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LY9 Gene

protein-coding   GIFtS: 56
GCID: GC01P160765

Lymphocyte Antigen 9

  See LY9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lymphocyte Antigen 91 2 3     CD2292
Cell Surface Molecule Ly-92 3     hly92
Signaling Lymphocytic Activation Molecule 32 3     mLY92
SLAMF32 3     T-Lymphocyte Surface Antigen Ly-92
SLAM Family Member 32 3     CD229 Antigen3

External Ids:    HGNC: 67301   Entrez Gene: 40632   Ensembl: ENSG000001222247   OMIM: 6006845   UniProtKB: Q9HBG73   

Export aliases for LY9 gene to outside databases

Previous GC identifers: GC01P158558 GC01P156498 GC01P157543 GC01P157982 GC01P157579 GC01P159032 GC01P132122


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LY9 Gene:
LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the
adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 (PubMed 16365421)).(supplied by OMIM, Mar 2008)

GeneCards Summary for LY9 Gene:
LY9 (lymphocyte antigen 9) is a protein-coding gene. Diseases associated with LY9 include dysgammaglobulinemia. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF9.

UniProtKB/Swiss-Prot: LY9_HUMAN, Q9HBG7
Function: May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic
interaction

Gene Wiki entry for LY9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LY9 gene promoter:
         AP-2alpha isoform 3   AML1a   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLY9 promoter sequence
   Search Chromatin IP Primers for LY9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LY9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

LY9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LY9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P160765:  view genomic region     (about GC identifiers)

Start:
160,765,864 bp from pter      End:
160,798,051 bp from pter
Size:
32,188 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LY9_HUMAN, Q9HBG7 (See protein sequence)
Recommended Name: T-lymphocyte surface antigen Ly-9 precursor  
Size: 655 amino acids; 72139 Da
Sequence caution: Sequence=CAH72360.1; Type=Erroneous gene model prediction; Sequence=CAH73509.1; Type=Erroneous
gene model prediction;
Secondary accessions: A8K7N3 Q14775 Q5VYI3 Q6P2J4 Q9H4N5 Q9NQ24
Alternative splicing: 4 isoforms:  Q9HBG7-1   Q9HBG7-2   Q9HBG7-3   Q9HBG7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LY9: NX_Q9HBG7

Explore proteomics data for LY9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn68, Asn95, Asn120, Asn169, Asn173, Asn285, Asn413, Asn424
  • Modification sites at PhosphoSitePlus

  • See LY9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001028839.1  NP_001248385.1  NP_001248386.1  NP_002339.2  

    ENSEMBL proteins: 
     ENSP00000357016   ENSP00000476321   ENSP00000376039   ENSP00000263285   ENSP00000357018  
     ENSP00000473643   ENSP00000357014   ENSP00000342921   ENSP00000357020   ENSP00000357019  

    LY9 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for LY9
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    Cloud-Clone Corp. Proteins for LY9

     
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    antibodies-online proteins for LY9 (10 products) 

     
    antibodies-online peptides for LY9

    LY9 Antibody Products:

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    LY9 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR015631 SLAM_fam_rcpts
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9HBG7

    ProtoNet protein and cluster: Q9HBG7

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: LY9_HUMAN, Q9HBG7
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Find genes that share domains with LY9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LY9_HUMAN, Q9HBG7
    Function: May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic
    interaction

         Genatlas biochemistry entry for LY9:
    lymphocyte surface antigen,murine Ly-9,immunoglobulin superfamily,putatively involved in adhesion reaction between
    T lymphocyte and accessory cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LY9           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ly9):
     hematopoietic system  immune system 

    Find genes that share phenotypes with LY9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ly9tm1Mckn for LY9

       genOway: Develop your customized and physiologically relevant rodent model for LY9

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate LY9:
    hsa-miR-3140-3p
    SwitchGear 3'UTR luciferase reporter plasmidLY9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LY9

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    Sino Biological Human cDNA Clone for LY9
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LY9

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LY9_HUMAN, Q9HBG7: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LY9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LY9
    Interactions:

        GeneGlobe Interaction Network for LY9

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for LY9 (Q9HBG73 ENSP000003570204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    SH2D1BO147963, ENSP000003569064I2D: score=1 STRING: ENSP00000356906
    SH2D1AO608803, ENSP000003601814I2D: score=4 STRING: ENSP00000360181
    AP2M1Q96CW13, ENSP000002928074I2D: score=2 STRING: ENSP00000292807
    GRB2P629933I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0016064immunoglobulin mediated immune response ----

    Find genes that share ontologies with LY9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LY9

    1 Novoseek inferred chemical compound relationship for LY9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 38.4 2 11689425 (1), 11862385 (1)



    Find genes that share compounds with LY9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LY9 gene (4 alternative transcripts): 
    NM_001033667.2  NM_001261456.1  NM_001261457.1  NM_002348.3  

    Unigene Cluster for LY9:

    Lymphocyte antigen 9
    Hs.403857  [show with all ESTs]
    Unigene Representative Sequence: NM_002348
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368037(uc001fwz.3) ENST00000474998 ENST00000392203(uc001fwy.1)
    ENST00000263285 ENST00000368039(uc001fwt.3) ENST00000480837 ENST00000490902
    ENST00000471816 ENST00000485624 ENST00000479663(uc010pjs.1) ENST00000368035
    ENST00000341032 ENST00000368041(uc001fwu.3 uc001fwv.3 uc001fww.3)
    ENST00000368040
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate LY9:
    hsa-miR-3140-3p
    SwitchGear 3'UTR luciferase reporter plasmidLY9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LY9
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LY9
      QuantiTect SYBR Green Assays in human, mouse, rat LY9
      QuantiFast Probe-based Assays in human, mouse, rat LY9

    Additional mRNA sequence: 

    AF055708.1 AF055709.1 AF244129.1 AK292048.1 AK303403.1 AY007142.1 BC027920.1 BC042905.1 
    BC062589.1 BC064485.1 BC121049.1 L42621.1 

    12 DOTS entries:

    DT.92070642  DT.100673801  DT.100805393  DT.408637  DT.92070640  DT.95371484  DT.100640625  DT.121397314 
    DT.95306636  DT.100714938  DT.101971381  DT.97786768 

    Selected AceView cDNA sequences (see all 62):

    BX090162 AY007142 CR595208 AI524095 BI905956 BC042905 BI906542 BC064485 
    BC062589 BX462597 CR590858 BG546913 BQ054142 AF055709 AV760237 BG744942 
    BM924954 BM922555 BQ051771 BC027920 AK128573 AI760825 BI912173 AF244129 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LY9 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a ·
    SP1:                                            -     -     -           -     -     -                                                                           
    SP2:                                            -     -     -           -     -     -                                                     -                     
    SP3:                                                                                                                                      -                 -   
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 15b ^ 16
    SP1:            
    SP2:            
    SP3:  -         
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for LY9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LY9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LY9 Expression
    About this image

    LY9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LY9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.403857
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for LY9 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ly91 , 5 lymphocyte antigen 91, 5 71.22(n)1
    55.83(a)1
      1 (79.54 cM)5
    170851  NM_008534.31  NP_032560.21 
     1715886245 


    ENSEMBL Gene Tree for LY9 (if available)
    TreeFam Gene Tree for LY9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LY9 gene
    SLAMF92  SLAMF72  SLAMF62  CD842  
    3 SIMAP similar genes for LY9 using alignment to 12 protein entries:     LY9_HUMAN (see all proteins):
    SLAMF9    CD84    SLAMF7

    Find genes that share paralogs with LY9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LY9 (see all 834)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38843821,2
    C--132135298(+) TACTA-/CTA/  
      TTACTA
    TTACC
    6 -- cds10--------
    rs1850440371,2
    --160764208(+) GCTTGA/GTAACA 4 -- us2k10--------
    rs1884627351,2
    --160764251(+) TGACCA/GTATGT 4 -- us2k10--------
    rs1915659981,2
    --160764322(+) AGACAC/TGCTCC 4 -- us2k10--------
    rs5351061,2
    C,H--160764353(-) AATCTT/CGAAAA 4 -- us2k113Minor allele frequency- C:0.01NA WA CSA EA 377
    rs5352411,2
    C,A,H--160764402(-) CTTTAG/AAGGCT 4 -- us2k18Minor allele frequency- A:0.36WA NA CSA EA 366
    rs1843948841,2
    --160764436(+) GTTATC/TTTAAT 4 -- us2k10--------
    rs5360151,2
    C,F,A,H--160764449(-) AGAGAG/CAGAAA 4 -- us2k1 tfbs3 trp39Minor allele frequency- C:0.35NA WA CSA EA 370
    rs1887844271,2
    --160764521(+) TATAGC/TAAGCT 4 -- us2k10--------
    rs66595691,2
    C,F,A,H--160764566(+) TAGAAT/CGGGGA 4 -- us2k18Minor allele frequency- C:0.30NA WA EA 370

    HapMap Linkage Disequilibrium report for LY9 (160765864 - 160798051 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LY9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662152CNV Deletion23128226
    esv2671152CNV Deletion23128226
    dgv84n67CNV Loss20364138
    nsv825087CNV Loss20364138
    nsv831714CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600684    OMIM disorders: --

    1 disease for LY9:    
    About MalaCards
    dysgammaglobulinemia

    1 disease from the University of Copenhagen DISEASES database for LY9:
    Dysgammaglobulinemia

    Find genes that share disorders with LY9           About GenesLikeMe

    1 Novoseek inferred disease relationship for LY9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoproliferative syndrome 91.1 1 12242590 (1)

    Genetic Association Database (GAD): LY9
    Human Genome Epidemiology (HuGE) Navigator: LY9 (3 documents)

    Export disorders for LY9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LY9 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with LY9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9. (PubMed id 8537117)1, 2, 3 Sandrin M.S....McKenzie I.F. (Immunogenetics 1996)
    2. Association of LY9 in UK and Canadian SLE families. (PubMed id 18216865)1, 4 Cunninghame Graham D.S....Rioux J.D. (Genes Immun. 2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Gene structure of the mouse leukocyte cell surface molecule Ly9. (PubMed id 10970093)1, 2 Tovar V.... Engel P. (Immunogenetics 2000)
    5. Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1. (PubMed id 7797269)1, 3 Kingsmore S.F....Seldin M.F. (Immunogenetics 1995)
    6. Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. (PubMed id 12242590)1, 9 Tovar V.... Engel P. (Immunogenetics 2002)
    7. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. (PubMed id 11689425)1, 9 Morra M.... Terhorst C. (EMBO J. 2001)
    8. Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells. (PubMed id 23956418)1 Hagberg N....RAPnnblom L. (J. Immunol. 2013)
    9. Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. (PubMed id 22184727)1 Chatterjee M....Tsokos G.C. (J. Immunol. 2012)
    10. CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORI^t recruitment to the IL17A promoter in human T lymphocytes. (PubMed id 22989874)1 Chatterjee M....Tsokos G.C. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4063 HGNC: 6730 AceView: LY9 Ensembl:ENSG00000122224 euGenes: HUgn4063
    ECgene: LY9 H-InvDB: LY9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LY9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LY9 gene:
    Search GeneIP for patents involving LY9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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