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Aliases for LY75 Gene

Aliases for LY75 Gene

  • Lymphocyte Antigen 75 2 3
  • C-Type Lectin Domain Family 13 Member B 3 4
  • GP200-MR6 3 4
  • CLEC13B 3 4
  • DEC-205 3 4
  • LY-75 3 4
  • CD205 3 4
  • CD205 Antigen 4

External Ids for LY75 Gene

Previous GeneCards Identifiers for LY75 Gene

  • GC02M158591
  • GC02M159188
  • GC02M160623
  • GC02M160862
  • GC02M160485
  • GC02M160368
  • GC02M152542
  • GC02M160659

Summaries for LY75 Gene

GeneCards Summary for LY75 Gene

LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. Diseases associated with LY75 include lipid pneumonia. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is PLA2R1.

UniProtKB/Swiss-Prot for LY75 Gene

  • Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Gene Wiki entry for LY75 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY75 Gene

Genomics for LY75 Gene

Regulatory Elements for LY75 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LY75 Gene

Start:
159,803,355 bp from pter
End:
159,904,756 bp from pter
Size:
101,402 bases
Orientation:
Minus strand

Genomic View for LY75 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LY75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LY75 Gene

Proteins for LY75 Gene

  • Protein details for LY75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60449-LY75_HUMAN
    Recommended name:
    Lymphocyte antigen 75
    Protein Accession:
    O60449
    Secondary Accessions:
    • O75913
    • Q53R46
    • Q53TF5
    • Q7Z575
    • Q7Z577

    Protein attributes for LY75 Gene

    Size:
    1722 amino acids
    Molecular mass:
    198311 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins

    Alternative splice isoforms for LY75 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LY75 Gene

Proteomics data for LY75 Gene at MOPED

Post-translational modifications for LY75 Gene

  • N-glycosylated.
  • Glycosylation at Asn135, Asn345, Asn377, Asn529, Asn843, Asn865, Asn934, Asn1076, Asn1103, Asn1225, Asn1320, Asn1392, Asn1593, Asn1626, and Asn1750
  • Modification sites at PhosphoSitePlus

Other Protein References for LY75 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LY75 Gene

Domains for LY75 Gene

Gene Families for LY75 Gene

HGNC:
  • CD :CD molecules
  • CLEC :C-type lectin domain containing

Suggested Antigen Peptide Sequences for LY75 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60449

UniProtKB/Swiss-Prot:

LY75_HUMAN :
  • O60449
Domain:
  • Contains 10 C-type lectin domains.
  • Contains 1 fibronectin type-II domain.
  • Contains 1 ricin B-type lectin domain.
genes like me logo Genes that share domains with LY75: view

Function for LY75 Gene

Molecular function for LY75 Gene

GENATLAS Biochemistry: lymphocyte antigen 75,putative antigen-uptake receptor on dendritic cells
UniProtKB/Swiss-Prot Function: Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Gene Ontology (GO) - Molecular Function for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9553150
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LY75: view

Phenotypes for LY75 Gene

genes like me logo Genes that share phenotypes with LY75: view

Animal Models for LY75 Gene

MGI Knock Outs for LY75:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LY75

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LY75 Gene

Localization for LY75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY75 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LY75 Gene COMPARTMENTS Subcellular localization image for LY75 gene
Compartment Confidence
plasma membrane 4
endosome 2
peroxisome 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9553150
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with LY75: view

Pathways for LY75 Gene

SuperPathways for LY75 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Interacting Proteins for LY75 Gene

Selected Interacting proteins: O60449-LY75_HUMAN for LY75 Gene via UniProtKB

Symbol External ID(s) Details
FATE1

Gene Ontology (GO) - Biological Process for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006954 inflammatory response TAS 9553150
GO:0006955 immune response TAS 9553150
genes like me logo Genes that share ontologies with LY75: view

No data available for Pathways by source for LY75 Gene

Compounds for LY75 Gene

(1) Novoseek inferred chemical compound relationships for LY75 Gene

Compound -log(P) Hits PubMed IDs
mannose 77.2 9
genes like me logo Genes that share compounds with LY75: view

Transcripts for LY75 Gene

mRNA/cDNA for LY75 Gene

Unigene Clusters for LY75 Gene

Lymphocyte antigen 75:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LY75

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LY75

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LY75 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for LY75 Gene

GeneLoc Exon Structure for
LY75
ECgene alternative splicing isoforms for
LY75

Expression for LY75 Gene

mRNA expression in normal human tissues for LY75 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LY75 Gene

SOURCE GeneReport for Unigene cluster for LY75 Gene Hs.153563

mRNA Expression by UniProt/SwissProt for LY75 Gene

O60449-LY75_HUMAN
Tissue specificity: Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
genes like me logo Genes that share expressions with LY75: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LY75 Gene

Orthologs for LY75 Gene

This gene was present in the common ancestor of animals.

Orthologs for LY75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
LY75 35
  • 99.36 (n)
  • 98.66 (a)
cow
(Bos Taurus)
Mammalia LY75 35
  • 86.28 (n)
  • 79.97 (a)
LY75 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
OneToMany
LY75 35
  • 87.61 (n)
  • 81.24 (a)
mouse
(Mus musculus)
Mammalia Ly75 35
  • 80.84 (n)
  • 76.89 (a)
Ly75 16
Ly75 36
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ly75 35
  • 80.36 (n)
  • 76.73 (a)
chicken
(Gallus gallus)
Aves LY75 35
  • 62.85 (n)
  • 53.21 (a)
LY75 36
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ly75 35
  • 55.82 (n)
  • 45.06 (a)
zebrafish
(Danio rerio)
Actinopterygii ly75 35
  • 49.41 (n)
  • 38.77 (a)
ly75 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea clec-148 36
  • 21 (a)
ManyToMany
clec-48 36
  • 26 (a)
ManyToMany
clec-49 36
  • 26 (a)
ManyToMany
clec-50 36
  • 26 (a)
ManyToMany
clec-51 36
  • 22 (a)
ManyToMany
clec-52 36
  • 23 (a)
ManyToMany
clec-53 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for LY75:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LY75 Gene

ENSEMBL:
Gene Tree for LY75 (if available)
TreeFam:
Gene Tree for LY75 (if available)

Paralogs for LY75 Gene

Paralogs for LY75 Gene

Selected SIMAP similar genes for LY75 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LY75: view

Variants for LY75 Gene

Sequence variations from dbSNP and Humsavar for LY75 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_024522 -
VAR_027824 -
VAR_027825 -
VAR_027826 -
VAR_027827 -

Structural Variations from Database of Genomic Variants (DGV) for LY75 Gene

Variant ID Type Subtype PubMed ID
dgv4351n71 CNV Loss 21882294
nsv875344 CNV Loss 21882294
nsv470497 CNV Loss 18288195
nsv834436 CNV Loss 17160897
nsv437546 CNV Loss 16327808
esv2358013 CNV Deletion 18987734
esv2665197 CNV Deletion 23128226
esv2721034 CNV Deletion 23290073
esv1275142 CNV Insertion 17803354
esv1586275 CNV Insertion 17803354
esv1681534 CNV Deletion 17803354

Relevant External Links for LY75 Gene

HapMap Linkage Disequilibrium report
LY75

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY75 Gene

Disorders for LY75 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for LY75 Gene including...

Search for LY75 Gene in MalaCards »

(1) University of Copenhagen DISEASES for LY75 Gene

(1) Novoseek inferred disease relationships for LY75 Gene

Disease -log(P) Hits PubMed IDs
hodgkin disease 27.5 1

Relevant External Links for LY75

Human Genome Epidemiology (HuGE) Navigator
LY75
genes like me logo Genes that share disorders with LY75: view

No data available for UniProtKB/Swiss-Prot for LY75 Gene

Publications for LY75 Gene

  1. cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells. (PMID: 9553150) Kato M. … Hart D.N.J. (Immunogenetics 1998) 2 3 4 23
  2. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (PMID: 12824192) Kato M. … Hart D.N.J. (J. Biol. Chem. 2003) 3 4 23
  3. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. (PMID: 10980384) Guo M. … Steinman R.M. (Hum. Immunol. 2000) 3 23
  4. Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. (PMID: 11058570) Kato M. … Hart D.N. (Int. Immunol. 2000) 3 23
  5. The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family. (PMID: 9862343) McKay P.F. … Ritter M.A. (Eur. J. Immunol. 1998) 3 4

Products for LY75 Gene

Sources for LY75 Gene

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