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Aliases for LYAR Gene

Aliases for LYAR Gene

  • Ly1 Antibody Reactive 2 3 5
  • Cell Growth-Regulating Nucleolar Protein 3
  • Ly1 Antibody Reactive Homolog (Mouse) 2
  • Ly1 Antibody Reactive Homolog 3
  • ZC2HC2 3
  • ZLYAR 3

External Ids for LYAR Gene

Previous GeneCards Identifiers for LYAR Gene

  • GC04M004146
  • GC04M004262
  • GC04M004333
  • GC04M004387
  • GC04M004206

Summaries for LYAR Gene

GeneCards Summary for LYAR Gene

LYAR (Ly1 Antibody Reactive) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for LYAR Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYAR Gene

Genomics for LYAR Gene

Regulatory Elements for LYAR Gene

Enhancers for LYAR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around LYAR on UCSC Golden Path with GeneCards custom track

Promoters for LYAR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for LYAR Gene

4,267,701 bp from pter
4,290,169 bp from pter
22,469 bases
Minus strand

Genomic View for LYAR Gene

Genes around LYAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYAR Gene

Proteins for LYAR Gene

  • Protein details for LYAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell growth-regulating nucleolar protein
    Protein Accession:
    Secondary Accessions:
    • D3DVS4
    • Q6FI78
    • Q9NYS1

    Protein attributes for LYAR Gene

    379 amino acids
    Molecular mass:
    43615 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LYAR Gene

Post-translational modifications for LYAR Gene

  • Ubiquitination at Lys 80
  • Modification sites at PhosphoSitePlus

Other Protein References for LYAR Gene

Antibody Products

  • Abcam antibodies for LYAR

No data available for DME Specific Peptides for LYAR Gene

Domains & Families for LYAR Gene

Gene Families for LYAR Gene

Protein Domains for LYAR Gene


Suggested Antigen Peptide Sequences for LYAR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2HC-type zinc fingers.
  • Contains 2 C2HC-type zinc fingers.
genes like me logo Genes that share domains with LYAR: view

Function for LYAR Gene

Gene Ontology (GO) - Molecular Function for LYAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LYAR: view
genes like me logo Genes that share phenotypes with LYAR: view

Animal Model Products

CRISPR Products

miRNA for LYAR Gene

miRTarBase miRNAs that target LYAR

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYAR Gene

Localization for LYAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYAR Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for LYAR Gene COMPARTMENTS Subcellular localization image for LYAR gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LYAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with LYAR: view

Pathways & Interactions for LYAR Gene

SuperPathways for LYAR Gene

No Data Available

Gene Ontology (GO) - Biological Process for LYAR Gene


No data available for Pathways by source and SIGNOR curated interactions for LYAR Gene

Drugs & Compounds for LYAR Gene

No Compound Related Data Available

Transcripts for LYAR Gene

Unigene Clusters for LYAR Gene

Ly1 antibody reactive:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYAR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -

Relevant External Links for LYAR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LYAR Gene

mRNA expression in normal human tissues for LYAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYAR Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for LYAR Gene

This gene is overexpressed in Platelet (35.4) and Lung (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LYAR Gene

Protein tissue co-expression partners for LYAR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYAR Gene:


SOURCE GeneReport for Unigene cluster for LYAR Gene:

genes like me logo Genes that share expression patterns with LYAR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LYAR Gene

Orthologs for LYAR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LYAR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LYAR 34
  • 84.72 (n)
  • 78.89 (a)
  • 77 (a)
(Canis familiaris)
Mammalia LYAR 34
  • 83.89 (n)
  • 79.72 (a)
  • 77 (a)
(Mus musculus)
Mammalia Lyar 34
  • 77.78 (n)
  • 74.67 (a)
Lyar 16
Lyar 35
  • 72 (a)
(Pan troglodytes)
Mammalia LYAR 34
  • 98.5 (n)
  • 96.57 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Lyar 34
  • 79.95 (n)
  • 77.01 (a)
(Monodelphis domestica)
Mammalia LYAR 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia LYAR 35
  • 60 (a)
(Gallus gallus)
Aves LYAR 34
  • 66.01 (n)
  • 57.82 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
-- 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lyar 34
  • 62.73 (n)
  • 56.64 (a)
(Danio rerio)
Actinopterygii -- 34
lyar 34
  • 60.4 (n)
  • 57.72 (a)
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12909 35
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C16C10.8 35
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
Species where no ortholog for LYAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYAR Gene

Gene Tree for LYAR (if available)
Gene Tree for LYAR (if available)

Paralogs for LYAR Gene Pseudogenes for LYAR Gene

genes like me logo Genes that share paralogs with LYAR: view

No data available for Paralogs for LYAR Gene

Variants for LYAR Gene

Sequence variations from dbSNP and Humsavar for LYAR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2272739 - 4,274,748(-) AACAG(A/G/T)ATCAA reference, missense
rs7376390 - 4,274,405(+) CCACG(C/T)GTGCC reference, missense
rs1130179 -- 4,274,370(-) ACTCG(A/G)AAGTT reference, missense
rs1298726 -- 4,279,015(-) TCTTA(C/G)TGCCT intron-variant
rs2117286 -- 4,286,069(-) CCATT(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LYAR Gene

Variant ID Type Subtype PubMed ID
esv2759219 CNV gain 17122850
esv34196 OTHER inversion 12058347
nsv1001885 CNV gain 25217958
nsv10437 CNV gain 18304495

Variation tolerance for LYAR Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYAR Gene

Disorders for LYAR Gene

Relevant External Links for LYAR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LYAR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYAR Gene

Publications for LYAR Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 65
  5. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. (PMID: 8491376) Su L. … Weissman I.L. (Genes Dev. 1993) 2 3 65

Products for LYAR Gene

Sources for LYAR Gene

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