Aliases for LY96 Gene
External Ids for LY96 Gene
Previous GeneCards Identifiers for LY96 Gene
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
GeneCards Summary for LY96 Gene
LY96 (Lymphocyte Antigen 96) is a Protein Coding gene. Diseases associated with LY96 include neonatal abstinence syndrome and intestinal botulism. Among its related pathways are Development Slit-Robo signaling and Development Slit-Robo signaling. GO annotations related to this gene include coreceptor activity and lipopolysaccharide receptor activity.
UniProtKB/Swiss-Prot for LY96 Gene
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS