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Aliases for LYL1 Gene

Aliases for LYL1 Gene

  • Lymphoblastic Leukemia Associated Hematopoiesis Regulator 1 2 3 5
  • Lymphoblastic Leukemia Derived Sequence 1 2 3
  • Class A Basic Helix-Loop-Helix Protein 18 3 4
  • BHLHa18 3 4
  • Lymphoblastic Leukemia-Derived Sequence 1 4

External Ids for LYL1 Gene

Previous GeneCards Identifiers for LYL1 Gene

  • GC19M013542
  • GC19M013055
  • GC19M013070
  • GC19M013209
  • GC19M012782

Summaries for LYL1 Gene

Entrez Gene Summary for LYL1 Gene

  • This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]

GeneCards Summary for LYL1 Gene

LYL1 (Lymphoblastic Leukemia Associated Hematopoiesis Regulator 1) is a Protein Coding gene. Diseases associated with LYL1 include Lymphoblastic Leukemia and Leukemia. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is HAND1.

Gene Wiki entry for LYL1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYL1 Gene

Genomics for LYL1 Gene

Regulatory Elements for LYL1 Gene

Enhancers for LYL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LYL1 on UCSC Golden Path with GeneCards custom track

Promoters for LYL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LYL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LYL1 Gene

13,097,188 bp from pter
13,103,161 bp from pter
5,974 bases
Minus strand

Genomic View for LYL1 Gene

Genes around LYL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYL1 Gene

Proteins for LYL1 Gene

  • Protein details for LYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lyl-1
    Protein Accession:
    Secondary Accessions:
    • O76102

    Protein attributes for LYL1 Gene

    280 amino acids
    Molecular mass:
    29938 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.
    • Sequence=AAA88084.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA88085.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA92488.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LYL1 Gene

Proteomics data for LYL1 Gene at MOPED

Post-translational modifications for LYL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LYL1 Gene

Domains & Families for LYL1 Gene

Gene Families for LYL1 Gene

Protein Domains for LYL1 Gene

Suggested Antigen Peptide Sequences for LYL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with LYL1: view

Function for LYL1 Gene

Molecular function for LYL1 Gene

GENATLAS Biochemistry:
DNA binding protein with helix loop helix motif,rearranged in T-ALL leukemia,with translocation t(7;19)

Gene Ontology (GO) - Molecular Function for LYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with LYL1: view

Phenotypes for LYL1 Gene

genes like me logo Genes that share phenotypes with LYL1: view

Human Phenotype Ontology for LYL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LYL1 Gene

MGI Knock Outs for LYL1:

Animal Model Products

miRNA for LYL1 Gene

miRTarBase miRNAs that target LYL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LYL1 Gene

Localization for LYL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYL1 Gene

Subcellular locations from

Jensen Localization Image for LYL1 Gene COMPARTMENTS Subcellular localization image for LYL1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for LYL1 Gene

Pathways & Interactions for LYL1 Gene

genes like me logo Genes that share pathways with LYL1: view

Pathways by source for LYL1 Gene

1 KEGG pathway for LYL1 Gene

SIGNOR curated interactions for LYL1 Gene


Gene Ontology (GO) - Biological Process for LYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 10023675
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 18160048
genes like me logo Genes that share ontologies with LYL1: view

Drugs & Compounds for LYL1 Gene

No Compound Related Data Available

Transcripts for LYL1 Gene

Unigene Clusters for LYL1 Gene

Lymphoblastic leukemia derived sequence 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LYL1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP2: -

Relevant External Links for LYL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LYL1 Gene

mRNA expression in normal human tissues for LYL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYL1 Gene

This gene is overexpressed in Whole Blood (x25.0).

Protein differential expression in normal tissues from HIPED for LYL1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LYL1 Gene

SOURCE GeneReport for Unigene cluster for LYL1 Gene Hs.46446

genes like me logo Genes that share expression patterns with LYL1: view

Protein tissue co-expression partners for LYL1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LYL1 Gene

Orthologs for LYL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LYL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LYL1 35
  • 87.26 (n)
  • 86.79 (a)
LYL1 36
  • 87 (a)
(Mus musculus)
Mammalia Lyl1 35
  • 79.86 (n)
  • 78.42 (a)
Lyl1 16
Lyl1 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Lyl1 35
  • 81.53 (n)
  • 80.58 (a)
(Canis familiaris)
Mammalia LYL1 36
  • 83 (a)
(Monodelphis domestica)
Mammalia LYL1 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia LYL1 36
  • 62 (a)
(Pan troglodytes)
Mammalia LYL1 36
  • 98 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
(Danio rerio)
Actinopterygii LOC100333113 35
  • 66.25 (n)
  • 61.49 (a)
CABZ01066695.1 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 36
  • 21 (a)
Species with no ortholog for LYL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LYL1 Gene

Gene Tree for LYL1 (if available)
Gene Tree for LYL1 (if available)

Paralogs for LYL1 Gene

Paralogs for LYL1 Gene

(3) SIMAP similar genes for LYL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LYL1: view

Variants for LYL1 Gene

Sequence variations from dbSNP and Humsavar for LYL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12978390 -- 13,099,505(+) CCGGG(A/T)GGGGT reference, synonymous-codon
rs1003391 -- 13,101,310(+) ggagg(A/G)gagga intron-variant
rs1003392 -- 13,101,314(+) gggag(A/G)agTTT intron-variant
rs1003393 -- 13,101,400(+) GGAGG(C/T)GCCCC intron-variant
rs1047789 -- 13,099,459(-) ACGGC(C/G)CCCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LYL1 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv911086 CNV Loss 21882294
nsv911087 CNV Loss 21882294
dgv3735n71 CNV Loss 21882294
nsv911090 CNV Loss 21882294
nsv828447 CNV Gain 20364138
dgv3736n71 CNV Loss 21882294

Variation tolerance for LYL1 Gene

Gene Damage Index Score: 2.62; 45.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LYL1 Gene

Disorders for LYL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LYL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoblastic leukemia
  • acute lymphocytic leukemia
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
- elite association - COSMIC cancer census association via MalaCards
Search LYL1 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.

Genatlas disease for LYL1 Gene

acute lymphoblastic leukemia (T-ALL) with translocation t(7;19)(q35;p13)

Relevant External Links for LYL1

Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LYL1: view

Publications for LYL1 Gene

  1. lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. (PMID: 2752424) Mellentin J.D. … Cleary M.L. (Cell 1989) 2 3 4 67
  2. Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines. (PMID: 19608273) Nagel S. … MacLeod R.A. (Leuk. Res. 2010) 3 23
  3. Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. (PMID: 18160048) San-Marina S. … Minden M.D. (Biochim. Biophys. Acta 2008) 3 23
  4. Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. (PMID: 10023675) Ferrier R. … Mathieu-Mahul D. (Oncogene 1999) 3 23
  5. Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. (PMID: 2067848) Kuo S.S. … Cleary M.L. (Oncogene 1991) 3 23

Products for LYL1 Gene

Sources for LYL1 Gene