL1 gene promoter:
         ER-alpha   HTF   SREBP-1b   GATA-1   AREB6   c-Myb   Sox9   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLYL1 promoter sequence
   Search Chromatin IP Primers for LYL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LYL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

LYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M013209:  view genomic region     (about GC identifiers)

Start:
13,209,842 bp from pter      End:
13,213,975 bp from pter
Size:
4,134 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LYL1_HUMAN, P12980 (See protein sequence)
Recommended Name: Protein lyl-1  
Size: 280 amino acids; 29938 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Sequence caution: Sequence=AAA88084.1; Type=Erroneous initiation; Sequence=AAA88085.1; Type=Erroneous initiation;
Sequence=AAA92488.1; Type=Erroneous initiation;
Secondary accessions: O76102

Explore the universe of human proteins at neXtProt for LYL1: NX_P12980

Explore proteomics data for LYL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LYL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005574.2  
    ENSEMBL proteins: 
     ENSP00000264824   ENSP00000468122  

    LYL1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for LYL1

     
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    antibodies-online peptides for LYL1

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    antibodies-online antibodies for LYL1 (38 products) 

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    antibodies-online kits for LYL1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P12980

    ProtoNet protein and cluster: P12980

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: LYL1_HUMAN, P12980
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with LYL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for LYL1:
    DNA binding protein with helix loop helix motif,rearranged in T-ALL leukemia,with translocation t(7;19)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA18160048
    GO:0005515protein binding IPI10023675
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with LYL1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lyl1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with LYL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LYL1: Lyl1tm1Mago Lyl1tm1Fsky

       genOway: Develop your customized and physiologically relevant rodent model for LYL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LYL1:
    hsa-mir-335-5p (MIRT017738)

    Block miRNA regulation of human, mouse, rat LYL1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LYL1:
    hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidLYL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LYL1
    Predesigned siRNA for gene silencing in human, mouse, rat LYL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYL1_HUMAN, P12980: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with LYL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LYL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with LYL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for LYL1):
        Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including LYL1: 
              Leukemia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LYL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for LYL1 (P129803 ENSP000002648244) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO1P258003, ENSP000003382074I2D: score=3 STRING: ENSP00000338207
    LMO2P257913, ENSP000002578184I2D: score=3 STRING: ENSP00000257818
    NFKB1P198383, ENSP000002265744I2D: score=3 STRING: ENSP00000226574
    DRG1Q9Y2953, ENSP000003297154I2D: score=2 STRING: ENSP00000329715
    TAL1P175423, ENSP000002943394I2D: score=1 STRING: ENSP00000294339
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001955blood vessel maturation IMP--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA10023675
    GO:0030183B cell differentiation ISS--
    GO:0045893positive regulation of transcription, DNA-templated IDA18160048

    Find genes that share ontologies with LYL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LYL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LYL1 gene: 
    NM_005583.4  

    Unigene Cluster for LYL1:

    Lymphoblastic leukemia derived sequence 1
    Hs.46446  [show with all ESTs]
    Unigene Representative Sequence: NM_005583
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264824(uc002mwi.3) ENST00000590974 ENST00000590120
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LYL1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LYL1:
    hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidLYL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LYL1
    Predesigned siRNA for gene silencing in human, mouse, rat LYL1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LYL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYL1
    Primer
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    OriGene qPCR primer pairs and template standards for LYL1
    OriGene qSTAR qPCR primer pairs in human, mouse for LYL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LYL1
      QuantiTect SYBR Green Assays in human, mouse, rat LYL1
      QuantiFast Probe-based Assays in human, mouse, rat LYL1

    Additional mRNA sequence: 

    BC002796.2 M22637.1 

    2 DOTS entries:

    DT.309710  DT.97835149 

    Selected AceView cDNA sequences (see all 70):

    BM971554 AI184953 BU689243 NM_005583 CR626486 BC002796 CR608162 R09896 
    BU727952 BM920603 AI249440 BI826659 BV184268 BM971064 BX381401 CA444958 
    AI807496 BM974651 BI908195 BP367249 AI003632 AI378149 BU689329 BX353347 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LYL1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for LYL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LYL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAGCAGT
    LYL1 Expression
    About this image


    LYL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    LYL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LYL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46446
        Pathway & Disease-focused RT2 Profiler PCR Array including LYL1: 
              Leukemia in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LYL1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lyl11 , 5 lymphoblastomic leukemia 11, 5 79.86(n)1
    78.42(a)1
      8 (41.02 cM)5
    170951  NM_008535.21  NP_032561.21 
     847014575 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    many ↔ many
    2(78358629-78367972)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003331131 protein lyl-1-like 66.25(n)
    61.49(a)
      100333113  XM_002662234.3  XP_002662280.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta HLH3B6
    Helix loop helix protein 3B
    21(a)
    1 → many
    X(2574232-2575756)


    ENSEMBL Gene Tree for LYL1 (if available)
    TreeFam Gene Tree for LYL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LYL1 gene
    NHLH12  TWIST12  TWIST22  HAND22  TAL12  NHLH22  TAL22  TCF152  
    SCXB2  HAND12  SCXA2  
    3 SIMAP similar genes for LYL1 using alignment to 2 protein entries:     LYL1_HUMAN (see all proteins):
    TAL2    NHLH2    NHLH1

    Find genes that share paralogs with LYL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LYL1 (see all 123)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867120161,2
    C--13148830(+) TGGCCC/TCCAAT 1 -- int10--------
    rs2009279411,2
    C--13148946(+) AGCAGC/TGGGGG 2 P syn10--------
    rs1998588901,2
    C--13148954(+) GGGCCA/GCAGAG 2 R W mis10--------
    rs1510733491,2
    C--13149039(+) GGCAGC/TCTGGG 2 R syn10--------
    rs1412743581,2
    C--13149055(+) AGGAGC/TCTCCT 2 D G mis10--------
    rs1170729281,2
    C,F--13149061(+) CTCCTC/TGGTGG 2 Q R mis11Minor allele frequency- T:0.12NA 120
    rs2017864091,2
    --13149096(+) CCAGGC/TGAGGC 2 S syn10--------
    rs3742433291,2
    C--13149105(+) GCAGGC/TTTAGG 2 K syn10--------
    rs121512481,2
    C,F,H--13149243(+) GAAGGC/TAGCCA 1 -- int112Minor allele frequency- T:0.05NS EA NA 1688
    rs1924948461,2
    C--13149246(+) GGCAGC/TCAGTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for LYL1 (13209842 - 13213975 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LYL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    dgv3736n71CNV Loss21882294
    dgv3735n71CNV Loss21882294
    nsv911087CNV Loss21882294
    nsv911086CNV Loss21882294
    nsv911090CNV Loss21882294
    nsv828447CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LYL1
    DNA2.0 Custom Variant and Variant Library Synthesis for LYL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151440    OMIM disorders: --

    UniProtKB/Swiss-Prot: LYL1_HUMAN, P12980
  • Note=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic
    leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB

  • 5 diseases for LYL1:    
    About MalaCards
    leukemia, t-cell acute lymphoblastoid    lymphoblastic leukemia    leukemia    acute leukemia
    acute myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for LYL1:
    Leukemia

    Find genes that share disorders with LYL1           About GenesLikeMe

    3 Novoseek inferred disease relationships for LYL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 84.9 8 10023675 (2), 8142619 (1), 7734349 (1), 19608273 (1) (see all 5)
    acute leukemia 56.7 1 8142619 (1)
    leukemia 33.7 1 18160048 (1)

    Genatlas disease: LYL1
    acute lymphoblastic leukemia (T-ALL) with translocation t(7;19)(q35;p13)

    Tumor Gene Database (TGDB): LYL1

    Export disorders for LYL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LYL1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with LYL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. (PubMed id 2752424)1, 2, 3 Mellentin J.D.... Cleary M.L. (Cell 1989)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. (PubMed id 18160048)1, 9 San-Marina S....Minden M.D. (Biochim. Biophys. Acta 2008)
    5. Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines. (PubMed id 19608273)1, 9 Nagel S....MacLeod R.A. (Leuk. Res. 2010)
    6. Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. (PubMed id 10023675)1, 9 Ferrier R....Mathieu-Mahul D. (Oncogene 1999)
    7. Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. (PubMed id 2067848)1, 9 Kuo S.S....Cleary M.L. (Oncogene 1991)
    8. Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization. (PubMed id 2268576)1, 9 Saltman D.L....Cleary M.L. (amp 1990)
    9. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. (PubMed id 23327922)1 Diffner E....Pimanda J.E. (Blood 2013)
    10. LYL1 degradation by the proteasome is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. (PubMed id 20844761)1 Lukov G.L. and Goodell M.A. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4066 HGNC: 6734 AceView: LYL1 Ensembl:ENSG00000104903 euGenes: HUgn4066
    ECgene: LYL1 Kegg: 4066 H-InvDB: LYL1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LYL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LYL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LYL1 gene:
    Search GeneIP for patents involving LYL1

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