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Aliases for LYAR Gene

Aliases for LYAR Gene

  • Ly1 Antibody Reactive 2 3 5
  • Ly1 Antibody Reactive Homolog (Mouse) 2
  • Ly1 Antibody Reactive Homolog 3
  • ZC2HC2 3
  • ZLYAR 3

External Ids for LYAR Gene

Previous GeneCards Identifiers for LYAR Gene

  • GC04M004146
  • GC04M004262
  • GC04M004333
  • GC04M004387
  • GC04M004206

Summaries for LYAR Gene

GeneCards Summary for LYAR Gene

LYAR (Ly1 Antibody Reactive) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for LYAR Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYAR Gene

Genomics for LYAR Gene

Regulatory Elements for LYAR Gene

Promoters for LYAR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LYAR on UCSC Golden Path with GeneCards custom track

Genomic Location for LYAR Gene

Chromosome:
4
Start:
4,267,701 bp from pter
End:
4,290,169 bp from pter
Size:
22,469 bases
Orientation:
Minus strand

Genomic View for LYAR Gene

Genes around LYAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYAR Gene

Proteins for LYAR Gene

  • Protein details for LYAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX58-LYAR_HUMAN
    Recommended name:
    Cell growth-regulating nucleolar protein
    Protein Accession:
    Q9NX58
    Secondary Accessions:
    • D3DVS4
    • Q6FI78
    • Q9NYS1

    Protein attributes for LYAR Gene

    Size:
    379 amino acids
    Molecular mass:
    43615 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LYAR Gene

Proteomics data for LYAR Gene at MOPED

Post-translational modifications for LYAR Gene

  • Ubiquitination at Lys 80
  • Modification sites at PhosphoSitePlus

Other Protein References for LYAR Gene

No data available for DME Specific Peptides for LYAR Gene

Domains & Families for LYAR Gene

Gene Families for LYAR Gene

Protein Domains for LYAR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LYAR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX58

UniProtKB/Swiss-Prot:

LYAR_HUMAN :
  • Contains 2 C2HC-type zinc fingers.
Similarity:
  • Contains 2 C2HC-type zinc fingers.
genes like me logo Genes that share domains with LYAR: view

Function for LYAR Gene

Gene Ontology (GO) - Molecular Function for LYAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with LYAR: view
genes like me logo Genes that share phenotypes with LYAR: view

Animal Model Products

miRNA for LYAR Gene

miRTarBase miRNAs that target LYAR

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYAR Gene

Localization for LYAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYAR Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYAR Gene COMPARTMENTS Subcellular localization image for LYAR gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for LYAR Gene

Pathways & Interactions for LYAR Gene

SuperPathways for LYAR Gene

No Data Available

Gene Ontology (GO) - Biological Process for LYAR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LYAR Gene

Drugs & Compounds for LYAR Gene

No Compound Related Data Available

Transcripts for LYAR Gene

Unigene Clusters for LYAR Gene

Ly1 antibody reactive:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LYAR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3:

Relevant External Links for LYAR Gene

GeneLoc Exon Structure for
LYAR
ECgene alternative splicing isoforms for
LYAR

Expression for LYAR Gene

mRNA expression in normal human tissues for LYAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYAR Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for LYAR Gene

This gene is overexpressed in Platelet (35.4) and Lung (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LYAR Gene



SOURCE GeneReport for Unigene cluster for LYAR Gene Hs.425427

genes like me logo Genes that share expression patterns with LYAR: view

Protein tissue co-expression partners for LYAR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LYAR Gene

Orthologs for LYAR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LYAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYAR 35
  • 98.5 (n)
  • 96.57 (a)
LYAR 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LYAR 36
  • 77 (a)
OneToOne
LYAR 35
  • 84.72 (n)
  • 78.89 (a)
dog
(Canis familiaris)
Mammalia LYAR 35
  • 83.89 (n)
  • 79.72 (a)
LYAR 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lyar 16
Lyar 35
  • 77.78 (n)
  • 74.67 (a)
Lyar 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LYAR 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYAR 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lyar 35
  • 79.95 (n)
  • 77.01 (a)
chicken
(Gallus gallus)
Aves LYAR 36
  • 59 (a)
OneToOne
LYAR 35
  • 66.01 (n)
  • 57.82 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lyar 35
  • 62.73 (n)
  • 56.64 (a)
zebrafish
(Danio rerio)
Actinopterygii LYAR 36
  • 41 (a)
OneToOne
-- 35
lyar 35
  • 60.4 (n)
  • 57.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12909 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C16C10.8 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for LYAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYAR Gene

ENSEMBL:
Gene Tree for LYAR (if available)
TreeFam:
Gene Tree for LYAR (if available)

Paralogs for LYAR Gene

Pseudogenes.org Pseudogenes for LYAR Gene

genes like me logo Genes that share paralogs with LYAR: view

No data available for Paralogs for LYAR Gene

Variants for LYAR Gene

Sequence variations from dbSNP and Humsavar for LYAR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2272739 - 4,274,748(-) AACAG(A/G/T)ATCAA reference, missense
rs7376390 - 4,274,405(+) CCACG(C/T)GTGCC reference, missense
rs1130179 -- 4,274,370(-) ACTCG(A/G)AAGTT reference, missense
rs2117286 -- 4,286,069(-) CCATT(C/T)GGCCT intron-variant
rs2980086 -- 4,273,140(-) GACCC(G/T)GTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LYAR Gene

Variant ID Type Subtype PubMed ID
dgv1566e1 CNV Complex 17122850
nsv10437 CNV Gain 18304495

Variation tolerance for LYAR Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LYAR Gene

HapMap Linkage Disequilibrium report
LYAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYAR Gene

Disorders for LYAR Gene

Relevant External Links for LYAR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LYAR

No disorders were found for LYAR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYAR Gene

Publications for LYAR Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. (PMID: 8491376) Su L. … Weissman I.L. (Genes Dev. 1993) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for LYAR Gene

Sources for LYAR Gene

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