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Aliases for LY96 Gene

Aliases for LY96 Gene

  • Lymphocyte Antigen 96 2 3
  • MD2 3 4 6
  • Protein MD-2 3 4
  • ESOP-1 3 4
  • Ly-96 3 4
  • Myeloid Differentiation Protein-2 3
  • ESOP1 4
  • MD-2 3

External Ids for LY96 Gene

Previous GeneCards Identifiers for LY96 Gene

  • GC08P074844
  • GC08P074626
  • GC08P074953
  • GC08P075066
  • GC08P070394

Summaries for LY96 Gene

Entrez Gene Summary for LY96 Gene

  • This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

GeneCards Summary for LY96 Gene

LY96 (Lymphocyte Antigen 96) is a Protein Coding gene. Diseases associated with LY96 include neonatal abstinence syndrome and intestinal botulism. Among its related pathways are Development Slit-Robo signaling and Development Slit-Robo signaling. GO annotations related to this gene include coreceptor activity and lipopolysaccharide receptor activity.

UniProtKB/Swiss-Prot for LY96 Gene

  • Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS

Gene Wiki entry for LY96 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY96 Gene

Genomics for LY96 Gene

Regulatory Elements for LY96 Gene

Genomic Location for LY96 Gene

Start:
73,991,329 bp from pter
End:
74,029,087 bp from pter
Size:
37,759 bases
Orientation:
Plus strand

Genomic View for LY96 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LY96 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LY96 Gene

Proteins for LY96 Gene

  • Protein details for LY96 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Y9-LY96_HUMAN
    Recommended name:
    Lymphocyte antigen 96
    Protein Accession:
    Q9Y6Y9
    Secondary Accessions:
    • B3Y6A5
    • E5RJJ7

    Protein attributes for LY96 Gene

    Size:
    160 amino acids
    Molecular mass:
    18546 Da
    Quaternary structure:
    • Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binds to the extracellular domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex.

    Three dimensional structures from OCA and Proteopedia for LY96 Gene

    Alternative splice isoforms for LY96 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LY96 Gene

Proteomics data for LY96 Gene at MOPED

Post-translational modifications for LY96 Gene

Other Protein References for LY96 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LY96 Gene

Domains for LY96 Gene

Protein Domains for LY96 Gene

Suggested Antigen Peptide Sequences for LY96 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LY96: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LY96 Gene

Function for LY96 Gene

Molecular function for LY96 Gene

UniProtKB/Swiss-Prot Function: Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS

Gene Ontology (GO) - Molecular Function for LY96 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001875 lipopolysaccharide receptor activity IDA 19252480
GO:0005515 protein binding IPI 17803912
GO:0015026 coreceptor activity TAS 10359581
genes like me logo Genes that share ontologies with LY96: view

Phenotypes for LY96 Gene

genes like me logo Genes that share phenotypes with LY96: view

Animal Models for LY96 Gene

MGI Knock Outs for LY96:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LY96

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LY96 Gene

Localization for LY96 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY96 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LY96 Gene COMPARTMENTS Subcellular localization image for LY96 gene
Compartment Confidence
extracellular 5
endosome 4
plasma membrane 4
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LY96 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane TAS --
GO:0046696 lipopolysaccharide receptor complex IDA 19252480
genes like me logo Genes that share ontologies with LY96: view

Pathways for LY96 Gene

genes like me logo Genes that share pathways with LY96: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Inflammatory Response & Autoimmunity in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat
    • Toll-Like Receptor Signaling Pathway in human,mouse,rat

Gene Ontology (GO) - Biological Process for LY96 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006915 apoptotic process TAS --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with LY96: view

Compounds for LY96 Gene

(2) Drugbank Compounds for LY96 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-Hydroxy-Myristic Acid
target
MYRISTIC ACID
target

(5) Novoseek inferred chemical compound relationships for LY96 Gene

Compound -log(P) Hits PubMed IDs
lipoteichoic acid 75.4 8
endotoxin 73.9 48
peptidoglycan 63.9 6
paclitaxel 23 23
lipid 21.7 17
genes like me logo Genes that share compounds with LY96: view

Transcripts for LY96 Gene

mRNA/cDNA for LY96 Gene

(18) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LY96 Gene

Lymphocyte antigen 96:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LY96

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LY96 Gene

No ASD Table

Relevant External Links for LY96 Gene

GeneLoc Exon Structure for
LY96
ECgene alternative splicing isoforms for
LY96

Expression for LY96 Gene

mRNA expression in normal human tissues for LY96 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LY96 Gene

This gene is overexpressed in Whole Blood (10.3) and Spleen (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LY96 Gene

SOURCE GeneReport for Unigene cluster for LY96 Gene Hs.726603

genes like me logo Genes that share expressions with LY96: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LY96 Gene

Orthologs for LY96 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LY96 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LY96 35
  • 100 (n)
  • 100 (a)
MD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LY96 35
  • 77.08 (n)
  • 65 (a)
MD2 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LY96 35
  • 81.25 (n)
  • 72.5 (a)
LY96 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ly96 35
  • 75.62 (n)
  • 64.37 (a)
Ly96 16
Ly96 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LY96 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ly96 35
  • 74.73 (n)
  • 64.84 (a)
chicken
(Gallus gallus)
Aves LY96 36
  • 32 (a)
OneToOne
Species with no ortholog for LY96:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LY96 Gene

ENSEMBL:
Gene Tree for LY96 (if available)
TreeFam:
Gene Tree for LY96 (if available)

Paralogs for LY96 Gene

No data available for Paralogs for LY96 Gene

Variants for LY96 Gene

Sequence variations from dbSNP and Humsavar for LY96 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs965872 -- 74,008,461(+) ACAGA(C/T)GCCAT intron-variant
rs1426060 -- 74,006,636(+) TTCCT(C/T)CACTT intron-variant
rs1481858 -- 73,992,840(-) acaca(C/T)acaGT intron-variant
rs1809440 -- 73,990,288(-) atcac(C/T)tgagg upstream-variant-2KB
rs1809441 -- 73,990,178(-) ctact(A/C)gggag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LY96 Gene

Variant ID Type Subtype PubMed ID
nsv831355 CNV Loss 17160897
nsv891013 CNV Gain 21882294
esv2668168 CNV Deletion 23128226
nsv6259 CNV Insertion 18451855

Relevant External Links for LY96 Gene

HapMap Linkage Disequilibrium report
LY96
Human Gene Mutation Database (HGMD)
LY96

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY96 Gene

Disorders for LY96 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for LY96 Gene including...

Search for LY96 Gene in MalaCards »

(3) University of Copenhagen DISEASES for LY96 Gene

(12) Novoseek inferred disease relationships for LY96 Gene

Disease -log(P) Hits PubMed IDs
gram-negative bacterial infections 66 1
sepsis 45.5 6
shock septic 38.5 2
inflammation 34.4 5
necrosis 24.7 5

Relevant External Links for LY96

Genetic Association Database (GAD)
LY96
Human Genome Epidemiology (HuGE) Navigator
LY96
genes like me logo Genes that share disorders with LY96: view

No data available for UniProtKB/Swiss-Prot for LY96 Gene

Publications for LY96 Gene

  1. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. (PMID: 11466383) Abreu M.T. … Arditi M. (J. Immunol. 2001) 2 3 23
  2. MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram- positive and Gram-negative bacteria and their cell wall components. (PMID: 11160242) Dziarski R. … Gupta D. (J. Immunol. 2001) 3 4 23
  3. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. (PMID: 17569869) Ohto U. … Satow Y. (Science 2007) 3 4 23
  4. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. (PMID: 17803912) Kim H.M. … Lee J.-O. (Cell 2007) 3 4 23
  5. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. (PMID: 10359581) Shimazu R. … Kimoto M. (J. Exp. Med. 1999) 2 3 4

Products for LY96 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Inflammatory Response & Autoimmunity in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat
    • Toll-Like Receptor Signaling Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate LY96
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for LY96
    • Block miRNA regulation of LY96 using miScript Target Protectors
    • Addgene plasmids for LY96

    Sources for LY96 Gene

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