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Aliases for LY75 Gene

Aliases for LY75 Gene

  • Lymphocyte Antigen 75 2 3 5
  • C-Type Lectin Domain Family 13 Member B 3 4
  • GP200-MR6 3 4
  • CLEC13B 3 4
  • DEC-205 3 4
  • LY-75 3 4
  • CD205 3 4
  • CD205 Antigen 4

External Ids for LY75 Gene

Previous GeneCards Identifiers for LY75 Gene

  • GC02M158591
  • GC02M159188
  • GC02M160623
  • GC02M160862
  • GC02M160485
  • GC02M160368
  • GC02M152542
  • GC02M160659

Summaries for LY75 Gene

GeneCards Summary for LY75 Gene

LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. Diseases associated with LY75 include Hodgkin Lymphoma and Lipid Pneumonia. Among its related pathways are Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is PLA2R1.

UniProtKB/Swiss-Prot for LY75 Gene

  • Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Gene Wiki entry for LY75 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY75 Gene

Genomics for LY75 Gene

Regulatory Elements for LY75 Gene

Enhancers for LY75 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LY75 on UCSC Golden Path with GeneCards custom track

Promoters for LY75 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LY75 on UCSC Golden Path with GeneCards custom track

Genomic Location for LY75 Gene

159,803,355 bp from pter
159,904,756 bp from pter
101,402 bases
Minus strand

Genomic View for LY75 Gene

Genes around LY75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LY75 Gene

Proteins for LY75 Gene

  • Protein details for LY75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lymphocyte antigen 75
    Protein Accession:
    Secondary Accessions:
    • O75913
    • Q53R46
    • Q53TF5
    • Q7Z575
    • Q7Z577

    Protein attributes for LY75 Gene

    1722 amino acids
    Molecular mass:
    198311 Da
    Quaternary structure:
    No Data Available
    • Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

    Alternative splice isoforms for LY75 Gene


neXtProt entry for LY75 Gene

Proteomics data for LY75 Gene at MOPED

Post-translational modifications for LY75 Gene

  • N-glycosylated.
  • Glycosylation at Asn 135, Asn 345, Asn 377, Asn 529, Asn 843, Asn 865, Asn 934, Asn 1076, Asn 1103, Asn 1225, Asn 1320, Asn 1392, Asn 1593, and Asn 1626
  • Modification sites at PhosphoSitePlus

Other Protein References for LY75 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LY75 Gene

Domains & Families for LY75 Gene

Suggested Antigen Peptide Sequences for LY75 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 10 C-type lectin domains.
  • Contains 10 C-type lectin domains.
  • Contains 1 fibronectin type-II domain.
  • Contains 1 ricin B-type lectin domain.
genes like me logo Genes that share domains with LY75: view

Function for LY75 Gene

Molecular function for LY75 Gene

GENATLAS Biochemistry:
lymphocyte antigen 75,putative antigen-uptake receptor on dendritic cells
UniProtKB/Swiss-Prot Function:
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Gene Ontology (GO) - Molecular Function for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9553150
genes like me logo Genes that share ontologies with LY75: view
genes like me logo Genes that share phenotypes with LY75: view

Animal Models for LY75 Gene

MGI Knock Outs for LY75:

Animal Model Products

  • Taconic Biosciences Mouse Models for LY75

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LY75 Gene

Localization for LY75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY75 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LY75 Gene COMPARTMENTS Subcellular localization image for LY75 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endosome 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for LY75 Gene

Pathways & Interactions for LY75 Gene

genes like me logo Genes that share pathways with LY75: view

Pathways by source for LY75 Gene

1 R&D Systems pathway for LY75 Gene

Interacting Proteins for LY75 Gene

Selected Interacting proteins: O60449-LY75_HUMAN for LY75 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for LY75 Gene


No data available for SIGNOR curated interactions for LY75 Gene

Drugs & Compounds for LY75 Gene

(1) Additional Compounds for LY75 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LY75: view

Transcripts for LY75 Gene

Unigene Clusters for LY75 Gene

Lymphocyte antigen 75:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LY75 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP2: - - -
SP6: -

Relevant External Links for LY75 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LY75 Gene

mRNA expression in normal human tissues for LY75 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LY75 Gene

This gene is overexpressed in Lymph node (23.5), Peripheral blood mononuclear cells (13.6), and Blymphocyte (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LY75 Gene

SOURCE GeneReport for Unigene cluster for LY75 Gene Hs.153563

mRNA Expression by UniProt/SwissProt for LY75 Gene

Tissue specificity: Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
genes like me logo Genes that share expression patterns with LY75: view

Protein tissue co-expression partners for LY75 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for LY75 Gene

Orthologs for LY75 Gene

This gene was present in the common ancestor of animals.

Orthologs for LY75 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LY75 35
  • 86.28 (n)
  • 79.97 (a)
LY75 36
  • 79 (a)
(Canis familiaris)
Mammalia LY75 35
  • 87.61 (n)
  • 81.24 (a)
-- 36
  • 80 (a)
(Mus musculus)
Mammalia Ly75 35
  • 80.84 (n)
  • 76.89 (a)
Ly75 16
Ly75 36
  • 76 (a)
(Pan troglodytes)
Mammalia LY75 35
  • 99.36 (n)
  • 98.66 (a)
-- 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ly75 35
  • 80.36 (n)
  • 76.73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Gallus gallus)
Aves LY75 35
  • 62.85 (n)
  • 53.21 (a)
LY75 36
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
-- 36
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ly75 35
  • 55.82 (n)
  • 45.06 (a)
(Danio rerio)
Actinopterygii ly75 35
  • 49.41 (n)
  • 38.77 (a)
ly75 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea clec-148 36
  • 21 (a)
clec-48 36
  • 26 (a)
clec-49 36
  • 26 (a)
clec-50 36
  • 26 (a)
clec-51 36
  • 22 (a)
clec-52 36
  • 23 (a)
clec-53 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for LY75:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LY75 Gene

Gene Tree for LY75 (if available)
Gene Tree for LY75 (if available)

Paralogs for LY75 Gene

Paralogs for LY75 Gene

(3) SIMAP similar genes for LY75 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LY75: view

Variants for LY75 Gene

Sequence variations from dbSNP and Humsavar for LY75 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_024522 -
VAR_027824 -
VAR_027825 -
VAR_027826 -
VAR_027827 -

Structural Variations from Database of Genomic Variants (DGV) for LY75 Gene

Variant ID Type Subtype PubMed ID
dgv4351n71 CNV Loss 21882294
nsv875344 CNV Loss 21882294
nsv470497 CNV Loss 18288195
nsv834436 CNV Loss 17160897
nsv437546 CNV Loss 16327808
esv2358013 CNV Deletion 18987734
esv2665197 CNV Deletion 23128226
esv2721034 CNV Deletion 23290073
esv1275142 CNV Insertion 17803354
esv1586275 CNV Insertion 17803354
esv1681534 CNV Deletion 17803354

Variation tolerance for LY75 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.13; 97.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LY75 Gene

Disorders for LY75 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LY75 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hodgkin lymphoma
  • hodgkin's lymphoma
lipid pneumonia
  • exogenous lipoid pneumonia
  • chronic adenoiditis
- elite association - COSMIC cancer census association via MalaCards
Search LY75 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LY75

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LY75: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LY75 Gene

Publications for LY75 Gene

  1. cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells. (PMID: 9553150) Kato M. … Hart D.N.J. (Immunogenetics 1998) 2 3 4 23 67
  2. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (PMID: 12824192) Kato M. … Hart D.N.J. (J. Biol. Chem. 2003) 3 23
  3. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. (PMID: 10980384) Guo M. … Steinman R.M. (Hum. Immunol. 2000) 3 23
  4. Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. (PMID: 11058570) Kato M. … Hart D.N. (Int. Immunol. 2000) 3 23
  5. Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study. (PMID: 25557950) Alonso A. … Gisbert J.P. (Gastroenterology 2015) 3

Products for LY75 Gene

Sources for LY75 Gene