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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LY75 Gene

protein-coding GIFtS: 55
GCID: GC02M160659

lymphocyte antigen 75

Explore 12 diseases affiliated with
LY75 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lymphocyte Antigen 75¹ ²		GP200-MR6²
CD205¹ ² ³		LY-75²
CLEC13B¹ ² ³		Ly-75³
DEC-205¹ ² ³		CD205 Antigen³
C-Type Lectin Domain Family 13 Member B² ³		Gp200-MR6¹

External Ids:	HGNC: 6729¹	Entrez Gene: 4065²	Ensembl: ENSG00000054219⁷	OMIM: 604524⁵	UniProtKB: O60449³

Export aliases for LY75 gene to outside databases

Previous GC identifers: GC02M158591 GC02M159188 GC02M160623 GC02M160862 GC02M160485 GC02M160368 GC02M152542

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LY75_HUMAN, O60449

Function: Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized

antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes

Gene Wiki entry for LY75

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LY75 gene promoter:
CUTL1 Nkx2-5 IRF-2 POU2F1 POU2F1a POU2F1b POU2F1c TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LY75 promoter sequence

Search SABiosciences Chromatin IP Primers for LY75

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LY75

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24 Ensembl cytogenetic band: 2q24.2 HGNC cytogenetic band: 2q24

LY75 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LY75 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M160659: view genomic region (about GC identifiers)

Start:	160,628,362 bp from pter	End:	160,761,262 bp from pter
Size:	132,901 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LY75_HUMAN, O60449 (See protein sequence)

Recommended Name: Lymphocyte antigen 75 precursor

Size: 1722 amino acids; 198311 Da

Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)

Miscellaneous: Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which

cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce

LY75/CD302 fusion proteins

Secondary accessions: O75913 Q53R46 Q53TF5 Q7Z575 Q7Z577

Alternative splicing: 5 isoforms: O60449-1 O60449-2 Q8IX05-2 O60449-3 Q8IX05-1 (Produced by intergenic splicing of LY75 and CD302)

Explore the universe of human proteins at neXtProt for LY75: NX_O60449

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60449

LY75 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002340.2

ENSEMBL proteins:

ENSP00000263636 ENSP00000451511 ENSP00000451446

Human Recombinant Protein Products for LY75:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LY75

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9553150

LY75 for ontologies About GeneDecksing

LY75 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LY75
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Assay Products for LY75:

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	Uscn ELISAs and CLIAs for LY75

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LY75 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000772 Ricin_B_lectin

IPR016187 C-type_lectin_fold

IPR013806 Kringle-like

IPR018378 C-type_lectin_CS

IPR000562 FN_type2_col-bd

Graphical View of Domain Structure for InterPro Entry O60449

ProtoNet protein and cluster: O60449

2 Blocks protein families:

IPB000562 Type II fibronectin collagen-binding domain

IPB000772 Ricin B lectin domain

UniProtKB/Swiss-Prot: LY75_HUMAN, O60449

Similarity: Contains 10 C-type lectin domains

Similarity: Contains 1 fibronectin type-II domain

Similarity: Contains 1 ricin B-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LY75_HUMAN, O60449

Function: Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized

antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes

Genatlas biochemistry entry for LY75:

lymphocyte antigen 75,putative antigen-uptake receptor on dendritic cells

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	9553150
GO:0030246	carbohydrate binding	IEA	--

LY75 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ly75):

hematopoietic system

immune system

mortality/aging

LY75 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ly75^tm1Mnz for LY75

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LY75

miRNA Products:		OriGene 3'-UTR Clone: LY75 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LY75
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate LY75 (see all 49):
		hsa-miR-548j hsa-let-7d hsa-miR-429 hsa-miR-548k hsa-miR-301a hsa-miR-548l hsa-miR-105 hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: LY75 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LY75 (see all 4) OriGene shRNA RFP: LY75 OriGene siRNA: LY75
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LY75 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LY75 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LY75

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LY75

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	IEA	--
GO:0006954	inflammatory response	TAS	9553150
GO:0006955	immune response	TAS	9553150

LY75 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LY75 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LY75
1 Novoseek chemical compound relationship for LY75 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose	77.2	15	10980384 (1), 11058570 (1), 16452473 (1), 17534864 (1) (see all 9)

Search CenterWatch for drugs/clinical trials and news about LY75

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LY75 gene:

NM_002349.3

Unigene Cluster for LY75:

Lymphocyte antigen 75

Hs.153563 [show with all ESTs]

Unigene Representative Sequence: NM_001198759

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263636(uc002ubc.4) ENST00000484559(uc010fot.2) ENST00000492955(uc002ubd.3)

ENST00000471164 ENST00000554112 ENST00000553424

miRNA Products:		OriGene 3'-UTR Clone: LY75 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LY75
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate LY75 (see all 49):
		hsa-miR-548j hsa-let-7d hsa-miR-429 hsa-miR-548k hsa-miR-301a hsa-miR-548l hsa-miR-105 hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: LY75 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LY75 (see all 4) OriGene shRNA RFP: LY75 OriGene siRNA: LY75
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		Sirion Biotech Custom design and validation of potent shRNA sequences against LY75

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		GenScript: all cDNA clones in your preferred vector: LY75 (NM_002349)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LY75
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LY75

Additional cDNA sequence:

AB208915.1 AF011333.1 AF064827.1 AK125488.1 AK126410.1 AK310678.1 BC057232.1

20 DOTS entries:

DT.110099 DT.75180760 DT.416796 DT.91743109 DT.417390 DT.101981462 DT.99952725 DT.91699621

DT.95075642 DT.97777699 DT.120993585 DT.120993720 DT.65288614 DT.75118981 DT.75128401 DT.91699622

DT.97763136 DT.99953370 DT.100777074 DT.95271043

24/253 AceView cDNA sequences (see all 253):

R47380 AA279284 AA364840 AW297924 AW151721 CK820032 AI865076 BF002778

AK125081 N99776 CB122654 AI829613 BE464368 AI621101 H95804 AW517147

BM354053 BI966750 AY314006 D57864 BI027069 BM273105 AW611786 H60460

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LY75 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12
SP1:
SP2:							-		-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for LY75

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LY75 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

LY75 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LY75 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LY75

SOURCE GeneReport for Unigene cluster: Hs.153563

UniProtKB/Swiss-Prot: LY75_HUMAN, O60449

Tissue specificity: Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and

B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and

Reed-Sternberg (HRS) cells

SABiosciences Expression via Pathway-Focused PCR Array including LY75:

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LY75

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LY75 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LY75¹	lymphocyte antigen 75	62.83(n) 53.21(a)		424192 NM_001037836.1 NP_001032925.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	57(a) 37(a)	many ↔ many many ↔ many	AAWZ02036395(3863-25271) GL343371.1(840691-894194)
zebrafish (Danio rerio)	Actinopterygii	ly75¹	lymphocyte antigen 75	49.91(n) 39.62(a)		504036 XM_690165.5 XP_695257.5

ENSEMBL Gene Tree for LY75 (if available)
TreeFam Gene Tree for LY75 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LY75 gene

ENSG00000183748² PLA2R1² MRC1² LY75-CD302² MRC2²

3 SIMAP similar genes for LY75 using alignment to 2 protein entries: LY75_HUMAN (see all proteins):

MRC2 PLA2R1 REG1B

LY75 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144409400^1,2		--	160659444(+)	`ACAGGG/TTCTTG`	3	--	int¹		0	--	--	--	--
rs4665118^1,2	C,F,A,H	--	160659449(+)	`GTCTTG/TCTCTG`	3	--	int¹		8		WA NA CSA EA	368
rs192010273^1,2		--	160659481(+)	`GGCACA/GTTCAT`	3	--	int¹		0	--	--	--	--
rs71000310^1,2	C	--	160659593(+)	`TTTTT-/TAGAAA`	3	--	int¹		2		NA	4
rs200114128^1,2		--	160659599(+)	`TTTTT-/CTTAGA`	3	--	int¹		0	--	--	--	--
rs72965376^1,2	C	--	160659737(+)	`AAAAAT/ATGCAC`	3	--	int¹		1		NA	2
rs116771418^1,2	F	--	160659890(+)	`ATAAAA/TCAACT`	3	--	int¹ ut3¹		1		WA	118
rs182702143^1,2		--	160659910(+)	`CATCAA/CCATTA`	3	--	int¹ ut3¹		0	--	--	--	--
rs188065789^1,2		--	160659972(+)	`TTAGTA/GACTAA`	3	--	int¹ ut3¹		0	--	--	--	--
rs13307^1,2	C,F,O,H	--	160659996(-)	`TTGTCC/TTGTGA`	3	--	int¹ ut3¹ ese³		19		MN NS EA NA	2584

HapMap Linkage Disequilibrium report for LY75 (160628362 - 160761262 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LY75
1 CNV: 1356

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LY75

DNA2.0 Custom Variant and Variant Library Synthesis for LY75

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LY75 for disorders           About GeneDecksing

OMIM gene information: 604524    OMIM disorders: --

12 diseases for LY75:    About MalaCards

pneumonic plague langerhans cell sarcoma plague lipid pneumonia

hodgkin's lymphoma bladder carcinoma hepatitis b nephropathy

hepatitis sarcoma pneumonia carcinoma

1 disease from the University of Copenhagen DISEASES database for LY75:

Lipid pneumonia

1 Novoseek disease relationship for LY75 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hodgkin disease	27.5	1	12824192 (1)

Human Genome Epidemiology (HuGE) Navigator: LY75 (1 document)

Export disorders for LY75 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LY75 gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with LY75)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells. (PubMed id 9553150)^{1, 2, 3, 9} Kato M.... Hart D.N.J. (1998)
Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (PubMed id 12824192)^{1, 2, 9} Kato M.... Hart D.N.J. (2003)
The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family. (PubMed id 9862343)^{1, 2} McKay P.F....Ritter M.A. (1998)
A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. (PubMed id 10980384)^{1, 9} Guo M....Steinman R.M. (2000)
Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. (PubMed id 11058570)^{1, 9} Kato M....Hart D.N. (2000)
PE-Cy5.5 conjugates bind to the cells expressing mouse DEC205/CD205. (PubMed id 22841832)¹ Park C.G....Steinman R.M. (2012)
Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibili ty Loci for type 2 diabetes mellitus. (PubMed id 22865700)¹ Greenawalt D.M....Hu F.B. (2012)
DEC-205 is a cell surface receptor for CpG oligonucleo tides. (PubMed id 22988114)¹ Lahoud M.H....Caminschi I. (2012)
Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo. (PubMed id 22736794)¹ Fukaya T....Sato K. (2012)
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic memb ranous nephropathy. (PubMed id 21323541)¹ Stanescu H.C....Kleta R. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4065	HGNC: 6729	AceView: LY75andDCL-1	Ensembl:ENSG00000054219	euGenes: HUgn4065
ECgene: LY75	H-InvDB: LY75

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LY75	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_250

Intellectual Property for LY75 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LY75 gene:
Search GeneIP for patents involving LY75

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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LY75 Gene

lymphocyte antigen 75

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LY75 Gene

lymphocyte antigen 75

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