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Aliases for LYAR Gene

Aliases for LYAR Gene

  • Ly1 Antibody Reactive 2 3
  • Cell Growth-Regulating Nucleolar Protein 3
  • Ly1 Antibody Reactive Homolog (Mouse) 2
  • Ly1 Antibody Reactive Homolog 3
  • ZC2HC2 3
  • ZLYAR 3

External Ids for LYAR Gene

Previous GeneCards Identifiers for LYAR Gene

  • GC04M004146
  • GC04M004262
  • GC04M004333
  • GC04M004387
  • GC04M004206

Summaries for LYAR Gene

GeneCards Summary for LYAR Gene

LYAR (Ly1 Antibody Reactive) is a Protein Coding gene.

Gene Wiki entry for LYAR Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYAR Gene

Genomics for LYAR Gene

Regulatory Elements for LYAR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LYAR Gene

Start:
4,267,701 bp from pter
End:
4,290,169 bp from pter
Size:
22,469 bases
Orientation:
Minus strand

Genomic View for LYAR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LYAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYAR Gene

Proteins for LYAR Gene

  • Protein details for LYAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX58-LYAR_HUMAN
    Recommended name:
    Cell growth-regulating nucleolar protein
    Protein Accession:
    Q9NX58
    Secondary Accessions:
    • D3DVS4
    • Q6FI78
    • Q9NYS1

    Protein attributes for LYAR Gene

    Size:
    379 amino acids
    Molecular mass:
    43615 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LYAR Gene

Proteomics data for LYAR Gene at MOPED

Post-translational modifications for LYAR Gene

  • Ubiquitination at Lys80
  • Modification sites at PhosphoSitePlus

Other Protein References for LYAR Gene

No data available for DME Specific Peptides for LYAR Gene

Domains for LYAR Gene

Gene Families for LYAR Gene

HGNC:
  • ZC2HC :Zinc fingers, C2HC-type containing

Protein Domains for LYAR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LYAR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX58

UniProtKB/Swiss-Prot:

LYAR_HUMAN :
  • Q9NX58
Similarity:
  • Contains 2 C2HC-type zinc fingers.
genes like me logo Genes that share domains with LYAR: view

Function for LYAR Gene

Gene Ontology (GO) - Molecular Function for LYAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LYAR: view

Animal Model Products

miRNA for LYAR Gene

miRTarBase miRNAs that target LYAR

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LYAR

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LYAR Gene

Localization for LYAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYAR Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYAR Gene COMPARTMENTS Subcellular localization image for LYAR gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LYAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with LYAR: view

Pathways for LYAR Gene

SuperPathways for LYAR Gene

No Data Available

Gene Ontology (GO) - Biological Process for LYAR Gene

None

No data available for Pathways by source for LYAR Gene

Transcripts for LYAR Gene

Unigene Clusters for LYAR Gene

Ly1 antibody reactive:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LYAR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYAR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3:

Relevant External Links for LYAR Gene

GeneLoc Exon Structure for
LYAR
ECgene alternative splicing isoforms for
LYAR

Expression for LYAR Gene

mRNA expression in normal human tissues for LYAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYAR Gene

This gene is overexpressed in Testis (6.0).

Protein differential expression in normal tissues for LYAR Gene

This gene is overexpressed in Platelet (35.4) and Lung (15.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LYAR Gene

SOURCE GeneReport for Unigene cluster for LYAR Gene Hs.425427

genes like me logo Genes that share expressions with LYAR: view

Expression partners for LYAR Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LYAR Gene

Orthologs for LYAR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LYAR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LYAR 35
  • 84.72 (n)
  • 78.89 (a)
LYAR 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LYAR 35
  • 83.89 (n)
  • 79.72 (a)
LYAR 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lyar 35
  • 77.78 (n)
  • 74.67 (a)
Lyar 16
Lyar 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LYAR 35
  • 98.5 (n)
  • 96.57 (a)
LYAR 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lyar 35
  • 79.95 (n)
  • 77.01 (a)
oppossum
(Monodelphis domestica)
Mammalia LYAR 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYAR 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves LYAR 35
  • 66.01 (n)
  • 57.82 (a)
LYAR 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lyar 35
  • 62.73 (n)
  • 56.64 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
lyar 35
  • 60.4 (n)
  • 57.72 (a)
LYAR 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12909 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C16C10.8 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for LYAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYAR Gene

ENSEMBL:
Gene Tree for LYAR (if available)
TreeFam:
Gene Tree for LYAR (if available)

Paralogs for LYAR Gene

Pseudogenes.org Pseudogenes for LYAR Gene

genes like me logo Genes that share paralogs with LYAR: view

No data available for Paralogs for LYAR Gene

Variants for LYAR Gene

Sequence variations from dbSNP and Humsavar for LYAR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1130179 -- 4,274,370(-) ACTCG(A/G)AAGTT missense, reference
rs1298726 -- 4,279,015(-) TCTTA(C/G)TGCCT intron-variant
rs2117286 -- 4,286,069(-) CCATT(C/T)GGCCT intron-variant
rs2120009 -- 4,268,356(-) GCCTA(A/G)ATTTT intron-variant
rs2272738 -- 4,281,949(-) ATTAG(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LYAR Gene

Variant ID Type Subtype PubMed ID
dgv1566e1 CNV Complex 17122850
nsv10437 CNV Gain 18304495

Relevant External Links for LYAR Gene

HapMap Linkage Disequilibrium report
LYAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYAR Gene

Disorders for LYAR Gene

No disorders were found for LYAR Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for LYAR Gene

Publications for LYAR Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. (PMID: 8491376) Su L. … Weissman I.L. (Genes Dev. 1993) 2 3
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for LYAR Gene

Sources for LYAR Gene

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