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Aliases & Descriptions for LYL1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Lymphoblastic leukemia-derived sequence 1 3 | | lymphoblastic leukemia derived sequence 1 2 |
|
| | Search outside databases for aliases for LYL1 genePrevious GC identifers: GC19M013542 GC19M013055 |
Summaries for LYL1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for LYL1 |
Genomic Location for LYL1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LYL1 gene 
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.13 HGNC cytogenetic band: 19p13.2LYL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M013070:
(about GC identifiers)
Start:
|
13,070,847 bp from pter |
End:
|
13,074,681 bp from pter |
Size:
|
3,835 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for LYL1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LYL1_HUMAN, P12980 (See
protein sequence)Recommended Name: Protein lyl-1 Size: 280 amino acids; 29938 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Subcellular location: Nucleus (Potential)
Secondary accessions: O76102REFSEQ proteins: NP_005574.2
ENSEMBL proteins: ENSP00000264824
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for LYL1: Assays for LYL1: | Protein
Domains/ Families for LYL1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P12980
ProtoNet protein and cluster: P12980 1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH
UniProtKB/Swiss-Prot: LYL1_HUMAN, P12980Similarity: Contains 1 basic helix-loop-helix (bHLH) domain | Gene Function for LYL1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005583
Applied Biosystems Silencer® siRNAs for LYL1
Sigma-Aldrich siRNA for LYL1  Sigma-Aldrich shRNA for LYL1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005583                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005583                                  untagged cDNA clone in CMV expression vector: NM_005583 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005583
Genatlas biochemistry entry for LYL1:DNA binding protein with helix loop helix motif,rearranged in T-ALL leukemia,with translocation t(7;19)2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Lyl1):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for LYL1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for LYL1 
5/10 Interacting proteins for LYL1 (ENSP000002648243) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for LYL1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LYL1
|
Transcripts for LYL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005583
Sigma-Aldrich siRNA for LYL1  Sigma-Aldrich shRNA for LYL1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005583 REFSEQ mRNAs for LYL1 gene: NM_005583.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005583               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005583                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005583                                  untagged cDNA clone in CMV expression vector: NM_005583  Additional cDNA sequence: AK311530.1 BC002796.2 CR608162.1 CR626486.1 M22637.1 3 DOTS entries: DT.309710 DT.97835149 DT.121482618 24/70 AceView cDNA sequences (see all 70
):BM971554 NM_005583 BC002796 BU727952 AI184953 CR608162 CR626486 R09896 BU689243 BM974651 CA444958 BM920603 BM971064 AI249440 BP367249 BV184268 BX381401 BX353347 AW295148 BU689329 BI826659 AI807496 BG757146 AI003632
highest scoring ESTs for LYL1:BC002796 BE396707 BE559551 BG686145 BG686687 BI838018 BI908195 BI908347 BI911873 BQ643386 Unigene Cluster for LYL1: Lymphoblastic leukemia derived sequence 1 Hs.46446 [show with all ESTs]Unigene Representative Sequence: BM924781
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for LYL1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | |
| SP1: | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LYL1
1 Ensembl transcript including schematic representation: ENST00000264824
|
Expression for LYL1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LYL1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LYL1
1 / 2 / 3 3 probe-sets matching LYL1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCAGAGCAGT
SOURCE GeneReport for Unigene cluster: Hs.46446
Expression variation in blood from EXPOLDB for LYL1 |
Orthologs for LYL1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LYL1 gene from 4 species
About this table Species with no ortholog for LYL1
ENSEMBL Gene Tree for LYL1 | Paralogs for LYL1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LYL1 gene
- NHLH12 TAL12 NHLH22 TAL22
|
SNPs/Variants for LYL1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LYL1 (up to first 250kb)
|
Disorders & Mutations for LYL1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 151440 UniProtKB/Swiss-Prot: LYL1_HUMAN, P12980
A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB3 Novoseek disease relationships for LYL1 gene
About this table
Genatlas disease: LYL1 acute lymphoblastic leukemia (T-ALL) with translocation t(7;19)(q35;p13) Tumor Gene Database: LYL1
|
Medical News for LYL1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LYL1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for LYL1 gene (see all 18
):- lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. (PubMed id 2752424)2, 3, 4 Mellentin J.D.... Cleary M.L. (1989)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)3, 4 Grimwood J.... Lucas S.M. (2004)
- Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. (PubMed id 18160048)1, 3 San-Marina S....Minden M.D. (2008)
- Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. (PubMed id 10023675)1, 3 Ferrier R....Mathieu-Mahul D. (1999)
- Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. (PubMed id 2067848)1, 3 Kuo S.S....Cleary M.L. (1991)
- Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization. (PubMed id 2268576)1, 3 Saltman D.L....Cleary M.L. (1990)
- Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia. (PubMed id 16094422)3 Meng Y.S....Minden M.D. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. (PubMed id 9242638)3 Langlands K....Prochownik E.V. (1997)
|
Search for LYL1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LYL1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LYL1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LYL1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LYL1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LYL1:

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