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Aliases for LY75 Gene

Aliases for LY75 Gene

  • Lymphocyte Antigen 75 2 3 5
  • C-Type Lectin Domain Family 13 Member B 3 4
  • GP200-MR6 3 4
  • CLEC13B 3 4
  • DEC-205 3 4
  • LY-75 3 4
  • CD205 3 4
  • CD205 Antigen 4

External Ids for LY75 Gene

Previous GeneCards Identifiers for LY75 Gene

  • GC02M158591
  • GC02M159188
  • GC02M160623
  • GC02M160862
  • GC02M160485
  • GC02M160368
  • GC02M152542
  • GC02M160659

Summaries for LY75 Gene

GeneCards Summary for LY75 Gene

LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. Diseases associated with LY75 include Lipid Pneumonia and Hodgkin Lymphoma. Among its related pathways are Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is LY75-CD302.

UniProtKB/Swiss-Prot for LY75 Gene

  • Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Gene Wiki entry for LY75 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY75 Gene

Genomics for LY75 Gene

Regulatory Elements for LY75 Gene

Enhancers for LY75 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G159902 1 ENCODE 51.8 -0.1 -96 4.9 PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ETS1 GATA2 ZNF143 LY75 BTF3L4P2 LY75-CD302 LOC105373717
GH02G160201 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.1 -302.1 -302142 9.8 PKNOX1 MLX SIN3A ZNF48 SLC30A9 GATA2 CBX5 ZNF143 FOS REST LY75 ITGB6 LINC02478 RBMS1 ENSG00000226266 PLA2R1 CD302 PIR61464
GH02G160219 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18 -320.2 -320234 11.4 PKNOX1 FOXA2 ZNF48 ZNF766 CBX5 GATA2 ZNF207 FOS SP5 ZHX2 ITGB6 LY75 PLA2R1 LINC02478 RBMS1 CD302 PIR61464
GH02G160213 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.9 -310.1 -310133 3.1 ZNF146 JUN MAX TEAD3 ZNF157 POLR2A RCOR1 FOS NR2F1 BHLHE40 LY75 PLA2R1 ITGB6 PIR61464
GH02G160156 1.3 FANTOM5 Ensembl ENCODE 20.2 -252.8 -252775 2.8 CTCF STAT1 PKNOX1 RFX1 TAL1 JUN RAD21 EP300 GATA3 GATA2 LY75 LINC02478 ITGB6 RBMS1 PLA2R1 ENSG00000226266 PIR61464
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LY75 on UCSC Golden Path with GeneCards custom track

Promoters for LY75 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125210 456 1801 TBP PKNOX1 WRNIP1 SIN3A BMI1 ETS1 EGR1 GATA2 ZNF143 FOS

Genomic Location for LY75 Gene

Chromosome:
2
Start:
159,803,355 bp from pter
End:
159,904,756 bp from pter
Size:
101,402 bases
Orientation:
Minus strand

Genomic View for LY75 Gene

Genes around LY75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LY75 Gene

Proteins for LY75 Gene

  • Protein details for LY75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60449-LY75_HUMAN
    Recommended name:
    Lymphocyte antigen 75
    Protein Accession:
    O60449
    Secondary Accessions:
    • O75913
    • Q53R46
    • Q53TF5
    • Q7Z575
    • Q7Z577

    Protein attributes for LY75 Gene

    Size:
    1722 amino acids
    Molecular mass:
    198311 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

    Alternative splice isoforms for LY75 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LY75 Gene

Post-translational modifications for LY75 Gene

  • N-glycosylated.
  • Glycosylation at Asn135, Asn345, posLast=377377, Asn529, Asn843, Asn865, posLast=934934, Asn1076, Asn1103, Asn1225, Asn1320, posLast=13921392, posLast=15931593, and posLast=16261626
  • Modification sites at PhosphoSitePlus

Other Protein References for LY75 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LY75 Gene

Domains & Families for LY75 Gene

Suggested Antigen Peptide Sequences for LY75 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LY75: view

No data available for UniProtKB/Swiss-Prot for LY75 Gene

Function for LY75 Gene

Molecular function for LY75 Gene

GENATLAS Biochemistry:
lymphocyte antigen 75,putative antigen-uptake receptor on dendritic cells
UniProtKB/Swiss-Prot Function:
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Gene Ontology (GO) - Molecular Function for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9553150
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LY75: view
genes like me logo Genes that share phenotypes with LY75: view

Animal Models for LY75 Gene

MGI Knock Outs for LY75:

Animal Model Products

  • Taconic Biosciences Mouse Models for LY75

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LY75

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LY75 Gene

Localization for LY75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY75 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LY75 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9553150
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with LY75: view

Pathways & Interactions for LY75 Gene

genes like me logo Genes that share pathways with LY75: view

Pathways by source for LY75 Gene

1 R&D Systems pathway for LY75 Gene

Gene Ontology (GO) - Biological Process for LY75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006954 inflammatory response TAS 9553150
GO:0006955 immune response TAS 9553150
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with LY75: view

No data available for SIGNOR curated interactions for LY75 Gene

Drugs & Compounds for LY75 Gene

(1) Additional Compounds for LY75 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LY75: view

Transcripts for LY75 Gene

Unigene Clusters for LY75 Gene

Lymphocyte antigen 75:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LY75

Alternative Splicing Database (ASD) splice patterns (SP) for LY75 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for LY75 Gene

GeneLoc Exon Structure for
LY75
ECgene alternative splicing isoforms for
LY75

Expression for LY75 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LY75 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LY75 Gene

This gene is overexpressed in Lymph node (23.5), Peripheral blood mononuclear cells (13.6), and Blymphocyte (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LY75 Gene



Protein tissue co-expression partners for LY75 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LY75 Gene:

LY75

SOURCE GeneReport for Unigene cluster for LY75 Gene:

Hs.153563

mRNA Expression by UniProt/SwissProt for LY75 Gene:

O60449-LY75_HUMAN
Tissue specificity: Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

Evidence on tissue expression from TISSUES for LY75 Gene

  • Spleen(3)
  • Lymph node(2.9)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with LY75: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LY75 Gene

Orthologs for LY75 Gene

This gene was present in the common ancestor of animals.

Orthologs for LY75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LY75 34
  • 99.36 (n)
-- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LY75 34
  • 87.61 (n)
-- 35
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LY75 34 35
  • 86.28 (n)
mouse
(Mus musculus)
Mammalia Ly75 34 16 35
  • 80.84 (n)
rat
(Rattus norvegicus)
Mammalia Ly75 34
  • 80.36 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves LY75 34 35
  • 62.85 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ly75 34
  • 55.82 (n)
zebrafish
(Danio rerio)
Actinopterygii ly75 34 35
  • 49.41 (n)
worm
(Caenorhabditis elegans)
Secernentea clec-48 35
  • 26 (a)
ManyToMany
clec-49 35
  • 26 (a)
ManyToMany
clec-50 35
  • 26 (a)
ManyToMany
clec-52 35
  • 23 (a)
ManyToMany
clec-53 35
  • 23 (a)
ManyToMany
clec-51 35
  • 22 (a)
ManyToMany
clec-148 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for LY75 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LY75 Gene

ENSEMBL:
Gene Tree for LY75 (if available)
TreeFam:
Gene Tree for LY75 (if available)

Paralogs for LY75 Gene

Paralogs for LY75 Gene

(3) SIMAP similar genes for LY75 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LY75: view

Variants for LY75 Gene

Sequence variations from dbSNP and Humsavar for LY75 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000020040 -- 159,868,591(+) ATCAT(A/T)AAAAT intron-variant
rs1000049809 -- 159,868,944(+) CACAT(A/G)TACAC intron-variant
rs1000050244 -- 159,869,602(+) TGATT(C/T)GAAAC intron-variant
rs1000054858 -- 159,880,291(+) AAAAA(A/C)TGTTT intron-variant
rs1000070654 -- 159,835,324(+) TACTT(A/G)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LY75 Gene

Variant ID Type Subtype PubMed ID
dgv1176e212 CNV loss 25503493
esv1275142 CNV insertion 17803354
esv1586275 CNV insertion 17803354
esv1681534 CNV deletion 17803354
esv2358013 CNV deletion 18987734
esv2665197 CNV deletion 23128226
esv2721034 CNV deletion 23290073
esv3893504 CNV loss 25118596
nsv1010774 CNV gain 25217958
nsv1116803 CNV deletion 24896259
nsv437546 CNV loss 16327808
nsv470497 CNV loss 18288195
nsv834436 CNV loss 17160897

Variation tolerance for LY75 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.13; 97.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LY75 Gene

Human Gene Mutation Database (HGMD)
LY75
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LY75

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY75 Gene

Disorders for LY75 Gene

MalaCards: The human disease database

(7) MalaCards diseases for LY75 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lipid pneumonia
  • exogenous lipoid pneumonia
hodgkin lymphoma
  • hodgkin's lymphoma
atrial septal defect 1
  • atrial heart septal defect 1
atrial septal defect 2
  • atrial heart septal defect 2
adenoiditis
  • chronic adenoiditis
- elite association - COSMIC cancer census association via MalaCards
Search LY75 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LY75

Human Genome Epidemiology (HuGE) Navigator
LY75
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LY75
genes like me logo Genes that share disorders with LY75: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LY75 Gene

Publications for LY75 Gene

  1. cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells. (PMID: 9553150) Kato M. … Hart D.N.J. (Immunogenetics 1998) 2 3 4 22 64
  2. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (PMID: 12824192) Kato M. … Hart D.N.J. (J. Biol. Chem. 2003) 3 4 22 64
  3. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. (PMID: 10980384) Guo M. … Steinman R.M. (Hum. Immunol. 2000) 3 22 64
  4. Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. (PMID: 11058570) Kato M. … Hart D.N. (Int. Immunol. 2000) 3 22 64
  5. The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family. (PMID: 9862343) McKay P.F. … Ritter M.A. (Eur. J. Immunol. 1998) 3 4 64

Products for LY75 Gene

Sources for LY75 Gene

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