Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LY96 Gene

protein-coding   GIFtS: 63
GCID: GC08P074953

Lymphocyte Antigen 96

  See LY96-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Lymphocyte Antigen 961 2     ly-962
MD22 3 5     Myeloid Differentiation Protein-22
Protein MD-22 3     ESOP13
ESOP-12 3     Ly-963
MD-22     

External Ids:    HGNC: 171561   Entrez Gene: 236432   Ensembl: ENSG000001545897   OMIM: 6052435   UniProtKB: Q9Y6Y93   

Export aliases for LY96 gene to outside databases

Previous GC identifers: GC08P074844 GC08P074626 GC08P075066 GC08P070394


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LY96 Gene:
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers
responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies
of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing
results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Sep 2010)

GeneCards Summary for LY96 Gene:
LY96 (lymphocyte antigen 96) is a protein-coding gene. Diseases associated with LY96 include neonatal abstinence syndrome, and botulism. GO annotations related to this gene include lipopolysaccharide receptor activity and coreceptor activity.

UniProtKB/Swiss-Prot: LY96_HUMAN, Q9Y6Y9
Function: Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2
in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent
activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS

Gene Wiki entry for LY96 (Lymphocyte antigen 96) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the LY96 gene promoter:
         TBP   STAT1   AP-1   ATF-2   IRF-1   STAT1alpha   MZF-1   c-Jun   Msx-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLY96 promoter sequence
   Search Chromatin IP Primers for LY96

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LY96


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q13.3

LY96 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LY96 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P074953:  view genomic region     (about GC identifiers)

Start:
74,903,564 bp from pter      End:
74,941,322 bp from pter
Size:
37,759 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LY96_HUMAN, Q9Y6Y9 (See protein sequence)
Recommended Name: Lymphocyte antigen 96 precursor  
Size: 160 amino acids; 18546 Da
Subunit: Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide
(LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binds to the extracellular
domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex
Selected PDB 3D structures from and Proteopedia for LY96 (see all 7):
1T2Z (3D)        2E56 (3D)        2E59 (3D)        2Z65 (3D)        3FXI (3D)        3ULA (3D)    
Secondary accessions: B3Y6A5

Explore the universe of human proteins at neXtProt for LY96: NX_Q9Y6Y9

Explore proteomics data for LY96 at MOPED

Post-translational modifications: 

  • N-glycosylated; high-mannose1
  • Glycosylation2 at Asn26, Asn114
  • Modification sites at PhosphoSitePlus

  • See LY96 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182726.1  NP_056179.3  

    ENSEMBL proteins: 
     ENSP00000284818   ENSP00000430533  
    Reactome Protein details: Q9Y6Y9

    LY96 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LY96 (MD-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LY96
    OriGene Protein Over-expression Lysate for LY96
    OriGene MassSpec for LY96
    OriGene Custom Protein Services for LY96
    GenScript Custom Purified and Recombinant Proteins Services for LY96
    Novus Biologicals LY96 Proteins
    Novus Biologicals LY96 Lysates
    Sino Biological Recombinant Protein for LY96
    Sino Biological Cell Lysate for LY96
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LY96

     
    Search eBioscience for Proteins for LY96 

    LY96 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LY96
    R&D Systems Antibodies for LY96 (MD-2)
    OriGene Antibodies for LY96
    OriGene Custom Antibody Services for LY96
    Novus Biologicals LY96 Antibodies
    Abcam antibodies for LY96
    Cloud-Clone Corp. Antibodies for LY96
    ThermoFisher Antibodies for LY96
    LSBio Antibodies in human, mouse, rat for LY96

    LY96 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LY96
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LY96
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LY96
    Cloud-Clone Corp. CLIAs for LY96
    Search eBioscience for ELISAs for LY96 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR003172 ML_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6Y9

    ProtoNet protein and cluster: Q9Y6Y9

    1 Blocks protein domain: IPB003172 E1 protein and Def2/Der2 allergen


    Find genes that share domains with LY96           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LY96_HUMAN, Q9Y6Y9
    Function: Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2
    in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent
    activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001875lipopolysaccharide receptor activity IDA19252480
    GO:0005515protein binding IPI17803912
    GO:0015026coreceptor activity TAS10359581
         
    Find genes that share ontologies with LY96           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for LY96:
     Elongated cells  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ly96):
     hematopoietic system  immune system 

    Find genes that share phenotypes with LY96           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ly96tm1Kmiy for LY96

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LY96
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LY96

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LY96
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LY96

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LY96 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LY96
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LY96
    Predesigned siRNA for gene silencing in human, mouse, rat LY96

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LY96

    Clone
    Products:
         
    OriGene clones in human, mouse for LY96 (see all 9)
    OriGene ORF clones in mouse, rat for LY96
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LY96 (NM_015364)
    Sino Biological Human cDNA Clone for LY96
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LY96
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LY96
    Addgene plasmids for LY96 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LY96
    Browse ESI BIO Cell Lines and PureStem Progenitors for LY96 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LY96


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LY96_HUMAN, Q9Y6Y9: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endosome4
    plasma membrane4
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane TAS--
    GO:0046696lipopolysaccharide receptor complex IDA19252480

    Find genes that share ontologies with LY96           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LY96 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    3Toll Comparative Pathway
    Toll Comparative Pathway0.61
    Immune response MIF in innate immunity response0.46
    4NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    5Development Slit Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41


    Find genes that share SuperPaths with LY96           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for LY96
        A-beta Uptake & Degradation
    Toll-Like receptor Signaling Pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LY96
        MIF Regulation of Innate Immune Cells
    Toll-Like Receptors Pathway
    Toll Comparative Pathway
    MIF Mediated Glucocorticoid Regulation
    MIF Action Through Endocytic Pathway

    Selected GeneGo (Thomson Reuters) Pathways for LY96 (see all 8)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Bacterial infections in CF airways

    3 BioSystems Pathways for LY96
        Toll-like receptor signaling pathway
    Pathogenic Escherichia coli infection
    Regulation of toll-like receptor signaling pathway


    Selected Reactome Pathways for LY96 (see all 7)
        IKK complex recruitment mediated by RIP1
    TRIF-mediated programmed cell death
    MyD88-independent cascade
    Toll Like Receptor 4 (TLR4) Cascade
    Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


    5 Kegg Pathways  (Kegg details for LY96):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    Pathogenic Escherichia coli infection
    Pertussis
    Toxoplasmosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LY96: 
              Innate & Adaptive Immune Responses in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LY96

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for LY96 (Q9Y6Y91, 3 ENSP000002848184) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    TLR4O002061, 3, ENSP000003630894EBI-1539247,EBI-528701 I2D: score=6 STRING: ENSP00000363089
    S100A8P051093, ENSP000003577214I2D: score=1 STRING: ENSP00000357721
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006954inflammatory response IEA--
    GO:0006968cellular defense response TAS10359581

    Find genes that share ontologies with LY96           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LY96

    2 DrugBank Compounds for LY96    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-Hydroxy-Myristic Acid-- --target--10592235
    MYRISTIC ACID-- --target--10592235

    5 Novoseek inferred chemical compound relationships for LY96 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipoteichoic acid 75.4 12 12594207 (3), 11160242 (3), 11521063 (2)
    endotoxin 73.9 92 17977838 (7), 15949139 (5), 17934216 (4), 18519568 (3) (see all 23)
    peptidoglycan 63.9 8 11160242 (3), 11521063 (2), 15142865 (1)
    paclitaxel 23 57 18650420 (10), 12496426 (6), 11123270 (4), 14577846 (3)
    lipid 21.7 22 16407172 (6), 15373971 (3), 18606678 (2), 19252480 (2) (see all 7)



    Find genes that share compounds with LY96           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LY96 gene (2 alternative transcripts): 
    NM_001195797.1  NM_015364.4  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284818(uc003yad.3 uc022awb.1) ENST00000518893
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LY96 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LY96
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LY96
    Predesigned siRNA for gene silencing in human, mouse, rat LY96
    Clone
    Products:
         
    OriGene clones in human, mouse for LY96 (see all 9)
    OriGene ORF clones in mouse, rat for LY96
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LY96 (NM_015364)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LY96
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LY96
    Addgene plasmids for LY96 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LY96
    OriGene qSTAR qPCR primer pairs in human, mouse for LY96
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LY96
      QuantiTect SYBR Green Assays in human, mouse, rat LY96
      QuantiFast Probe-based Assays in human, mouse, rat LY96

    18 AceView cDNA sequences:

    AI652240 BC020690 AI424897 AA099571 NM_015364 BX282899 AA825754 AF168121 
    AW235398 AI656256 BG435728 BG571597 AW055084 BU198898 AB018549 AV732918 
    BG618440 BM918324 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LY96 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTTCCAA
    LY96 Expression
    About this image


    LY96 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
    LY96 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LY96 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including LY96: 
              Innate & Adaptive Immune Responses in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LY96
    OriGene qSTAR qPCR primer pairs in human, mouse for LY96
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LY96
    QuantiTect SYBR Green Assays in human, mouse, rat LY96
    QuantiFast Probe-based Assays in human, mouse, rat LY96
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LY96

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for LY96 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ly961 , 5 lymphocyte antigen 961, 5 75.62(n)1
    64.37(a)1
      1 (5.10 cM)5
    170871  NM_016923.21  NP_058619.11 
     166884565 
    chicken
    (Gallus gallus)
    Aves LY966
    lymphocyte antigen 96
    32(a)
    1 ↔ 1
    2(117745310-117753197)


    ENSEMBL Gene Tree for LY96 (if available)
    TreeFam Gene Tree for LY96 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LY96 (see all 836)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs598323081,2
    C--74905076(+) GTGTG-/TGTGTGTG
    TGTGTGTGTG
    ACAGA
    1 -- int10--------
    rs47384101,2
    C--74905763(+) acgacC/Tgcctc 1 -- int10--------
    rs557224041,2
    C--74906058(+) ATTCTC/-CCACC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs603677121,2
    C--74910926(+) AAAAA-/AGGAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs356927871,2
    C--74911210(+) TTTTTT/-GAGGC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs795260901,2
    C,F--74914245(+) TTCTTT/CCTTCC 1 -- int11Minor allele frequency- C:0.00WA 2
    rs584624161,2
    --74914309(+) TCCTTC/TCTTTC 1 -- int10--------
    rs347679071,2
    C--74914981(+) TTGTA-/TTTTTT 1 -- int10--------
    rs587562901,2
    C--74915439(+) CAGGA-/GGACGAGA 1 -- int10--------
    rs64728121,2,,4
    C,F,H--74917084(+) TGAAAG/AGATCC 1 -- int1 ese324Minor allele frequency- A:0.03NS EA NA WA CSA EU 7355

    HapMap Linkage Disequilibrium report for LY96 (74903564 - 74941322 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LY96:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668168CNV Deletion23128226
    nsv6259CNV Insertion18451855
    nsv831355CNV Loss17160897
    nsv891013CNV Gain21882294

    Human Gene Mutation Database (HGMD): LY96
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LY96
    DNA2.0 Custom Variant and Variant Library Synthesis for LY96

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605243    OMIM disorders: --

    4 diseases for LY96:    
    About MalaCards
    neonatal abstinence syndrome    botulism    wound botulism    intestinal botulism

    3 diseases from the University of Copenhagen DISEASES database for LY96:
    Neonatal abstinence syndrome     Intestinal botulism     Wound botulism

    Find genes that share disorders with LY96           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LY96 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gram-negative bacterial infections 66 1 19109192 (1)
    sepsis 45.5 8 19209789 (2), 15328161 (2), 15656985 (1), 17203997 (1)
    shock septic 38.5 2 15328161 (2)
    inflammation 34.4 9 19109192 (1), 19710105 (1), 15328161 (1), 16547263 (1) (see all 5)
    necrosis 24.7 7 15109052 (1), 19824106 (1), 12032143 (1), 18650420 (1) (see all 5)
    inflammatory bowel diseases 21.2 3 19710105 (2), 16547263 (1)
    shock 8.51 3 15679844 (1), 20070394 (1), 11801686 (1)
    neck cancer 8.3 2 15289356 (1), 12591988 (1)
    infectious disease 6.11 1 12015453 (1)
    cancer 4.79 2 15057266 (1)

    Genetic Association Database (GAD): LY96
    Human Genome Epidemiology (HuGE) Navigator: LY96 (18 documents)

    Export disorders for LY96 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LY96 gene, integrated from 10 sources (see all 246):
    (articles sorted by number of sources associating them with LY96)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. (PubMed id 10359581)1, 2, 3 Shimazu R....Kimoto M. (J. Exp. Med. 1999)
    2. MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram- positive and Gram-negative bacteria and their cell wall components. (PubMed id 11160242)1, 2, 9 Dziarski R.... Gupta D. (J. Immunol. 2001)
    3. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. (PubMed id 11466383)1, 3, 9 Abreu M.T....Arditi M. (J. Immunol. 2001)
    4. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. (PubMed id 17569869)1, 2, 9 Ohto U.... Satow Y. (Science 2007)
    5. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. (PubMed id 17803912)1, 2, 9 Kim H.M.... Lee J.-O. (Cell 2007)
    6. Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PubMed id 19200604)1, 4, 9 Verstraelen H....Temmerman M. (J. Reprod. Immunol. 2009)
    7. Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)1, 2, 9 Nakajima T....Kimura A. (Immunogenetics 2008)
    8. Lack of association between MD-2 promoter gene variants and tuberculosis. (PubMed id 20730709)1, 4 Xue Y....Li J.C. (Genet. Mol. Res. 2010)
    9. Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE. (PubMed id 19254290)1, 4 Tewfik M.A....Desrosiers M. (Allergy 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23643 HGNC: 17156 AceView: LY96 Ensembl:ENSG00000154589 euGenes: HUgn23643
    ECgene: LY96 Kegg: 23643 H-InvDB: LY96

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LY96 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LY96 gene:
    Search GeneIP for patents involving LY96

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of LY96
     
     EMD Millipore genomic analysis products

      
     Antibodies for LY96 (MD-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for LY96 (MD-2)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LY96   OriGene RNAi products in human, mouse, rat for LY96  
     OriGene qPCR primer pairs and template standards for LY96   OriGene Protein Over-expression Lysate for LY96  
     OriGene MassSpec something-or-other for LY96   OriGene clones in human, mouse for LY96  
     OriGene qSTAR qPCR primer pairs in human, mouse for LY96   OriGene Purified Protein for LY96  
     OriGene ORF clones in mouse, rat for LY96   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LY96   OriGene Custom Protein Services for LY96  

     
     
     Block miRNA regulation of human, mouse, rat LY96 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LY96
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LY96 Predesigned siRNA for gene silencing in human, mouse, rat LY96
     QuantiFast Probe-based Assays in human, mouse, rat LY96 QuantiTect SYBR Green Assays in human, mouse, rat LY96
     PCR Arrays including human, mouse, rat LY96 Search Chromatin IP Primers for LY96
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LY96  GeneGlobe Interaction Network for LY96
     Regulatory tfbs in LY96 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LY96 GenScript cDNA clones with any tag delivered in your preferred vector for LY96
     GenScript Custom Assay Services for LY96 GenScript Custom overexpressing Cell Line Services for LY96
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LY96
     Proteins for LY96
     Cell Lysates for LY96
     cDNA Clones for LY96
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LY96 antibodies
     LY96 proteins
     LY96 lysates
     Antibodies for LY96
     See all of Abcam's Antibodies, Kits and Proteins for LY96
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LY96
     Antibodies for LY96
     ELISAs for LY96
     CLIAs for LY96



     Browse ESI BIO Cell Lines and PureStem Progenitors for LY96
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LY96
     Browse SwitchGear 3'UTR luciferase reporter plasmids for LY96
     SwitchGear Promoter luciferase reporter plasmids for LY96
     ThermoFisher Antibodies for LY96
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LY96
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LY96
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LY96
     LSBio Antibodies in human, mouse, rat for LY96
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for LY96
      Search eBioscience for proteins for LY96
      Search eBioscience for elisas for LY96
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LY96 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4