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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LYL1 Gene

protein-coding GIFtS: 54
GCID: GC19M013209

lymphoblastic leukemia derived sequence 1

Explore 11 diseases affiliated with
LYL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lymphoblastic Leukemia Derived Sequence 1¹ ²
BHLHa18¹
Class A Basic Helix-Loop-Helix Protein 18² ³
Protein Lyl-1²
BHLHA18³
Lymphoblastic Leukemia-Derived Sequence 1³

External Ids:	HGNC: 6734¹	Entrez Gene: 4066²	Ensembl: ENSG00000104903⁷	OMIM: 151440⁵	UniProtKB: P12980³

Export aliases for LYL1 gene to outside databases

Previous GC identifers: GC19M013542 GC19M013055 GC19M013070 GC19M012782

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LYL1:

This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel

maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on

chromosome 7 has been associated with acute lymphoblastic leukemia. (provided by RefSeq, Sep 2010)

Gene Wiki entry for LYL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LYL1 gene promoter:
ER-alpha HTF SREBP-1b GATA-1 AREB6 c-Myb Sox9 Pax-4a ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LYL1 promoter sequence

Search SABiosciences Chromatin IP Primers for LYL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LYL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

LYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LYL1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M013209: view genomic region (about GC identifiers)

Start:	13,209,847 bp from pter	End:	13,213,975 bp from pter
Size:	4,129 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LYL1_HUMAN, P12980 (See protein sequence)

Recommended Name: Protein lyl-1

Size: 280 amino acids; 29938 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=AAA88084.1; Type=Erroneous initiation; Sequence=AAA88085.1; Type=Erroneous initiation;

Sequence=AAA92488.1; Type=Erroneous initiation;

Secondary accessions: O76102

Explore the universe of human proteins at neXtProt for LYL1: NX_P12980

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P12980

LYL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005574.2

ENSEMBL proteins:

ENSP00000264824 ENSP00000468122

Human Recombinant Protein Products:

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	Novus Biologicals LYL1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LYL1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

LYL1 for ontologies About GeneDecksing

LYL1 Antibody Products:

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	Uscn ELISAs and CLIAs for LYL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LYL1 for domains About GeneDecksing

1 InterPro domain/family:

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry P12980

ProtoNet protein and cluster: P12980

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: LYL1_HUMAN, P12980

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for LYL1:

DNA binding protein with helix loop helix motif,rearranged in T-ALL leukemia,with translocation t(7;19)

miRNA Products:		OriGene 3'-UTR Clone: LYL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LYL1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate LYL1:
		hsa-miR-1248
		SwitchGear 3'UTR luciferase reporter plasmid: LYL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LYL1 (see all 7) OriGene shRNA RFP: LYL1 OriGene siRNA: LYL1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LYL1

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LYL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LYL1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LYL1 (NM_005583)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LYL1
		Search LifeMap BioReagents cell lines for LYL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYL1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IDA	18160048
GO:0005515	protein binding	IPI	18160048
GO:0046983	protein dimerization activity	IEA	--

LYL1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for LYL1: Lyl1^tm1Mago Lyl1^tm1Fsky
     3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lyl1):

cellular

hematopoietic system

immune system

LYL1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LYL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for LYL1 (P12980³ ENSP00000264824⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LMO1	P25800³, ENSP00000338207⁴	I2D: score=3 STRING: ENSP00000338207
LMO2	P25791³, ENSP00000257818⁴	I2D: score=3 STRING: ENSP00000257818
NFKB1	P19838³, ENSP00000226574⁴	I2D: score=3 STRING: ENSP00000226574
DRG1	Q9Y295³, ENSP00000329715⁴	I2D: score=2 STRING: ENSP00000329715
TAL1	P17542³, ENSP00000294339⁴	I2D: score=1 STRING: ENSP00000294339

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001955	blood vessel maturation	IMP	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IDA	10023675
GO:0030183	B cell differentiation	ISS	--
GO:0045893	positive regulation of transcription, DNA-dependent	IDA	18160048

LYL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LYL1
Search CenterWatch for drugs/clinical trials and news about LYL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LYL1 gene:

NM_005583.4

Unigene Cluster for LYL1:

Lymphoblastic leukemia derived sequence 1

Hs.46446 [show with all ESTs]

Unigene Representative Sequence: NM_005583

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000264824(uc002mwi.3) ENST00000590974 ENST00000590120

miRNA Products:		OriGene 3'-UTR Clone: LYL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LYL1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate LYL1:
		hsa-miR-1248
		SwitchGear 3'UTR luciferase reporter plasmid: LYL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LYL1 (see all 7) OriGene shRNA RFP: LYL1 OriGene siRNA: LYL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LYL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LYL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LYL1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LYL1 (NM_005583)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LYL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LYL1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LYL1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LYL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LYL1

Additional cDNA sequence:

BC002796.2 M22637.1

2 DOTS entries:

DT.309710 DT.97835149

24/70 AceView cDNA sequences (see all 70):

BM971554 R09896 BC002796 CR608162 AI184953 NM_005583 BU689243 CR626486

BU727952 BM971064 BX381401 BI826659 BX353347 AI003632 BM920603 BM974651

BI908195 BU689329 BV184268 AI378149 CA444958 BG757146 BP367249 AW295148

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for LYL1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4
SP1:
SP2:					-

ECgene alternative splicing isoforms for LYL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LYL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGAGCAGT

About this image

LYL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Cardiac Crescent

Cardiac Crescent Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

See LYL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LYL1

SOURCE GeneReport for Unigene cluster: Hs.46446

SABiosciences Expression via Pathway-Focused PCR Array including LYL1:

Leukemia in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LYL1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LYL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LYL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LYL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LYL1 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lyl1^{1 , 5}	lymphoblastomic leukemia 1^{1, 5}	79.86(n)¹ 78.42(a)¹		8 (41.02 cM)⁵ 17095¹ NM_008535.2¹ NP_032561.2¹ 84701457⁵
lizard (Anolis carolinensis)	Reptilia	--	--	54(a)	1 ↔ 1	2(78361616-78367972)
zebrafish (Danio rerio)	Actinopterygii	LOC100333113¹	protein lyl-1-like	61.67(n) 56.11(a)		100333113 XM_002662234.2 XP_002662280.2
fruit fly (Drosophila melanogaster)	Insecta	HLH3B⁶	Helix loop helix protein 3B	17(a)	1 → many	X(2574232-2575756)

ENSEMBL Gene Tree for LYL1 (if available)
TreeFam Gene Tree for LYL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LYL1 gene

TCF24² NHLH1² TWIST1² TWIST2² TAL1² HAND2² TCF23² NHLH2²

TAL2² TCF15² SCXB² TCF21² HAND1² MSC² SCXA²

3 SIMAP similar genes for LYL1 using alignment to 2 protein entries: LYL1_HUMAN (see all proteins):

TAL2 NHLH2 NHLH1

LYL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs57244590^1,2	C,F,	--	13209662(+)	`GTCGGT/CAGGGT`	4	--	ds500¹		3		WA CSA	122
rs147127906^1,2		--	13209814(+)	`CGCGAC/TCCCAG`	4	--	ds500¹		0	--	--	--	--
rs189103076^1,2		--	13209892(+)	`CCTGGA/GAAGGG`	4	--	ut3¹ ds500¹		0	--	--	--	--
rs180723412^1,2		--	13209923(+)	`AGAGGA/GTTGTG`	4	--	ds500¹ ut3¹		0	--	--	--	--
rs200277875^1,2		--	13210107(+)	`CCCTCC/TGGCTC`	4	--	ds500¹ ut3¹		0	--	--	--	--
rs12975595^1,2	C	--	13210320(+)	`CGGGAA/GGGGTG`	2	P L	mis¹ ese³		0	--	--	--	--
rs140631734^1,2	C,	--	13210463(+)	`AGCTCC/GGCGAA`	2	A	syn¹		0	--	--	--	--
rs62109907^1,2	C,F,	--	13210620(+)	`ACACGC/TAGCAC`	1	--	int¹		4		NA CSA	125
rs145557415^1,2	C,	--	13210826(+)	`CCTTG-/TGTT TGTTT`	1	--	int¹		0	--	--	--	--
rs137905871^1,2		--	13211016(+)	`GGCTG-/GTTTTCA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LYL1 (13209847 - 13213975 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LYL1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LYL1

DNA2.0 Custom Variant and Variant Library Synthesis for LYL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LYL1 for disorders About GeneDecksing

OMIM gene information: 151440 OMIM disorders: --

UniProtKB/Swiss-Prot: LYL1_HUMAN, P12980

Note=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia

(T-ALL). Translocation t(7;19)(q35;p13) with TCRB

11 diseases for LYL1: About MalaCards

lymphoblastic leukemia acute lymphoblastic leukemia leukemia leukemia, t-cell acute lymphoblastoid

stem cell leukemia acute lymphocytic leukemia lymphocytic leukemia acute leukemia

t-cell leukemia myeloid leukemia hematopoiesis

1 disease from the University of Copenhagen DISEASES database for LYL1:

Leukemia

3 Novoseek disease relationships for LYL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
t-all	84.9	8	10023675 (2), 8142619 (1), 7734349 (1), 19608273 (1) (see all 5)
acute leukemia	56.7	1	8142619 (1)
leukemia	33.7	1	18160048 (1)

Genatlas disease: LYL1

acute lymphoblastic leukemia (T-ALL) with translocation t(7;19)(q35;p13)

Tumor Gene Database (TGDB): LYL1

Export disorders for LYL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LYL1 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with LYL1)

Utopia: connect your pdf to the dynamic
world of online information

lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. (PubMed id 2752424)^{1, 2, 3} Mellentin J.D.... Cleary M.L. (1989)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. (PubMed id 18160048)^{1, 9} San-Marina S....Minden M.D. (2008)
Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines. (PubMed id 19608273)^{1, 9} Nagel S....MacLeod R.A. (2010)
Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. (PubMed id 10023675)^{1, 9} Ferrier R....Mathieu-Mahul D. (1999)
Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. (PubMed id 2067848)^{1, 9} Kuo S.S....Cleary M.L. (1991)
Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization. (PubMed id 2268576)^{1, 9} Saltman D.L....Cleary M.L. (1990)
LYL1 degradation by the proteasome is directed by a N -terminal PEST rich site in a phosphorylation-independent manner. (PubMed id 20844761)¹ Lukov G.L. and Goodell M.A. (2010)
LYL1 activity is required for the maturation of newly formed blood vessels in adulthood. (PubMed id 20418284)¹ Pirot N....Pinet V. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4066	HGNC: 6734	AceView: LYL1	Ensembl:ENSG00000104903	euGenes: HUgn4066
ECgene: LYL1	H-InvDB: LYL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LYL1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LYL1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LYL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LYL1 gene:
Search GeneIP for patents involving LYL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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LYL1 Gene

lymphoblastic leukemia derived sequence 1

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LYL1 Gene

lymphoblastic leukemia derived sequence 1

Aliasesfor LYL1 gene

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Genome Databases showing LYL1 gene

Other Databases showing LYL1 gene

Specialized Databases showing LYL1 gene

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for LYL1 gene

Summaries
for LYL1 gene

Genomic Views
for LYL1 gene

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for LYL1 gene

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Families
for LYL1 gene

Function
for LYL1 gene

Pathways & Interactions
for LYL1 gene

Drugs & Compounds
for LYL1 gene

Transcripts
for LYL1 gene

Expression
for LYL1 gene

Orthologs
for LYL1 gene

Paralogs
for LYL1 gene

Genomic Variants
for LYL1 gene

Disorders / Diseases
for LYL1 gene

Publications
for LYL1 gene

Intellectual Property
for LYL1 gene

Products
for LYL1 gene