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Aliases for LYL1 Gene

Aliases for LYL1 Gene

  • Lymphoblastic Leukemia Associated Hematopoiesis Regulator 1 2 3
  • Lymphoblastic Leukemia Derived Sequence 1 2 3
  • Class A Basic Helix-Loop-Helix Protein 18 3 4
  • BHLHa18 3 4
  • Lymphoblastic Leukemia-Derived Sequence 1 4
  • Protein Lyl-1 3

External Ids for LYL1 Gene

Previous GeneCards Identifiers for LYL1 Gene

  • GC19M013542
  • GC19M013055
  • GC19M013070
  • GC19M013209
  • GC19M012782

Summaries for LYL1 Gene

Entrez Gene Summary for LYL1 Gene

  • This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]

GeneCards Summary for LYL1 Gene

LYL1 (Lymphoblastic Leukemia Associated Hematopoiesis Regulator 1) is a Protein Coding gene. Diseases associated with LYL1 include lymphoblastic leukemia and leukemia. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is HAND1.

Gene Wiki entry for LYL1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYL1 Gene

Genomics for LYL1 Gene

Regulatory Elements for LYL1 Gene

Genomic Location for LYL1 Gene

Start:
13,097,188 bp from pter
End:
13,103,161 bp from pter
Size:
5,974 bases
Orientation:
Minus strand

Genomic View for LYL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYL1 Gene

Proteins for LYL1 Gene

  • Protein details for LYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12980-LYL1_HUMAN
    Recommended name:
    Protein lyl-1
    Protein Accession:
    P12980
    Secondary Accessions:
    • O76102

    Protein attributes for LYL1 Gene

    Size:
    280 amino acids
    Molecular mass:
    29938 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein
    SequenceCaution:
    • Sequence=AAA88084.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA88085.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA92488.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LYL1 Gene

Proteomics data for LYL1 Gene at MOPED

Post-translational modifications for LYL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LYL1 Gene

Domains for LYL1 Gene

Gene Families for LYL1 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for LYL1 Gene

Suggested Antigen Peptide Sequences for LYL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12980

UniProtKB/Swiss-Prot:

LYL1_HUMAN :
  • P12980
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with LYL1: view

Function for LYL1 Gene

Molecular function for LYL1 Gene

GENATLAS Biochemistry: DNA binding protein with helix loop helix motif,rearranged in T-ALL leukemia,with translocation t(7;19)

Gene Ontology (GO) - Molecular Function for LYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 18160048
GO:0005515 protein binding IPI 10023675
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with LYL1: view

Phenotypes for LYL1 Gene

genes like me logo Genes that share phenotypes with LYL1: view

Animal Models for LYL1 Gene

MGI Knock Outs for LYL1:

Animal Model Products

CRISPR Products

miRNA for LYL1 Gene

miRTarBase miRNAs that target LYL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LYL1 Gene

Localization for LYL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYL1 Gene COMPARTMENTS Subcellular localization image for LYL1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LYL1: view

Pathways for LYL1 Gene

genes like me logo Genes that share pathways with LYL1: view

Pathways by source for LYL1 Gene

1 KEGG pathway for LYL1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001955 blood vessel maturation IMP 20418284
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 10023675
GO:0030183 B cell differentiation ISS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 18160048
genes like me logo Genes that share ontologies with LYL1: view

Transcripts for LYL1 Gene

Unigene Clusters for LYL1 Gene

Lymphoblastic leukemia derived sequence 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LYL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYL1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for LYL1 Gene

GeneLoc Exon Structure for
LYL1
ECgene alternative splicing isoforms for
LYL1

Expression for LYL1 Gene

mRNA expression in normal human tissues for LYL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYL1 Gene

This gene is overexpressed in Whole Blood (25.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LYL1 Gene

SOURCE GeneReport for Unigene cluster for LYL1 Gene Hs.46446

genes like me logo Genes that share expressions with LYL1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LYL1 Gene

Orthologs for LYL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LYL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYL1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LYL1 35
  • 87.26 (n)
  • 86.79 (a)
LYL1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LYL1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lyl1 35
  • 79.86 (n)
  • 78.42 (a)
Lyl1 16
Lyl1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LYL1 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYL1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lyl1 35
  • 81.53 (n)
  • 80.58 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01066695.1 36
  • 33 (a)
ManyToMany
LOC100333113 35
  • 66.25 (n)
  • 61.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 36
  • 21 (a)
OneToMany
Species with no ortholog for LYL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LYL1 Gene

ENSEMBL:
Gene Tree for LYL1 (if available)
TreeFam:
Gene Tree for LYL1 (if available)

Paralogs for LYL1 Gene

Paralogs for LYL1 Gene

Selected SIMAP similar genes for LYL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LYL1: view

Variants for LYL1 Gene

Sequence variations from dbSNP and Humsavar for LYL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1003391 -- 13,101,310(+) ggagg(A/G)gagga intron-variant
rs1003392 -- 13,101,314(+) gggag(A/G)agTTT intron-variant
rs1003393 -- 13,101,400(+) GGAGG(C/T)GCCCC intron-variant
rs1047789 -- 13,099,459(-) ACGGC(C/G)CCCGC missense, reference
rs1122233 -- 13,102,702(+) TCGGA(A/G)GGCCA utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LYL1 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv911086 CNV Loss 21882294
nsv911087 CNV Loss 21882294
dgv3735n71 CNV Loss 21882294
nsv911090 CNV Loss 21882294
nsv828447 CNV Gain 20364138
dgv3736n71 CNV Loss 21882294

Relevant External Links for LYL1 Gene

HapMap Linkage Disequilibrium report
LYL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYL1 Gene

Disorders for LYL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for LYL1 Gene including...

Search for LYL1 Gene in MalaCards »

UniProtKB/Swiss-Prot

LYL1_HUMAN
  • Note=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.

(1) University of Copenhagen DISEASES for LYL1 Gene

(3) Novoseek inferred disease relationships for LYL1 Gene

Disease -log(P) Hits PubMed IDs
t-all 84.9 6
acute leukemia 56.7 1
leukemia 33.7 1

Genatlas disease for LYL1 Gene

acute lymphoblastic leukemia (T-ALL) with translocation t(7;19)(q35;p13)

Relevant External Links for LYL1

Tumor Gene Database (TGDB):
LYL1
genes like me logo Genes that share disorders with LYL1: view

Publications for LYL1 Gene

  1. lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. (PMID: 2752424) Mellentin J.D. … Cleary M.L. (Cell 1989) 2 3 4
  2. Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. (PMID: 2067848) Kuo S.S. … Cleary M.L. (Oncogene 1991) 3 23
  3. Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization. (PMID: 2268576) Saltman D.L. … Cleary M.L. (Genes Chromosomes Cancer 1990) 3 23
  4. Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. (PMID: 10023675) Ferrier R. … Mathieu-Mahul D. (Oncogene 1999) 3 23
  5. Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. (PMID: 18160048) San-Marina S. … Minden M.D. (Biochim. Biophys. Acta 2008) 3 23

Products for LYL1 Gene

Sources for LYL1 Gene

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