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LY75-CD302 Gene

protein-coding   GIFtS: 18
GCID: GC02M160630

LY75-CD302 Readthrough

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LY75-CD302 Readthrough1 2
DEC-205/DCL-1 Fusion2
LY75-CD302 Fusion Protein2

External Ids:    HGNC: 388281   Entrez Gene: 1005266642   Ensembl: ENSG000002486727   

Export aliases for LY75-CD302 gene to outside databases

Previous GC identifers: GC02U902275 GC02M160629


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LY75-CD302 Gene:
This locus represents naturally occurring read-through transcription between the neighboring lymphocyte antigen 75
(LY75) and CD302 molecule (CD302) genes. Alternative splicing results in multiple transcript variants encoding
fusion products that share sequence identity with each individual gene product. (provided by RefSeq, Nov 2010)

GeneCards Summary for LY75-CD302 Gene:
LY75-CD302 (LY75-CD302 readthrough) is a protein-coding gene. An important paralog of this gene is LY75.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for LY75-CD302
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LY75-CD302


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24.2

LY75-CD302 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LY75-CD302 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M160630:  view genomic region     (about GC identifiers)

Start:
160,625,139 bp from pter      End:
160,761,267 bp from pter
Size:
136,129 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --
REFSEQ proteins (2 alternative transcripts): 
NP_001185688.1  NP_001185689.1  

ENSEMBL proteins: 
 ENSP00000423463   ENSP00000421035  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030246carbohydrate binding ----
     
Find genes that share ontologies with LY75-CD302           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LY75-CD302
Interactions:

    Search GeneGlobe Interaction Network for LY75-CD302

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for LY75-CD302



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for LY75-CD302 gene (2 alternative transcripts): 
NM_001198759.1  NM_001198760.1  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000504764(uc002ubb.4) ENST00000505052(uc010fos.3)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LY75-CD302 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
LY75-CD302 Expression
About this image

LY75-CD302 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LY75-CD302 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves LY756
Gallus gallus lymphocyte antigen 75 (LY75), mRNA.
50(a)
1 → many
7(21382006-21420596)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
56(a)
35(a)
many ↔ many
many ↔ many
AAWZ02036395(3863-27590)
GL343371.1(840700-894312)
zebrafish
(Danio rerio)
Actinopterygii ly756
lymphocyte antigen 75
36(a)
1 → many
11(11186575-11314431) ENSDARG00000053113
worm
(Caenorhabditis elegans)
Secernentea clec-486
clec-506
(see all 7)
Protein CLEC-50 (clec-50) mRNA, complete cds
(see all 7)
26(a)
26(a)
(see all 7)
many ↔ many
many ↔ many
(see all 7)
V(18158027-18159610) WBGene00007565
V(19752401-19755363) WBGene00012253
        Species with no ortholog for LY75-CD302

ENSEMBL Gene Tree for LY75-CD302 (if available)
TreeFam Gene Tree for LY75-CD302 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LY75-CD302 gene
LY752  ENSG000001837482  PLA2R12  MRC12  MRC22  

Find genes that share paralogs with LY75-CD302           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LY75-CD302 (see all 60)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1152634081,2
F--160656831(+) CAAGGG/AGTCTA 2 -- int11Minor allele frequency- A:0.02WA 118
rs710003081,2
C--160656867(+) TGGTA-/GGGGTCATCTTCATCT
A
/GGGGTCATCTTCATTTA
CTAGT
2 -- int11NA 2
rs768882901,2
C--160656868(+) TGGTAC/GTAGTA 2 -- int10--------
rs773691791,2
C--160656869(+) GGTACG/TAGTAA 2 -- int10--------
rs781120781,2
C--160656870(+) GTACTA/GGTAAG 2 -- int10--------
rs752167951,2
C--160656873(+) CTAGTA/CAGGAA 2 -- int10--------
rs124744651,2
C,F,H--160656913(+) CCCCCG/ATGGGC 2 -- int11Minor allele frequency- A:0.50NA 4
rs1828399671,2
--160656951(+) GAGCCA/CAGCTC 2 -- int10--------
rs1126730081,2
C,F--160657010(+) TATTAA/CGGTCT 2 -- int12Minor allele frequency- C:0.02NA 122
rs1436799491,2
--160657270(+) TTTGTC/GTTAAG 2 -- int10--------

HapMap Linkage Disequilibrium report for LY75-CD302 (160625139 - 160761267 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for LY75-CD302 (see all 12):    About this table    
Variant IDTypeSubtypePubMed ID
esv1681534CNV Deletion17803354
esv1001679CNV Deletion20482838
esv2721034CNV Deletion23290073
esv2358013CNV Deletion18987734
esv2665197CNV Deletion23128226
esv1586275CNV Insertion17803354
esv1275142CNV Insertion17803354
nsv470497CNV Loss18288195
dgv4351n71CNV Loss21882294
nsv437546CNV Loss16327808

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LY75-CD302 gene integrated from 10 sources:
(articles sorted by number of sources associating them with LY75-CD302)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  2. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (PubMed id 12824192)1 Kato M.... Hart D.N.J. (J. Biol. Chem. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100526664 HGNC: 38828 Ensembl:ENSG00000248672 euGenes: HUgn100526664 ECgene: LY75-CD302
H-InvDB: LY75-CD302

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LY75-CD302 gene:
Search GeneIP for patents involving LY75-CD302

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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