Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LY75 Gene

Aliases for LY75 Gene

  • Lymphocyte Antigen 75 2 3 5
  • C-Type Lectin Domain Family 13 Member B 3 4
  • GP200-MR6 3 4
  • CLEC13B 3 4
  • DEC-205 3 4
  • LY-75 3 4
  • CD205 3 4
  • CD205 Antigen 4

External Ids for LY75 Gene

Previous GeneCards Identifiers for LY75 Gene

  • GC02M158591
  • GC02M159188
  • GC02M160623
  • GC02M160862
  • GC02M160485
  • GC02M160368
  • GC02M152542
  • GC02M160659

Summaries for LY75 Gene

GeneCards Summary for LY75 Gene

LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. Diseases associated with LY75 include Pneumonic Plague and Lipid Pneumonia. Among its related pathways are Dendritic Cells Developmental Lineage Pathway. Gene Ontology (GO) annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is LY75-CD302.

UniProtKB/Swiss-Prot for LY75 Gene

  • Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Gene Wiki entry for LY75 Gene

Additional gene information for LY75 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY75 Gene

Genomics for LY75 Gene

GeneHancer (GH) Regulatory Elements for LY75 Gene

Promoters and enhancers for LY75 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I159902 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 601.8 -0.1 -96 4.9 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 IRF4 ZNF48 ETS1 ZNF143 ATF7 LY75 LY75-CD302 BTF3L4P2 LOC105373717
GH02I160061 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 21.4 -158.9 -158887 3.7 SUZ12 SIN3A CEBPB REST SP1 ZNF335 GATA3 POLR2A POU5F1 ZNF143 PLA2R1 LY75 LOC105373717 PIR61464
GH02I160201 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.1 -302.1 -302141 9.8 PKNOX1 FOXA2 SIN3A IRF4 ZNF48 ZNF143 ATF7 FOS RUNX3 REST LY75 ITGB6 LINC02478 RBMS1 ENSG00000226266 PLA2R1 CD302 PIR61464
GH02I160219 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18 -320.2 -320234 11.4 PKNOX1 FOXA2 SIN3A ZNF48 ATF7 FOS RUNX3 RXRA SP5 JUNB ITGB6 LY75 PLA2R1 LINC02478 RBMS1 CD302 PIR61464
GH02I160213 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 20.9 -310.1 -310133 3.1 JUN NR2F1 MAX CEBPB REST DPF2 TEAD3 SP1 JUND IKZF1 LY75 PLA2R1 ITGB6 PIR61464 LINC02478
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LY75 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LY75 gene promoter:

Genomic Locations for LY75 Gene

Genomic Locations for LY75 Gene
101,402 bases
Minus strand

Genomic View for LY75 Gene

Genes around LY75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LY75 Gene

Proteins for LY75 Gene

  • Protein details for LY75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lymphocyte antigen 75
    Protein Accession:
    Secondary Accessions:
    • O75913
    • Q53R46
    • Q53TF5
    • Q7Z575
    • Q7Z577

    Protein attributes for LY75 Gene

    1722 amino acids
    Molecular mass:
    198311 Da
    Quaternary structure:
    No Data Available
    • Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

    Alternative splice isoforms for LY75 Gene


neXtProt entry for LY75 Gene

Post-translational modifications for LY75 Gene

  • N-glycosylated.
  • Glycosylation at posLast=135135, posLast=345345, isoforms=2, 3377, posLast=529529, isoforms=2, 3843, posLast=865865, posLast=934934, isoforms=2, 31076, isoforms=2, 31103, posLast=12251225, isoforms=2, 31320, isoforms=2, 31392, isoforms=2, 31593, and isoforms=21626

Other Protein References for LY75 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LY75 Gene

Domains & Families for LY75 Gene

Suggested Antigen Peptide Sequences for LY75 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LY75: view

No data available for UniProtKB/Swiss-Prot for LY75 Gene

Function for LY75 Gene

Molecular function for LY75 Gene

GENATLAS Biochemistry:
lymphocyte antigen 75,putative antigen-uptake receptor on dendritic cells
UniProtKB/Swiss-Prot Function:
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Phenotypes From GWAS Catalog for LY75 Gene

Gene Ontology (GO) - Molecular Function for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9553150
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LY75: view
genes like me logo Genes that share phenotypes with LY75: view

Animal Models for LY75 Gene

MGI Knock Outs for LY75:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LY75 Gene

Localization for LY75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY75 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LY75 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 2
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9553150
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 20458337
genes like me logo Genes that share ontologies with LY75: view

Pathways & Interactions for LY75 Gene

genes like me logo Genes that share pathways with LY75: view

Pathways by source for LY75 Gene

1 R&D Systems pathway for LY75 Gene

Gene Ontology (GO) - Biological Process for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006954 inflammatory response TAS 9553150
GO:0006955 immune response TAS 9553150
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with LY75: view

No data available for SIGNOR curated interactions for LY75 Gene

Drugs & Compounds for LY75 Gene

(1) Drugs for LY75 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LY75: view

Transcripts for LY75 Gene

Unigene Clusters for LY75 Gene

Lymphocyte antigen 75:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LY75 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP2: - - -
SP6: -

Relevant External Links for LY75 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LY75 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LY75 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LY75 Gene

This gene is overexpressed in Lymph node (23.5), Peripheral blood mononuclear cells (13.6), and Blymphocyte (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LY75 Gene

Protein tissue co-expression partners for LY75 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LY75 Gene:


SOURCE GeneReport for Unigene cluster for LY75 Gene:


mRNA Expression by UniProt/SwissProt for LY75 Gene:

Tissue specificity: Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

Evidence on tissue expression from TISSUES for LY75 Gene

  • Spleen(3)
  • Lymph node(2.9)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with LY75: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LY75 Gene

Orthologs for LY75 Gene

This gene was present in the common ancestor of animals.

Orthologs for LY75 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LY75 33
  • 99.36 (n)
-- 34
  • 99 (a)
(Canis familiaris)
Mammalia LY75 33
  • 87.61 (n)
-- 34
  • 80 (a)
(Bos Taurus)
Mammalia LY75 33 34
  • 86.28 (n)
(Mus musculus)
Mammalia Ly75 33 16 34
  • 80.84 (n)
(Rattus norvegicus)
Mammalia Ly75 33
  • 80.36 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
(Gallus gallus)
Aves LY75 33 34
  • 62.85 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
-- 34
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ly75 33
  • 55.82 (n)
(Danio rerio)
Actinopterygii ly75 33 34
  • 49.41 (n)
(Caenorhabditis elegans)
Secernentea clec-48 34
  • 26 (a)
clec-49 34
  • 26 (a)
clec-50 34
  • 26 (a)
clec-52 34
  • 23 (a)
clec-53 34
  • 23 (a)
clec-51 34
  • 22 (a)
clec-148 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for LY75 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LY75 Gene

Gene Tree for LY75 (if available)
Gene Tree for LY75 (if available)

Paralogs for LY75 Gene

Paralogs for LY75 Gene

(3) SIMAP similar genes for LY75 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LY75: view

Variants for LY75 Gene

Sequence variations from dbSNP and Humsavar for LY75 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000020040 -- 159,868,591(-) A/T intron_variant
rs1000049809 -- 159,868,944(-) A/G intron_variant
rs1000050244 -- 159,869,602(-) C/T intron_variant
rs1000054858 -- 159,880,291(-) A/C intron_variant
rs1000070654 -- 159,835,324(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LY75 Gene

Variant ID Type Subtype PubMed ID
dgv1176e212 CNV loss 25503493
esv1275142 CNV insertion 17803354
esv1586275 CNV insertion 17803354
esv1681534 CNV deletion 17803354
esv2358013 CNV deletion 18987734
esv2665197 CNV deletion 23128226
esv2721034 CNV deletion 23290073
esv3893504 CNV loss 25118596
nsv1010774 CNV gain 25217958
nsv1116803 CNV deletion 24896259
nsv437546 CNV loss 16327808
nsv470497 CNV loss 18288195
nsv834436 CNV loss 17160897

Variation tolerance for LY75 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.13; 97.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LY75 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY75 Gene

Disorders for LY75 Gene

MalaCards: The human disease database

(10) MalaCards diseases for LY75 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
pneumonic plague
  • primary pneumonic plague
lipid pneumonia
  • exogenous lipoid pneumonia
atrial septal defect 1
  • asd1
  • chronic adenoiditis
atrial septal defect 2
  • asd2
- elite association - COSMIC cancer census association via MalaCards
Search LY75 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LY75

genes like me logo Genes that share disorders with LY75: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LY75 Gene

Publications for LY75 Gene

  1. cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells. (PMID: 9553150) Kato M … Hart DN (Immunogenetics 1998) 2 3 4 22 58
  2. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (PMID: 12824192) Kato M … Hart DN (The Journal of biological chemistry 2003) 3 4 22 58
  3. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. (PMID: 10980384) Guo M … Steinman RM (Human immunology 2000) 3 22 58
  4. Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. (PMID: 11058570) Kato M … Hart DN (International immunology 2000) 3 22 58
  5. The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family. (PMID: 9862343) McKay PF … Ritter MA (European journal of immunology 1998) 3 4 58

Products for LY75 Gene

Sources for LY75 Gene

Loading form....