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Aliases for LYAR Gene

Aliases for LYAR Gene

  • Ly1 Antibody Reactive 2 3 5
  • Cell Growth-Regulating Nucleolar Protein 3
  • Ly1 Antibody Reactive Homolog (Mouse) 2
  • Ly1 Antibody Reactive Homolog 3
  • ZC2HC2 3
  • ZLYAR 3

External Ids for LYAR Gene

Previous GeneCards Identifiers for LYAR Gene

  • GC04M004146
  • GC04M004262
  • GC04M004333
  • GC04M004387
  • GC04M004206

Summaries for LYAR Gene

GeneCards Summary for LYAR Gene

LYAR (Ly1 Antibody Reactive) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for LYAR Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYAR Gene

Genomics for LYAR Gene

Regulatory Elements for LYAR Gene

Enhancers for LYAR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G004288 1.1 ENCODE 39.6 +0.2 183 2.4 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 KLF13 LYAR ZBTB49 GC04P004281
GH04G004323 1.2 Ensembl ENCODE 28 -33.9 -33936 1.6 HDAC1 ATF1 ARNT ZBTB40 RARA TCF12 ZNF766 GATA2 CAVIN1 ZBTB2 LYAR TMEM128 ZBTB49 ENSG00000248516 PIR59167
GH04G004264 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +21.5 21471 7.5 CTCF ZNF146 JUN MAX CEBPB CEBPG RAD21 POLR2A CEBPA ZBTB33 TMEM128 LYAR ZBTB49 GC04P004281
GH04G004284 0.6 ENCODE 39.6 +5.1 5101 0.3 HDAC1 SOX13 KLF1 NFIA MNT RARA NFIC KLF9 NR2F6 MYC LYAR GC04P004281
GH04G004327 1.2 Ensembl ENCODE 16.2 -37.8 -37751 0.8 HDAC1 ATF1 CBX3 CREB3L1 ARID4B DMAP1 RAD21 ZNF48 RARA CHAMP1 LYAR TMEM128 ADRA2C NSG1 PIR59167 ENSG00000248516
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LYAR on UCSC Golden Path with GeneCards custom track

Genomic Location for LYAR Gene

Chromosome:
4
Start:
4,267,701 bp from pter
End:
4,290,169 bp from pter
Size:
22,469 bases
Orientation:
Minus strand

Genomic View for LYAR Gene

Genes around LYAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYAR Gene

Proteins for LYAR Gene

  • Protein details for LYAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX58-LYAR_HUMAN
    Recommended name:
    Cell growth-regulating nucleolar protein
    Protein Accession:
    Q9NX58
    Secondary Accessions:
    • D3DVS4
    • Q6FI78
    • Q9NYS1

    Protein attributes for LYAR Gene

    Size:
    379 amino acids
    Molecular mass:
    43615 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LYAR Gene

Post-translational modifications for LYAR Gene

  • Ubiquitination at Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for LYAR Gene

No data available for DME Specific Peptides for LYAR Gene

Domains & Families for LYAR Gene

Gene Families for LYAR Gene

Protein Domains for LYAR Gene

Suggested Antigen Peptide Sequences for LYAR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LYAR: view

No data available for UniProtKB/Swiss-Prot for LYAR Gene

Function for LYAR Gene

Gene Ontology (GO) - Molecular Function for LYAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LYAR: view
genes like me logo Genes that share phenotypes with LYAR: view

Animal Model Products

CRISPR Products

miRNA for LYAR Gene

miRTarBase miRNAs that target LYAR

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYAR Gene

Localization for LYAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYAR Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYAR gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LYAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22720776
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with LYAR: view

Pathways & Interactions for LYAR Gene

No Data Available

Gene Ontology (GO) - Biological Process for LYAR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LYAR Gene

Drugs & Compounds for LYAR Gene

No Compound Related Data Available

Transcripts for LYAR Gene

Unigene Clusters for LYAR Gene

Ly1 antibody reactive:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYAR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3:

Relevant External Links for LYAR Gene

GeneLoc Exon Structure for
LYAR
ECgene alternative splicing isoforms for
LYAR

Expression for LYAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYAR Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for LYAR Gene

This gene is overexpressed in Platelet (35.4) and Lung (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LYAR Gene



Protein tissue co-expression partners for LYAR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYAR Gene:

LYAR

SOURCE GeneReport for Unigene cluster for LYAR Gene:

Hs.425427
genes like me logo Genes that share expression patterns with LYAR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYAR Gene

Orthologs for LYAR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LYAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYAR 34 35
  • 98.5 (n)
cow
(Bos Taurus)
Mammalia LYAR 34 35
  • 84.72 (n)
dog
(Canis familiaris)
Mammalia LYAR 34 35
  • 83.89 (n)
rat
(Rattus norvegicus)
Mammalia Lyar 34
  • 79.95 (n)
mouse
(Mus musculus)
Mammalia Lyar 34 16 35
  • 77.78 (n)
oppossum
(Monodelphis domestica)
Mammalia LYAR 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYAR 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves LYAR 34 35
  • 66.01 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 85 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lyar 34
  • 62.73 (n)
zebrafish
(Danio rerio)
Actinopterygii lyar 34
  • 60.4 (n)
LYAR 35
  • 41 (a)
OneToOne
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG12909 35
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C16C10.8 35
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToOne
Species where no ortholog for LYAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYAR Gene

ENSEMBL:
Gene Tree for LYAR (if available)
TreeFam:
Gene Tree for LYAR (if available)

Paralogs for LYAR Gene

Pseudogenes.org Pseudogenes for LYAR Gene

genes like me logo Genes that share paralogs with LYAR: view

No data available for Paralogs for LYAR Gene

Variants for LYAR Gene

Sequence variations from dbSNP and Humsavar for LYAR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000033386 -- 4,282,069(+) GAACC(A/T)CATCC intron-variant
rs1000159393 -- 4,292,113(+) TCGTC(C/G)TTACT intron-variant, upstream-variant-2KB
rs1000296031 -- 4,276,395(+) AGGCT(C/T)GATCC intron-variant
rs1000408128 -- 4,267,323(+) CAGGC(-/G)GATCA downstream-variant-500B
rs1000466940 -- 4,291,941(+) CTGGC(C/T)AACAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LYAR Gene

Variant ID Type Subtype PubMed ID
esv2759219 CNV gain 17122850
esv34196 OTHER inversion 12058347
nsv1001885 CNV gain 25217958
nsv10437 CNV gain 18304495

Variation tolerance for LYAR Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYAR Gene

Disorders for LYAR Gene

Relevant External Links for LYAR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYAR

No disorders were found for LYAR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYAR Gene

Publications for LYAR Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64
  5. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. (PMID: 8491376) Su L. … Weissman I.L. (Genes Dev. 1993) 2 3 64

Products for LYAR Gene

Sources for LYAR Gene

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